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Zoledronic acid for Osteoporosis User Reviews

Brand names: Reclast, Zometa, Aclasta

Zoledronic acid has an average rating of 4.9 out of 10 from a total of 239 reviews for the treatment of Osteoporosis. 34% of reviewers reported a positive experience, while 45% reported a negative experience.

Zoledronic acid rating summary

4.9/10 average rating

239 ratings from 284 user reviews.

Compare all 132 medications used in the treatment of Osteoporosis.

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Reviews for Zoledronic acid

  • active...
  • September 3, 2020

Reclast (zoledronic acid) "I am 73 years old and had my first infusion of Reclast two weeks ago. I fought doing this for the past three years. I had been on Fosamax for over 10 years but went off it over 7 years ago when I had some questionable side effects (jaw and chest pain) that could not be explained as coming from any other medical problem. My dexa scans had been getting continually worse (now -2.8) and a rheumatologist told me I really did not have a choice - I needed to do SOMETHING, so I relented. I followed all the recommendations about drinking a lot of water and taking Tylenol. I am elated to report that I had no ill side effects - not one! I've been able to continue my daily walking regimen without any problems. I am writing this review in the hopes that it might encourage others who might be terrified as I was after reading so many horror stories. I am hoping that after another dose my next scan in two years will show some improvement."

10 / 10
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  • Wendy
  • August 16, 2020

Reclast (zoledronic acid) "I am 71 years old with a Dex of -2.9. I just got my 1st Reclast infusion this past Thursday (Aug 13, 2020). I was petrified walking in the door. I made sure I followed all the prep instructions they gave me. I drank more water than normal, and took Calcium with D3 (x2 times a day) 1 week prior. 2 days before, I started taking extra-strength pain reliever (2) once a day. The day of infusion, I took 2 pain pills 2 hours prior, and drank a lot of water (64 oz). These 2 things I believe are the key (water and pain pills). The infusion was simple and easy. After, I felt no pain or confusion. It is now Sunday, 3 days later and I feel exactly as I did on the first day. I have drunk a total of about 60 oz of water a day, and taken the maximum dosage of pain relievers a day for the first 2 days. They say we might feel flu-like symptoms for a few days, I only feel a little tired. No fever either. I wish you the best."

10 / 10
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  • First...
  • April 23, 2020

Reclast (zoledronic acid) "I am 51 years old with no health issues, and had my first Reclast infusion one week ago. After the 10 am procedure, I felt ok until the evening, at which time I developed a 101-degree fever, chills, elevated pulse, headache, nausea, vomiting, and diarrhea. I did not take Tylenol or pain relievers of any kind, either before or after the procedure, although most of you will be advised to do so (as was I). By the next morning, I felt much better, but definitely not back to normal. But felt increasingly better as the day progressed, to the point that in the afternoon, I was able to resume my weightlifting and walking routine. By the next morning, I was back to 100%, feeling wonderful and eating well. I have felt great ever since. I hope this post will make you feel better if you have a bad first night. Hang in there, my prayers are with you!"

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Frequently asked questions

  • Mcme
  • Taken for 6 months to 1 year
  • June 2, 2020

Reclast (zoledronic acid) "Short & sweet - Never, ever again will I take this drug. This knocked me on my butt and took everything out of me for several days. The worst headache I've ever had in my life (could not even open my eyes it hurt so much), excruciating bone pain (pain you don't understand unless you've experienced it), fever, severe weakness, etc. My doctor was extremely vague and aloof. When I called to explain what I was experiencing and asking if I should go to the hospital because seriously I thought I was dying, he was so callous and unsympathetic and just said 'yeah, those are side effects, just take Tylenol'. It's been a year and I still have negative effects of this drug! Awful experience!"

1 / 10
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  • the...
  • Taken for less than 1 month
  • August 29, 2020

Reclast (zoledronic acid) "I had my first infusion on August 27, 2020. I had an appointment on August 25, 2020, with my primary care doctor. I was diagnosed with osteoporosis recently. I'm 64 years old. She told me this was the same medicine that the oral was. I tried the oral for a few months, but it made me severely constipated. So I asked what the side effects were, and she says constipation, lol. She didn't mention the preparation before receiving the infusion. Six hours later, the body aches and fever started. Then the nausea started. Then the vomiting. My highest temperature was 103. Taking Tylenol helped bring down the fever some, but after it wore off, it would come back. Today, my bones hurt so bad I can hardly move. My ribs hurt to the point I feel like they are broken. I'm not sure I want to go through this again."

