Tirzepatide and Diarrhea: What Users Say (Page 5)

• kjo...
• Taken for less than 1 month
• October 18, 2022

For Weight Loss (Obesity/Overweight) "I've been on 2.5 mg Mounjaro for exactly 2 weeks now for weight loss, and I have lost 8 pounds. I'm feeling great; however, I have had a stomach ache twice and diarrhea once. Can't eat too much, or my stomach will hurt. I'm also walking 3x/week and logging my food & beverage in an app - staying at 1200 calories or below is super easy on this med. I have felt more energetic on it - which might be because I am so excited that there could be a solution to my overweight problem! It seems like a long-awaited answer to my prayer - I'm feeling very hopeful and optimistic!"

• Jan...
• Taken for less than 1 month
• November 24, 2024

Tirzepatide for Type 2 Diabetes "I've only had 2 shots and 2 days until the next one. I find it very convenient to administer. However, I have had some nasty side effects! I've had diarrhea, nausea, vomiting, fatigue. I will continue taking the medication hoping the side effects will 'calm down.'"

• Anonymous
• Taken for 1 to 6 months
• June 26, 2023

Tirzepatide for Type 2 Diabetes "I took the 2.5 mg for four weeks, then I did the 5.0 mg for four weeks. I am now taking 7.5 mg. I am taking it for eight weeks. I did the research and studies on what to do. I do not eat fried foods. I do not eat sweet things, especially ice cream, which is my absolute favorite food. I have not been sick. I have not had diarrhea or been constipated. I do not overeat, which is in the instructions. My blood glucose has dropped 30 points. I won't know what my A1C is until I go back to my doctor for a test. My only problem is the cost. So far, I am doing very well on Mounjaro. It is very easy to use."

• Pre...
• Taken for less than 1 month
• June 12, 2023

Tirzepatide for Type 2 Diabetes "First week, I had massive diarrhea and a splitting headache. Week 2 was better. Just a headache. Week 3, still have a headache. Down 8 pounds in 3 weeks. Blood sugar is fine. I find I don’t eat much. I have to force myself to drink too."

• Rob...
• Taken for 6 months to 1 year
• June 16, 2023

Tirzepatide for Type 2 Diabetes "I started at the lowest dose, even though I was switching over from Ozempic, and I had been on 7.5 mg of that for over a year or longer. It was out of stock, and they didn’t know when it would be back in. I switched to Mounjaro. I have been taking the once-a-week injection for about 6 months, I think. I am on 10 mg now. Yesterday, I had my A1C checked, and it had gone down from 6.7 in March to 5.9. I was thrilled. I’ve lost 19 lbs, which isn’t huge, but it’s something. I was 250 lbs and now 231 lbs. I’ve been pretty happy and eating less and feeling fuller longer. The side effects I’ve noticed are sometimes I have low sugars, but I need my insulin adjusted, and I have diarrhea every morning and occasionally during the day. I think I’m going to start a probiotic. The goal is to get off my insulin. That is the plan of me and my endocrinologists."

• She...
• Taken for 1 to 6 months
• May 23, 2023

Tirzepatide for Type 2 Diabetes "I started with 2.5 mg, then increased the dosage to 5.0 mg, and then 7.5 mg without any success. Skipped 10.0 mg and then moved up to 12.5 mg, and that is when the success came! I lost 25 lbs in 3 months, and it brought down A1c from 8.0 to 7.0. I had minor side effects such as diarrhea and some stomach upset. Overall, a very positive experience."

• Hop...
• Taken for 1 to 6 months
• May 16, 2023

Tirzepatide for Type 2 Diabetes "Not long after I began taking Mounjaro, my A1C dropped from 8.1 to 6.7. Finally, something that's helping. I’ve also lost some weight, although it's been a slow process. Now I’m beginning to have stomach issues along with diarrhea. Just makes me feel sluggish. I’m on the 10.0 dose, and the doctor said I may need to drop down to a lower dose. It's very easy to use. Giving myself a shot is not a problem."

• Zep...
• Taken for less than 1 month
• August 1, 2024

For Weight Loss (Obesity/Overweight) "Pros: 20 lbs lost in 4 weeks, zero appetite, able to move joints freely, more energy. Cons: Diarrhea (gallbladder removed 13 years ago), hypoglycemic episode once in 3 weeks of use - learned to consume good carbs. Overall, the medication is working great for me, and I only wish I were able to start it sooner."

• Yik...
• Taken for less than 1 month
• January 2, 2023

Tirzepatide "I started at the 2.5 mg dose for weight loss. I felt little to no appetite for the day. Then that night, I was throwing up and having severe diarrhea, like it was the worst stomach flu I’d ever had. I decided I’d not take it again. It would’ve helped me lose weight, just not the way I’d want."

• Ste...
• Taken for 1 to 6 months
• July 28, 2024

For Weight Loss (Obesity/Overweight) "I’ve lost about 10 pounds in probably 6 to 8 weeks. I feel okay on this drug. I have experienced some tiredness and fatigue, and some diarrhea as well, but nothing too bad. There was only one week where it was bad enough that I might rethink using it. Now it’s mild and lasts for about 2 days post-shot. Some blurry vision as well. I most likely won’t stay on this drug for the long haul."

