Trintellix and Itching: What Users Say (Page 3)

• sta...
• Taken for 1 to 2 years
• September 28, 2017

For Major Depressive Disorder "I have been on Trintellix for over a year. I don't think it is the best medication I have been on (I have tried several), but it certainly helps. I do experience side effects if I miss a dose, especially for longer than 48 hours. I usually get very headachey and itchy, everywhere. Maybe this is a good sign, as it indicates maybe it does something. I don't feel very drastic, life-altering relief, but I do believe that if I weren't taking it, things would be much worse. I don't think you feel the support it provides in a strong way, but in a more subtle, long-term way."

• god...
• Taken for 1 to 6 months
• September 20, 2015

For Major Depressive Disorder "I was horribly nauseous and threw up every day for the first month. The itching was horrible too for the first month as well, but I suffered through, and Brintellix has been a miracle drug for me. I have been taking it for over 4 months now. I am slowly feeling the depression creep back in. I am not sure if I need the dosage increased or if it is just everything I am having to deal with in my life right now. I am currently taking 10 mg at night. No side effects at all now."

• hut...
• November 30, 2015

For Depression "I've been taking this medication for approximately 5 months. It lifted me out of a severe depression. Had been on Effexor for 5 years. The side effects for me are extreme itching and sexual side effects."

• Kit...
• Taken for 1 to 6 months
• August 27, 2019

For Depression "I had some real trouble with depression on Lexapro that I had been taking for years. So the doctor prescribed Trintellix 10 mg as a new drug, which he said is well tolerated and does not have sexual side effects. I am an eternal optimist and thought I would not experience any side effects: I have itchy skin, nausea, and had diarrhea for the first two weeks. I started with 5 mg and then went to 10 mg the second week. So I have been on 10 mg for 4 weeks now. The depression seems worse now, and I feel restless. A bit more anxiety too. I am going to discontinue this now as I have given it a fair shot, and it did not work. Other medications have not worked either, so now I am going to the gym every morning and trying to eat better and hope for the best."

• Lau...
• September 23, 2015

For Major Depressive Disorder "I suspected sexual side effects from Lexapro, so my doctor switched me to Brintellix. It made me itch like crazy every single night, even though I took it in the morning. There wasn't a rash or anything, so I just felt like I was losing my mind, and my doctor hadn't heard of the side effect. I also got pretty nauseous on a few occasions. It was not nearly as effective as Lexapro for depression. While on Brintellix, I found myself getting devastated by things that would have been minor disappointments while I was on Lexapro. On Brintellix, I cried a few times at work. I got really frustrated with people over nothing. I lost a lot of motivation. I wasn't myself. I've heard it works for other people, but not me."

• Dai...
• Taken for 1 to 6 months
• September 5, 2017

For Depression "I've been on Trintellix for 7 weeks along with Buspirone for anxiety, which is my biggest problem. About 1 month in on Trintellix, I got hives and itchy skin too. Wasn't sure what that was about. The hives seem to be going away slowly, not all gone yet, but the itchy skin remains. It's manageable, just annoying. Not really sure this medication is helping me. Right now, just trying to get/keep the anxiety under control."

• AsC...
• Taken for 1 to 6 months
• November 8, 2022

For Depression "I started Trintellix for depression approximately 4 weeks ago, 5 mg once a day. Good God, the itching! Thought it was just seasonal dry skin or my psoriasis, but nope! I itch especially when I'm trying to sleep. I'm trying to avoid taking antihistamines every day due to the risk of dementia, per my family history. Has anyone overcome this side effect? Other than the awful itching, I'd say my depression and subsequent massive fatigue and listlessness are starting to improve. It's a very slow... ITCHY process. But yeah. Did the itching ever stop for y'all?? P.S. I am still using trial packages of Trintellix 5 mg, kindly given to me courtesy of my psychiatrist. I will update with more info relating to cost as I'm able. Blessings and healing to all, A."

• gca...
• September 11, 2018

For Major Depressive Disorder "As I'm on it only for 3 weeks, my rating goes mostly for the minimal side effects. I tried several other antidepressants, and this didn't create sexual dysfunction. I had an annoying itching all over my body, which went off after the first week. Be patient and don't give up if you find you can tolerate the side effects for a few weeks. Now I can say I have zero side effects. Unfortunately, though, I cannot say it is helping with my depression as of yet. I will wait another week."

