Vortioxetine and Depression: What Users Say (Page 2)

• Abc...
• Taken for 1 to 6 months
• July 8, 2019

Vortioxetine for Major Depressive Disorder "Started with 7.5 mg and had a weird positive boost the first 3-5 days, and then it settled out to the same way I was feeling before. At week 3-4, started increased anxiety, worsening depression, and impulsive rage/anger. Never experienced rage from an antidepressant before, and I've been on 15+ different antidepressants. After one particular rage-filled event, I started titrating down best I could and now off of it. Anxiety and rage went away within 2 days of stopping this medication. I've never experienced anything like this. Could be a miracle drug for someone else, but it certainly didn't work for me. Also not covered by my insurance. Was trialing with samples from the doctor's office. Just be cautious, like with every medication, of the adverse side effects."

• ken...
• Taken for 1 to 6 months
• February 16, 2017

Vortioxetine for Major Depressive Disorder "I was on this medication for about 4 weeks. I kept telling my doctor from the first week that it was making my depression worse, but he made me stay on it for four weeks. I was crying all the time, lying in bed and having severe, really bad thoughts. Not a good drug for me."

• Gee...
• June 1, 2016

For Depression "Horrible. I started on 5 mg. I didn't have any side effects until week 2. I started to have worse anxiety and depression. I often felt like driving my car into the river or throwing myself down the stairs. I never had any feelings of harming myself until I started taking this med. My dr told me to go up to 10 mg, and after 3 days of this, I was doubled over in pain. I refused to continue taking it and tapered off, 5 mg every 2 then 3 days, and then I stopped. I would not recommend this to anyone."

• 188...
• Taken for 1 to 6 months
• June 25, 2021

Vortioxetine for Depression "Terrible medication. When I first started it, it made me severely depressed. It makes me irritable and angry. I'm taking it for severe anxiety, but it makes my anxiety worse. Was previously on Lexapro, and it was so much better and made me so much happier."

• Ari...
• Taken for less than 1 month
• December 6, 2019

Vortioxetine for Depression "I was RX'd this medication, Trintellix, for depression. I only took it for four days, and it was awful. My side effects were I was angry, agitated, and my depression worsened. I cried and sobbed uncontrollably. Discontinued."

• A g...
• October 11, 2015

Vortioxetine for Depression "Been on this stuff for like almost two months, and I haven't felt better. In fact, I've been feeling more aggressive and sadder. I have crazy mood swings (didn't have them before this med), and I feel extremely angry and sad all the time. This didn't work on me. Worst antidepressant I've tried."

• Ror...
• November 12, 2017

Vortioxetine for Major Depressive Disorder "I had sudden large amounts of projectile vomiting the 5 weeks I was on this med. Other untoward side effects include headache, eye pain, visual changes, emotionally labile, very anxious, depressed, very tired, no energy, racing thoughts."

• LNd...
• Taken for less than 1 month
• May 24, 2017

Vortioxetine for Major Depressive Disorder "On week 3, 10 mg, terrible debilitating headaches every day, eye pain, vision blurry, mood swings (quick and aggressive!), zero motivation, although the crying has lessened. Anyone else getting these side effects? Any suggestions on the time of day to take? This is my last hope, I've tried all other meds. My last 2 years have been so painful with sadness. If this doesn't work, MD recommend ECT..."

• dee...
• Taken for 6 months to 1 year
• February 12, 2016

Vortioxetine for Depression "My Dr. started me on 10 mg for a month, and then raised it to 20 mg. I was having general anxiety and some depression. It does seem to have helped, though no cure. The psychological side effects are much better for me than with other antidepressants, which sometimes caused odd feelings of separation from the world around me and a 'foggy' state. I also have lost weight since beginning Brintellix. There is a huge reduction in sex drive and response. Other than that, it's a positive experience. Cialis would help with the sexual performance issues, but I'm unable to take it since it causes severe back pain for me. After about 5 months, I'm not sure I'm willing to stay on it. Also, it's expensive, even with the $150 per month discount coupon."

• Tee...
• December 16, 2015

Vortioxetine for Depression "I've been taking this for about two months. I had previously taken Cymbalta for the past three to five years, but felt it had lost its effectiveness and was causing severe decreased libido. I have gained two to four pounds, constantly itch, am very moody, easily agitated, feel more depressed than before, and still no sexual desire. 40-year-old female."

• dar...
• Taken for 1 to 6 months
• February 18, 2019

Vortioxetine for Depression "I have dysthymia, social phobia, and I moved from Zoloft to Trintellix and got worse. I started using it to have more energy and initiative. However, I began to oscillate between being aggressive and sad. If it wasn't for Vyvanse (I have severe ADHD), I couldn't get out of bed. I've already used 15 mg, and I'm now on 10 mg with almost 6 months of use. I intend to stop and switch back to Wellbutrin XR - and maybe Zoloft - which is way more effective. Trintellix is a lie: it has an abusive price and does not cause any significant change. This medication is garbage and a waste of money."

