Zepbound User Reviews & Ratings (Page 4)
Zepbound has an average rating of 8.8 out of 10 from a total of 418 reviews on Drugs.com. 83% of reviewers reported a positive experience, while 2% reported a negative experience.
Reviews for Zepbound
- On...
- Taken for less than 1 month
- February 18, 2025
For Weight Loss (Obesity/Overweight) "With the initial injection of 2.5 taken before bed. I woke up with painful, swollen neck lymph nodes and extreme fatigue. The next day, the swollen lymph nodes seemed to have moved down, now in the chest/armpit area. On the 3rd day, one of my knees is swollen and horribly painful. I have absolutely never had any knee issues prior to the injection. If I get nauseous, drinking more water helps. At this start of the med, continuing is definitely not worth it."
- Bor...
- Taken for 1 to 6 months
- January 17, 2025
For Weight Loss (Obesity/Overweight) "I’m almost 46. I have been struggling with weight loss all my life, joined food addiction programs, and tried other diets, and nothing worked. I lost some but gained it right back. I started at 220, but in numbers, I was not diabetic, so my insurance wouldn’t cover weight loss medication. My doctor worked with me for months and kept trying until it was finally approved. I did manage to get down to 186 pounds before starting on Zepbound. I have lost an additional 22 lb in 2.5 months! I’m at 164 now, and I haven’t been here in years. I can relate to many of the comments here. I don’t think about food, no cravings. I feel satisfied. I have been doing one meal a day, and I feel great. I don’t feel anxious, deprived, or hungry. I don’t worry about what I’m going to eat next. I don’t catch myself always snacking. It’s changed my brain in a way that I’m at peace. Just started on a 7.5 gm, and I did have some nausea just the very first day, but no other side effects."
Frequently asked questions
- Zepbound vs. Mounjaro: Comparison Guide for Weight Loss and Diabetes Treatment
- Why am I not losing weight on Mounjaro?
- Ozempic Mounjaro Wegovy & Zepbound: Weight Loss Compared
- Which GLP-1 drug is best for weight loss?
- mis...
- Taken for 1 to 6 months
- January 23, 2025
For Weight Loss (Obesity/Overweight) "I have had a good experience with Zepbound. So far, I have lost 30 lbs in 6 months. This is my take and experience. You will feel sick if you eat improperly. You're not going to lose weight and continue to eat like you have been. Butter, fat, oil, and overeating will make you feel nauseous. These drugs slow down your digestion. I learned that in the first 24 hrs. I was at a barbecue and piled the food on my plate like normal. I felt sick the rest of the day. I learned my lesson. Make sure you drink plenty of fluids. Since digestion is slower, other functions slow down too! (If you know what I mean). Don't starve yourself, that will make you feel sick too. I have found that avoiding too many carbs and eating high in protein is working for me. I'm hoping my brain is rewired for when I go off Zepbound. I don't plan on being on this forever."
- Dav...
- Taken for 1 to 6 months
- September 17, 2024
For Weight Loss (Obesity/Overweight) "I started at the beginning of May 2024 at a weight of 236. My doctor recently retired, and I was seeing his PA, and he started me on Zepbound 2.5 for a month. I had lost several pounds and moved to 5.0 mg, which I am still on, today is September 17. The PA and I agreed that this dose seems to be working well for me - today, I am 186 pounds! This medication is amazing! I have had no side effects at all."
- JWa...
- Taken for 1 to 6 months
- March 28, 2025
For Weight Loss (Obesity/Overweight) "Zepbound was effective within the first week. I experienced a significant decrease in hunger and decreased interest in food. I also found that I could not always finish a meal serving in one sitting. Initially, I had minor issues in bowel habits (constipation and diarrhea). Both symptoms are minor and managed with adequate hydration and fiber-rich foods. More disconcerting have been the “egg burps” caused by bacterial action on sulfur-rich foods in a slowed GI system. I have selected less sulfur-rich foods and make a concerted effort to drink more water during a day or two following the weekly injection. This side effect seems to have moderated, perhaps as I am into the second month of my current dosage and third month on Zepbound and/or temporarily minimizing sulfurous food intake in a short period following injection. I also track my food intake and assure I am eating an adequate level of protein. I have lost 15 pounds in 10 weeks. I am 77 and a woman."
- BK...
- Taken for 1 to 6 months
- April 5, 2025
For Weight Loss (Obesity/Overweight) "I started this journey at 387 lbs. On the initial dosage of 2.5 mg, I lost 12 lbs in the first month. I have no side effects to speak of, and the food noise is 90% gone - although it seems to know when I'm within 24 hours of my next injection. The weight loss from the 5 mg cycle feels like another 10 lbs, but my Dr. visit will tell the tale. I am VERY happy with this decision, and I have NO regrets."