• Flo...
• August 17, 2017

For Depression "Been on 10 mg Trintellix for 9 days after weaning off Zoloft 150 mg over a month. Really feel much better on Trintellix, but I have itchy skin and hives. I got hives on one side of my face the first day, now they move around. Take hydroxyzine, which has helped some. Going to stop Trintellix and start back on Zoloft to see if hives go away per Dr. suggestion. Has anyone else gotten hives, and do they go away over time? If I knew they would go away, I would stick with it a little longer."

• Swe...
• Taken for less than 1 month
• October 4, 2019

For Depression "Have been on citalopram for the past 10 years!! Dr. suggested I give Trintellix a try!! Been on it for 1 week, day 1-3, dizzy and nauseous, day 4-7, started with a small amount of itchy skin!! Has increased to the point where I feel like my body is crawling with bugs, took antihistamine on Dr.'s approval!! Soooo irritable that the rest of my family would love me to move elsewhere!! Been on the verge of tears constantly!! Sweating all the time and last night so worried about these meds that I didn't sleep at all!! Actually could not figure out when I was sleeping and when I wasn't!! Called doc and going back to cipralex!!!!!"

• Non...
• Taken for 1 to 6 months
• July 5, 2019

For Major Depressive Disorder "Been on 5 mg Trintellix for four months. Don't feel bad, don't feel great as far as mood goes. Been hard to keep up with chores, not really motivated. What brought me here is the hair loss, I am getting large hairballs every time I brush. No bald spots-yet. The itching is intense too, had no idea it was the Trintellix. Sigh, always something."

• CDN...
• Taken for less than 1 month
• May 1, 2015

For Major Depressive Disorder "I've been on Brintellix for four days now after switching from Cymbalta, and I am completely regretting it. I felt great for the first day but now feel as bad as I did when I first sought treatment. I'm dizzy and nauseous; I've had trouble falling asleep, I'm constantly hungry, I itch everywhere, and I feel like I'm always about to start crying. I've had suicidal thoughts of a severity and frequency I haven't had since before I went on Cymbalta. I very nearly contacted a crisis help center last night; I felt so bad -- and I don't even really know what triggered it. I'll discuss it with my therapist tomorrow, but I really want to stop taking it; I'm actually nervous about trying to hold out for a month before I see my psychiatrist again."

• Itc...
• Taken for less than 1 month
• November 11, 2017

For Major Depressive Disorder "Have been on antidepressants for 20 years, trying more than I can remember. Was on Cymbalta for 8 years, but it quit working for me. Depression was my biggest problem when I was younger, but now anxiety seems to be the bigger problem. Been on Trintellix for 2 weeks now (first week 5 mg; second week 10 mg). The side effects I can handle are nausea and headaches. The ones I can’t handle are feeling high as a kite every day, brain on warp speed and can’t focus or concentrate. The absolute worst side effects are high blood pressure and itching!! I cannot stop itching! My skin is ripped apart all over my whole body, and my skin feels about 100 degrees constantly! The itching is driving me insane. Seeing a psychiatrist next week. I need help with this!"

• Aaa...
• Taken for 1 to 6 months
• July 25, 2018

For Depression "Initially helped pull me out of depression. But made anxiety and restlessness worse and worse. Gave me restless leg syndrome and had a 3-day stretch where I had 0 sleep even with Vistaril the first night, double the Vistaril the second, and 3 Ativans to finally enjoy maybe 4 hours on the 3rd. Made my mind feel so stimulated my thoughts were racing and even vivid, like I was living in a dream. And the worst effect was the itching and the feeling of wanting to jump out of my skin. Went off completely and started Zoloft. It's a lot better for anxiety."

• jor...
• December 7, 2017

For Major Depressive Disorder "After being on 90 mg of Cymbalta for three years, and with gradual increases and no betterment to my conditions, a counselor through my school suggested trying Trintellix at 10 mg. First of all, this makes me sick to my stomach whether I eat or not, causes constipation, horrible irritability, night sweats, and itchiness. I can't tell if the itching is my anxiety or if it's from the medication, but it's horrible. It's either causing me great amounts of itching or it's not helping my anxiety-both cases suck. I can no longer drive on the highway or go to school because I'm too anxious and depressed. I hope I find a better medication because this one sucks."