• sls...
• Taken for 1 to 6 months
• November 22, 2022

For Weight Loss (Obesity/Overweight) "I started Mounjaro almost 5 weeks ago with the 2.5 injection. One shot weekly in my stomach area. I have lost 16 lbs so far and will be starting my new dose of 5.5 tomorrow for 4 weeks. I have been very pleased so far with Mounjaro. I am not hungry at all, in fact, I have to remind myself to eat. So far, the only side effects I've experienced are diarrhea, constipation, and I appear to have a change in how some things taste. Certain things I liked the taste of before now have a strange aftertaste. I am loving losing the weight and hopeful I will lose more."

• Kat...
• Taken for 1 to 6 months
• September 2, 2024

Tirzepatide for Type 2 Diabetes "I began my journey on April 12th, 2024. I'm currently on my second dose of 7.5. A bit more stomach issues, diarrhea, and extreme fatigue. No desire to eat whatsoever. Since I've started, I have lost a total of 50 lbs. as of 9/2/24. Yes, I'm Type 2 diabetic, but I wanted to give this medication a try to see if it would be of any help for me to lose weight. It has far exceeded my expectations! It's been a bit rough, but I'm seeing great results. I'll continue on this journey with hopes of meeting my own personal weight loss goals."

• ILo...
• Taken for 6 months to 1 year
• June 26, 2023

Tirzepatide for Type 2 Diabetes "Lowered A1C from 8.7 to 7.2 in 90 days on the 2.5 mg. I have not checked on the 5.0 mg. Blood sugar is down from 180s to 110s. The blood sugars stay consistent for the most part. I know which foods will raise it, such as corn products and wine, though it does not go beyond 130s for me. Started on 2.5 mg and just raised to 7.5 mg, which is hard to get. It took 3 months of backorder. If I overindulge in food or wine, I will not have a pleasant night. Nausea and diarrhea will happen. It helps with appetite control. This starts happening with the 5.0 mg, but I have really noticed the difference in the 7.5 mg. I typically need a snack between meals, now I can go longer without feeling so hungry or jittery. I have yet to lose any weight, but I think it will come as I continue with the 7.0 mg. I have lowered my Toujeo dosage from 82 to 50 units per day. It is a big drop with each higher dosage. I believe I will be in the 30s by the time I step up to the 10.0s. I also take Metformin XL."

• CMH...
• Taken for 6 months to 1 year
• July 13, 2023

For Weight Loss (Obesity/Overweight) "Started Jan 6 at 191. 57F, 5'6'. July 12, 143. So almost 50# in 6 mo. First month or so on 2.5, I had mild nausea (Zofran worked great), indigestion (Pepcid chewables for that), and occasional constipation. Diarrhea maybe twice. Experienced some fatigue initially, but likely the result of very low calorie intake. Have been on 5 mg since, with only mild constipation. This drug is an absolute game changer for me. I had tried for almost 2 years to drop the weight with diet and exercise with basically zero success. Now I'm approaching my lowest adult weight with minimal effort! Biggest downfall is having to spend money on new smaller clothes."

• Lis...
• Taken for 1 to 2 years
• July 14, 2025

Tirzepatide for Type 2 Diabetes "I had initial nausea for about the first 4 weeks, then just intermittent after. I feel I was not getting in enough calories at the time. My appetite has greatly diminished, but I eat smaller, healthy meals more frequently. I have had a 70+ lb weight loss in the last year, and I am still losing. I have had constipation and diarrhea, but not frequently. Drinking enough liquids is essential. I have experienced some rashes with itching, but they are controlled with OTC meds of Benadryl and Pepcid. Good luck on your journey, everyone. Take it a day at a time!"

• Sco...
• Taken for 1 to 6 months
• March 18, 2025

Tirzepatide for Type 2 Diabetes "So far, so good until yesterday. I think I ate too much, and then the stomach pain started, and diarrhea followed all night. As I tried to ingest water, I became nauseous and had to throw up, but that decreased the pain. I think I’m just getting used to the drug since this was my first dose of 7.5 mg pen."

• Ano...
• Taken for less than 1 month
• August 30, 2025

For Weight Loss (Obesity/Overweight) "Just had my first injection on 8-27-2025. Was compounded by pharmacist. Had severe acid reflux. Already taking pantoprazole 40 mg once daily and didn’t touch my symptoms. Very deep-rooted burping and diarrhea. Fatigue and some nausea. Gonna give it one more go and see if my body has had time to adjust."

• Ano...
• Taken for 1 to 6 months
• July 28, 2025

For Weight Loss (Obesity/Overweight) "My experience with tirzepatide has been quite good, with relatively few side effects and a weight loss of 17 pounds over the past 4 months. The early side effects I experienced were mild constipation and diarrhea, both of which have gone away. I also noticed I was feeling more tired than usual. About midway through my 4 months of tirzepatide, I changed e-pharmacies. The e-pharmacy I'm working with right now adds Vitamin B-6 to the formulation, and I'm currently experiencing some sleeplessness on days 1 and 2 of my injection cycle and no more tiredness. I just completed my refill conversation with the e-pharmacy provider and will be moving to the highest tirzepatide dosage available... somewhere in the 13 mg range. I will also mention that I noticed my mood was a little 'down' when I first started taking tirzepatide, and that (if it was a side effect) has also gotten better over time."