More FAQ
- How much is Zepbound with or without insurance?
- How long does it take for Zepbound to work?
- Can you get tirzepatide from a compounding pharmacy?
- How do Zepbound and Wegovy compare?
- Tpo...
- Taken for 1 to 6 months
- March 3, 2024
For Weight Loss (Obesity/Overweight) "50-year-old female with 100 lbs to lose and PCOS. Been on Zepbound for 6 weeks (just took 7th shot). Minimal side effects. Occasional nausea, headaches, and sore muscles, usually the day after injection, but they go away by the next day. Taking the 5 mg dose right now. I have been getting large injection site rashes with itching, burning, and swelling with the last 3 doses. The swelling and itching go down after 3-4 days, but the red spots are still visible from all 3 of the previous doses. I didn't get this with the 2.5mg dose at all. Hoping it was just this last box of the medicine and the next will be better. I have only lost 5 lbs in the 6 weeks I have been on it, which has been very disappointing. It has lowered my blood pressure though. It was on the high side of normal before, now it's perfect. Really hoping that going up to the 7.5mg dose will start having better results for me as I have got a long way to go, and hopefully the skin reactions won't get worse."
- And...
- Taken for 1 to 6 months
- June 8, 2024
For Weight Loss (Obesity/Overweight) "Started out great. Moved to 5.0 and had AWFUL vomiting on day 3 after injection. Dr. tried to move me back to 2.5 but Rx store was unable to get it. Went 5 weeks before it was restocked. Started 2.5 again with 0 effect. And I mean zero. Moved to 5.0 and the nausea is there, but so far, no vomiting. What concerns me is that I have suddenly been struggling with an elevated pulse and higher than normal BP. Wasn't an issue before, so not sure if it's related or incidental. May stop it because I just don't feel good. In addition over the 5 months of on and off again, I am down 4 pounds...and following a reasonable diet plan. Discouraged."
- Nan...
- Taken for less than 1 month
- January 30, 2025
For Weight Loss (Obesity/Overweight) "I have just started on the 2.5 mg dose. This is the end of my second week. I’m not experiencing any side effects except belching. I’m really looking forward to my weight loss and feel confident that with some walking daily and use of light weights I will reach my goal. I’m not overdoing the exercise, as when I do, I regrettably always quit. I’m paying for this out of pocket, so this is also a great motivator for me (get my money’s worth!) Using the injection is no problem, and I’m also looking forward to no more snoring (sleep apnea), which is a bonus as I didn’t know about that until I started taking it. This will please my husband! I’m purchasing it through Eli Lilly and my dr. sends them my script, I pay them monthly, and they send it to me via mail. I’m hoping Medicare may cover this in the future, as it’s been in the news it will if you have sleep apnea."
- D R...
- Taken for 1 to 6 months
- March 14, 2025
For Weight Loss (Obesity/Overweight) "It definitely curbs your appetite, however, it destroyed my stomach. After 5 weeks, I couldn’t tolerate it anymore. I’m disappointed that my stomach and vomiting were so severe that it was not worth the risk. In a 3-week period, I had to go to the emergency room twice. I hope others have a better experience than I did."
- NJ-...
- Taken for 1 to 6 months
- January 23, 2025
For Weight Loss (Obesity/Overweight) "I've finished my 5th month of Zepbound injections. The dose pen makes the injection simple and painless. It took me a few weeks to actually feel that this was changing my appetite or cravings, but once it did, I have no problem resisting the habitual munching. Although my diet changes have helped the amount of food I eat at one time, I don't get the full feeling that a lot of people talk about. So I have to know when to push away from the servings. This was prescribed for weight loss, but I do have sleep apnea as well. I've lost 20 lbs, which matches the estimated 1 lb per week under this med. My goal weight is a 40 lb reduction. The only side effects that I've noticed are primarily increased gas and constipation if I don't push the fluids. So far, it's been a positive experience and I look forward to added results."
- Daw...
- Taken for less than 1 month
- March 18, 2024
For Weight Loss (Obesity/Overweight) "Started Zepbound 2.5 mg just 3 days ago. For the first time in my LIFE, I am eating to nourish my body, and not to satisfy hunger or cravings! Super excited to see how the weight will drop with new habits. Downside, I wasted a pen the very first time I injected because I didn't remove the grey closure. My fault for not thoroughly following the instructions but total bummer because the cost of this med is not cheap and the pharmacy says they can't fill an Rx for just one pen. It would be nice if the manufacturer of the drug would allow a single pen to be purchased for a lesser cost."
