Tranylcypromine User Reviews & Ratings (Page 4)

• Downer
• Taken for 1 to 6 months
• June 6, 2018

Parnate (tranylcypromine) for Depression "Started out great lots more energy very upbeat then at around week 3 after upping the dose to 60mg day I went downhill couldn't get out of bed extremely low mood back to square 1 had high hopes for this med was very positive to be starting it I'm so disappointed now ."

• mrb
• Taken for 1 to 6 months
• December 4, 2021

Parnate (tranylcypromine) for Depression "I've tried almost every SSRI and SNRI, SSRI's flat lined my emotions, SNRI's made me feel energetic but unsatisfied with anything I was doing, DRI's like Wellbutrin made me seem and act irritable. Parnate was the first MAOI I ever tried and it worked like a dream. Honestly super disappointed in the psychiatric practice for making this a "last resort" drug and trying to push safer less effective drugs on people. I've spoken to Ken Gillman personally and the amount of fear, uncertainty and doubt that's been perpetuated around MAOI's has been extremely exaggerated. Only side effect was that it accelerated my hair thinning (male). But that was probably going soon anyway. This needs to be prescribed more often. If it's not obvious yet, it's far more effective than any SSRI, SNRI or DRI."

• Isurv...
• Taken for 1 to 2 years
• March 3, 2020

Parnate (tranylcypromine) for Depression "I was in acute withdrawal for FIVE YEARS from this dirty drug. The Dr had no clue what she was doing, nor what to do with me. I'm amazed I survived this torture. This is a dirty dangerous drug. I now see there is "Parnate Withdrawal Syndrome", this is an actual thing. Funny how true statistics of what this drug is doing to people aren't being collected???"

• megla...
• March 26, 2014

Parnate (tranylcypromine) for Depression "I have been on Parnate for about 3 weeks. Am finding the insomnia really hard, as in the day I can be really tired, like fatigue at times and am unsure whether this is coming from switching medicines. Zoloft to Parnate, or from just the Parnate, and not being able to sleep properly. "

• Anonymous
• November 19, 2010

Parnate (tranylcypromine) for Depression "Side effects are terrible. They inlcude diarrhea, dry mouth, in my case weight gain, it also made me agitated. I have been trying to withdraw from it and now have neuromuscular symptoms of cramping, teeth grinding, eye blinking."

• Just...
• Taken for 1 to 6 months
• February 7, 2016

Parnate (tranylcypromine) for Depression "I have found that people around me say that I have improved and seem better yet, inside I still feel like I'm in a deep dark hole. I've only been on 40mg for 3 months however. As for increased sex drive!?! When does that happen? It's killed my sex life. Have lost a lot of weight due to food restrictions, but needed to shed a few kilos. I also find it messes with my bladder. Anyone else have this issue? Some days I can pee no problems, others, it's just painful and I struggle to pass urine even when busting to go! Though after reading others stories, it gives me hope, that this drug, will bring me out of the darkness...... As I'm really over being in here. (I had a nervous breakdown)."

• Halo
• Taken for 6 months to 1 year
• August 28, 2016

Parnate (tranylcypromine) for Depression "Everyone responds differently to medications, and no two people are alike - so I kind of find these forums as being useless (if not borderline ridiculous). But just to share my experience...I have MDD (treatment resistant) along with Complex PTSD. I have tried every medication under the sun (over 90 different meds) before finally being introduced to Parnate in March of 2016. I was initially started at 10mg and eventually moved up to 60mg within 3-4 months. It seemed to be somewhat helpful for my depressive symptoms yet it created so many other horrific side effects along with it, that life is now worse than ever. Never have I been on a med with so many unwanted side effects. I'd rather be severely depressed any day of the week."

• Lincoln
• Taken for 1 to 2 years
• November 9, 2019

For Depression "I'm a practicing psychotherapist, and like many people on these pages, my REAL nightmares started not when I was sleeping but when I WOKE in the morning ! The depth of my depression was crippling my family and work life. Also, like many others here, I tried almost every other antidepressant with NO improvement, just negative side effects. I knew about Parnate (tranylcypromine) but was wary of diet restrictions until I realised I'd rather live on plain rice the rest of my life rather than fight off the crippling depression! And, yes, my life changed! Enthusiasm returned. Hope returned. Laughter returned.Leaving me only to echo what other people have written here.  This truly is the "ONLY GENUINE, EFFICACIOUS ANTIDEPRESSANT" available today! PLEASE try it ..please recommend it.. PLEASE spread the word !"

