Zepbound User Reviews & Ratings (Page 3)
Zepbound has an average rating of 8.8 out of 10 from a total of 418 reviews on Drugs.com. 83% of reviewers reported a positive experience, while 2% reported a negative experience.
Reviews for Zepbound
- mje...
- Taken for 1 to 6 months
- May 9, 2024
For Weight Loss (Obesity/Overweight) "I originally started the Zepbound shot at the end of this past January. I weighed a total of 202 lbs when I started it. That would be about 3-4 months ago. I was very self-conscious, I didn't want to take any pictures of myself, I felt disgusted by myself, I always brought myself down, etc. But now, now I weigh 154 lbs. I'm at the 10 mg of the Zepbound. I started off as the lowest and I'm still not at the highest, to be honest. I lost about 50 pounds in the last 4 months! I researched it and it'll take 16 months to lose about 50 pounds for a normal person who doesn't take anything. And I did it in 4 months with that shot! I never thought I would get to this weight, to be honest. In the beginning, I was going to the YMCA to work out every week to put in the extra work, etc. At first, I started losing like a pound a day, not even kidding, sometimes 2 lbs a day. Then it went to a pound every couple days, and it would vary."
- Anonymous
- Taken for less than 1 month
- March 24, 2024
For Weight Loss (Obesity/Overweight) "Ten days on Zepbound. Love this medication. The energy it gives you is amazing. 1st day injection in thigh developed bruise and slight nausea and headache. But no biggie. 2nd shot belly super easy. Takes away urge to eat. No more stomach grumbling when hungry either. I have a protein shake in the morning, mid-morning protein bar, little bites throughout the morning. Small lunch and salmon or chicken for dinner. Veggies and fruit are important. No issue with bathroom. I take a fiber gummy and multivitamin daily. Treadmill and gym. After showering, I've been using lots of lotion on skin, massaging in. You'll be fine. Smart choices in foods. Yogurt gave me nausea as did tuna with mayonnaise. 6 lbs so far."
Frequently asked questions
- Zepbound vs. Mounjaro: Comparison Guide for Weight Loss and Diabetes Treatment
- Why am I not losing weight on Mounjaro?
- Ozempic Mounjaro Wegovy & Zepbound: Weight Loss Compared
- Which GLP-1 drug is best for weight loss?
- bae...
- Taken for 1 to 6 months
- March 18, 2024
For Weight Loss (Obesity/Overweight) "Absolutely life-changing. For the first time in my life, I'm satisfied by reasonable portions. I'm not always thinking about the next thing that I'll be eating. I'm able to feel and respond to my actual hunger cues without my scarcity brain taking over. Even if I wasn't losing weight, the relief of food obsession and binge eating disorder would be worth it. Four weeks in, down 13 lbs and very satisfied. Only side effect has been feeling cold and some mild constipation."
- ali...
- Taken for 1 to 6 months
- April 29, 2024
For Weight Loss (Obesity/Overweight) "Started at the end of Jan 24. 4 weeks at 2.5mg, 8 weeks at 5mg due to lack of supply. I've had to seek alternatives due to the shortage of this drug, but it is worth it. I've lost 30 pounds in 14 weeks and moved up to 7.5mg on my last dose. The food noise is gone. The alcohol noise is gone. Other than some nausea and fatigue on shot day, side effects have been mild and easily manageable. I wish I'd have been able to start this long ago and gotten my life back. 30 pounds to go and I have no doubt I will be successful."
- Dee...
- Taken for 1 to 6 months
- April 6, 2025
For Weight Loss (Obesity/Overweight) "I started in January and have moved doses up monthly. This morning I took my 4th 7.5 mg dose. I did have a 2.5 mg pen malfunction and moved up to 5 a week early. I've been losing 1-3 pounds a week, for a total today of 28 lb loss. My goal is to lose 50. As far as side effects, they really aren't too bad for me. Daily Colace helps any constipation, which has not been much of an issue anyway. Occasional nausea is fleeting and is helped with Coke One. I know some are against drinking soda, but Coke One does not have sugar and has been my nausea cure for as long as it's been on the market. My appetite is diminished, but not gone. I've changed my eating pattern to several small, healthy mini-meals during the day instead of 3 'regular' meals. Zero cravings for junk food or much snacking at all. Part, I'm sure, is that I'm keeping those mini meals full of protein and vegetables. The only real issue that I've had is fatigue. It hits about an hour after the shot and lasts about 36 h."
- Ano...
