Zilretta and Pain: What Users Say

• Anonymous
• Taken for 1 to 6 months
• June 24, 2019

For Osteoarthritis "Since getting an injection of Zilretta after years of cortisone injections for bone on bone in my knees, my worse knee has gotten unbearable. I now not only have knee pain, but it feels like a rubber band breaking behind my kneecap and excruciating nerve pain down my whole left leg, even while sleeping. I don't recommend getting this shot. Because of it, I now will have to have my knee replaced sooner rather than later."

• Hav...
• Taken for 6 months to 1 year
• May 26, 2019

For Osteoarthritis "The first set of injections kept me in pain and off of my feet for over a week. I've had to get the injections every 3 months instead of every 6 like my last medication. Every time it is the same thing, both knees end up swollen and painful for a week or longer. The effects of Zilretta are semi-beneficial for about 8 weeks. I've had a lot more pain, stiffness, and swelling in my knees since taking Zilretta. There are days that I can't fully straighten or bend my legs. The inflammation is bad, and my symptoms are becoming worse than they were before I started Zilretta. This is a serious concern. I'm glad that it is helping some people, but for me, the short 8 weeks of slight relief is not worth the pain and worsening of symptoms that I have for the rest of the time between injections."

• Tag...
• Taken for 1 to 6 months
• September 19, 2019

For Osteoarthritis "I also have bone-on-bone in my knee. I was using cortisone injections, and then the doctor told me about Zilretta. I got the injection in May, and by August, it was wearing off. I am in more pain now than ever before. It felt great at first, but WOW. I do not recommend this."

• She...
• Taken for less than 1 month
• June 13, 2021

For Osteoarthritis "I fell at work more than 2 years ago, broke my patella. After 3 surgeries, the last one seemed to have worked well, my pain level was down to a 2-3. My doctor suggested getting this injection to get me lasting pain relief going forward. I wish now I hadn't. My pain level increased to at least a 5 within a week, sometimes it hurts as much as a 6-7. I have pain where I didn't have pain before. Calling my doctor this week. My surgery was at the end of April, the injection was done at 4 weeks. I am now 3 weeks past the injection date, and it has only worsened my knee pain. I am so over this knee pain."

• Gar...
• Taken for 1 to 6 months
• May 6, 2022

For Osteoarthritis "Issue is osteoarthritis of the knee and a partially torn meniscus. Had GenVisc850 injections (5 over 5 weeks as required), but still had knee pain, so doctor prescribed a Zilretta injection. Within 1 day, my knee pain became a lot worse, then for about 2 weeks the pain subsided some, so I thought the Zilretta was finally working. The relief was short-term and the pain increased to the point where it was difficult to put any weight on my leg. Now, 6 weeks after the Zilretta injection, I am scheduled for surgery."

• Anonymous
• February 10, 2022

For Osteoarthritis "I have bone-on-bone and bone spurs, and it did not work for me. Yet it’s been 10 days, and it’s really swollen, and now there’s crunching. It was very painful afterwards, and it didn’t hurt at all getting it, but now awful pain and a horrendous runny nose. I am definitely regretting getting it."

• Gen...
• Taken for less than 1 month
• June 8, 2024

For Osteoarthritis "My knee doctor recommended Zilretta, so I had it injected in my right knee. It felt great at first, but then 4 weeks to the day, the pain came back. Making another appointment on Monday to see what's next. I guess each person has a different effect. Worked great while it lasted."