Alli Alternatives Compared
| Alli (orlistat) | Wegovy (semaglutide) | Semaglutide |
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| Alli (orlistat) | Wegovy (semaglutide) | Semaglutide |
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Over-the-counter
Prescribed for Weight Loss (Obesity/Overweight). Alli may also be used for purposes not listed in this medication guide. |
Prescription only
Prescribed for Weight Loss (Obesity/Overweight), Cardiovascular Risk Reduction, Nonalcoholic Steatohepatitis. Wegovy may also be used for purposes not listed in this medication guide. |
Prescription only
Semaglutide (Ozempic, Rybelsus) lowers blood sugar levels by mimicking the effects of GLP-1, a naturally occurring hormone that stimulates insulin secretion and lowers glucagon secretion from the... View more |
Related suggestions Weight Loss (Obesity/Overweight)
Popular comparisons
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| More about Alli (orlistat) | More about Wegovy (semaglutide) | More about Semaglutide | ||||||||
| Ratings & Reviews | ||||||||||
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Alli has an average rating of 6.3 out of 10 from a total of 122 ratings on Drugs.com. 51% of reviewers reported a positive effect, while 30% reported a negative effect. |
Wegovy has an average rating of 7.6 out of 10 from a total of 530 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 15% reported a negative effect. |
Semaglutide has an average rating of 6.9 out of 10 from a total of 2783 ratings on Drugs.com. 56% of reviewers reported a positive effect, while 20% reported a negative effect. |
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| Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified. | ||||||||||
View all Alli side effects |
View all Wegovy side effects |
View all Semaglutide side effects |
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| Drug Class | ||||||||||
| Generic Availability | ||||||||||
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N/A |
N/A |
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| Pricing and Coupons * Prices are without insurance | ||||||||||
View all Alli prices |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
We could not find an exact match for this medicine. Try searching the Price Guide directly. |
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| Dosage Forms | ||||||||||
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N/A |
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| Brand Names | ||||||||||
| Other orlistat brands include: Xenical | Other semaglutide brands include: Ozempic, Rybelsus | Ozempic, Rybelsus, Wegovy | ||||||||
| Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value. | ||||||||||
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13.5 hours |
168 hours |
168 hours |
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| CSA Schedule 1 View glossary of CSA terms | ||||||||||
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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| Pregnancy Category | ||||||||||
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Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
Summary unavailable. See the full pregnancy warnings document. |
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| Drug Interactions | ||||||||||
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A total of 145 drugs are known to interact with Alli:
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A total of 275 drugs are known to interact with Wegovy:
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A total of 275 drugs are known to interact with Semaglutide:
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| Alcohol/Food/Lifestyle Interactions | ||||||||||
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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| Disease Interactions | ||||||||||
| First Approval Date | ||||||||||
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February 07, 2007 |
N/A |
December 05, 2017 |
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| WADA Class View classifications | ||||||||||
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N/A |
N/A |
N/A |
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| More Information | ||||||||||
| Patient Resources | ||||||||||
| Professional Resources | ||||||||||
| Related Treatment Guide | ||||||||||
1 The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.