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Xeljanz User Reviews & Ratings (Page 5)

Xeljanz has an average rating of 5.7 out of 10 from a total of 145 reviews on Drugs.com. 43% of reviewers reported a positive experience, while 40% reported a negative experience.

Reviews for Xeljanz

Commonly mentioned side effects
  • Fre...
  • December 12, 2021

For Ulcerative Colitis "Using Xeljanz for UC 10 mg 2x a day about 4 months. Good results right away within days. Fatigue in the beginning slowly getting better. Weight gain, but not sure if I can blame the drug. Some nausea in the morning. I now know what foods to avoid. Four months in and no real bad side effects."

8 / 10
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  • Els...
  • Taken for 6 months to 1 year
  • September 20, 2021

For Rheumatoid Arthritis "When I started taking Xeljanz, I was also on Methotrexate and hydroxychloroquine (Plaquenil). I was having GREAT results! My doctor had me slowly taper off the Plaquenil and Methotrexate, and I was still doing really well. BUT, then came Covid-19, and I was told to stop the Xeljanz for two weeks prior to and following my vaccinations (Moderna two-shot vaccine). So, I was off Xeljanz for two months. The pain that returned was so severe. Once I could restart the Xeljanz, my doctor also put me on a low dose of Prednisone to speed up my recovery. However, it's been 5 months back on Xeljanz, and I'm only getting very, VERY minimal relief from my pain. It seems that being off Xeljanz for those two months caused my body to not react the same as before. It's very frustrating. I hope my doctor can figure out a new way forward soon. PS: I had no known side effects from taking Xeljanz."

7 / 10
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  • Dia...
  • Taken for 2 to 5 years
  • March 9, 2023

For Psoriatic Arthritis "I’ve had psoriatic arthritis for 32 years. This drug is the best of all that I’ve been on, which was Remicade, Humira, Stelara, and Otezla, the latter two had no effect on my arthritis or psoriasis. This is the first one that has completely eliminated psoriasis on my scalp. Overall, I am about 90% improved on the psoriasis on other parts of the body. My arthritis is so much better and few flare-ups. It started working after about two weeks. I highly recommend this drug for both my severe arthritis and my psoriasis."

10 / 10
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Frequently asked questions

  • Kim...
  • Taken for 1 to 6 months
  • July 2, 2024

For Rheumatoid Arthritis "Worked in about 1 month. 5 mg twice a day with hydrochloroquine (plaquenil). No side effects!! I am also super sensitive to most meds, for anything! Tried Humira and Enbrel. Those BOTH I had swelling, headaches (bad), diarrhea. Just all around sick."

10 / 10
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  • Anonymous
  • Taken for 1 to 6 months
  • July 2, 2024

For Rheumatoid Arthritis "Worked in about 1 month. 5 mg twice a day with hydrochloroquine (plaquenil). No side effects!! I am also super hyper-reactions to most meds, for anything! Tried Humira and Enbrel. Those BOTH I had swelling, headaches (bad), diarrhea. Just all around sick."

10 / 10
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  • Lef...
  • Taken for 1 to 6 months
  • November 28, 2020

For Rheumatoid Arthritis "I was getting Orencia infusions for a few years and was pain-free from my RA. Started on Xeljanz due to the COVID situation (I didn't want to risk going to the hospital). I'm taking 10 mg twice a day. So far, I'm still barely able to function. I am hoping that it just needs to build up in my system. Male, 63, 180#."

2 / 10
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  • 198...
  • Taken for 1 to 6 months
  • August 14, 2019

For Psoriatic Arthritis "I was not optimistic about Xeljanz, but it has worked very well. Five years on Enbrel, and it was great. Two injections of Humira, and it was horrible. So I have to say, it's not that bad, it really isn't great."

7 / 10
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More FAQ

  • Nam...
  • Taken for 6 months to 1 year
  • December 15, 2023

For Rheumatoid Arthritis "Have been on Xeljanz for a year, and now it’s not as effective. Got a blood clot in my leg. My doctor says it's not from Xeljanz and that there’s no way of knowing. This drug has an interaction with aspirin, so if you did get a blood clot, taking aspirin wouldn’t be optimal. I told my doctor that I want to switch medications to avoid long-term problems that may develop with this drug. If you take a look at all the different medications prescribed for rheumatoid arthritis, you will see how differently they work. I am trying to figure out what to target. These drugs all work differently. Methotrexate (Mtx) was the most effective for me, but it meant one to two days in bed due to nausea. You will notice that as you continue taking it over time, you feel sicker than the week before. However, I had absolutely no pain with this drug (Mtx). I think maybe switching drugs yearly may prevent side effects."

6 / 10
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  • Ven...
  • February 7, 2019

For Psoriatic Arthritis "On my 5th week, and my pain is gone, however, I had a herpes flare at 4 weeks and it came back a week later. I just realized today that it might be causing severe anxiety, and my husband noticed this because I’m acting paranoid and obsessive. So scary. I have the same problem with prednisone, and it nearly drove me to suicide. My doctor should have known better."

5 / 10
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  • Kay...
  • Taken for 1 to 6 months
  • June 1, 2019

For Psoriatic Arthritis "I found relief from inflammation pain after 4 weeks on Xeljanz. Just as I was feeling fairly well, I was diagnosed with influenza, therefore, I was advised to temporarily discontinue Xeljanz until I was better. Eight weeks after resuming, my symptoms gradually became worse, not better. I'm really disappointed and do not understand how this could happen. 2.5 days after the discontinuation, I actually feel a little better. Again, this makes no rational sense to me, since I have not started another biologic yet."