• Marty
• Taken for 5 to 10 years
• November 21, 2021

Parnate (tranylcypromine) for Depression "After using anti-depressants for 20 year's with minimal success, my psych put me on Parnate in combination with Seroquel. I take the max dose of 120 milligrams though I'm diagnosed with major depressive disorder, severe anxiety, PTSD. When my depression and anxiety kicked in it tended to manifest itself into OCD and compulsive thinking. After 2 weeks my symptoms were almost non existent, and since my state of mind has been a god send. Insomnia can be an issue at times but that's the only negative effect I've had. For anyone who has tried and had no success with other medications, asked your health professionals about Parnate. It was developed in the 70's and only prescribed as a bit of a last resort where other medications haven't worked. For me it's been a wonder drug. In Oz (Australia) the drug is on the PBS schedule of drugs meaning the price is substantially subsided by the government"

• mike2u
• Taken for 10 years or more
• January 6, 2023

Parnate (tranylcypromine) for Depression "I have suffered from chronic depression for years and tried multiple medications. My doctor suggested trying Parnate and it's changed my life. I have had no food issues while taking it but have had problems with over-the-counter antihistamines. This drug really works, wish it was cheaper but it is worth it. Note: generic does not work for me. Hopefully, it will for others."

• alex_t
• Taken for 1 to 6 months
• November 6, 2017

Parnate (tranylcypromine) for Depression "After failing to get any improvement with a whole range of antidepressants (incl. TCAs and wellbutrin), I was very much looking forward to starting on Parnate. Alas, unlike other pills, that had literally zero effect, this one added some negative side effects: heartaches, high BP, tense feeling in the chest, and even a visit to a hospital after I fainted (luckily nothing life-threatening). I envy people whose condition improved though. Also not sure what to do next, as this is literally the last-ditch measure, and ketamine in my country is administered only to hospital inpatients."

• Emdubya
• Taken for 10 years or more
• November 10, 2022

Parnate (tranylcypromine) for Depression "I'm torn between a positive review and something less optimistic. I've been on and off Parnate since 1982. Now that Nardil is gone I'm unable to switch between the two if one fails. I take high-dose Parnate, up to 140mg per day. I might get 4 good weeks then a relapse. If I go cold turkey for a week I can reinstate Parnate, and it works ... but never for long enough. I'm on a merry-go-round. No other drugs (antidepressants at least) do anything."

• Delaz...
• Taken for 1 to 6 months
• September 17, 2016

Parnate (tranylcypromine) for Depression "I have been taking 20mg of Parnate every day for a little over a month now after finally convincing my Psychiatrist to prescribe it. I really can't say how effective it has been in terms of alleviating the symptoms of my depression. Diet restrictions have not really bothered me at all . No real physical side effects apart from extreme sun sensitivity. This REALLY bothers me because I'm extremely fair skinned and burn so easily - frequent, and I mean FREQUENT reapplications of sunscreen and sun avoidance are a must for me. Parnate has also decreased the effectiveness of benzodiazepines such as valium and imovane. This has been really frustrating because I also suffer from anxiety and insomnia."

• KAKhan
• Taken for 1 to 6 months
• December 4, 2018

For Depression "I am not going to tell you how effective this drug is, as most users referred to it properly and accurately, and another user called it "the only true antidepressant in the market". Honestly I can't agree enough. I am diagnosed with MDD, ADD, GAD, panic disorder and social phobia. I was on several medication for years and none worked. let me tell you ,the tyramine free diet is not that hard as media are exaggerating. It is all about eating fresh and healthy food and avoiding drugs. The diet will make feel fresh and healthy, I highly recommend going for such a diet, it's an effective antidepressant on its own. I hope doctors consider this drug more, if taken properly, it's better tolerated than most and the most effective overall."

• Colin...
• Taken for 1 to 6 months
• April 17, 2022

Parnate (tranylcypromine) for Depression "Might be good for depression if you like feeling manic and talking way more than usual. Also the hypo-tension and raised liver count was alarming to say the least. If you decide to take it, make sure you get your liver checked monthly, as I was only on it for two months thank God and a low dose of 20mg per day, I had to stop when my blood pressure dropped to 60 over 10 lucky I was in a hospital at the time."

• Big...
• November 15, 2018

For Depression "This is the best drug for depression. It is also used in treatment resistant ADHD. Works better than Dexedrine (which I was on for years before discovering this drug). Unlike Dexedrine, there is no 'tolerance' and it is not neurotoxic (it is actually neuroprotective) despite being an amphetamine analogue. Only side effect is insomnia which gets better with time and can be easily managed with occasional use of a hypnotic. Taking 20mg x 3 (60mg). 10/10, highly recommended."

• Fluffy
• Taken for 1 to 6 months
• July 8, 2021

Parnate (tranylcypromine) for Depression "I’ve been on parnate 60 milligrams for 2 months. I take medicine for sleep. I’m unable to sleep and still have anxiety. On medication for both. Recently my dr decided to decrease my dose to 40mg. Saying there’s a chemical in it that can cause my symptoms. Can a lower dose help these symptoms? I take klonopin and ambien."

