Trintellix and Nausea: What Users Say (Page 5)

• GTL...
• Taken for 1 to 6 months
• April 9, 2020

For Major Depressive Disorder "I've tried citalopram, Effexor, Wellbutrin SR and XL, and Trintellix for anxiety issues, but all seemed to cause more anxiety and added depression than I had before I started taking them. Every time I stop taking them, I feel significantly better. Other negative side effects for Trintellix specifically included nausea (I had to stop eating specific foods, and because I was taking the medication with water, I felt sick every time I drank it throughout the day), lower sexual appetite (significantly, it was affecting my relationship), and lack of focus (I'm honestly lucky that I didn't lose my job the week before I stopped taking them). I know I've had anxiety my whole life, but the more I observe my issues, I'm fairly certain that the majority of my anxiety is caused by ADD."

• Cha...
• Taken for less than 1 month
• August 28, 2019

For Major Depressive Disorder "Will probably update later when I’ve been on longer, but so far it’s been very helpful. I’ve been on several antidepressants over the last decade (only one has ever worked and had to be discontinued due to worsening side effects) and had no problem getting approval from insurance. I started on 5 mg for a week and had slight nausea on days 2-5 a couple of hours after taking with food that lasted about 20-30 minutes. I’ve been on 10 mg for a week and no nausea. It’s actually improved my IBS. Appetite has been the same. My depression symptoms mainly manifest as fatigue/exhaustion, brain fog, forgetfulness, lack of motivation. I feel great, I’m motivated, I’ve been working out, getting more done at work and at home, sleeping less (now I’m sleeping more like 8 hours instead of 10-12). My out-of-pocket is $100 for a 30-day supply of 10 mg, I’m looking into bringing the cost down, but if I can’t it’ll be well worth it for how good I feel."

• Gai...
• Taken for less than 1 month
• October 30, 2018

For Depression "I’d been on Cymbalta for 3 years after taking every antidepressant up till now. I thought my depression was situational (marriage and financial issues), but as those things resolved, my depression was still intense. My psychiatrist told me how great Trintellix is, but to avoid side effects, he had me titrate starting with 5 mg Trintellix and decreasing Cymbalta 10 mg every week. Last week I finished my Cymbalta and now taking 10 mg of Trintellix. I haven’t had any stomach/nauseous side effects, but I do have difficulty falling asleep and have the most intense dreams ever, and although I sweat a lot with Cymbalta, I sweat all the time now. I’m not sure if Trintellix is working, although it’s only been a week. But I cry at the drop of a hat; I mean sobbing. Anyone feel or felt like that early on?"

• Tas...
• February 7, 2016

For Depression "So far, it has been a little over a month and a half on 5 mg for my depression and constant ups and downs. I have bipolar disorder, PTSD, anxiety, and depression. Of all the meds, this has helped tremendously, with only nausea as a side effect. I eat toast and peanut butter, and it seems to help. I feel like myself again, with better concentration, more energy, and I'm smiling again. This honestly saved my life with the help of other meds that I am on!"

• Tra...
• Taken for 6 months to 1 year
• September 6, 2017

For Major Depressive Disorder "I've been on Trintellix 20 mg for 10 months, 53-year-old female with long-standing, chronic MDD and anxiety since pre-teen years. Been on far too many antidepressants over the decades to list them all here. Been hospitalized a number of times, and in my 30s, resorted to ECT as a last resort, which did absolutely nothing. My psychiatrist says my MDD is very treatment-resistant. Antidepressants, even in high doses or combined, have no effect. But I do believe for once in my life, the Trintellix is making some difference for the better in me; it hasn't been a 'miracle' drug, but it does help! No nausea or side effects, either! Also on Xanax, trazodone for sleep, and 10 mg Adderall daily."

