Tirzepatide and Diarrhea: What Users Say (Page 2)

• Jan...
• Taken for 1 to 6 months
• June 22, 2025

For Weight Loss (Obesity/Overweight) "I’m a 68-year-old female and have lost 50 lbs from January to June 2025. Started with 5 mg injections and now am getting 15 mg injections once per week. Minimal side effects unless I eat too much or eat unhealthy foods - and then I will have nausea and/or diarrhea. The biggest benefit has been that my blood pressure went from approximately 140/90 or so to a very consistent 110/60 or slightly above that, but hasn’t been anywhere near 140/90 since a couple of weeks after I began the injections. The cost has been a bit prohibitive, and I’m hoping that I’ll be able to transition off after I reach my goal weight loss of 75 lbs (without too much weight gain) OR that there will be a generic available and covered by Medicare. I can also breathe much better after climbing stairs and feel so much healthier and am able to play with my grandkids much more! Thanks so much!"

• Ano...
• Taken for less than 1 month
• May 15, 2025

For Weight Loss (Obesity/Overweight) "First 2 weeks on low dose was okay. Minor GI disturbances. I normally have loose stools but had well-formed stools during those 2 weeks. Stayed on low dose for the 3rd week. Was a little constipated at first, so ordered a large salad from my favorite café. Maybe that's what triggers everything. That night I could not sleep because my gout became very painful, and I had to deal with the diarrhea. I am now feeling pretty drained and weak. Generally feel a tad light-headed."

• Che...
• Taken for less than 1 month
• July 31, 2024

For Weight Loss (Obesity/Overweight) "I am 55 years old and going through menopause. From weighing 165 pounds, I have gained 40 pounds. I started having sleep apnea, high cholesterol, and high blood pressure. I am on my second shot of Zepbound. The side effects of the first dose were really bad, I had diarrhea for one week. The side effects are not bad now. I am sleeping better, I don't hear myself snoring, and I have lost 6 pounds."

• Anonymous
• Taken for 1 to 6 months
• December 17, 2024

For Weight Loss (Obesity/Overweight) "I am 5'2" and 46 years old. I started Zepbound on 8/20/2024 at 166 pounds. I took the 2.5 mg dose for one month, then increased to 5 mg in Oct. and Nov. I had very mild side effects, and I steadily lost weight until last week. I have now increased to the 7.5 mg dose, and the nausea and diarrhea are pronounced. I'm down 30 pounds, but I may switch back to the 5 mg dose if the side effects don't subside."

• Ton...
• Taken for 6 months to 1 year
• February 26, 2023

For Type 2 Diabetes "I started on a 2.5 mg dose for 30 days and had nothing positive or negative. The doctor increased it to 12.5 mg, and my appetite went to zero, stomach pain, throw-up, diarrhea, general nausea, and ill feeling, but did lose 15 lbs in 3 weeks, and my blood labs were near perfect. I was ready to quit until I saw this. The second month, my appetite came back slightly, and I learned to eat less and cleaner so it wouldn’t make me throw up, lost another 15 lbs, and it excited me to get back in the gym daily. Since the drug slows your digestion, it slows the bowel too, which gave me insane constipation and made sure I eat enough fiber daily. At first, the side effects are hell, but stick with it as they only lasted a month, then your body adjusts and you learn how to eat and work with it. The end results are worth it. It's been 9 months, and I have lost 35 lbs, labs are excellent, and for the first time, I have seen glucose under 100 in 30 years."

• Ano...
• May 20, 2025

For Weight Loss (Obesity/Overweight) "Side effect I’d say I’ve had is a little bit of diarrhea and nausea. I’ve been on it for over a year now. I’ve lost over 140 pounds, still have a lot more to go, but it also helps control my type two diabetes, brought my A1c down from 10.8 to 4.6. Very happy with that, but I just had to have my appendix out right away because it was just about to rupture. Never had a problem with it until recently, so a coincidence or is it the medicine? Who knows, but I do know that this medicine has been a godsend for me. I do have gastroparesis along with IBS, and I tried to take Ozempic before this, and it about killed me, so an ambulance had to come and get me on the Ozempic. I do know I’m able to handle Mounjaro a lot easier on my system. If it wasn’t for Mounjaro, I don’t know where I’d be with my health right now, trying to raise three kids under the age of 14. So thank you."