1 / 10
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Are you taking this medicine?

  • Konas...
  • Taken for 6 months to 1 year
  • May 29, 2020

Reclast (zoledronic acid) "Just completed a full year after my Reclast dose in May 2019. Very, very important to follow instructions for dosing Reclast! Water and Acetaminophen (Tylenol) will be your best friend. I messed up after my dose. I felt fine with the pain meds in my system, and as the day progressed, I decided not to continue with pain meds. Very bad idea! That night I felt like a freight train had hit me and then ran over me. I had to get up in the middle of the night and start the Acetaminophen again. It took a while, but it finally kicked in and I was back to normal. Lesson learned, follow your doctor’s orders! I did find out that my bone density improved significantly, so I am very pleased with the whole situation."

10 / 10
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  • KAano
  • August 15, 2019

Reclast (zoledronic acid) "After reading all the bad experiences of Reclast, I almost canceled my appointment. But there were positive comments too, so I did it. I made sure to drink lots of water. I was floating when I got there. It took about 45 minutes, and the people were very nice. It's been 4 days, and I've had no reaction at all. So that's my experience. Hope it eases some fears."

10 / 10
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  • Gail
  • August 23, 2020

Reclast (zoledronic acid) "I’m a 63 year old woman who had my first reclast infusion on August 6th. So I’m 17 days out. Today I’m experiencing the worst joint pain in my legs, hips, arms and the worst is in my neck. It seems like it is progressively getting worse. I’m trying so hard to remain hopeful that this disappears. It’s very hard to get out of bed each morning. Also, I was one that the flu-like symptoms hit me hard at midnight right after I had the infusion. Worst chills ever. Couldn’t control them. My husband thought I was having convulsions. Fever spiked to 103.7. Those symptoms were gone after 3 days. But, the joint pain is more than awful. I’m looking to hear from someone with the same symptoms that the pain actual went away after awhile. Don’t know if I can do this again. I had been on Prolia and it didn’t work as the doctor expected."

2 / 10
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  • rshelin
  • Taken for less than 1 month
  • June 9, 2021

Reclast (zoledronic acid) "I am a 59 yo male with a L spine T Score of -3.9. I had ignored my osteoporosis for many, many years until I felt that I had no choice to do something. As a radiologist, I have seen many a spine with osteoporosis and multiple compression fractures that significantly reduce quality of life so I took the risk. I hydrated prior to infusion but did not immediately take NSAIDs. What a mistake. 8 hours after infusion (3 AM) I started to have severe, uncontrollable rigors (shaking chills) and diffuse bone and muscle pain that I have never experienced before. As a reference point, I fractured my right pelvis years before in the Navy and I know what pain is. Fever and chills improved with NSAID (first tried Tylenol and may switch to Naprosyn. The pain is still severe. The other testimonials are scary but I also know that there is no free lunch in medicine. Everything we do is a balance between what helps and what does not."

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  • Usually...
  • July 10, 2021

Reclast (zoledronic acid) "I am 64 and received my first reclast infusion on June 21st to treat osteoporosis. I was careful to hydrate well and didn't develop any flu symptoms. My problems started the third day when I developed extremely severe eye pain. After 4 1/2 hours in Urgent care and multiple tests, the physician didn't think it looked like a typical reclast reaction, but had no other explanation. A few days later my eye recovered, but then my hands swelled up. Fortunately, this resolved also, but then came the knee and joint pain. I suddenly have horrible knee bursitis for the first time in my life, and tendonitis in my ankles. My doctor thinks perhaps I'm dealing with some sort of auto-immune problem. I am now 18 days post-infusion, and I can barely walk or even get up out of a chair. Sheesh."

2 / 10
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  • Pione...
  • February 2, 2020

Reclast (zoledronic acid) "I was told IF I had any side effects it would probably take about a week and then it would be flu-like symptoms. I had the infusion about 3pm on a Tuesday and the side effects started about 8:30pm that night. It attacked my muscles and locked up my neck, hips, arms and legs. I have never felt such excruciating pain in my life. I ran a low grade fever. I vomited a couple of times. I drank a lot of water but was unable to urinate. I could barely walk, raise my arms or move. It is now Sunday and I am still suffering with pain and stiff muscles. My doctor could not tell me how long this will last. I'm taking a steroid RX now. This has completely drained me of all energy, I have no appetite and what I do eat doesn't taste good. I pray I do not have long lasting muscle pain from this. On a scale of 1 to 10, on day 5, I'm at a 5-6 pain level. I am working, active 62 year old woman who was brought to her knees with this drug. I will never take this drug again."