- Vio...
- Taken for less than 1 month
- May 30, 2024
For Weight Loss (Obesity/Overweight) "I started Zepbound about a week ago. Only had 1 injection, but for me personally, as soon as I did the injection, I immediately began to feel nauseated and dizzy for a good couple of hours, but then it subsided. I did have some anxiety about the side effects, and sometimes when I do have anxiety, I will feel nauseous and dizzy as well, so I really can’t tell if that was from the injection or anxiety. Either way, it stopped. Since then, I barely eat. I NEVER feel hungry at all, and when I do, I eat hardly a handful of something before I feel full and stop eating. I don’t know if that’s normal. I’m supposed to get 60 grams of protein a day. I drink 2 of those 30 grams of the Premier protein shakes, not my favorite, but it will do, and that keeps me feeling full for pretty much the ENTIRE day. I don’t snack at all anymore. Again, I’ve only had 1 injection but have noticed some immediate changes."
- Ano...
- Taken for less than 1 month
- January 16, 2025
For Weight Loss (Obesity/Overweight) "I started 2.5 on 1/12/25. I haven't had any side effects. What I have noticed is the reduction in my need to snack. I was always wanting something after dinner. One snack turned into 2 or 3. I don't feel that way anymore. Sometimes I feel that I don't want to eat what's in front of me at mealtimes, but I am trying very hard to eat and keep protein up. I lift heavy weights 4 days a week, and I want to retain muscle if this ends up helping me finally lose the weight I've been burdened with for my entire life. I did get a bruise at the injection site. I can't wait to weigh myself to see if I've lost. So far, feeling great!"
- Mer...
- Taken for 1 to 6 months
- November 5, 2024
For Weight Loss (Obesity/Overweight) "I started this medication in August 2024, and I have lost 35 lbs as of the beginning of November. I am very satisfied with this medication. I have rheumatoid arthritis, and being able to lose this weight has definitely helped my joint pain. I have tried other medications along with diet and exercise, and none have been as successful as Zepbound. I have been lucky that I have not had any side effects with this medication. I only have 15 more lbs to go. I would recommend this medication to anyone that has had trouble losing weight with other regimens."
- Kat...
- Taken for less than 1 month
- January 26, 2025
For Weight Loss (Obesity/Overweight) "I am so happy with Zepbound! I have lost 20 pounds in 3 months after 25 years of trying every diet, gimmick, supplement known to man, and nothing worked except this! My frustration and disappointment come from the insurance company that won't pay for it. I have been paying out of pocket, I get vials and do my own injections to save money. Now I need to go up in dose, and my new insurance turned me down even though I meet all the criteria. I did an appeal, and they came up with another reason to turn me down. I'm on my second appeal, and it's not looking good, so I guess I just have to blow up to 300 lbs and get diabetes and have a heart attack, which all runs in my family, before they will have to pay for it. The system is rigged! I have not had any side effects or problems with this medication."
- ric...
- Taken for less than 1 month
- May 26, 2024
For Weight Loss (Obesity/Overweight) "So, I took one dose, unfortunately, my doctor screwed up and started me at 15mg. I've been in the ED for 36 hours and have had the worst 3 weeks of my life. This is not a review but a caution, check your script thoroughly, make sure you're taking the right dose. I need to purge this dose from my system and then start a 2.5mg dose."
- Ano...
- Taken for 1 to 6 months
- June 11, 2025
For Weight Loss (Obesity/Overweight) "As soon as I began at the 2.5 dosage, I modified my diet radically to mitigate or even entirely avoid the dreaded side effects of indigestion, nausea, constipation, heartburn, and vomiting. I also embarked on a free-weight program to build muscle. Fortunately, I’ve experienced none of the unpleasant side effects. I’ve titrated up after each 4-week dosage and am now in the middle of 7.5 mg. My doctor tells me I have lost more weight than most patients have at this point. I also have chronic inflammation, which extra weight exacerbates, and I’m watching carefully to see that marker decrease. That’s the good news. Zepbound has completely changed my relationship to food. I consider myself a “foodie.” That’s now behind me. I remind myself that it’s been only 10 weeks. I’m hopeful that at some point, I will be able to enjoy more of the foods that were once such a large part of my life."
- Sus...