• Car...
• Taken for 1 to 2 years
• July 8, 2019

Vortioxetine for Depression "Worked GREAT for about 8 months. The doctor prescribed Ondansetron 8 mg to take about 15 minutes before taking Trintellix to stop the nausea! If this medication makes you sick to your stomach, ask your doctor for Ondansetron! I have combined this drug with 20 mg of Citalopram, but I can't shake the fatigue and depression that has come back after 8 months."

• Nic...
• Taken for 1 to 6 months
• July 30, 2019

Vortioxetine for Major Depressive Disorder "I was on Trintellix for 3 months, started on 5 mg. I felt somewhat better, then the doctor increased it to 10 mg, still about the same, then increased it to 20 mg. The longer I have been on the medication, the worse the fog is getting. I am not sleeping any better, in fact, now I am taking meds for sleep also. But the fog has been terrible, so much so that I have been put on probation at work because I am making so many mistakes, memory is horrible, and no motivation at all. We fought like heck to get my insurance to pay for it, and now we are going to have to go on something different. The funny thing is, I called the doctor to make them aware, and they said to drop it down to 15 mg. I was not getting any better, so I started to titrate down, and now I am off. I feel better, more motivation, and the fog is starting to go away. I hope it goes completely away very soon. This was not a miracle drug for me, sadly. Back to the drawing board."

• Smi...
• October 23, 2019

For Depression "I have been on Zoloft for over 10 years, suddenly started feeling really depressed in January and very anxious. Anxiety was crippling and depression got worse. It lasted for 9 months! I finally changed to Trintellix. I was too anxious to change medicine and read every review. I was armed with nausea tablets. I have been on it for over a month now, 2 weeks, 10mg, ZERO nausea. I take it at night, just before bedtime. I felt better within days, however, I had nightmares. These stopped within 2 weeks. I was on 50mg Zoloft, then upped to 100, then to 150, to see if that would work, but did not work at all, went down to 50 again. Started Trintellix without weaning off Zoloft, as the doctor said this is what I could do, being on only 50mg. I am now on 20mg, have lots of energy, libido returning after 10 years. I am focused. So excited. Had the worst 9 months, can finally see the light. Ride out the first two weeks of nightmares, and once you get on 20mg, it's a game changer. Best of luck."

• Coo...
• Taken for 1 to 2 years
• July 30, 2022

For Major Depressive Disorder "I’ve been struggling with different levels of depression since I was a teen, which gradually led to increased anxiety and alcohol abuse. In 2017, I was diagnosed with MDD after a traumatic event. From 2017 to 2021, I lived in HELL. It’s hard to describe the amount of angst, anhedonia, self-deprecation, inadequation, lack of interest in anything, total loss of hope, need for reclusion, and recurrent suicide thoughts I had to deal with. I’ve seen highly respected (and expensive) doctors, tried 16 different antidepressants (yeah, I have a list) in different dosages and combinations, alongside 3 benzos and 2 hypnotics. I never got any improvement from MDD. The best those meds could do was turn me into a zombie, but the terrible feelings were never gone. I was 100% convinced that was it for me… till I met vortioxetine. IT SAVED MY LIFE. I already felt better on day 3. Depression is gone, just like that. It’s been 15 months now of finally feeling good. Sometimes I still don’t believe."

• Coo...
• Taken for 1 to 2 years
• July 30, 2022

For Major Depressive Disorder "I’ve been struggling with different levels of depression since I was a teen, which gradually led to increased anxiety and alcohol abuse. In 2017, I was diagnosed with MDD after a traumatic event. From 2017 to 2021, I lived in HELL. It’s hard to describe the amount of angst, anhedonia, self-deprecation, inadequation, lack of interest in anything, total loss of hope, need for reclusion, and recurrent suicide thoughts I had to deal with. I’ve seen highly respected (and expensive) doctors, tried 16 different antidepressants (yeah, I have a list) in different dosages and combinations, alongside 3 benzos and 2 hypnotics. I never got any improvement from MDD. The best those meds could do was turn me into a zombie, but the terrible feelings were never gone. I was 100% convinced that was it for me… till I met vortioxetine. IT SAVED MY LIFE. I already felt better on day 3. Depression is gone, just like that. It’s been 15 months now of finally feeling good. Sometimes I still don’t believe."

• Mom...
• December 23, 2016

Vortioxetine for Depression "I have been on 10 mg for 6 weeks. Very little nausea at first and some headaches, but nothing ibuprofen did not take away. I did not notice much at first, then, maybe 3-4 weeks in, I noticed a little relief from frustration and sad feelings. I can't find a job and have gained a good amount of weight over the past year, so I am having self-esteem issues anyway, but over the past week, I am a mess. I am sad and cry a lot. I cannot focus and feel cloudy in my thoughts. I am very irritable and short-tempered. I will try to see about increasing the dose. It seems like a slow progression, but I am hopeful a higher dose may help."

