Zepbound User Reviews & Ratings (Page 2)
Zepbound has an average rating of 8.8 out of 10 from a total of 418 reviews on Drugs.com. 83% of reviewers reported a positive experience, while 2% reported a negative experience.
Reviews for Zepbound
- Jen...
- Taken for 1 to 6 months
- March 11, 2024
For Weight Loss (Obesity/Overweight) "I have been on the medication since 1/19/2024. I did 4 injections of 2.5, then went up to 5 mg. I will be staying with this dosage for at least 2 months. I have dropped 18 pounds so far. I have nausea for a day or two after injection (still able to function at work). I still have about 30ish pounds to lose, but I no longer think about food. I am also so happy that my pain from fibromyalgia has gotten so much better. I don't have the inflammation all the time. I am 50 and in menopause, I have done the eat less, move more with little results. I am very happy with this medication. You still have to do the work (eat little sugar, high protein, exercise), but it is nice to see it actually working now!"
- dis...
- Taken for 1 to 6 months
- April 1, 2024
For Weight Loss (Obesity/Overweight) "After so many people I knew were doing so well on these injections, I started Zepbound 6 weeks ago. I was fine for 24 hours, then the side effects kicked in. I don't recall ever feeling this sick. Sulfur burps, churning stomach, started vomiting and diarrhea for 3 full days. I was sick for days after the first shot. I had no hunger while so very sick. Week 2 and 3 had no problems and the food cravings were gone. I was prepared to be very successful on this medication. Week 4 sulfur burps came back again, 24 hours after my injection. The same reactions returned but less violent, I was sick for 24 hours. Maybe a fluke? Week 5 and 24 hours in, same sulfur burps started it again: diarrhea, stomach spasms, and vomiting. Nope, off the Zepbound. I would rather stay fat than make myself sick with every dose. I never got beyond 2.5. I know this has been wonderful for some people, it's just not for me."
Frequently asked questions
- Zepbound vs. Mounjaro: Comparison Guide for Weight Loss and Diabetes Treatment
- Why am I not losing weight on Mounjaro?
- Ozempic Mounjaro Wegovy & Zepbound: Weight Loss Compared
- Which GLP-1 drug is best for weight loss?
- Ric...
- Taken for 1 to 6 months
- May 21, 2025
For Weight Loss (Obesity/Overweight) "This Zepbound is an absolute miracle! Prior to starting I was 210 and in less than two months down 18 pounds. My triglycerides dropped from 600 to 220. No real side effects other than constipation and nausea if I eat too much. Very grateful for this medication, don’t be afraid of Zepbound, it has changed my life in a very short period of time. Was on 2.5 mg for the first month and now started on the 5 mg with no issue. The food noise is GONE, which I never really knew was a thing, but as an overeater, I definitely understand what that means now. 10/10 all day folks."
- Pat...
- Taken for less than 1 month
- March 26, 2024
For Weight Loss (Obesity/Overweight) "I started Zepbound 17 days ago. 64-year-old woman, 210 lbs, BMI 33.9, height 5 ft 6 inches. Insulin resistant, high blood pressure, and cholesterol, sleep apnea. No problem at all with the injection. I don't even feel it. I do bring it to room temperature before injecting. I was terrified of the potential side effects but thankfully haven't experienced any that aren't very manageable. I notice if I eat certain foods for dinner, they aren't digested by morning, so I avoid those. I might feel a bit of nausea from time to time but use ginger chews. I definitely feel full faster and eat less. I've only weighed myself once so far, on day 9, and was down 7 pounds. Frankly, I have been a little scared of the scale after failing so many different diets (Keto, Intermittent Fasting, South Beach, Weight Watchers, to name a few). I'd diligently stay on them for several weeks only to have the scale not budge, or sometimes my weight went up! So discouraging. I'm so hopeful with this new medication!"
- ibd...
- Taken for less than 1 month
- January 28, 2025
For Weight Loss (Obesity/Overweight) "Started the shot on Wednesday, was kind of nervous. Ate small portions, so I wouldn't get nausea. Didn't really think it was working, didn't feel any different. It is now Monday, I have lost eight pounds. I'm never hungry, have to remember to eat, don't think about food really except fruit, it always sounds good. Absolutely no negative side effects. Started at 187, am now at 179. This is on my first shot! This stuff is amazing, looking forward to that second shot! It's expensive since state insurance doesn't cover it, and I only work part-time, but worth every cent!"
- Ann...