- Taken for 1 to 6 months
- October 19, 2024
For Weight Loss (Obesity/Overweight) "Been taking Zepbound 2.5 mg for four weeks - just had my fifth injection last night. Started at 254 lbs. and have lost 18 lbs!! My last weigh-in was 236 lbs.! The only annoying side effect I had was mild constipation. I had no idea what food noise was until it was gone. Wow. Finally understand what it is to be normal. Not sure what my goal weight will be yet, somewhere between 175-150 lbs. I'm in my early 50s and finally confident I'll have sustainable weight loss."
- Ani...
- Taken for 1 to 6 months
- August 15, 2024
For Weight Loss (Obesity/Overweight) "I am 72 years old, starting weight of 210 on June 13, 2024. 1 month of 2.5 mg, then been on 5 mg. Absolutely no side effects. August 14, 2024, down to 189. Never hungry. Was concerned this was slow weight loss with reviews of 20 in one month. These reviews were reassuring to me."
- jos...
- Taken for 6 months to 1 year
- May 11, 2025
For Obstructive Sleep Apnea/Hypopnea Syndrome "I started Zepbound in September 2024 to treat severe sleep apnea as diagnosed through sleep studies. I have been on the drug for 8 months and lost 35 pounds, reaching a normal weight range, and my sleep apnea is about 90-95% improved. I had mild stomach discomfort in the first month or two, but nothing very concerning. I also had some itching at the injection sites periodically over the first few months. I currently have no side effects whatsoever. I gradually ramped up from the 2.5 mg/0.5 mg dose to 5.0 mg/ml to 7.5 mg/ml, which is my final dose. This medicine was an absolute game changer. Can't emphasize how much this has improved my quality of life. I had struggled with sleep apnea and using a CPAP for about 10 years, with little success before trying this. It is important to be monitored by a doctor throughout treatment, including bloodwork, including lipase to monitor for pancreatitis."
- cli...
- Taken for 1 to 6 months
- July 31, 2024
For Weight Loss (Obesity/Overweight) "I asked my doctor about starting Wegovy since my efforts weren't working, but she recommended Zepbound - and I am so glad she did! My appetite is no longer controlling me, and yet those pre-diabetic low blood sugar drops are gone. After 3 months at the 5 mg dose, I'm still consistently losing about 1% of my weight each week. The only side effects are minor constipation and heartburn, but they encourage me to drink more water. I was hesitant to start because...needles...but it's so tiny I don't feel it at all. I wish I had started sooner!"
- Bob...
- Taken for 6 months to 1 year
- February 23, 2025
For Weight Loss (Obesity/Overweight) "I’ve been taking Zepbound for 9 months and have lost approximately 25% of my original body weight, 267 lbs down to 200 lbs. I’m a 76-year-old white male with peripheral neuropathy. One noticeable side effect that I have experienced is loss of taste, which makes it hard to enjoy food. I have reached my original goal. Another benefit I have experienced is that I can sleep without using my CPAP."
- Mar...
- Taken for 1 to 6 months
- May 25, 2024
For Weight Loss (Obesity/Overweight) "Started using Zepbound in March 2024, at 2.5 mg. History of Obesity (BMI > 29) and Hypertension. Starting weight was 202 lb. and Blood Pressure Avg. of 153/90. As of today, May 24, 2024, currently on 10mg. My weight is currently 177 lb, having lost 25 lbs (12%) of starting weight. It was easy to learn how to use the injection pen, and it is a painless process. I am also exercising, running 4-5 days per week and weight training 2 days per week. Exercise is an important adjunct to weight loss treatment, and can help maintain muscle mass while losing weight. It is also imperative to eat foods rich in protein and green, leafy vegetables. Side effects have been minimal, with occasional constipation, which is remedied by using Miralax or similar products."
See also:
More about Zepbound (tirzepatide)
- Check interactions
- Compare alternatives
- Pricing & coupons
- Drug images
- Latest FDA alerts (2)
- Side effects
- Dosage information
- During pregnancy
- Support group
- FDA approval history
- Drug class: GLP-1 Agonists (Incretin Mimetics)
- Breastfeeding
- En español
For Weight Loss (Obesity/Overweight) "I started in October and am now on 10 mg. I have lost 106 lbs. I feel better than I have in years. I’m 69 and will be 70 in August. I do more, I get out more, I’m involved again. I have 60 more to go. I’m not saying it’s been a bed of roses, but the good outweighs the bad days 95%. Also, in the beginning, I would give myself the injection at night and then take something for nausea my doctor prescribed and no longer felt nauseous. Good luck, everyone, to a longer and better life."