• Anonymous
• Taken for 1 to 6 months
• March 5, 2014

For Depression "I have been on Trintellix for nearly six weeks. I experienced severe nausea for the first 10 days, but thankfully it subsided after that time. The medicine has mellowed me out, but I still feel very zoned out, tired, and listless. I don't have the same 'joy' for life with this medicine that I experienced on another antidepressant in the past. My major concern is an increase in blood pressure. I am an extremely healthy 35-year-old female whose blood pressure has ALWAYS been 110/70. Since starting this medication, my blood pressure has gone from 110/70 to 120/82, then 139/74, and now 149/80. Nothing has changed in the past six weeks other than the addition of the medicine. I'm hoping to find something that is going to work soon."

• Lea...
• Taken for 1 to 6 months
• February 12, 2020

For Major Depressive Disorder "After 2+ months on Trintellix (10 mg), I am weaning myself off as quickly as possible. The side effects have been almost unbearable for me and my family. Daily feelings of nausea and frequent vomiting were bad enough, but the significant irritability and difficulty getting a deep breath were increasing and were the final straw for me! I ended up in the ER 3 weeks ago because I was struggling to get a deep breath. After thorough testing, it was determined nothing was wrong. A deep search on Trintellix side effects made it clear the problem was this medication. I am now taking it every other day until next week when I meet with my doctor. I hope no one else responds to this drug as badly as I did! Take care! I definitely received no improvement in my depression and only major side effects that I can't live with."

• Cle...
• Taken for less than 1 month
• September 18, 2018

For Depression "I’ve been on this for a week and a half. So far, I feel an increase in energy. Pros: I’m much more productive and outgoing than normal. I now feel like I have things to look forward to in life. Cons: a bit of nausea, gas (eek) that is definitely the worst side effect."

• BoK...
• Taken for 1 to 6 months
• February 23, 2016

For Depression "Male, age 50, in good shape. I was prescribed this stuff for what I call 'brain fog,' which I was experiencing three to four times per month and lasted a minimum of 24 hours. Also for attention span, which has been limited as of late. I am on 20 mg once a day and graduated up from 5 mg a day over 5 weeks. The first week I experienced some very slight dizziness and slight nausea. Nothing that I would describe as trying or difficult. At about week 3, I started to notice an increase in attention span. After 2 months, I have not had one brain fog episode. I have not noticed a change in mood, though I was not/am not depressed. I will say I am having some of the best orgasms of my life - and I have been on Wellbutrin, which does not compare!"

• Nik...
• Taken for less than 1 month
• October 5, 2014

For Depression "In the beginning, I only had a problem with itching. I kept thinking my body would get used to it and it would stop. It didn't, it only got worse. I wasn't experiencing any other severe issues, so I had planned to stay on it, but on Day 7, I noticed that I was having trouble finding my words, my vocabulary was impaired, and there was almost a stutter present. On Day 8, I became very nauseous and decided that would be my last day. The side effects were just too much to wait it out. Day 9, no medication, my husband told me that I seemed much more relaxed and 'involved.' I cannot wait for this itching to go completely away! I did seem to have a little more positive attitude and motivation, but the side effects were too much!"

• Dig...
• May 27, 2016

For Depression "I was on Brintellix for a short time while trying to transition from Lexapro. Unfortunately, it was just not the drug for me. I had terrible nausea that never went away, as well as vomiting. Brintellix didn't really do anything for my anxiety, either, and I definitely noticed symptoms of that again. By the time I stopped taking it, my depression was actually worse, but I think it didn't help that I was feeling so bad physically. If you already have digestive issues, this might not be the med for you."

• Con...
• Taken for 1 to 6 months
• September 13, 2019

For Depression "My Dr. began me on 10 mg of Trintellix on Aug 6. As of Aug 7, I vomited violently every morning and had diarrhea as well. Sometimes both at the same time. Nasty. Nausea persisted through the day, making eating virtually impossible until dinner time. By Aug 21, I was so irritable I became mean. I couldn't stop verbally berating my husband. It was awful. I began taking the pill at night to escape the GI side effects. I escaped the vomiting but still had gas, bloating, and loose stool. As of today, I still have nausea and loose stool. My Dr. increased my dose to 20 mg on Aug 29. I think it finally started working on Sept 12. I feel like 'me' again. Fingers crossed! As I live in Canada and have drug coverage through work, I am fortunate to not have to pay out of pocket for this med."