- Taken for 1 to 2 years
- May 24, 2025
For Weight Loss (Obesity/Overweight) "I have been struggling with my weight my entire life. It wasn't until I went on Zepbound that I began to lose weight and truly believed that this time I would keep it off for good. After 8 months, I have lost almost 50 lbs and feel better than I ever have about myself. I have more energy, more confidence, and am simply a much happier person. For me, I believe that Zepbound has helped me by regulating my blood sugar level and also making me feel full. While it is a major financial investment that needs to be changed, it has completely changed my outlook on life and fortunately I am able to afford it. This should be offered to everyone at an affordable rate!"
More FAQ
- How much is Zepbound with or without insurance?
- How long does it take for Zepbound to work?
- Can you get tirzepatide from a compounding pharmacy?
- How do Zepbound and Wegovy compare?
- Kgr...
- Taken for less than 1 month
- January 22, 2025
"I am 45, 5’5 currently weighing 187 lbs. I wanted to share my weight-loss journey thus far as well as share my progress moving forward. I started a 1,200-calorie or less diet and 45 min exercise plan in Sept 2024 weighing in at 192 lbs with consultation from my PCP. With the weight loss of 5 lbs I’ve started feeling very defeated. Along with being obese, I was diagnosed with OSA in 2018. Now the FDA has approved Zepbound for the treatment of sleep apnea (OSA), and I decided to take advantage of that decision. I spoke with my GP, she shared my office consultation notes with my sleep doctor. My sleep doctor thought Zepbound would be of great benefit to me since I have been on a calorie deficit diet and consistent exercise routine over 3 months with less than 5% weight loss. My insurance agreed and approved Zepbound with a copay of $60. With the Zep savings card, I paid $25. I will provide you all with an update in 4 weeks."
- Fin...
- Taken for 6 months to 1 year
- April 25, 2025
For Weight Loss (Obesity/Overweight) "I have struggled with weight loss for the past 10 years. Healthy diet, regular exercise used to work for me but stopped working, and my weight steadily increased. I became afraid of food and barely ate 1,200 calories a day. Still, the weight wouldn’t budge. Doctors told me it was because I wasn’t 35 anymore or I was insulin resistant. I was diagnosed with fatty liver, and my frustration was at its peak. I am now 60, and at my peak, I was 216 lbs at 5'10" and pre-diabetic. I didn’t feel good and didn’t like how I looked. I was able to get Zepbound approved with my insurance, and it has been a lifesaver! I am now 160 and feel better than I’ve felt in years! I’ve had minimal side effects, and I’m just grateful that there was finally something to help me lose weight. I have saggy skin and don’t care. My knees don’t hurt, and I feel great! I’m not afraid of food and even eat treats in small portions without fear of gaining weight."
- Anonymous
- Taken for 1 to 6 months
- February 26, 2024
For Weight Loss (Obesity/Overweight) "So far, so good. Rarely get hungry and can't eat too much. Side effects: Heartburn, reflux, constipation, hair loss. I will have to weigh myself in the morning, but I am guessing I am down about 8 lbs. in 5 weeks. Just started on the 5 ml. No exercise yet. Wine and alcohol will definitely slow down the progress. Not a lot of cravings for junk. Every now and then I want something fried, but it will have you on the crapper by the next morning! Stay away from greasy food on this! And YES, the needle DOES hurt to me!"
- Lis...
- Taken for less than 1 month
- May 19, 2025
For Weight Loss (Obesity/Overweight) "I just started taking Zepbound for less than a week now. I am 5 days in. I have not had any major side effects. I have felt very little nausea at times. I had a very mild tummy ache a couple of times. I felt a little dizzy the first day and then nothing after that. I felt very fatigued the third day but have been good since. I have lost 4 lbs so far. I am 5' 2" and weighed 161. I am down to 157 as of today (5th day). My goal is 130 at least. I don't feel hungry. I don't think about snacking. I forget to eat most of the time because I am not hungry. I have to remind myself to eat something. I eat very small portions and feel satisfied. I am loving this! I do recommend it to anyone wanting to lose weight."
- CJa...
- Taken for 1 to 6 months
- April 1, 2025
For Weight Loss (Obesity/Overweight) "I started 3 months ago with the 2 ml, then 5, and now 7.5. I have been nauseous every single day for those 3 months. I have been constipated almost every week. I finally am able to go. I noticed that after the injection, I vomit every time the next day. I am 5'7 and weighed 233. I am now 209. The nausea is sometimes unbearable. I feel like not taking this medicine. Everyone's body is different."
- Chr...
- Taken for 1 to 2 years
- May 11, 2025
For Weight Loss (Obesity/Overweight) "In the past year, I’ve lost 86 pounds on Zepbound—and while that alone is incredible, the real transformation goes so much deeper. I feel alive again. I’m moving more, rediscovering joy in my body, and for the first time in years, I’m not battling daily IBS symptoms. It’s not just about the weight—it’s about finally having a quality of life I never thought possible, even when I was younger and thinner. I'm truly grateful for this life-changing medication."
