Comparing Adriamycin vs Methotrexate
| Adriamycin Remove Adriamycin from your drug comparison | Methotrexate Remove Methotrexate from your drug comparison |
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| Adriamycin doxorubicin Remove Adriamycin from your drug comparison | Methotrexate Remove Methotrexate from your drug comparison | ||||||||||||||||
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Prescribed for Breast Cancer, Bladder Cancer, Acute Lymphoblastic Leukemia, Neuroblastoma, Thyroid Cancer, Stomach Cancer, Soft Tissue Sarcoma, Ovarian Cancer, Osteosarcoma, Lymphoma, Multiple... View more |
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
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Prescription only |
Prescription only |
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Ratings & ReviewsRecent helpful reviews |
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6.6
For Breast Cancer: Adriamycin made me really weak and I had to have blood transfusions. I had 4 doses. I'm coming up on 3 years cancer free so I think it worked well. I'm concerned about the long term side effects. |
6.7
For Rheumatoid Arthritis: I had taken MTX in past but it did not work out for me due to rash proplem caused by MTX so Doctor recommended Sulfasalazine and it worked out very good for about 4 years but the end of friendship came to us...Sulfasalazine was not effective anymore. I met a Doctor who practice natrual madicine also ER Dortor at the local hospital....He recommended 3 natrual Supplements for RA and pain( Turmeric, Wobenzym N, White Willow) and they are very effective (on me) and it is better than Chemical based medications. I have been off from those deadly medications for 5 months now. For Rheumatoid Arthritis: I have been on 15mg then 20mg for two years. Then developed constant explosive diarrhea, dizziness, and confusion. Judged to be allergic, and told to stop the medication immediately. The symptoms continue...how long before it gets better? I am not taking anything for RA right now after a week off methotrexate. |
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Drug Class |
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Side Effects |
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Common side effects include: severe nausea and vomiting, nausea and vomiting, and alopecia. See the full Adriamycin side effects document. |
Commonly reported side effects include: increased liver enzymes. See the full methotrexate side effects document. |
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Pricing and Coupons* Prices are without insurance |
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View all Adriamycin prices and generic prices |
View all methotrexate prices |
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Generic Availability |
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Yes (this medicine) |
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Dosage Form(s) Available |
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Brand Names |
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| Other doxorubicin brands include: Adriamycin PFS, Adriamycin RDF | Methotrexate LPF Sodium, Otrexup, Rasuvo, RediTrex, Trexall, Xatmep | ||||||||||||||||
Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. |
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30 hours |
12 hours |
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CSA Schedule**View glossary of terms. |
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Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category |
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Category D
Positive evidence of risk
See the full Pregnancy Warnings document. |
Category X
Not for use in pregnancy
See the full Pregnancy Warnings document. |
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FDA Alerts |
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N/A |
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Drug Interactions |
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A total of 476 drugs are known to interact with Adriamycin:
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A total of 589 drugs are known to interact with methotrexate:
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Alcohol/Food/Lifestyle Interactions |
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No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider. |
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Disease Interactions |
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First Approval Date |
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N/A |
December 07, 1953 |
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WADA ClassView World Anti-Doping Agency classifications. |
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N/A |
N/A |
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More Information |
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Consumer Resources |
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Professional Resources |
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Related Treatment Guide |
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
For Breast Cancer: I did not experience any side effects, but based on a clinical trial result, I walked at a brisk pace for an hour most days to avoid cardiotoxicity.