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Xeljanz and Pain: What Users Say

Pain: mentioned by 6 users (4.1%)

Based on user experiences from 145 Xeljanz reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

headaches 10.3%
fatigue 7.6%
nausea 7.6%
diarrhea 6.9%
upset stomach 6.9%
swelling 4.8%
pain 4.1%
stomach pain 4.1%
anxiety 3.4%
back pain 3.4%

Reviews for Xeljanz

Commonly mentioned side effects
  • Jar...
  • Taken for 1 to 6 months
  • February 4, 2019

For Ulcerative Colitis "Xeljanz has been a miracle drug for me. Finally, after almost two years of horrible pain, severe diarrhea, etc., I have a life again. I have tried so many pills, enemas, suppositories, biologics, and everything failed me. The reason I rated it a 9 instead of 10 is because I still have an occasional day that I’m not doing well, but I was in pain and had diarrhea EVERY DAY 20 plus times a day before Xeljanz. I never thought I would be so excited to say I finally have solid stool. Xeljanz started to work for me within two weeks and is still working to this day. I have been on it for four months. I highly recommend this medicine."

9 / 10
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71 Report
  • Ann...
  • Taken for 1 to 6 months
  • January 28, 2019

For Rheumatoid Arthritis "It's been almost two months on this medication. Stomach issues, but I've always had stomach issues. No relief from pain, in fact, it's been worse, and I've had to get back on prednisone to knock the pain out. I'm off and on Pred for three or four days to see if this drug is working, but I don't think so because every time I get off the prednisone, the pain rolls in again, and prednisone does not even seem as effective as in the past."

2 / 10
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27 Report
  • Jul...
  • Taken for 1 to 6 months
  • January 7, 2017

For Rheumatoid Arthritis "I could tell it was going to work from the second day and had a wonderful 6 or so pain-free weeks until it started to stop working. Having bad flares again at the 2-month mark-swelling seems to still be slightly controlled, but pain and stiffness are bad and about to turn to prednisone."

6 / 10
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31 Report

Frequently asked questions

  • Ann...
  • Taken for 1 to 6 months
  • January 14, 2018

For Rheumatoid Arthritis "I have been taking Xeljanz for 7 weeks now. Not only did it not improve anything, but each day it gets worse. I was happy to go to sleep before because that was the only time I did not have much pain. Now, when I sleep, I am in pain, and for a week or so now, I wake up with horrible pain in my leg, and I take 2 Tylenol and stay awake in bed till early morning when I can sleep a little. I am going to write to my rheumatologist to tell her that I think it's insane to keep taking this medicine that makes my pain worse, no doubt about it. I am sorry I did not do it before."

1 / 10
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18 Report
  • ade...
  • July 19, 2019

For Rheumatoid Arthritis "Been off of Xeljanz since June 5th. I am in so much pain going on Cimzia, but insurance denied it, but Dr. is working on getting it approved as I am in so much pain. I can honestly say this is the worst I have felt."

2 / 10
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15 Report
  • Bab...
  • Taken for 1 to 6 months
  • December 8, 2019

For Rheumatoid Arthritis "Chronic fatigue, aches, pain, and feeling sick and toxic without much change. The first couple of months created more problems than improvement."

2 / 10
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27 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.