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User Reviews for Zonegran to treat Migraine Prevention

Zonegran has an average rating of 7.2 out of 10 from a total of 18 ratings for the treatment of Migraine Prevention. 50% of reviewers reported a positive effect, while 11% reported a negative effect.

Zonegran Rating Summary

7.2/10 average rating

18 ratings from 20 user reviews.

Compare all 59 medications used in the treatment of Migraine Prevention.

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Reviews for Zonegran

Still Looking January 4, 2012

“I've been taking Zonegran for a few years now at 300mg per day. It had really gotten my headaches under control to where I would only have a headache periodically. Weight loss has been a side effect that I haven't minded. The problem is I've had significant memory and focus issues. I hardly felt competent most of the time. I have slowly weened myself down to 100mgs per day (I notified my neurologist of this because its an anti-seizure medicine so you shouldn't stop it cold turkey or it could cause a seizure). My memory has improved significantly, but the headaches have returned with a vengeance. I'm back to taking narcotics to address each debilitating headache. I used to take Topamax. It too worked beautifully, but also wiped out the memory.”

9 / 10
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Tara h. December 8, 2016

“Well it all started with dizzy spells that got so bad I couldn't even stand up. I was in the hospital for almost 24hr. They had no idea what was wrong. They suggested I see a neurologest ASAP. After making the appointment to see who they suggested, I wouldn't be able to see them for 4months. So I reached out to my family. They said to see a headache specialist. That sounded crazy to me at first. After meeting this new Doctor the same day I called him. He put me on Topamax I believe it was called, which I had almost every side effect from. So he decided to put me on zonegran small doses and work my way up. This medicine is amazing. I have no side effects at all and no more migraines for about a year now.”

9 / 10
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What memory January 12, 2014

“I took Topamax for a while and it worked wonders but the side effects were insane. However, the zonesamide works very well for preventing my migraines. I take 400 mg a day. Word finding and memory, I don't even know what those are anymore. However, I was living in constant pain. Nothing was working for me. This is the only thing that has done anything for me in years.”

7 / 10
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Zonegran User March 30, 2011

“I have used Zonegran for headaches only. It is the only thing that seems to have lessened them somewhat, but I still have headaches and they affect me cognitively. I'm mentally slower, have word-finding problems, my memory is bad, and my attention is terrible. I've tried to go off it on occasion, but my headaches get absolutely awful, so I stay on it.”

6 / 10
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James_D · Taken for 1 to 6 months January 5, 2016

“I was taking 6-8 Excedrine Migraine daily to control my headaches. I saw a neurologist and was put on Zonegram. It took 1 month to build up to 100 mg per day. I was headache free after 2 months and have been that way for 3 months now. I will step down from the pills in 6 months. No side affects for me at all .”

10 / 10
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Steve_pain November 26, 2014

“I have been given many different diagnosis (Hemicrania continua, primary trochlear headache, Atypical Trigeminal Neuralgia) currently I have migrainous type chronic headache with Atypical Facial Pain. I was on 300 mg Topamax with a bunch of other stuff and this helped, but I couldn't add 2 2. It was like north pole magnets coming together. Now I have been on 200mg Zonisamide (Zonegran) for about 2 years and I have a 50% reduction in pain. As for cognitive impairment, I can live with the loss of spelling and reduced vocabulary. It's not that bad compared to either the pain or Topamax.”

9 / 10
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BLove01 March 18, 2016

“I took 300mg of zonegran for nearly 2 years. It worked really well to prevent my migraines at the start--it was like a dream come true. I did experience appetite reduction and weight loss, but I put it back on after about a year. The negative side effects were extreme for me over time. First, my depression got much worse. That could have been external factors, but the time that I started taking Zonegran and the severe increase in my symptoms match. Also, after some time, I noticed my cognitive function was severely inhibited. I was in graduate school at the time and began failing classes, slurring my words when 100% sober, and unable to remember things. When I went off, my migraines returned severely, especially period and allergy migraines”

7 / 10
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HeadacheFree28 February 26, 2017

“In the past, I had been given all types of medicines for migraine prevention and by far Zonegran has been THE BEST. I've had very few side effects that I can notice. The number of headaches that I normally have are decreased tremendously! I can really tell when I miss doses of the medication because the headaches come back full force but once I get the medicine in my system again, everything is all good! If you haven't tried Zonegran, PLEASE DO!”

