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User Reviews for Vortioxetine to treat Depression

Also known as: Trintellix

Vortioxetine has an average rating of 5.9 out of 10 from a total of 757 ratings for the treatment of Depression. 46% of those users who reviewed Vortioxetine reported a positive effect, while 33% reported a negative effect.

Vortioxetine Rating Summary

5.9/10 average rating

757 ratings from 814 user reviews.

Compare all 189 medications used in the treatment of Depression.

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Reviews for Vortioxetine

Lee1309 · Taken for 1 to 6 months June 14, 2021

“This medication turned out to be an awful drug for me and my anxiety, it sent me loopy and I am still recovering from it 5 months later. I have had so many side effects that I have lost count. It is an absolute head mangler. I hope no one else has the same experience. All the best. Ps wouldn't even give it one out of 10 more like minus 10”

1 / 10
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SilverKeith · Taken for 1 to 6 months June 13, 2021

“Switched from escitalopram 20mg to vortioxetine 20mg because of sexual side effects. It was the best decision of my life. I felt constantly sleepy, down, and emotionally blunted with zero libido on Lexapro, Zoloft and other SSRIs. Vortioxetine took longer to have an effect, but once it kicked in at the 3 week mark, I finally felt better. Emotions were normalized and I started feeling much more confident about myself and around other people. It helped my social anxiety in that regard and also made me super motivated and willing to go outside. Interacting with people finally felt easy and natural. I think some of these effects can also be attributed to the previous addition of 300mg bupropion which also raises plasma levels of Brintellix and makes it more effective.”

10 / 10
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doomcop · Taken for 1 to 6 months May 31, 2021

“I’d been wanting to try vortioxetine for a long time and after a bout with venlafaxine that led me to A&E very ill my CMHT agreed to let me try it. I’ve been on it for about 6 weeks at 10mg and I feel alive again. For awhile I’d been in some sort of post psych ward fog where I had accepted I was alive but begrudgingly. Now since starting this drug I am happy to be alive - and even better no side effects not even sexual (something that’s affected me with every anti depressants but mirtazapine). If you find the effects of other anti depressants lacklustre or give you sexual side effects I would really push your psych to let you try it, it costs the NHS (here in the UK) a lot but it’s inexpensive compared to the management of poorly medicated depression/poor adherence due to sexual side effects. Etc - since starting it I’ve been able to drop my CPN appointments from weekly to fortnightly hopefully to non soon”

10 / 10
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Frequently asked questions

Owenby · Taken for 6 months to 1 year January 18, 2021

Trintellix (vortioxetine): “I was so far down I was ready to give up. I begged my Dr for help, I cried all day everyday, I couldn't get out of bed, i thought i was going to die . I prayed, i begged for someone to please help me. My husband an kids didnt know what to do. I was I in a black hole but He kept me on the same old antidepressants. I decided to changed doctors , I dont beleive for one minute that my old doctor cared if I died . So i went online and found a different doctor and my new Dr put me on Trentellix. Along with Katmin treatment. I finally was able to get out of bed, to be able to go to work, cook a meal, not cry everyday. It was like I woke up . I truly beleive if I hadn't changed doctors and found Trentellix I would not be here today. It's the best medication in the world for ME! This medication saved my life.”

10 / 10
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GrNana · Taken for 1 to 6 months February 23, 2021

Trintellix (vortioxetine): “Four weeks on Trintellix and I feel it is working better than any other antidepressant mostly due to the fact the side effects are almost non existent. I am not noticing my eating habits going through the roof and I don't have that apathy that I've had with almost all other drugs. It was tough for a couple of weeks until my digestive systems got use to Trintellix but now it is working great. I am just starting to enjoy some of the things I use to love. I am no longer mourning the two deaths in our family a year ago. I have nothing but good reviews for Trintellix. I am on 10g.”

10 / 10
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Snake · Taken for 1 to 6 months August 22, 2020

Trintellix (vortioxetine): “This medication has been a lifesaver. I have tried so many different antidepressants (Prozac, Zoloft, Wellbutrin, Lexapro, etc.) and none of them have worked as well as Trintellix. My “episodes” have disappeared and I finally feel stable which has allowed me to make important life decisions that I was always too fearful to do. In the past, I felt that I couldn’t trust my emotions because they felt too extreme. After years of constant sadness, worrying, and lack of motivation, I am relieved to feel like my normal self. I had maybe 3-4 days where I felt nauseous but overall, I do not experience this side effect. I have been on 10mg for approximately one month and it’s been the most joyous month I’ve had in years. I highly recommend this medication.”