- Mik...
- Taken for 1 to 6 months
- May 30, 2025
For Weight Loss (Obesity/Overweight) "This medication has absolutely changed my life. In almost 4 months, I am down 30+ lb (205 to 175). Now I dosed up very quickly because the drug has also helped me with addiction issues as well (I think). I haven’t changed anything else except pretty quickly ramping up my dosage to 10 mg, and my urge to drink/use is virtually non-existent. Not sure if it’s because I know I’ll throw up if I drink the way I used to drink (I’m getting nauseous now just thinking about it), or if this miracle drug is somehow filling that void that alcohol and drugs had filled for years. Now to be clear, I do smoke weed pretty consistently throughout the day, so I’m not 100% sober by any means, but I’m at a point where it’s very manageable. I actually very much look forward to taking my shot. For example, my fiancé went out of town for an entire week, and I haven’t even tried to seek out drugs or even had a drink for that matter."
- foo...
- Taken for 1 to 6 months
- July 22, 2024
For Weight Loss (Obesity/Overweight) "I've been on this medication for 6 weeks and have never felt better about my body or my day. I didn't realize I could have a day where I wasn't thinking about food from the minute I got up until I fell asleep at night. I feel free to think about other things and to not be distracted by trying to have willpower to not eat. It's a huge relief. Is this what thin people feel like? People who have never struggled with being overweight? I have always thought my weight was based on my genetics, and maybe it is-but it's also my brain that literally is addicted to food. It feels like I've been released from an addiction. I haven't noticed any side effects. I tried Ozempic before this and was very constipated and had stomach issues. I don't feel that way at all on Zepbound, my stomach is fine. I'm on 2.5, it's very easy to administer, and I feel like it really works. I hope I'm able to take it for a long time, I'm sort of afraid to go back to the brain I had before taking it."
- Mil...
- Taken for 6 months to 1 year
- December 1, 2024
For Weight Loss (Obesity/Overweight) "I started Zepbound in April 2024 at 193 lbs. It’s December 2024, I’m now 140 lbs. I have stayed at the 10 mg dose for almost 3 months now, as I am trying to tone my body since I lost 50 lbs fast. The side effects suck when I go up a dose, but my body adjusts after 4 weeks, so it’s been great. I have noticed that I wake up with hunger pains now, but my plan is to get used to them again before I start weaning off the drug. Side effects for me include headaches and fatigue. It’s not that bad after a while, the main thing is being strategic and proactive about getting your fiber, protein, and water in. I haven’t been to the gym since I started the 10 mg, and I’ve slowed down on the weight loss (which I’m okay with). I like 140, I’m just trying to tone now, so when I wean off, it won’t all come back. I’ll update you guys in a couple of months."
- Can...
- Taken for 1 to 6 months
- April 18, 2024
For Weight Loss (Obesity/Overweight) "I am in my 50s and I stayed on the 2.5 for 2 months and just began the 5 mg today. I had gastric sleeve exactly a year before covid, lucky me, huh? Working from home, no gym, already had depression, joint, and severe back issues. It all did not mix with slowing down and sitting down. I gained half of the weight I lost, and the high cholesterol returned. I started Zepbound on Feb 17, 2024, and lost 18 lbs by my first check-up on April 1. Very fast. My cholesterol dropped significantly. I do not have high blood pressure, but it was down too. All blood work is great. The only side effect is constipation that I fixed with Miralax. There are no food cravings or noise in my head. I get full very fast, although I have to remind myself to eat. I have dry mouth, I bought sugar-free popsicles to deal with that. I have been sleeping better, although I stay up late due to the energy it gives me."
- Lin...
- Taken for 1 to 6 months
- December 5, 2024
For Weight Loss (Obesity/Overweight) "I started taking Zepbound on the first of September, am 5'8, was weighing 190. I stopped taking Zepbound on November 18th, had no serious side effects, I was just feeling moody. Stopped at my goal of 175.9 and still losing on my own. It's December 5, and I weigh 172.9. Zepbound has taught me to eat a balanced, healthy meal without all the cravings, portion size, and exercise. Down 16 pounds."
- Kat...