• Chr...
• Taken for 1 to 6 months
• September 6, 2022

For Depression "My anxiety was so bad I was having body twitches. After starting Trintellix 5 mgs, I started to see a significant decrease in the body twitching, and my mood was better, happier, more at peace. I had some nausea for the first two weeks, then it went away. I am now at 10 mgs once a day and have been on this medication for two months now. It’s a journey, and everyone is different, but don’t lose hope."

• ear...
• April 21, 2015

For Depression "I started on 5 mg, and after a couple of weeks didn't notice any changes and went to 10 mg. Been on the 10 mg for over a month now. I feel more calm and 'easygoing' now. I used to have panic attacks and anxiety, and those are gone. For those experiencing nausea: I also have a lot of nausea soon after taking the pill, but I now take it right as I go to bed, and I am not bothered by it at all. Mild headaches sporadically. Great alternative to what is on the market right now, especially for those with anxiety who don't want the sedation."

• Sun...
• April 22, 2017

For Depression "Day 1 on Trintellix. Have been on Zoloft for 1 1/2 years. It helped my PMDD immensely, but I started to feel like I was losing any emotions. Not sad, not happy either. Recently started to feel so blah that nothing I did brought me any joy, I could basically take it or leave it. I told my doctor that I wasn't sad, just wasn't feeling the 'zest' for life that I knew I should be feeling. He switched me to Trintellix. I was reading reviews on it last night, just to know what to expect, so I had anticipated the nausea after my first dose. And sure enough, about 15 minutes later, the wave of nausea hit me, and then I was off to the bathroom. I'm more than willing to get through the side effects in the beginning if it means feeling more like me again."

• Lyn...
• Taken for 1 to 6 months
• April 18, 2019

For Depression "I have been on Trintellix (5 mg) for about 4 months, and many days I feel better, but some days I feel suicidal. Not sure if it is the drug making me suicidal or if it is my depression. So I am debating, do I increase to 10 mg to see if the suicidal thoughts go away, or is it going to make the suicidal thoughts increase? The nausea is still pretty bad. Tums help, and I take the drug with food. Plus, I have IBS, so I am worried about getting pancreatitis. Drugs are so scary, and depression is so depressing, lol. What to do???"

• pro...
• Taken for 1 to 6 months
• November 18, 2014

For Major Depressive Disorder "I've been on Brintellix for just over 2 months, and it's helped my depression tremendously. I've been on several SSRIs, and this is far and away the best one I've tried. It kicked in a little faster, and the lack of side effects is remarkable. I was irritable when I increased my dose from 5 mg to 10 mg, but it subsided after a month, and I took Klonopin as needed to help. I also noticed some mild scalp tingling, which another person mentioned. No sexual side effects, no weight gain, no TMJ, no night sweats! I'd recommend titrating up SLOWLY if you have anxiety/irritability (cut those annoying egg-shaped pills in half) and taking it with a meal to prevent nausea."

• D91...
• Taken for 1 to 6 months
• January 31, 2023

For Depression "Four weeks in and starting to feel like my old self. I was prescribed Trintellix after being diagnosed with General Anxiety Disorder, which was feeding into some new depression-like feelings I have never experienced before. I had trouble sleeping the first two weeks, but I contribute that mainly to my already existing anxiety and stress. Besides that, I have not experienced any side effects as of yet, knock on wood. No nausea, no itching, no dizziness. My energy levels are definitely increased, and I can now focus more clearly on my current tasks. I am no longer completely fixated on ruminating negative thoughts. I am feeling optimistic, and I hope this is a sign of good things to come. I am currently on 10 mg after being on 5 mg for the first 7 days. I wanted to leave a review after I spent a lot of time reading some myself before starting the medication, and it was a lot to take in. I know it is different for everyone, so keep that in mind. Stay strong, everyone."