10 / 10
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Anonymous · Taken for 2 to 5 years July 27, 2020

Trintellix (vortioxetine): “The day I took trintellix I feel my throat open up. I felt the effects of it almost immediately. It has changed my life. I have taken other antidepressants and they’re only made me feel so terrible with vomiting and feeling so down. I was hesitant to try anything else yet my amazing doctor who I trust very dearly told me how effective trintellix has been for anxiety although it is commonly used for depression. Changed my life. Highly recommend. Ps. My doctor reassured me that trintellix would be the right drug for me if I had no side effects. That’s why I trusted to try it. If you’re having side effects it’s not the right drug for you and you should commit to trying other meds till you find the right fit. The right fit may take several tries yet I promise and can reassure you, it will change your life for the better. Trust in the process and commit to finding the right fit with the help and surveillance of your doctor. You won’t regret it.”

10 / 10
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More FAQ

NovelReader April 25, 2021

Trintellix (vortioxetine): “I was prescribed Trintellix for my GAD and MDD. I’ve been taking 5 mgs for a week now. The first two days I experienced nausea and I am still experiencing headaches and some fatigue, which I suspect will go away In the next week. So far, I am very pleased with Trintellix. I have already begun to see a reduction of my GAD and MDD symptoms. Before Trintellix I tried Paxil, Zoloft, Lexapro, Pristiq and Effexor all of which gave me horrible side effects and left me feeling very zombie like. So far no zombie like feeling with Trintellix. I will post an updated review when I hit the 4 week mark. I’m hopeful that my GAD and MDD symptoms will continue to improve.”

9 / 10
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Lee1209 · Taken for 1 to 6 months June 9, 2020

Trintellix (vortioxetine): “I started Trintellix 2 months ago for anxiety/depression. I've been on Wellbutrin which helps my mood & can counteract some sexual side effects so I’ve stayed on it but it hasn’t really helped my anxiety. I’ve been on Zoloft, lexapro (horrible experience) and cymbalta, all had side effects I ultimately found unlivable. Honestly, starting trintellix was rough but if you can manage, stick with it! I had pretty bad nauseousness but only threw up once within the first few days of starting, & I started super slow & low. No other side effects and this is the first med that has not affected my sexual function. My anxiety is lessened and I feel hopeful. The daily nausea has gone away although I’ve noticed I’m more prone to motion/car sickness but my doctor gave me zofran for that. So far this Wellbutrin/trintellix combo is the best I’ve found for me. P.S. go through their website to get your Rx card to help with costs it helped my price tremendously”

9 / 10
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Clara · Taken for 6 months to 1 year September 28, 2020

Trintellix (vortioxetine): “I have Anxiety/OCD/Depression. I took this pill for a year and it was the most amazing medication I had ever been on for my anxiety. I started low and took it at night to try and sleep away most side effects. But I did have diarrhea for the first 3 days of upping my dose and I only went up to 10mg. But then it would go away and I noticed a difference in my anxiety at 7.5mg but I seriously was able to live my life and I never knew what genuine happiness was until this medicine. BUT after taking it for 6 months I started to gain weight so fast.. I gained 40 pounds the following 6 months and then stopped taking it because it made me starving, I never felt full and these kinds of meds are known to effect your metabolism in a bad way. So yes this pill is amazing but I got fat on it.”

10 / 10
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p247 February 4, 2021

Trintellix (vortioxetine): “I've been on most of SSRIs, SNRIs & Buproprion. My depression started to worsen & my Dr suggested trying Trintellix with a caution that 1/5 people suffered from nausea severe enough to stop taking it. I started on 5mg in the morning and I'm not sure if it was the Trintellix but my mood and depression worsened to the point of suicidal ideation. Fortunately, I was in a hospital environment. I suffered nausea but it was manageable. Around day 6, I started to feel a little better. By day 8 I actually felt happy for the first time in a long time. Additionally, my thinking became much clearer. Cloudy thinking had been a problem with other SSRIs. I'm now on day 10 and increased to 10mg with no adverse reactions. One lesson I've learned is that SSRIs do different things to different people. Given Psychiatrists don't know exactly how these drugs work/differ from each other, it's a case of trying one, giving it 6-8 weeks to work and if it's not working go back to your Doctor.”

9 / 10
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TB · Taken for 1 to 2 years March 16, 2021

Trintellix (vortioxetine): “Been on it for over a year. 10 mg daily. Best antidepressant for me ever! Tried them all & all with HORRIBLE constipation & other side effects. This is the only one that took care of my depression & didn't have any awful side effects other than a little nausea in the beginning. No weight gain, no decreased libido. It's definitely worth a try!”

10 / 10
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Elle · Taken for 1 to 2 years December 8, 2019

Trintellix (vortioxetine): “This medication saved my life. I have tried several other drugs which did not help. Wellbutrin was the worst for me, giving me racing and really dark thoughts. Before taking any meds, I had an insane appetite and would wake up starving no matter how much I ate. (In addition to excessive crying, feeling hopeless, not being able to do simple chores like shower). I went a few years suffering like this because I was in denial that I was depressed. Well fast forward a few years later after trying 3 different drugs at different strengths, and Trintellix is the one for me. I never thought I would sleep through the night again. I sleep so soundly now. My appetite is back to normal. My depressive thoughts have been tamed. I am so grateful for this drug and all it has done to improve my quality of life.”