• 35-...
• February 16, 2021

For Depression "I was suffering from OCD and anxiety. My doctor put me on Trintellix 10 mg/day. I took it for about a month, but my anxiety got worse after a few days. I contacted my doctor and let him know that this medication has made me more anxious, but he said that it is not Trintellix causing these symptoms and your anxiety is too high. He increased the dose to 20 mg/day. After a few days, the pins-and-needles sensation became a permanent issue and I had significant apprehension, got insomnia, stomach pain, and itchy skin. My psychiatrist was still insisting that I should give this medication at least one more month. So, I decided to change my psychiatrist. The new doctor asked me to gradually reduce the Trintellix dose and get rid of it within two weeks. He prescribed me Clonazepam 0.5 mg twice a day. After a few days, I am feeling much better. Everything has improved, and I am getting my life back. I know that Clonazepam might not be a reasonable long-term solution, but Trintellix was a real nightmare."

• kth...
• February 16, 2015

For Depression "So I love how I feel I am on this stuff. Little background info: I am bipolar and suffering postpartum from having my first daughter three months ago. Two things I've noticed: I don't cry as much, however, I itch constantly. I mean, like a crackhead itching. Also, having headaches and crazy dreams (snakes, spiders), but the postpartum is mostly gone. I still feel however, no weight loss, and that is still a major depression symptom for me, and probably my biggest. I make myself sick in the mirror when I'm naked, and I like the way it's taken away the postpartum, but still no self-esteem. What do I do? Also, I would love to chat, or if there is a group I can look into about this, please let me know. I am on my second week of 10 MG. Thank you!"

• sim...
• June 13, 2015

For Major Depressive Disorder "Started 4 days ago and noticed a calming effect during the first day, which made me excited and hopeful. I am cross-titrating off Cipralex with this med, though I feel I can just stop the 20 mg of Cipralex. On day 3, I developed an itch in random parts throughout my body, just got allergy medication in attempts of making this uncomfortable side effect subside. I am hopeful this goes away. I am on 5 mg currently."

• kee...
• Taken for 1 to 6 months
• November 1, 2021

For Major Depressive Disorder "I have been on Trintellix so far for 10 weeks. I started 5 mg for a few days, then 10 mg for a few weeks, and then had some major depression where I couldn't stop crying during my period, and my husband was also starting a new job, so some family changes were happening. I upped to 15 mg, and it has helped level me out with my anxiety and depression most of the time, but again, a month later now, and I am at the end of my period, and I am a crying mess. Literally crying at work, and no, my job is not stressful. So I am worried that it is affecting my cycle and making my emotions worse during that time of the month because I don't remember dealing with this on a monthly basis previously. Anyways, I am going to stick it out for a few more months because it is working most of the time and helped me get out of a really dark place. Yes, you need to take it with food, and it made me tired at first, so I take it with my dinner. I also got itchy when I upped to 15 mg, but that went away after a week."

• Jok...
• Taken for less than 1 month
• July 22, 2018

For Major Depressive Disorder "I have been on Viibryd for 3 years and noticed my depression was starting to get worse recently. I’ve been on all medicines imaginable. My Dr. put me on this starting out at 10 mg and reduced my Viibryd to 20 at the same time. I was on this less than a week and I was a complete wreck, and I was itching all over."

• BRi...
• November 11, 2014

For Depression "Started medication three days ago. So far my energy level has gone up. I feel happier and more positive. I have experienced itchy skin. Hoping that side effect subsides."

• bra...
• Taken for less than 1 month
• September 28, 2014

For Depression "Been taking this medicine for two weeks. I noticed I'm really itchy, my stomach is so sick, headaches, and I'm very tired. I hope it gets better."

• Amb...
• Taken for less than 1 month
• May 5, 2015

For Depression "I went to the doctor about the itching, and it turns out I had a severe allergic reaction to Brintellix. 103 temp, so I have to wait a week to get the meds out of my system."

• Bra...
• Taken for less than 1 month
• May 26, 2023

For Depression "I have never had a reaction to any medication, but this medication made me itch all over my body. There was no place I did not itch, it was miserable."

• Dol...
• Taken for less than 1 month
• September 8, 2014

For Major Depressive Disorder "Itchy beyond belief!"