• Mom...
• December 23, 2016

Vortioxetine for Depression "I have been on 10 mg for 6 weeks. Very little nausea at first and some headaches, but nothing ibuprofen did not take away. I did not notice much at first, then, maybe 3-4 weeks in, I noticed a little relief from frustration and sad feelings. I can't find a job and have gained a good amount of weight over the past year, so I am having self-esteem issues anyway, but over the past week, I am a mess. I am sad and cry a lot. I cannot focus and feel cloudy in my thoughts. I am very irritable and short-tempered. I will try to see about increasing the dose. It seems like a slow progression, but I am hopeful a higher dose may help."

• Kat...
• Taken for 1 to 6 months
• September 26, 2022

Vortioxetine for Depression "I had a pretty great experience with Venlafaxine, which basically worked immediately when I started taking them. However, after a couple of years, I grew intolerant to them. My Dr. suggested Trintellix - and gawd, do I wish I hadn't tried them. I eventually went as high as 20 mg. They gave me insane nausea, vomiting, seasickness, and intense mood swings, if you can even call it that, because those mood swings were more a combo of all negative emotions: depression, hopelessness, anger, anxiety, panic, which caused me to have some severe suicidal urges just because I desperately needed it to stop. It was the absolute opposite experience of Venlafaxine, which had made me practically high and euphoric when I started on them. Now that I'm no longer on these demon pills, I still struggle with a sensitivity to nausea that can cause me to vomit, which I can't seem to get rid of. Perhaps they've changed me forever, and that really bums me out."

• Kat...
• Taken for 1 to 6 months
• September 26, 2022

Vortioxetine for Depression "I had a pretty great experience with Venlafaxine, which basically worked immediately when I started taking them. However, after a couple of years, I grew intolerant to them. My Dr. suggested Trintellix - and gawd, do I wish I hadn't tried them. I eventually went as high as 20 mg. They gave me insane nausea, vomiting, seasickness, and intense mood swings, if you can even call it that, because those mood swings were more a combo of all negative emotions: depression, hopelessness, anger, anxiety, panic, which caused me to have some severe suicidal urges just because I desperately needed it to stop. It was the absolute opposite experience of Venlafaxine, which had made me practically high and euphoric when I started on them. Now that I'm no longer on these demon pills, I still struggle with a sensitivity to nausea that can cause me to vomit, which I can't seem to get rid of. Perhaps they've changed me forever, and that really bums me out."

• aly...
• Taken for less than 1 month
• June 3, 2019

Vortioxetine for Major Depressive Disorder "It was great the first few days, but then I started getting severe nausea and motion sickness every day around 1 pm. Now I’ve been having akathisia (like restless legs, but it’s your whole body) mixed with severe depression and dark thoughts. Not sure if that’s this or another med I’m also trying. But the nausea was definitely this medicine."

• Vie...
• Taken for less than 1 month
• June 12, 2019

Vortioxetine for Depression "Terrible side effects from Trintellix. My dose was 5 mg for 2 weeks, no nausea, but anxiety was overload! Then, at one and a half weeks, I went to a 10 mg dose, and my left shoulder blade locked up just because, did not injure it, and I had severe pain. Went to the chiropractor for treatment, and no relief. Actually felt more depressed."

• joa...
• June 7, 2018

Vortioxetine for Major Depressive Disorder "My doctor put me on Trintellix, and it was the worst experience of my life. He kept telling me it needed to get into my system. I took it for about 6 months, and it made my depression/anxiety worse than ever. I could not function. I completely lost my appetite. I could not get out of bed. I could not go to work. I was a mess. He finally took me off and put me on something else, and within 2 days, I was feeling better-within 2 weeks, I was functioning again, and within 4 weeks, I feel great."

• fis...
• Taken for 6 months to 1 year
• January 12, 2018

Vortioxetine for Depression "After many years of trying different antidepressants, my doctor prescribed Trintellix. After about 3 months, I started sleeping 9-12 hours a day, was extremely apathetic, and had no motivation. I had all kinds of tests done because none of these were listed as side effects. I ran out of my pills over the holidays. After being off Trintellix for six days, I woke up feeling like the bell jar had been lifted off of me. Now, a week later, my sleep is starting to get closer to normal, my empathy is returning, and I have had more motivation. I also gained weight."

• NJs...
• Taken for 6 months to 1 year
• October 17, 2016

Vortioxetine for Major Depressive Disorder "I suffer from bipolar with depression. I had been on Trintellix (along with a mood stabilizer) to treat depression for approximately 7 months. My moods had been stable for that long. Then I had some added stress, though, and had severe depression... worst I have ever had. This ended with me being hospitalized and taken off Trintellix. My thoughts are it worked well for short-term for me, but not long term. So take this medication with caution, and if depression gets worse, then seek help immediately."