• Non...
• Taken for 1 to 6 months
• June 30, 2024

"I wanted to share my experience on this. I'm a 20-year-old male. I've been on several antidepressants over my adolescence. Zoloft made me irritated/aggressive, as well as Buspar. Effexor made me more anxious, I didn't like SNRIs. Then I went on Lamictal and stayed on it for 2 years. Then got off (very miserable). I stopped taking antidepressants until my anxiety took over, and I snapped, starting a terrible 1 month of depression. I never felt it in my life until now. I went on Trintellix. It made me super nauseous. I started at 10mg for the first 2 months. I felt a slight change in mood, my thoughts are less erratic, and I'm not fixated on daily stressful stuff. I went up to 15mg, hopefully, this does the job. Good med. -1 for the nausea."

• Cra...
• July 8, 2015

For Depression "I've tried others years ago and could never tolerate them. I've been battling some health issues for a while, which has caused anxiety and recently depression. I am one of those people who are sensitive to everything I take, so I was nervous about trying this. I've only been on it for 5 days at 5 mg in the morning. Mild nausea that goes away. I'm hoping for some energy as fatigue is a big issue for me. I think I'm feeling a bit less down, but still too early to say, I guess. I'll keep updating. Good luck, everyone."

• Aut...
• Taken for 1 to 2 years
• April 5, 2019

For Major Depressive Disorder "I’ve read many of these posts. I too had nausea (would throw up within 15 minutes of taking the Trintellix pill, every single day). My doctor told me to take an anti-nausea med like Zofran (or generic) 30 minutes before I take this pill. It worked. No nausea at all if you follow that rule. Please try that if that’s your only hold-up. I’ve been on it about 2 years. I STILL have to take a Zofran 30 minutes before Trintellix, or I will puke. Also, take it around bedtime."

• Wes...
• September 19, 2016

For Depression "Started this almost 3 weeks ago, no side effects except dry/flaky skin on hands. Now, week 3, nauseous 24/7 and headache 24/7, nothing is taking the headache away, not Imitrex (RX headache reliever), not Excedrin, NOTHING. I can't even eat, I feel like it's going to just come right back up. It's like it built up in my system for weeks, and now my body is rejecting it. It made me feel better emotionally, but physically I can't take it, I just want to stay in bed because I feel like crap. I know it's the med because it started on the exact day I started the 3rd sample bottle. I'm stopping it. I haven't had a headache like this in years or been nauseous."

• Ale...
• March 2, 2016

For Depression "This is my second month on 10 mg daily Brintellix. I'll start by saying that I'm 18 and suffer from major depression, anxiety, suicidal thoughts, ADHD, and PTSD. I take this every day along with 50 mg Vyvanse to help with my ADHD. I have to say that the combination of these medications has helped me tremendously in just the month that I've added Brintellix. I no longer have panic attacks daily, I don't cry all the time anymore, I don't feel hopeless or isolated, I don't feel negative constantly anymore, and I honestly feel like I'm more of myself again. The only issue I have is that I vomit daily, my nausea can get intense, and some days I tend to lay around more than usual. The vomiting can get really bad for me, however. It worries me sometimes."

• Liz...
• Taken for 6 months to 1 year
• September 23, 2020

For Depression "So perhaps I am a lucky one, but I have not experienced nausea from this drug. I am on 20mg Trintellix, and I do find it to be more activating if not taken with food, but I like it - I am on it for bipolar 2 disorder. I have been taking it for around 7 months now. I am taking it along with 50mg Pristiq and 150mg Lamictal. This is a supplemental medication for me, meant to help more with the cognitive aspects of my illness, and I feel as though it is working to that end. The only downside is that it is as expensive as anything."

• Mag...
• March 1, 2016

For Depression "I have been on Brintellix for 6 months. Started on 10 mg. Initially, like everyone else, thought it was great, with the exception of nausea. It also helped with the quality of my sleep. After about a month, it plateaued, so I went up to 20 mg, but it made me extremely tired, so I went back down to 10 mg. Five months into taking this ridiculously expensive drug, I felt my personality was completely changing and not for the better. I became quick to anger, on the verge of tears (not typical for me), with an explosive and unpredictable personality. If that was not enough, I was also very tired all the time. The personality changes cost me my job, and at home, well, it hurt people that I love. Going off of it, I was in pain and tears for days..."