• Lin...
• Taken for 1 to 6 months
• November 10, 2024

For Type 2 Diabetes "I’ve been taking 2.5 ml for 4 weeks and had few side effects apart from zero appetite, a little nausea, and a migraine (think the migraine was due to not eating). Now, week 5, increased to 5 ml and a different story: quite a lot of nausea, diarrhea, headache, and tiredness. Also again, total lack of appetite. Fortunately, these side effects more or less calmed down 2 or 3 days after taking the dose. I’m hoping it’s a temporary thing when you take a new dose - I can live with that."

• Ms ...
• Taken for 6 months to 1 year
• March 11, 2025

For Weight Loss (Obesity/Overweight) "I started my Zepbound journey in August 2024. I have been on .50 the whole time. I've lost 40 lbs using this medicine, which is amazing! In February, out of nowhere, I started to get side effects after my shot: nausea and diarrhea. Thinking it was the flu, I nursed myself back. Shot day is Wednesdays. On Saturday, the diarrhea came back again. I truly am excited for my weight loss journey but am literally pooped out."

• Din...
• Taken for less than 1 month
• December 10, 2024

For Type 2 Diabetes "In the two doses, my blood sugar has been lower, my appetite has diminished, and I had no side effects. At the end of the second week (Saturday), I woke up during the night with stomach pain, diarrhea, and belching. After 6 hours, I finally vomited up undigested food that had been in my stomach for over 12 hours. It looked like I had just eaten. I avoided all food until Sunday morning, eating 1/2 of a plain English muffin. I had Lipton chicken soup, a piece of Bavarian pretzel, and a few french fries (picking from my wife’s meal). Monday, I finally felt hungry and had a Whopper Jr. (not a good choice I know), and Tuesday I woke up with food sitting in my stomach and one diarrhea BM. NOTE: I have not taken dose #3, nor do I plan to. This is slowing my digestion down too much. I have never had digestive issues, and I’m not going to start now."

• ECT...
• Taken for 6 months to 1 year
• April 11, 2025

For Weight Loss (Obesity/Overweight) "Effortlessly went from 250 lbs to 198 lbs in 9 months, with very minimal side effects! It took me this long to go through the gradual dosage increases. When I missed a few weeks here and there, I regained weight. I’ve been extra committed to the regularity of doses after that! My only side effects have been: some mild constipation (take mg citrate to fight that), very mild diarrhea, heartburn that increased as the dosage mg increased, although eating TUMS like candy took care of it (but expensive because I insist on having the TUMS that taste good to me), and injection site reactions (similar to a mosquito bite ≈ 3 days, managed with OTC cortisol cream and/or OTC roll-on 4% lidocaine). I used to have no off switch; was always hungry! Now, my mom (Wegovy) and I look at each other in amazement and ask, “Is this what it feels like to be normal?” She’s been up to 300 lbs, had bariatric surgery, we’ve both done keto, nothing lasted. She’s now 160!"

• Jac...
• Taken for 1 to 6 months
• May 15, 2025

For Type 2 Diabetes "2.5 and 5.0 worked fine with minimal side effects. Once I started 7.5, nausea and diarrhea took over. I’ve only taken 1 dose, and don’t plan on continuing 7.5. 5.0 lowered my blood sugar just fine."

• MAW...
• Taken for 1 to 6 months
• November 11, 2022

For Type 2 Diabetes "I started out on the 2.5 for 2 months and lost 15 lbs, and my A1C dropped from 6.7 to 6.0. Mild side effect symptoms of abdominal pain and nausea. I started the 5 mg and had explosive diarrhea and uncontrollable vomiting, with abdominal and back pain. My blood pressure dropped to 88/55. I had to stop taking the Mounjaro. After 3 weeks, I am starting to feel normal again. Sorry it didn’t work for me. It did curb the appetite."

• WE...
• Taken for less than 1 month
• November 8, 2022

For Type 2 Diabetes "Went to the doctor and asked for something to help lose weight. He prescribed this medication. Day 1 and 2... nothing. Day 3 woke up with horrible heartburn and sour sulfur burps and facts and was constipated. By day 3 evening, I no longer had constipation but just the opposite... diarrhea! And not just any kind, it was like yellow water and very acidic. It hurt! Had horrible gas and belching all day Saturday, and Sunday couldn't hardly leave the bathroom to go buy Imodium. Imodium helped with that, but the gas is now trapped, and my stomach hurts badly, and I am full of gas with bad heartburn and belching. I saw a correlation between fatty foods and severe side effects of this product. But unless you're a vegan, you eat fat, and that's a major problem with this product. It is now Monday night, and I cannot seem to get my work done, I hurt so badly. I will never take this product again, and I cannot in good conscience recommend it with all the terrible side effects. Shame on Mounjaro!"