10 / 10
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Copenhagun · Taken for 1 to 6 months March 23, 2014

Trintellix (vortioxetine): “I've been suffering from major depression since I was a teen. I've had issues with panic attacks, severe anxiety, obsessive compulsive disorder, and just about everything else. For years I've been on Lexapro because it's the only medication that would work for me. The side effects of Lexapro however were horrendous! The side effects outweighed the benefits. After a few months of discussing it, my doc switched me to Brintellix. I have done a 180! I feel so much better that it scares me! I haven't felt this good in so long that I forget how to act. I'd say it's a miracle., but I know it's no miracle.. it's science! After a lifetime of depression, I'm excited for the future.”

10 / 10
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Doc Savage · Taken for less than 1 month September 20, 2019

Trintellix (vortioxetine): “I can't understand the negative reviews. Have been on Celexa for 15 years and after taking Trintellix for a week... no comparison. Gentle, totally effective, no side effects, no fatigue nor cognitive impairment, great feeling of comfort and lack of anxiety. Fingers crossed but it sure works for me.”

9 / 10
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LaurenZzzzz December 8, 2019

Trintellix (vortioxetine): “Short and sweet— miracle drug for me. I have MDD and anxiety with panic attacks. This medication made me feel like myself again and did not cause any significant side effects. I’m pretty drug naive and I’d never been on a psychiatric drug until now. My life has significantly changed for the best. Please try this drug if you struggle with crippling anxiety that feeds your depression. I started off on a really tiny low dose since I’m super sensitive to medication, and any side effects were tolerable and went away within a week. Give this 2 months to work.”

10 / 10
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Joyce January 9, 2021

Trintellix (vortioxetine): “I struggle with severe anxiety, worrying and OCD. I’ve been on Trintellix for 2 months. I started taking it because I was obsessing and catastrophizing over a toxic person. My thoughts would repeat in my mind and I felt suicidal. It was a legal situation that I thought would ruin me. Wellbutrin 300 XL did absolutely nothing; in fact it may have made me worse. So I started on 5 mg of Trintellix and in days I felt my thoughts more glued and my fear and anxiety subsided enough to stop my suicide ideation. When this situation ends I may not need it but for now it’s helping me out a lot. I’m on 10 mg now and I think I’ll stay on 10 mg. One last benefit is my cognition/concentration is sharper; a bonus for work. Hope it works for you!”

10 / 10
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annie · Taken for 6 months to 1 year October 8, 2020

Trintellix (vortioxetine): “I have been on trintellex (have worked my way from 5mg dose to 20mg) for 8 months now. Has helped with anxiety a lot. It got me out of a sad place initially but depressive symptoms came back after 4-5 months of taking it. I gained about 25 pounds and have stomach bloat. Sex drive is gone. I don't recommend trintellex for long term use. The weight gain and loss of sex drive only make the depressive symptoms worse”

3 / 10
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boss April 29, 2021

Trintellix (vortioxetine): “I was extremely skeptical about SSRI's all of them made me sick , Zoloft, escitalopram , Effexor (hypomania), I am now with Trintellix 10mg since 3 days and I am feeling a little better already without any side effects. I hope I'm good with it for a while so this depression and anxiety stop wasting my precious life time. God be with you all. Depression shouldn't exist. I believe that there is an antidepressant that can fit for everyone. Trintellix was my third try with antidepressant , I was so scared about my depression. Been 1 months and a half suffering from anxiety and depression and it feels already like a life long threats.”

9 / 10
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Winnie333 September 5, 2019

Trintellix (vortioxetine): “I have had constant anxiety my entire life. I am 40 years old now. Zoloft helped with my agoraphobia, anxiety, panic attacks, and general feelings of daily anxiety. However, about 2 months ago I started feeling something that I'd never encountered in my life: depression. I had absolutely NO motivation to get out of bed, go to work, be around anyone, and felt horribly uncomfortable/sad daily. My doctor recommended Trintellix. I, obviously, have still been weaning off of the Zoloft. (I'm now on 50 mg of Zoloft and 10 mg of Trintellix.) Good luck to anyone out there who reads this...Know that you're definitely not alone or "crazy"! People who have never had anxiety, depression, or other mental illnesses will never understand what you're going through. What may seem extremely easy for them to do daily can be so tiresome, exhausting, and unexplainably difficult. Keep trying and don't ever give up on yourself!! Life can and will get better...Even if it means waiting over 30 years!!”