- Taken for less than 1 month
- January 9, 2024
For Weight Loss (Obesity/Overweight) "In the last 7 months, I went on a medically supervised, 1100-calorie per day diet to lose weight. I'm a 52-year-old female, 5'9'', and weighed 282 lbs. I managed to get down to 255 lbs and was feeling physically better, but constantly hungry, cranky, and miserable (also miserable to be around). After much discussion with my doctor (who was in favor of the medication), I started taking 2.5mg of Zep just before Christmas. After 3 weeks of use and despite many holiday celebrations, I'm down 4 lbs and all my cranky hanger is gone. I feel much better - all the noise in my head about food has disappeared, along with much of my appetite. I had constipation for the first couple of days after the first shot, but now I don't have any. My side effects have been minimal thus far, but I notice cravings and a bit of hunger coming back on days 5 and 6. I'm amazed at how easy this makes managing my diet, and it is so nice to not feel like a failure for once! I'm paying out of pocket with the savings card, but the $560 per month is so worth it."
More FAQ
- How much is Zepbound with or without insurance?
- How long does it take for Zepbound to work?
- Can you get tirzepatide from a compounding pharmacy?
- How do Zepbound and Wegovy compare?
- Suz...
- Taken for 1 to 6 months
- December 2, 2024
For Weight Loss (Obesity/Overweight) "I started on Zepbound Sept 3rd, 2024. The sulfur burps started but subsided after a day or so. Each time I give the shot, I get a little of this. I’ve stayed at .05 mL because I have a bit of a sour stomach, so don’t want to have worse, and I like my slow weight loss (14 lbs) as of 11/30/24. I heard if one loses too fast, it results in saggy skin. I had a problem with the protein powder, so discontinued, but realize making sure to get enough protein is crucial. My positive effect I’d like to report is I’m no longer lactose intolerant! So exciting! I can eat whatever I want without fear of the usual aftereffects. I didn’t need to lose much weight, but my added concern is that I have sleep apnea (couldn’t tolerate C-PAP). I’ll report back when I make a recording to see if it’s been eliminated. I only live with dogs, and they refuse to tell me if I’m still snoring or not."
- Sus...
- Taken for 1 to 6 months
- March 26, 2024
For Weight Loss (Obesity/Overweight) "I've been on Zepbound for about 3 months. I'm 5'3' and started at 167. So far I have lost 12 lbs. trying to maintain a 1,200 calorie diet. The main thing is to watch what you eat and quit when you are full. The only side effects I've seen are fatigue and constipation. The shots don't bother me at all and no nausea, thank goodness. The only thing I'm really worried about is gaining it back when I stop. Good luck to all!"
- SJM...
- Taken for 1 to 6 months
- January 24, 2025
For Weight Loss (Obesity/Overweight) "I normally do not write reviews, but this medication has been very helpful. I have struggled with being overweight my entire life. I have always felt like my medical conditions were fighting against me, but week 1, I lost 5.8 lbs. This is not a miracle drug, I do run 6 mi 5 days a week (started at 1 mi) and lift weights 3 times a week. I also have an active lifestyle with 6 kids. I eat a high-protein, low-carb diet and make sure I drink 100 oz of water a day. I have been able to lose 40 lbs in 12 weeks. I started at 2.5 mg for 4 weeks, bumped up to 5 mg, and my doctor is keeping me at that because I have done so well. I have 25 lbs until I reach my goal weight. Without this medication, I would have still been depressed, overweight, and my health would still be declining. I have tried every workout, every diet. Zepbound has been the game changer. I have not experienced any negative side effects."
- Anonymous
- Taken for 1 to 6 months
- February 26, 2024
For Weight Loss (Obesity/Overweight) "I have been taking Zepbound for seven and a half weeks now. I have lost 20 lbs! I am happy about that. I love how it takes that constant hunger I felt and cravings for junk are gone - that’s a miracle in itself. I did have some side effects of bloating, nausea, and sulfur burps and gas, but they do seem to taper off as your body adjusts to the dose. I am now up to a 5 mg dose but have opted to stay here for now because the nausea was increasing. I have no hunger at all. I will try it another month at 5 mg and if no relief in the nausea, I will ask to go back to the 2.5 dose. I continue to lose 2-3 pounds a week and it is adding up."
- Mik...
- Taken for 1 to 6 months
- March 5, 2024
For Weight Loss (Obesity/Overweight) "Been on Zepbound 7 weeks now. Lost about 22 lbs so far with no exercise. This stuff is amazing at curbing your appetite. But beware, stick to healthy foods and minimal portions because the nausea is otherworldly. I ate too much too late in the day yesterday. I had to leave work early today for the second time since being on this med. Light-headed, profuse sweating, chills, diarrhea almost non-stop and even puking. This med is a miracle, but you cannot mess around. Take it seriously. Cut back portions, minimal dairy, low sugar and don't eat too late. I'm excited to see how far I can go on this med. So thankful I have access."
