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Xeljanz and Upset Stomach: What Users Say

Upset stomach: mentioned by 10 users (6.9%)

Based on user experiences from 145 Xeljanz reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

headaches 10.3%
fatigue 7.6%
nausea 7.6%
diarrhea 6.9%
upset stomach 6.9%
swelling 4.8%
pain 4.1%
stomach pain 4.1%
anxiety 3.4%
back pain 3.4%

Reviews for Xeljanz

Commonly mentioned side effects
  • Bri...
  • Taken for 1 to 6 months
  • March 27, 2020

For Rheumatoid Arthritis "Been on this Xeljanz poison for three and a half months. I got worse and worse with pain. Muscle weakness. Enlarged liver. Terrible stomach problems, excruciating pain in my guts, and constant nausea. Liver pain, swelling in feet, hands, wrists, and general unwell feeling. Developed chest infections. The chemist ran out, so I was without it for three days. Stomach... good! No liver pain!!! Not one ounce of swelling. Night sweats stopped. Burning up feeling stopped. Day one back on it... all symptoms back!!! Dreadful poison. I'm stopping it."

1 / 10
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68 Report
  • san...
  • Taken for 1 to 6 months
  • December 20, 2013

For Rheumatoid Arthritis "I experienced an improvement in pain, swelling, and stiffness within the first two weeks. I was able to titrate off of prednisone and hydrocodone. However, I am experiencing stomach upset and rapid hair loss, which is very disconcerting."

9 / 10
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88 Report
  • SHE...
  • Taken for 1 to 6 months
  • January 7, 2020

For Rheumatoid Arthritis "Woke up with a severe migraine the morning after starting treatment. Took it for 4 weeks, headaches constantly, like my head and eyes were in a vice. Backache. Nausea burning in stomach, chest, and throat. Stopped after 6, as I couldn't stand it anymore, quality of life was zero by then."

1 / 10
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35 Report

Frequently asked questions

  • Moo...
  • Taken for 1 to 6 months
  • July 25, 2019

For Rheumatoid Arthritis "Over 23 years, I have been on many pills for arthritis. The latest is Xeljanz. It's only been 9 weeks. I cannot stand the pain. I struggle to climb the stairs. I've had flu-like symptoms, upset stomach, yet something else that doesn't work."

1 / 10
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29 Report
  • Bai...
  • Taken for less than 1 month
  • August 20, 2018

For Rheumatoid Arthritis "Took this one time. Next morning, my stomach hurt horribly, as well as my back. Also gave me a rash. Did not take it a second time. My back is still killing me. I think these medications are scary to take, worse than the disease itself."

1 / 10
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29 Report

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  • Ann...
  • Taken for 1 to 6 months
  • January 28, 2019

For Rheumatoid Arthritis "It's been almost two months on this medication. Stomach issues, but I've always had stomach issues. No relief from pain, in fact, it's been worse, and I've had to get back on prednisone to knock the pain out. I'm off and on Pred for three or four days to see if this drug is working, but I don't think so because every time I get off the prednisone, the pain rolls in again, and prednisone does not even seem as effective as in the past."

2 / 10
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27 Report
  • net...
  • Taken for 1 to 6 months
  • April 6, 2018

For Rheumatoid Arthritis "Xeljanz started working by the first week. I felt a surge of energy and was able to get out of bed and walk with very little pain and stiffness. I am on my 6th week, and I feel better than I have since I was diagnosed with RA. So far, my side effects are upset stomach, headaches, tiredness, and insomnia. So far, so good. I pray it continues to work with little to no side effects. My insurance only covers a portion, but with the copay card, I have no copay. This drug gives me hope. I am able to get more cleaning and chores done since I have been on this drug."

9 / 10
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26 Report

More FAQ

  • Anonymous
  • Taken for 6 months to 1 year
  • September 29, 2019

For Rheumatoid Arthritis "Xeljanz for arthritis has caused stomach aches so bad I'm crying in pain. Feel very weak and fatigued all the time. Very bad back pain and blood pressure very high."

2 / 10
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28 Report
  • She...
  • Taken for less than 1 month
  • August 1, 2019

For Rheumatoid Arthritis "Extreme stomach upset after 2 weeks. Almost ended up in the ER last night due to pain. I am discontinuing immediately. Also hated the fatigue. No thanks!"

1 / 10
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22 Report
  • Car...
  • Taken for less than 1 month
  • November 4, 2018

For Rheumatoid Arthritis "Just started two weeks ago. Pain in all joints throughout the day, mild stomach cramps (feels like a ball in my stomach), horrible back pain."

3 / 10
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20 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.