• Dru...
• Taken for 1 to 6 months
• April 12, 2025

Tirzepatide for Type 2 Diabetes "Currently on 750 Mounjaro. 2nd injection on Wednesday, had a 17-hour episode of vomiting and diarrhea on Sunday afternoon into Monday morning. I did not take the 3rd injection the following Wednesday. By Friday, I had the hungry horrors and joint pain in my hips and knees. Weight loss about 25 lbs, and my A1C only came down from 7.5 to 7.1 in the 5 months I’ve been on Mounjaro. If you take these meds, please listen to your body and the way it reacts to these meds."

• Don...
• Taken for 1 to 6 months
• November 20, 2024

For Weight Loss (Obesity/Overweight) "So far, I have lost about 2 lbs per week. Side effects include some constipation and periodic diarrhea. I am taking 10 mg subcutaneously weekly. I have been taking it for a month and have noticed a marked decrease in appetite without stimulant-type effects! I am very pleased with this medication."

• CHI...
• Taken for 1 to 6 months
• September 4, 2024

Tirzepatide for Type 2 Diabetes "When I first started taking Mounjaro, I didn't feel like eating at all, and I started to lose weight quickly. In fact, I lost 9 pounds in two weeks. I had diarrhea about three times a day in the beginning, it wasn't until about three months for that to stop. But now I have issues with belching and gas. I am now down 50 lbs, which is great, but I lost a lot of muscle tone. All in all, my blood sugar is doing great. I do recommend staying hydrated and taking some anti-gas meds if stomach pain persists."

• Ano...
• Taken for 1 to 6 months
• August 18, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I have been taking Zepbound for four months and have lost 23 lbs so far. In terms of facilitating weight loss, it is a miracle drug. I eat less without feeling hungry, and I don't think about food. But there are definite side effects-diarrhea (this is the worst-can last for days), constipation (yes, the diarrhea quickly turns to constipation), heartburn (easily controlled), and some fatigue in the first 24 hours. I was on 2.5 for 1 month, then went up to 5 (ish). For me, the worst side effects kick in at 5. I am getting the medication in a vial so I can easily adjust the dose a bit. A couple of weeks ago, I went down to 4.5, and the side effects were much less severe. I'm experimenting to see where in the 4.5 to 5 range I get a balance between weight loss and side effects that I feel comfortable with. Right now, I am still losing weight. After another 10 lbs, I will be at a healthy weight and hope I can decrease the dose to maintain weight loss and reduce side effects."

• Ame...
• Taken for 6 months to 1 year
• September 10, 2024

For Weight Loss (Obesity/Overweight) "We don't all lose weight quickly with this. I've taken Ozempic, then Tirzepatide for 29 weeks today. Starting weight was 187 lbs, now down 25 pounds. I maintained my weight on diets and with exercise until I was about 32 when I had a thyroidectomy and was diagnosed with Hashimoto's disease. I've tried 20+ diets, and the only one that works for me is the HCG diet. I have to eat 500-800 calories per day to lose a little weight. And... I'm hungry so much of the time. Hunger is my enemy. After reading lots of reviews, I knew I'd be a slow loser, and I am still thrilled with the results!!! Hunger doesn't rule my world. I eat about 1000 calories a day, naturally, and try to eat less than 150 g carbs, 25 g+ fiber, and 90 protein. I'm now on 7.5 mg of Tirzepatide. I had horrible diarrhea and nausea for 3 weeks at about week 7. Now I take loperamide hydrochloride 1-2/week to stop the diarrhea. Worth it!!!"

• Ano...
• Taken for 1 to 6 months
• April 23, 2025

For Obstructive Sleep Apnea/Hypopnea Syndrome "I am only able to get this drug because I have OSA, even though I have struggled with weight issues for years. I have been on Zepbound for 5 weeks. I have lost 10 pounds so far. I have also had 2 full days of bad “sewer burps,” gas, and bad diarrhea. I ate sugary foods one day I was sick, the other time I was sick I have no idea what I had done wrong. Both the burps and the diarrhea are bad and nasty. One day I had to stay home from church, and the second day I was at work (that created a certain level of anxiety for me). I have noticed a huge difference in food cravings and appetite. Sometimes I have struggled to find something I actually wanted to eat. I have eaten a greater amount of fruits (especially raspberries, strawberries, apples, and bananas). I eat protein bars (20 grams) 3-4 days per week, and I try to drink as much water as I can hold. I am recovering from Achilles tendinopathy followed by a broken patella, so I have not been exercising yet."

• Rob...
• Taken for less than 1 month
• September 2, 2025

Tirzepatide for Type 2 Diabetes "Took a long time to get it. I just administered my last (4th) shot and have noticed a drop in my blood glucose levels. Also, I do get full/satisfied much faster. Not sure if it has anything to do with Mounjaro, but I have been having sudden loose bowel movements."