- Ang...
- Taken for less than 1 month
- February 10, 2024
For Weight Loss (Obesity/Overweight) "I started taking Zepbound approximately 3 weeks ago, and this is after having the Gastric Sleeve a year ago. Due to becoming ill, I gained about 30lbs back and was not happy at all. So finally, my doctor prescribed Zepbound. The nausea is unreal, but I tolerate it. When trying to eat anything fried, it's a vomiting situation that's going to happen. But overall, I have lost about 4lbs in the 3 weeks with no exercise. I will try and start exercising with the next mg upgrade. Guys, please realize everybody's journey is different, and you will lose what your body is supposed to lose, so don't overdo it. Zepbound is working great for me at the moment."
- Mel...
- Taken for less than 1 month
- March 6, 2024
For Weight Loss (Obesity/Overweight) "I just had my 2nd shot of Zepbound and the side effects so far are that I burp a lot (lol) & feel a little tired, but nothing major at all. I can’t eat much at all, maybe a few bites, and it takes me forever to get those few bites down, then I’m full for a few hours. I have been keeping a complete diary of this. So determined. Hope this helps."
- Gen...
- Taken for 6 months to 1 year
- June 19, 2024
For Weight Loss (Obesity/Overweight) "After many years of trying to lose weight only to keep gaining, I finally had enough and decided to start Zepbound last December when I found out my insurance would pay for it. I started on 2.5mg like everyone else and increased the dose monthly. It’s June and I currently take 15mg. I have lost 55 pounds. I consistently lose 2 pounds per week. I had side effects as I titrated up. I no longer have any side effects. I am still losing weight and I have never felt better. I plan to stay on this long term. My doctor is on board with that plan as well. I would recommend this to anyone that has tried everything and has been unable to lose the weight. I am 50 years old and want to be able to stay active and have little to no pain. This medicine has changed my life."
- Anonymous
- Taken for 2 to 5 years
- March 26, 2025
For Weight Loss (Obesity/Overweight) "This medication saved my life! In the beginning, the nausea was very noticeable but worth every bit! I never really had a problem with my weight until after my pregnancies. I gained over 90 lbs with each of my two pregnancies. Being at over 300 lbs and only 5’1” was a miserable existence. I couldn’t breathe and was exhausted all of the time, not to mention pre-diabetic and very high blood pressure. It has definitely been a journey, but I stand by that this medication saved my life. I’ve lost 125 lbs. I still have a way to go to get to my goal, but I’m so happy to be alive to see how much better life can be! By the way, my A1C is now normal, and the hypertension has also resolved! I’m very grateful!"
- Chw...
- Taken for less than 1 month
- July 27, 2024
For Weight Loss (Obesity/Overweight) "I am one week in and on the 2.5 dose. I was really afraid to start because I didn’t want to get hypoglycemia, which is something I have dealt with my whole life. (I’m not diabetic and do not take insulin, I think I just have plenty of insulin.) But I did it and am so happy I did! I am down 4 lbs in one week and have had minimal side effects. I am eating much less, and food noise is almost gone. I’m excited to keep on going! For reference, I am a 59-year-old woman, 5’ 4”, and my starting weight was 192. So far, this is like a miracle! I highly recommend it if you can get it."
- SMP...
- Taken for 6 months to 1 year
- February 5, 2025
For Weight Loss (Obesity/Overweight) "I’ve lost 43 lbs in the last 9 months. I experienced some mild hair loss (but started this in menopause, so that contributed to hair loss as well), increased heart rate, although mine was low to start, some burping, and tiredness. The worst side effect for me is the diarrhea. I have it starting about 24-48 hrs after injection. It lasts on and off for about 3 days. Overall, these side effects have been mild and manageable. The weight loss has been life-changing!!"
- Bye...
- Taken for 1 to 6 months
- July 23, 2025
For Weight Loss (Obesity/Overweight) "Lifelong dieter here. Despite successes, the weight always crept back. Zepbound feels like a game changer thus far. I feel fabulous overall. Nobody knows of my decision to try Zep, yet already everywhere I go people comment on how healthy I look. I’m 73 years old, female, 5’6”, SW 185 and goal 145. I’m on my fifth week @2.5, with a steady loss of 2 lbs per week. Minor nausea on injection day with the abdominal injection. The tartness of gummy fiber/vitamins is great for relieving nausea. Periodic fatigue mostly on day two. Friday is injection day so I can crash on Saturday if necessary. I eat six small meals each day and try to get a total of 120-140 grams per day. I get food noise, but it’s good noise thinking about nutrient-dense and low-cal foods. Protein/collagen powders/snacks are essential to keeping healthy muscles, hair, skin. Drink water!!!"
