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Zilretta and Swelling: What Users Say

Swelling: mentioned by 4 users (7.0%)

Based on user experiences from 57 Zilretta reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

pain 12.3%
swelling 7.0%
stiffness 5.3%

Reviews for Zilretta

Commonly mentioned side effects
  • Kat...
  • Taken for less than 1 month
  • October 6, 2018

For Osteoarthritis "One day I was hobbling at work, walking with a cane. I was done! Some days I couldn’t get up out of a chair. My Dr. told me about Zilretta injections for both my knees. I was shocked my insurance covered it! Only $50 for both knees. Had both knees drained and injections with Zilretta. WOW! After 2 days of ice, I stood up and walked normally for the first time in 12 years, I had no knee pain at all. I had little to no swelling from the knees down. I have told everyone I know about Zilretta! So happy to be pain-free! Thank you!"

10 / 10
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52 Report
  • Hav...
  • Taken for 6 months to 1 year
  • May 26, 2019

For Osteoarthritis "The first set of injections kept me in pain and off of my feet for over a week. I've had to get the injections every 3 months instead of every 6 like my last medication. Every time it is the same thing, both knees end up swollen and painful for a week or longer. The effects of Zilretta are semi-beneficial for about 8 weeks. I've had a lot more pain, stiffness, and swelling in my knees since taking Zilretta. There are days that I can't fully straighten or bend my legs. The inflammation is bad, and my symptoms are becoming worse than they were before I started Zilretta. This is a serious concern. I'm glad that it is helping some people, but for me, the short 8 weeks of slight relief is not worth the pain and worsening of symptoms that I have for the rest of the time between injections."

4 / 10
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29 Report
  • Hav...
  • Taken for 6 months to 1 year
  • May 26, 2019

For Osteoarthritis "The first set of injections kept me in pain and off of my feet for over a week. I've had to get the injections every 3 months instead of every 6 like my last medication. Every time it is the same thing, both knees end up swollen and painful for a week or longer. The effects of Zilretta are semi-beneficial for about 8 weeks. I've had a lot more pain, stiffness, and swelling in my knees since taking Zilretta. There are days that I can't fully straighten or bend my legs. The inflammation is bad, and my symptoms are becoming worse than they were before I started Zilretta. This is a serious concern. I'm glad that it is helping some people, but for me, the short 8 weeks of slight relief is not worth the pain and worsening of symptoms that I have for the rest of the time between injections."

4 / 10
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29 Report

Frequently asked questions

  • sil...
  • Taken for 6 months to 1 year
  • August 23, 2022

For Osteoarthritis "I'm 79, I have arthritis under both patellas. Zilretta is a great product. Both knees have been treated 4 times. Treatments lasted only 2 months. (I tried exercise and no exercise.) I was asked if I wanted to try Hymovis or Eflexa. I checked the product reviews, and I'll stay with Zilretta. I have no stiffness, swelling, or other complications."

9 / 10
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1 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.