9 / 10
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Budd171 · Taken for less than 1 month September 28, 2020

Trintellix (vortioxetine): “Have been taking Trintellix for 18 days for anxiety accompanied with depression Side effects started in first week. Everything from lowering sexual performance to constant itching with slight headache among others including insomnia. Feel worse than before taking it. Cannot recommend for anyone. Seems to bring on anxiety. Anyone suffering for so long with anxiety and depression certainly doesn't need this added pain. We suffer so much we'll basically try any new med for relief. DON'T TRY THIS ONE!!”

1 / 10
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bobbya · Taken for less than 1 month December 27, 2020

Trintellix (vortioxetine): “Started on 5 MG daily for two weeks after taking wellbutrin 300 xl and duloxetine 20 daily which caused severe tinnitus and jaw pain and bruxism fracturing three teeth. Initially got some minor nausea but the jaw pain lessened and totally disappeared. I felt good with some minor anxiety. After 2 weeks increased to 10 mg daily. Again, then nausea returned but was gone on day four. I do have some jaw tension now but not too bad. I feel more alive. Doing tasks are easier. My spouse says I look more relaxed. On a scale of 1:10 I give myself a 6. Laughter comes naturally now. Sad movies give me a lump in the throat and tears. Thank God for Trintellix as it is returning my life to me.”

9 / 10
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Lf · Taken for less than 1 month June 9, 2020

Trintellix (vortioxetine): “I just started two days on this drug. I was told take it with food in the morning to stop nausea. First day my stomach was upset but no vomiting. Today I took it after I ate and within a hour or so I vomited so badly my throat is completely sore. Is this normal? This is such an expensive drug, even with insurance I paid almost $200. I don’t want to discontinue the use just yet but I am not sure I can handle the nausea and vomiting. Anyone else having these same issues?”

1 / 10
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Benicia, CA · Taken for less than 1 month August 17, 2014

Trintellix (vortioxetine): “My initial experience with Brintellix is very promising. I've suffered from treatment resistive depression and Generalized anxiety disorder for many years. Name it, I've been on it. Many medicines flatlined me emotionally, other's amped anxiety and left me sleepless, others were weight sensitive, causing rapid weight gain (hello Remeron); others worked like a charm - until they stopped working. It's been a 25 year struggle. My new Doc put me on Brintellix and within short days I felt more alert and 'content' with no sleeping problems. No side effects on entry dose of 5 mg. I take 2.5 mg Klonopin when required if I have an anxiety peak - other than that I feel like the "Me" I knew was in there.”

9 / 10
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Sheltielady May 2, 2021

Trintellix (vortioxetine): “This medicine makes me super nauseous, more depressed, very agitated, cry non stop and my head hurts. I feel like a crazy person. And this is on just 1/3 of a 5 Ml tablet. Not taking it anymore.”

2 / 10
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cali999 February 23, 2020

Trintellix (vortioxetine): “Trintellex started working by the end of the second week and continues to. I am happier than I have ever been and so impressed that Trintellex was able to get me through the incredibly difficult last two months, e.g changed jobs, had a project with an impossible deadline, the holidays, etc. I'm on 10mg daily. Side effect-wise I have some sexual dysfunction (loss of libido, difficult to achieve orgasm) but right now it seems worth it to feel this good. I've also lost weight. A new wrinkle as of 2 weeks ago is a tinnitus. I only notice it when its totally quiet which hasn't made sleeping the best so I take Trazadone to help with that which works great. After two months, I'm still feeling great on the Trintellex but the side effects aren't dissipating and I'm wondering how long I will be able to deal with them. Definitely not forever. Will update if things change.”

9 / 10
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Anonymous · Taken for less than 1 month November 22, 2014

Trintellix (vortioxetine): “Have anxiety and depression and have been on medicines for 20 years. Have taken Paxil, Zoloft, Prozac, Wellbutrin, Lexapro. Just switched 3 weeks ago from Prozac/Wellbutrin to Brintellix with Wellbutrin. Feel fantastic - much better mood, clear head, no anxiety. No side effects at all. Taking 10mg.”

9 / 10
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asadlife May 27, 2020

Trintellix (vortioxetine): “I'm in my early 30's- been dealing with depression for almost 15 years. My former doc prescribed me trintillex. he swore it was a super "clean" med with out side effects. it's been 2+ years taking it (max 20mg) & I had no positive effects. Don't let your doc tell you it won't/rarely causes weight gain. IT DOES, especially if you're a female. It will continue the longer on it/dose increased. Also, awful GI problems- bad nausea or bad constipation. Also only makes anxiety worse especially if you take in the AM- take in PM you can't sleep ^_^ I would stay away from this drug DEFINITELY if you have anxiety, sensitive stomach, prone to weight gain from meds. I'm done off this in 4 days! can't wait”

2 / 10
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This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.