- Ano...
- Taken for 6 months to 1 year
- May 22, 2025
For Weight Loss (Obesity/Overweight) "I have been taking Zepbound for 8 months. I am on the highest dosage and 6 pounds away from my goal weight. I have lost 65 pounds. I do get nauseous around the 2nd or 3rd day after my injection, but it has not resulted in throwing up. I really don’t have much of an appetite. When I do eat, I’m not eating nutritional food as much as I should. This has resulted in muscle loss. I recently started eating more protein. I would recommend it, but just know what to expect, read over all the possible side effects and just be careful and be very truthful about how it makes you feel and what it does. Zepbound really has changed my life. I started Zepbound shortly after I was laid off from a job. I was there for 24 years, three months later my two littermates that were 16 years old went to the rainbow bridge. Had it not been for my weight loss, I would be a mess. Take vitamins, drink lots of water. Good luck."
- Ano...
- Taken for 1 to 6 months
- May 28, 2025
For Weight Loss (Obesity/Overweight) "I love Zepbound. I was on Wegovy prior to switching to Zepbound and lost 20 pounds in 6 months. I was nauseous, fatigued, and dizzy for 3-4 days after taking my shot. However, on the Zepbound, I have no side effects other than slight pain at the injection site for 2-3 minutes after I take my shot. After switching to Zepbound, I lost another 20 pounds in just 3 months."
- Tit...
- Taken for less than 1 month
- January 22, 2025
For Obstructive Sleep Apnea/Hypopnea Syndrome "Second week, as of yesterday, no side effects other than not sleeping well the first couple of nights after injecting. I’ve lost close to 5 lbs in the first week. I’ve been reading that if you experience insomnia it is because of the rapid weight loss and to try and change the time of injection. I did it at 6 PM both last Tuesday and yesterday, next Tuesday I’m doing it in the morning. The key for me if not having the side effects that many people experience is that I have been eating clean before starting the medication and continue to eat clean as well as having a high-protein meal 45 minutes to an hour prior to injection. We’ll see how it goes next week when I inject in the morning instead of the evening."
- Nan...
- Taken for 1 to 6 months
- July 26, 2025
For Weight Loss (Obesity/Overweight) "I have had great success with Zepbound! I am down almost 40 pounds in 3 months. I started at 201 lbs. I have been lucky not to have any issues or side effects. I do work at it. I drink lots of water and walk 20 minutes twice a day."
- Mik...
- Taken for 1 to 6 months
- January 15, 2024
For Weight Loss (Obesity/Overweight) "I’m a 6’4", 275-pound male, 62 years old - no diabetes or health issues, on no other meds. Obtained prescription via Dr. and took the first 2.5 mg injection on Dec. 24. Lost 10 pounds with the first 3 shots, then Dr. said I could go to 5 mg (saved the last 2.5 mg pen for future use) because weight loss had stopped. After starting 5 mg, lost 2 pounds in 2 days - so combined weight loss using 2.5/5 mg is now at 12 pounds in six weeks! No significant or terrible side effects except some constipation, intermittent fatigue, and minor chills at times (not a lot - could just be the cold weather). I've yo-yoed up and down with weight for years. Because of my size, I can eat a lot of food - but this drug has significantly reduced my appetite, and I have more energy overall. I can’t wait to see the results in a few more months. Zepbound has so far been perfect for me. I don’t mind the $550 price (with the Lilly savings card - has been hard to get CVS to make it work, but that’s another story/nightmare)."
- Sus...
- Taken for 1 to 6 months
- June 24, 2024
For Weight Loss (Obesity/Overweight) "I’ve used Zepbound for almost 5 months & have lost 15 lbs. I experienced diarrhea at the beginning but much less now. What I didn’t expect was that my bladder issues like leaking, etc. would stop. It has been amazing! I went from needing valve & bladder surgeries to complete stoppage. I hope this info will help other women with their urology issues. Even if I never lost another pound, if another Zepbound side effect helps my bladder, I’m in!!"
See also:
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For Weight Loss (Obesity/Overweight) "My insurance won't cover Zepbound. I get it through the 'Lilly Direct Cash Pay for Zepbound vials.' I started with 2.5 mg for 1 month and lost 12 pounds. I moved up to 5 mg and lost 30 pounds in 4 months. Total loss so far, 42 pounds! Starting weight was 184, height is 5'3'. Current weight is 142. Only side effect for me is seldom nausea. Price is $504 each month, and that includes the needles, otherwise, it's $499. Now that Lilly offers the higher doses for the same price, next week I start 7.5 mg. I will update again in a month or so."