Tranylcypromine and Fatigue: What Users Say

• ret...
• January 17, 2010

Tranylcypromine for Depression "I give it a 10, and I would give SSRIs and SNRIs only a 5. It's our first experience with MAOIs and it's still early days. But what a difference with fatigue (none). Other side effects, in our case, are minimal or non-existent. I wonder what percentage of people actually notice severe side effects (maybe less than 20%). It appears that MAOIs are well known these days. I presume it's because they are old generic drugs (not covered by active patents) and hence will not get high advertising budgets from the pharmaceutical companies. I also presume that many GPs have no knowledge of this class of drugs or that these are too risky, adverse (side effects) to recommend a trial. It took us at least 7 years of battling depression and fatigue before we found out!"

• Anonymous
• Taken for 5 to 10 years
• July 19, 2015

Tranylcypromine for Depression "Have taken Parnate for 5 years. Tried 5-10 other medications before trying Parnate. Had a bad reaction to most of these - worsening depression and anxiety. Currently taking 80 mg of Parnate, which is above the normal therapeutic range. Have a few side effects that still come and go, including daytime fatigue/some tachycardia right after dosing. Take 30 mg in the morning, 20 mg in the afternoon, and 30 mg in the evening. When I started taking it, I had pretty bad orthostatic hypotension for a week or two. The medicine works well. Depression and anxiety have been kept at bay for 5 years. I can enjoy life. Highly recommended."

• Jul...
• November 6, 2015

Tranylcypromine for Depression "I've been taking Parnate for 8 weeks now. It has helped my depression, PTSD tremendously. I started off at 20 mg, and now I'm at 30 mg. I follow the strict diet and don't allow myself to have anything with tyramine. (Maybe I'm a little too cautious?) The side effects that I can't stand, but I tolerate, are BP drop, dizzy almost fall over, extreme fatigue when Parnate is supposed to give you energy. I will stay in a place for some time like I have no ambition. I have lost a lot of weight on Parnate. That has to be the best side effect! :) Rarely have an appetite, nor do I care to drink anything half the time. I wish I knew what to do so I don't get those horrible dizzy spells. They happen maybe 5 or more times a day, and I have to hold on to the wall."

• meg...
• March 26, 2014

Tranylcypromine for Depression "I have been on Parnate for about 3 weeks. Am finding the insomnia really hard, as in the day I can be really tired, like fatigue at times, and am unsure whether this is coming from switching medicines, Zoloft to Parnate, or from just the Parnate, and not being able to sleep properly."

• pea...
• Taken for 1 to 2 years
• October 31, 2024

For Depression "The only drug that's helped. Insomnia and fatigue are rough, but no such thing as a free ride. 10/10 med. Anxiety and depression are controlled."