- Taken for 1 to 2 years
- June 8, 2025
For Weight Loss (Obesity/Overweight) "I have used this for over 1 1/2 years now. I have never increased from the initial 2.5 dose and have lost over 45 lbs! 63 yrs old and always fought my weight. I could literally fast for a couple of days, stay on my tuna, veggies, and berries the rest of the week, exercise every day and gain 2 lbs if my week was stressful at work. This turns on a couple of hormones that just were not working no matter what I tried. I have no plans to increase this dose, but will probably need to stay on this forever. It is the key and the answer I’ve been looking for. Most every post I’m reading talks about increasing the dose, and I wanted to share that you can get there without risking additional side effects. It’s a great tool, and with all the good things we do already for ourselves, this will take you all the way! I’m about 12 pounds to my goal, now normal cholesterol levels and no side effects after the first two weeks :). It makes the journey easier when you see success for your efforts :)"
- R S...
- Taken for 6 months to 1 year
- December 31, 2024
For Weight Loss (Obesity/Overweight) "I've been on Zepbound for 6 months, and it has worked great for me! 40 lbs. down!!! I only feel yucky the day after the injection, but other than that, no other concerns. I just received a letter from my insurance company (Keystone East) stating that beginning 1/1/2025, IBX in whole is no longer covering weight loss drugs. WOW!!!! :( People like myself have been waiting most of their lives for a drug like this, and here we go with corporate America. Even though I'm 40 lbs. down, I still need to lose an additional 40 lbs. just to be considered overweight and not obese in the medical world. My joints no longer hurt, and I can work out without the aches and pains. My overall health has improved so much, and I am greatly disappointed and upset with this decision from IBX. I wish everyone much luck if this will be happening to you too after the new year."
- Ano...
- Taken for 1 to 6 months
- May 14, 2025
For Weight Loss (Obesity/Overweight) "I started on Friday, March 21, and had no side effects for the first two weeks. Then I overate cheesy pasta and had severe diarrhea. The next 10 days, I had three more episodes of diarrhea and vomiting. And severe fatigue. I was not able to continue my exercise routine as often as usual. The fatigue after minimal activity was interfering with my life. I cannot walk more than a few blocks. I stopped the injections three weeks ago, and for the most part, I have intermittent fatigue. It apparently takes about 25 days for the med to be out of the system. I lost 9 pounds after the first 3 or 4 weeks and have not gained them back. I didn't have quite the same separation of thoughts of food as I had expected. Hopefully, only another week or two to get my energy back."
- Ano...
- Taken for 1 to 6 months
- April 19, 2025
For Weight Loss (Obesity/Overweight) "Began 1 month ago, March 2025, starting with 2.5 mg at 210 lbs, and I am 5'4", size 14. 2nd month, same dosage, 2.5 mg. Now my weight is 183 lbs, size 10. I do have nausea, but it goes away when I drink plenty of water/seltzer. I can eat what I want, but small portions, and I can put the fork down. I take the shot at bedtime. I have only used my arms. It does not hurt. I am happy this is working."
- Ill...
- Taken for 1 to 6 months
- February 14, 2024
For Weight Loss (Obesity/Overweight) "I have been on Zepbound for 6 weeks. (4 weeks 2.5) (2 weeks at 5.0) I have lost 23 lbs. 307-284 I ride bike/treadmill and lift weights. I eat 2300 calories a day. If I happen to eat too much, I don't seem to notice. But what I do notice is I don't crave food like before. Before, I used to still be hungry after dinner. Not anymore. That part of my brain that was ravenous for more is gone."
- she...
- Taken for 1 to 6 months
- March 18, 2024
For Weight Loss (Obesity/Overweight) "I have been on Zepbound for two months and have lost only 9 pounds. I don't eat breakfast because I am not hungry, this has been a lifelong habit of mine. I am hungry at noon and eat more than I should. I have found that I am eating too fast, which is causing me to not have the weight loss that I would have if I ate slower. I have noticed that when I eat slower, I stop eating when I am halfway done with my meal. Hopefully, I can break a lifelong habit of eating fast. I have no side effects from the drug or overeating."
- dil...
- Taken for 1 to 6 months
- March 10, 2025
For Weight Loss (Obesity/Overweight) "I have been taking Zepbound for 4 weeks. I have lost 20 pounds. I am not hungry, no side effects, more energy, and I sleep so much better. I am on 2.5. I love this drug. I did not want to believe the good reviews or the bad ones, I just needed to know for myself, and now I do. It is great. Take a chance, you will see it really works."
See also:
More about Zepbound (tirzepatide)
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- Drug class: GLP-1 Agonists (Incretin Mimetics)
- Breastfeeding
- En español
For Weight Loss (Obesity/Overweight) "When I started out on the lowest dosage, everything went great. I have lost 40 pounds and have been pleased. I requested from my doctor to up my dosage to 5 mg. Now I have an allergic reaction, mostly on my face. Red, splotchy, hot marks all over my face. Have there been any other patients that have experienced the same reaction?"