5 / 10
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  • Bea...
  • Taken for 6 months to 1 year
  • July 30, 2021

For Rheumatoid Arthritis "Ineffective for me. While it was great not to have infusions, I had the worst flares I'd had since my onset. Huge, awful flares that steadily increased in frequency, duration, and severity. Was happy to return to Remicade. I guess it works for some people, but for me, it was a long, painful disaster."

2 / 10
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  • luc...
  • Taken for 10 years or more
  • July 21, 2019

For Psoriatic Arthritis "I've been on Remicade for 15 years, and from day one it has produced excellent results. Hate the two hours of sitting, but it cleared up 100% of my psoriasis. However, my insurance company cut off the rheumatologists I had for 13 years, and I had to get a referral to another doctor. Problem was it took 7 months to get into the new doctor to get back on Remicade. I begged my old doctor to help me, and he got me on Xeljanz. But Xeljanz did not work. I was covered with plaques everywhere, like I was 20 years ago. I just think the delivery system is everything with our disease. A pill takes time to take effect, which an infusion gets right to the problem quickly. I am back on Remicade and completely clear skin with no side effects. I love Remicade, but I'm worried that the preexisting condition part of ACA will be shot down in court and then in the Supreme Court. But Remicade is great, and they have a program that makes it reasonable and literally pays off my deductibles."

3 / 10
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  • ts6...
  • Taken for 2 to 5 years
  • August 15, 2024

For Ulcerative Colitis "I started on Xeljanz when it was a trial medicine. It worked within 2 weeks of starting the trial. I had tried lots and lots of other meds, and none worked. This is the only medicine that has worked for me. I have had zero side effects from it so far. It's been at least 5 years since I have been on it. UC is a distant memory for me now. Although it is very expensive, which I think is a rip-off, but at least my insurance company pays most of the cost."

10 / 10
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  • kle...
  • Taken for 6 months to 1 year
  • February 7, 2019

For Psoriatic Arthritis "You can buy any biologics in Germany for 1,000 a month, whereas they charge Medicare 15,000.00 a month. Why? It does absolutely nothing. I take it with Tremfya, it also does nothing. Otezla helps but gives you diaper rash, bad bowels, and Jakavi, which grows back cartilage, gums are healing, but does nothing for plaques. If I used four at a time, it would cost me one with insurance, and none do anything. It is only good for big pharma profits."

2 / 10
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  • Old...
  • Taken for 2 to 5 years
  • March 25, 2025

For Rheumatoid Arthritis "I have used various biologics, but none as effective as Xeljanz. Initially, I had nausea and diarrhea for a few weeks, which disappeared and nothing else since. It is great to have a medication that keeps my pain and inflammation levels at an acceptable level. I have been on Xeljanz for about three years with no issues."

8 / 10
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  • Anonymous
  • Taken for less than 1 month
  • November 11, 2019

For Rheumatoid Arthritis "I took this drug for 2 weeks (5 mg dose twice daily) and had a heart attack."

1 / 10
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50 Report
  • Tri...
  • Taken for 2 to 5 years
  • November 12, 2015

For Rheumatoid Arthritis "Been on it since 2013. Has been very effective, especially against the awful fatigue, and has dramatically decreased the pain."

10 / 10
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66 Report
  • Kay...
  • June 14, 2015

For Rheumatoid Arthritis "I saw a difference in about 2 days. I tried everything under the sun, this drug is awesome so far."

9 / 10
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61 Report
  • 43...
  • Taken for 2 to 5 years
  • June 11, 2017

For Rheumatoid Arthritis "So far, so good. Just like all the other medications, you have to monitor your symptoms. It took about 4-5 months for full effect. Haven't had to use prednisone since then, going on 2+ years now."

10 / 10
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54 Report
  • Paj...
  • Taken for less than 1 month
  • February 20, 2019

For Rheumatoid Arthritis "After 2 weeks, my hair began falling out. I attempted to contact the company, but they had no interest in my situation or my phone call."

1 / 10
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39 Report
  • Blo...
  • May 29, 2014

For Rheumatoid Arthritis "Worked amazingly the first month, but then swelling and stiffness came back. I've also had hair loss."

9 / 10
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60 Report
  • T M...
  • August 14, 2016

For Rheumatoid Arthritis "Took it for about 2 months. Lost my voice, perpetual sore throat, major sinus issues. I haven't taken it for months and can't shake the burning in my throat. I have to go to an ENT. Not a safe drug."

1 / 10
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40 Report
  • Bab...
  • Taken for 1 to 6 months
  • December 8, 2019

For Rheumatoid Arthritis "Chronic fatigue, aches, pain, and feeling sick and toxic without much change. The first couple of months created more problems than improvement."

2 / 10
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  • Anonymous
  • Taken for 6 months to 1 year
  • September 29, 2019

For Rheumatoid Arthritis "Xeljanz for arthritis has caused stomach aches so bad I'm crying in pain. Feel very weak and fatigued all the time. Very bad back pain and blood pressure very high."

2 / 10
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28 Report
  • Ala...
  • Taken for 2 to 5 years
  • February 12, 2021

For Rheumatoid Arthritis "Do not take this pill. Took it since it came out, I've had a lot of side effects. It is not good, stay away."

1 / 10
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23 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.