1 / 10
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  • Pam
  • Taken for 1 to 2 years
  • February 28, 2021

Reclast (zoledronic acid) "I have severe osteoporosis. When I was about 56, my internist told me I needed Reclast which was relatively new. I tolerated it well and had another infusion the next year. Because my deductible went up, I neglected getting my infusions after that. I am now 67. Last year my lumbar bone density was -4.5. I asked my doctor to order Reclast for me since I had it in the past. Again, I tolerated it well. It has been a year since that infusion. I had a bone density test 2 days ago and my lumbar spine increased 6%! I also had an increase in one of my hips which took me from -2.5 (osteoporosis) to -2.4 (osteopenia). I will be having another Reclast infusion this week. I am anxious to see what results I get next year. I started lifting light weights 4 months ago. I hope all of you having a negative reaction find a medication you can tolerate."

10 / 10
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  • Anonymous
  • June 29, 2020

Reclast (zoledronic acid) "I had my first infusion of Reclast in early March 2020. Within a day I was in the ER. I suffered greatly with nausea, vomiting, extreme bone pain and fever. The fever, loss of appetite, fatigue, malaise and other symptoms lasted for 21 days. My rheumatologist was beside herself with worry yet very helpful and compassionate. I could not eat more than toast and soup and kept a thermometer and Tylenol at bedside to treat the recurring fever. By the way I tested negative twice for Covid-19 with a negative antibody test so coronavirus was excluded as the cause. Please do your research when deciding on an osteoporosis drug. I cannot rate the effectiveness until my next DEXA scan in 2021. But in the words of my doctor, "never, ever again will you receive Reclast.""

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  • Beach...
  • Taken for less than 1 month
  • January 24, 2020

Reclast (zoledronic acid) "This is my 4th reclast infusion and all 4 were completely uneventful. No side effects whatsoever. Everyone is different so keeping this in mind don't let some of the negative stories scare you away from treatment."

7 / 10
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  • Anony...
  • February 7, 2021

Reclast (zoledronic acid) "This is the story of my nightmare with a reclast infusion. First I was a very active 59 year old female, I was only on an acid reflux medication. The infusion was done in August 2020. Two weeks later I started having all kinds of problems. This should not have been recommended to me due to my pre-existing conditions. Which my medical professional was aware of. I weighed 115 lbs. @ 5'2". I now weight 80 lbs. This has destroyed my health and my life. I want my life back."

1 / 10
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  • MeMe
  • Taken for 1 to 2 years
  • July 1, 2020

Reclast (zoledronic acid) "I’m 64 years old and had my first Reclast infusion May of 2019 after decreasing bone mass although trying several different medications. I drank at least 32 ounces of water the day before and 16 oz the morning of. I was not given any instructions but lucky enough to look it up online prior to. I had no side affects what so ever. I’m now on my second Reclast 6/2020. 20 hours later so far so good. I’ll reposts if this changes."

8 / 10
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  • CLM
  • Taken for less than 1 month
  • August 1, 2020

Reclast (zoledronic acid) "I had my first Reclast infusion on July 27. Today is August 1. I was very nervous after reading all of the negative reviews. I drank around 40 ounces of water the day before and about 20 ounces the morning of the infusion. When I arrived they gave me fluids for about 20 minutes and then the infusion for another 20 minutes. The infusion was uneventful. So far I have not had any of the negative side effects others have mentioned. Praying it helps my bones!"

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  • Latinlo
  • Taken for less than 1 month
  • April 15, 2021

Reclast (zoledronic acid) "The Dr never explained to me the adverse effects of this drug. I had a slight fever and severe joint pain, a headache worse than the covid19 vaccine. It is now 20 days since I had it and the severe joint pains still persist. I am very upset because they did not prepare me for it, now I have to take Tylenol when I had never done it in addition to vitamin D and calcium, also my platelets were high. Dr. says he does not know if the combination between the covid19 vaccine and this, is the problem and they claim has to do with it. Anyway t I still have bone pains .. ..The medicine came out worse than the disease !!! .."

