Zepbound and Heartburn: What Users Say

• cli...
• Taken for 1 to 6 months
• July 31, 2024

For Weight Loss (Obesity/Overweight) "I asked my doctor about starting Wegovy since my efforts weren't working, but she recommended Zepbound - and I am so glad she did! My appetite is no longer controlling me, and yet those pre-diabetic low blood sugar drops are gone. After 3 months at the 5 mg dose, I'm still consistently losing about 1% of my weight each week. The only side effects are minor constipation and heartburn, but they encourage me to drink more water. I was hesitant to start because...needles...but it's so tiny I don't feel it at all. I wish I had started sooner!"

• Mat...
• Taken for 6 months to 1 year
• March 18, 2025

For Weight Loss (Obesity/Overweight) "Question: Why wouldn’t you use this to get a head start on a new life? I started on Monjaro for weight loss and had to switch to Zepbound after three months (insurance). I always dieted and would stall after 20 pounds. My ultimate goal was to lose enough weight to safely run again. After a year, I had lost 80 lbs and was able to start running. I just finished a half marathon, one year after starting this journey. The side effects of it are what is advertised; some nausea, it can hit you but goes away quickly, the heartburn was less with Zepbound than Monjaro, and the decrease in using the bathroom is a godsend for anyone experiencing IBS. The injection is not bad with the auto pen. Take the leap and change your life!"

• TCK...
• Taken for 1 to 6 months
• April 9, 2025

For Obstructive Sleep Apnea/Hypopnea Syndrome "I started taking Zepbound in September of 2024. At that time, I was about 70 pounds overweight. I started at 2.5 mg, was raised to 5 mg, then 7.5 mg, and now I'm on 10 mg. I have been able to tolerate it reasonably well. Since I started using it, I would say I have lost over 50 pounds. The medicine definitely has changed my eating habits. I still probably eat more sweets than I should, but not nearly as much as I used to. I have GERD and severe heartburn, and I'd say the medicine does negatively affect that, but I have been on Prilosec or another one of those meds for nearly 10 years, so I am at least able to manage it. If I don't take the Prilosec, I oat dearly. One other thing I have noticed most recently is a metallic taste in my mouth and some hair loss. Sometimes the taste is stronger than others, and I did not notice it until my dose went up to 10 mg. Another thing I noticed is that I have lost a lot of muscle as well as fat. I do get lots of compliments about my weight loss."

• Ste...
• Taken for 6 months to 1 year
• October 3, 2024

For Weight Loss (Obesity/Overweight) "I've been on the shot for 5 months now, and at first, the appetite suppression was strong, with no side effects. After I went up in dose month two, I had extreme bloating and nausea to the point where I nearly took myself to the emergency room. Since then, the side effects have gone down, and the only one I deal with regularly is heartburn. Ask your doctor for Zantac and keep it and Tums on you at all times. Thankfully, it has mostly subsided, and I'm down 80 pounds with moderate exercise in 5 months. I have basically 0 appetite most days and have grown to work with it. I'd give it a 4/5. It's not easy, but if you're serious about losing weight and taking back control of your body, do it. Make sure you work out and follow a strict diet while you're doing it to get the most out of the medication. ALSO! Go to the manufacturer Lilly's website and sign up for the savers card. Saves me $300 a month with insurance."

• ECT...
• Taken for 6 months to 1 year
• April 11, 2025

For Weight Loss (Obesity/Overweight) "Effortlessly went from 250 lbs to 198 lbs in 9 months, with very minimal side effects! It took me this long to go through the gradual dosage increases. When I missed a few weeks here and there, I regained weight. I’ve been extra committed to the regularity of doses after that! My only side effects have been: some mild constipation (take mg citrate to fight that), very mild diarrhea, heartburn that increased as the dosage mg increased, although eating TUMS like candy took care of it (but expensive because I insist on having the TUMS that taste good to me), and injection site reactions (similar to a mosquito bite ≈ 3 days, managed with OTC cortisol cream and/or OTC roll-on 4% lidocaine). I used to have no off switch; was always hungry! Now, my mom (Wegovy) and I look at each other in amazement and ask, “Is this what it feels like to be normal?” She’s been up to 300 lbs, had bariatric surgery, we’ve both done keto, nothing lasted. She’s now 160!"

• Lac...
• Taken for 1 to 6 months
• February 27, 2025

For Weight Loss (Obesity/Overweight) "On my fourth week and it seems to be working fine with no side effects; maybe a bit of heartburn, but I've always had that. Increasing my second round over the weekend; fingers crossed it goes just as well."

• Joa...
• Taken for less than 1 month
• November 10, 2024

For Weight Loss (Obesity/Overweight) "I'm a 64-year-old woman. 5'2" and weighed 177. I've lost 10 pounds in my first 3 weeks. With the heartburn, I had to force myself to eat last night when I wasn't really hungry. I think I ate the scrambled eggs too late in the evening. I had horrible diarrhea and vomiting. That was the first time that happened. I'm hoping it's just because I ate so late on such an empty stomach. I have had no desire to eat the first 3 or 4 days after injection. I have to remind myself to eat something."

• Skm...
• Taken for less than 1 month
• July 7, 2024

For Weight Loss (Obesity/Overweight) "I've only been on it for 5 days. I had heartburn for the first few days, but that's better now. Yesterday, the fourth day, midafternoon, I started getting very cold. I'm never cold, and it’s summer, about 78 degrees outside. I don't have air conditioning. I got so cold that I had to take a hot shower. Then I had to turn on my electric blanket and lay in bed until I warmed up. I started to go back to normal temperature after an hour. I find it difficult to eat. I'm not hungry but have drunk protein shakes. I felt a little nauseous the first day but it passed. I'm hopeful it will help me. So far, my blood sugars are about the same and haven't gone down."

• Ano...
• Taken for 1 to 6 months
• May 6, 2025

For Weight Loss (Obesity/Overweight) "I've been on Zepbound 2.5 since April and have lost 18 pounds so far. My main problem with it is the horrible heartburn that I get while taking it. No matter what I eat or drink, I get heartburn. If I didn't get that, it would be perfect."

• Anonymous
• Taken for 1 to 6 months
• September 24, 2024

For Weight Loss (Obesity/Overweight) "Down 14 lbs first month, started 2.5, after first month, bumped up to 5.0. Side effects minimal, a little heartburn with 5.0 first day taking."

• Dua...
• Taken for 1 to 6 months
• April 16, 2025

"I wake up very early, late at night with a heartburn sensation. I take 3 Rolands and sleep well afterwards. Nothing more for side effects. I am up to 15 mg dosage currently for two weeks now."