9 / 10
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Brittani31 · Taken for 6 months to 1 year November 29, 2016

“For Migraine Prevention Ive tried amitriptyline, Imitrex, propranolol ,Fioricet & Topamax and for a while and they worked but the side effects were insane. However, the zonesamide works very well for preventing my migraines. I take 300 mg a day. Word finding and memory, I don't even know what those are anymore. However, I was living in constant pain. Nothing was working for me. This is the only thing that has done anything for me in quite some time, so do I walk around with a child like mind or not be able to get out of bed because of the pounding migraines?!?”

3 / 10
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Chris · Taken for less than 1 month March 29, 2021

“Zonegran (zonisamide) did ease my chronic migraine but about 10 days after starting 100mg/day, I developed 'acute myopia,' which means I essentially lost my vision over the course of about 24 hours. Thankfully my vision returned a few days after stopping the drug. An ophthalmologist examined me and there is no long-term damage. If you try Zonegran, please watch for changes to your vision and call your doctor immediately should you notice any changes at all.”

2 / 10
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Meemfelds · Taken for 1 to 6 months May 19, 2017

“The medication worked well to prevent migraines. However after one month of use I developed joint pain/swelling and a rash. It was determined I had drug induced lupus and the medication was discontinued.”

5 / 10
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Sarah · Taken for 1 to 6 months March 3, 2020

“I woke up one day with a feeling that I was rocking in a boat, severe head pressure, and nausea. This lasted 3 months until my neurologist prescribed this medication for migraines. It made me feel like I could live my life again. I do get a little forgetful on it but it is worth it to not have my migraines and constant dizziness.”

8 / 10
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Holly19 · Taken for 1 to 6 months February 14, 2018

“I just turned 19 and I've seen 3 neurologists, 4 neurosurgeons, and a epileptic specialist all in the last 6 months. None of them can really tell me what’s wrong with me but Zonegran has helped a lot with the hard hitting headaches. I still get dull “I can feel it” headaches almost everyday but nothing compared what I used to get. I don’t get any major side effects, sometimes I slur or jumble worlds but I can recover them quickly, if I take it on an empty stomach my thought process is cloudy but nothing major. Also, I was normal weight before but I’ve lost 15 pounds since I started this medication 3 months ago.”

8 / 10
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Anonymous June 9, 2018

“I have been taking zonegran for migraines for about a month. It has helped tremendously. Unfortunately the past few days my eyes have been in so much pain. And that is causing my head to hurt. I am wondering will this side effect go away?”

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Ashlee · Taken for 1 to 6 months September 9, 2021

“I started using Topamax and had a full body reaction so my neurologist switched to Zonegran. I have been taking 300mg for awhile and I no longer have migraines but I now have acne that I have never experienced before. It’s starting to get so bad that I’ve considered stopping this medication. Aside from the acne, it really does help with the migraines.”

7 / 10
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Migrainemiss August 21, 2016

“I have been taking 100 mg of Zonegran daily for about a month, and have noticed a reduction in the amount and severity of my migraines.”

8 / 10
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Anonymous · Taken for 2 to 5 years October 25, 2012

“I don't notice any side effects compared to some of the other anti-seizure medicines.”

9 / 10
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Anonymous March 19, 2011

“I just got put on this medication for migraines. I took Topamax in the past but side effects were way too much for me.”

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Anonymous November 28, 2011

“On 50 mg and have seen a huge improvement in my migraines. Down to 5 per month.”

7 / 10
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Anonymous · Taken for 1 to 6 months March 11, 2019

“Zonegran works great for my pain but I am so tired ALL THE TIME. I'm getting off of it soon I can't handle it anymore.”

7 / 10
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This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare professionals.