4 / 10
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  • MAW
  • Taken for less than 1 month
  • April 8, 2021

Reclast (zoledronic acid) "I had a Reclast infusion 10 days ago. I had flu like symptoms for a two days and femur and pelvic pain one day. Thought I was past it. On day day 8 I woke up with swelling in my hands, knees and thighs. I cannot bend my leg to kneel with very bad pain. I’m 72 and very active. I easily do yoga, Pilates and Qi Gong. Currently walking like a 90 year old. I’m fatigued and in pain. It’s significantly interfering with my daily activities. Very fatigued. I drank water as instructed. Currently have a call into my rheumatologist"

1 / 10
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  • Kurt...
  • Taken for less than 1 month
  • February 21, 2020

Reclast (zoledronic acid) "I have -3.5 spine osteoporosis, am 76 years old, was reluctant to get the reclast infusion but finally decided to receive it on Feb 12. I hydrated with more than 64 ounces of water for 2 weeks before the infusion and took 2000 units of Vit D and consumed 1200 mg of calcium daily. Received the infusion over 40 min. The next day was nauseous, second day back and leg pain. Minor inconvenience."

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  • Cat
  • Taken for less than 1 month
  • March 8, 2020

Reclast (zoledronic acid) "I had my first Reclast infusion one week ago. The night before the infusion and for 3 nights after, I took loratadine (Claritin). The day of the infusion I drank a lot of water, took electrolytes, and 500 mg Tylenol. I asked that the infusion be given over 60 minutes rather than 30 minutes, and that was done. I had some fatigue and minor muscle aches for a few days afterwards, but no other side effects."

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  • Leigh
  • Taken for 1 to 2 years
  • February 25, 2020

Reclast (zoledronic acid) "My first infusion with Reclast was rough. Side effects lasted 2-3 weeks. I already have Psoriatic Arthritis, and a high tolerance for pain. But I was so sick with pain and nausea, I dreaded the next treatment. 6 days ago, I did it again, believing the side effects would be less. They aren’t. I can hardly get out of bed. All my bones and joints ache. I ran a low grade fever the first 2 days and vomited. I feel like I have shin splints and all I want to do is sleep. I know the medication works, but for some of us, it’s terribly difficult."

4 / 10
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  • SAN
  • Taken for 1 to 6 months
  • May 12, 2024

Reclast (zoledronic acid) "I received my first injection mid-March this year. I have had no unpleasant side effects since. I am hoping this drug will help me, and my next DEXA scan will be better than what I saw in December 2023. I was on Fosamax for two years previously, and very little change to my bone density. I am 75, and my last 2 DEXA scans showed osteoporosis."

10 / 10
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  • B Du ...
  • Taken for 2 to 5 years
  • December 5, 2019

Aclasta (zoledronic acid) "I had Aclasta once a year 2012 - 2015 due to osteoporosis - Worst mistake I ever made! I have daily incapacitating and severe joint, muscle and back pain, cannot have a tooth extracted due to osteonecrosis of the jaw (as per the maxillo facial surgeon), my vision became blurred almost immediately after The first session ... my life is no longer my healthy happy life and I have to endure rhizotomies (Which have not helped one bit) because of the back pain. Walking is painful. Shoulders are messed. There is no antidote for this drug either! This was not something we are told beforehand ... we are still deciding to join a class action against the company that manufactures this drug KNOWING what the aide effects are! We would NEVER have said yes! Do your research guys! Bev - South Africa"

1 / 10
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  • Keebler
  • Taken for less than 1 month
  • April 28, 2020

Reclast (zoledronic acid) "I am a 58 year old woman, and yesterday afternoon I had my Reclast Intravenous Procedure done for the first time. I drank plenty of water (64 oz) the day before, and drank more water (32 oz) the morning of. I took two (2) Extra Strength Tylenol one hour prior to the Procedure. The nurse first administered the Saline and then the Zoledronic Acid (RECLAST). I was also given juice to drink during this time. The whole process took about 40 minutes. I continued to drink plenty of liquids the rest of the day and took two (2) more Extra Strength Tylenol 4 hours later. So far, I have only felt a little tired and slightly achy. I am continuing to drink plenty of water as recommended, and hopefully all is good from here out!"

9 / 10
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Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

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