• Tales
• Taken for 1 to 6 months
• January 26, 2024

For Depression "I'm 26 years old man who suffered from depression and anxiety since 15 years old. The first medicine that I took back in the day was Paroxetine. At the time, it worked great for me. But, as time went by, paroxetine started to lose effect, Even at the highest dose. I had to add Xanax to control my anxiety. Now, I'm currently on Escitalopram 20mg + Lyrica 150mg + Parnate 10mg per day. Thank God I'm feeling better and no anxiety. And I recently quit taking Xanax."

• Sabaka
• Taken for 5 to 10 years
• March 6, 2021

For Depression "MAOIs saved my life. After a protracted depression of intense unrelieved psychic pain, I woke up one morning feeling a weight had been lifted. It is borderline malpractice that doctors will not even consider a drug that is considerably more effective than other class of drugs. There are people suffering unnecessarily. The food restrictions are eminently manageable. Talk to your dollar about MAOI."

• pumpi...
• Taken for 1 to 6 months
• August 5, 2022

For Depression "I realize everyone reacts differently and some have bad experiences but it's still worth putting down the good stories as encouragement. Depression is terrible and any light has to be good. My depression/anxiety started after Roaccutane as a teen - granted I had the worse acne going so can't blame the drug entirely. Then flared up after a nasty divorce and ended up in Psych hospital. I have been on it all; diagnosed all sorts of stuff and even splashed out on Ketamine (have to go private in NZ and not govt approved) without success. I thought it was my end and suicide was my only escape. Talk therapy had been done to death - excuse pun. No where to turn. Then my psychiatrist mentioned he could try a little used and outdated drug. So began my walk back into the sunlight. MAOI - why is it left so late to try? Parnate 30 mg. I did go up to 50 mg but it started my Delusions. It's augmented with Lamotrigine - still to get to the full dose of 200mg but wow I'm human again. No side effects."

• Was...
• Taken for 6 months to 1 year
• June 21, 2016

For Depression "Suffered YEARS from severe depression and anxiety. SSRIs, SNRIs naturally didn't work, and I tried every one I could! With Parnate (Tranylcypromine) I've felt normal for the first time in 15 - 20 years. I actually enjoy the flavor of food again, the green of the grass, the freshness of a nice evening breeze, as well as my old hobbies and friends and family. I still can't believe my luck. Also, haven't needed to change my diet at all. Fear of these drugs is overblown and usually irrational. Most psychiatrists today have no clue about them, so I would advise that you or a friend/relative self-educate before asking your psychiatrist about taking Parnate or another MAOI. There are some internet sites that can help with this. Don't quit!"

• Albinus
• Taken for 1 to 6 months
• March 20, 2013

For Depression "After a hospitalisation where no net good came about, I changed psychiatrist. The new guy is semi-retired, only works two half days a week - but is extremely familiar with MAOIs and one of the few doctors in a state of 4 million that will prescribe them. My symptoms were more refractory and atypical depression, and it's been quite a journey to try and work something out. I've been on tranylcypromine for 3 months now. As it's an analog of amphetamine, my major side effects have been similar to amphetamine - sleeplessness (3 hours a night), hyper alertness, agitation when the dose wears off (sucks as it's only 3 hours or so) and when really worn out it keeps going and I feel alert but make judgement errors. Depression is gone though!"

• Bert
• Taken for 1 to 6 months
• July 27, 2020

For Depression "Worked my way up to a dose of 30mg/day of tranylcypromine over the course of 7 weeks for my depression, then a dose of 10mg for 3 weeks, then 20mg for 2 weeks, then 30mg for 2 weeks. Felt weird on it the first couple of weeks. Felt like I was on low-grade speed for a few hours after dosing, then just felt lethargic and tired the rest of the day but could not sleep or nap. I know people say you gotta give this drug time, but my insomnia was so severe I simply couldn't wait any longer to wait for it to 'kick in'. Seriously, I don't know why more people aren't mentioning how bad the insomnia is and I wish I'd known before starting. It's the most common side effect and even with 3mg of Ativan, I just wasn't able to get more than a 2 to 3 hours, at best. Some nights I'd get no sleep. After several weeks of this, I had to throw in the towel (especially since I had serious sleep issues even before taking Parnate)."

• dorde...
• Taken for 6 months to 1 year
• February 9, 2019

For Depression "A decent medication, unlike many others. However, if you're one of the unlucky ones (like me) who get the afternoon somnolence it turns out impractical to take long term. Parnate didn't completely resolve my depression but offered some relief compared to SSRIs, which don't do anything. I can imagine this being a perfect drug if you don't turn into a zombie in the afternoon."

• Summm...
• October 2, 2018

"I have a very bad Panic Disorder. Tried many meds for four years to no avail. Finally Dr. told me about Parnate and it scared me but went ahead and took it. The next day was WOW complete change that fast. I could concentrate, happy, panic attacks basically stopped as I was having at least 4 a day and trying to take care of a toddler and work. It was my miracle to be able to have a so called normal life. Of course it does not take away all panic attacks but when I do feel one coming on it goes away very fast. Been taking it 40mg for 30 years and still works great."