• Not...
• Taken for less than 1 month
• October 23, 2022

For Type 2 Diabetes "I’m struggling to get below 154 lbs, and being 5’, that’s a lot of weight to carry, which induces back pain. Lost 20 lbs on Ozempic from the beginning of the year till June, have managed to gain back 5 lbs, which isn’t awful but still not at my goal weight. I just left the ER from getting a bolus of saline due to dehydration. I’m battling hypoglycemia. I took my first shot on Tuesday. Wednesday felt decent, but malaise was setting in. Thursday, I didn’t even realize I had not eaten all day and all night at work. Friday night, I tried to eat half of a sandwich and was completely nauseous. Tonight at work, after eating half a sandwich and a few green beans, I had terrible diarrhea and became so dizzy and nauseated I was forced to leave work, having someone else take over my patients. Just a word of advice: if you’re a busy person, this med may not be for you. I had side effects of fever, chills, nausea, diarrhea, fatigue, and muscle pain, and I was negative for flu, COVID, and strep. The doctor said to go back to Ozempic :( but I’ve lost 6 lbs already!"

• Mou...
• Taken for 1 to 6 months
• January 27, 2025

For Type 2 Diabetes "I have been on Mounjaro for 7 weeks. The first 4 weeks the dosage was 2.5, and the last 3 weeks it was 5. I love Mounjaro! It takes away my food obsessions and sugar cravings. It lets me focus on life rather than on food. I did get a few minor incidents of diarrhea and an occasional minor feeling of nausea, but they were nothing serious. Mounjaro has helped me lose 15 pounds in 7 weeks and brought my blood sugar from 220 to 120. I wish it were cheaper, but it has been worth it for me."

• 1 d...
• Taken for 1 to 6 months
• July 18, 2024

For Weight Loss (Obesity/Overweight) "I have had zero issues with the drug when I do right. If I overeat, I have diarrhea and sulfur burps for sure. When I start my day with protein and coffee, and drink lots of water, I have zero issues. But if I mess up like I did this week (ate breakfast, lunch, happy hour, snacked), I was up all night in a world of hurt, and I still haven't fully recovered. I haven't noticed a significant weight loss in 5 weeks (10 pounds), but it’s been steady. Just DO NOT OVEREAT and drink plenty of water."

• Dut...
• Taken for 1 to 6 months
• March 8, 2025

For Type 2 Diabetes "My appetite and being a lifelong ‘foodie’ hit a final conflict point four years ago when I lost my ability to work off my weight easily. My knee pain and depression combined to make me asocial, deeply uncaring about my condition and convinced of no hope. I am pretty miserable. At 15 mg a week, food has moved from center stage to a stronger support character. Only one bout of intestinal irritation has marred my experience with diarrhea, vomiting, pain. But my insulin levels remain superb and my glucose monitor has become a friend, not an inevitable betrayer."

• Lis...
• Taken for 1 to 6 months
• April 19, 2025

For Weight Loss (Obesity/Overweight) "48 years old female started 2.5 mg one month ago and experienced very little, if any, side effects. I lost 10 lbs, started at 274. Just took my first dose of 5.0 on Thursday and initially felt fine but started to struggle with diarrhea that just won't stop. Will see if it's unrelated or not and adjust accordingly. This medication also immediately got rid of my swollen feet, and so far it has not returned. That alone is worth the cost."

• Tim...
• Taken for 1 to 6 months
• July 27, 2024

For Weight Loss (Obesity/Overweight) "Severe nausea, horrid vomiting and diarrhea after 7.5 mg dose - did okay with 2.5 and 5 mg doses - there should be more warnings with the higher doses as this was severe. Higher doses should be reviewed further for safety reasons."

• PRe...
• Taken for less than 1 month
• February 12, 2025

For Weight Loss (Obesity/Overweight) "On week number three, I started with stomach cramps and diarrhea. The night before, I had a huge helping of Boom Chicka Pop kettle corn. While the packaging states it only uses cane sugar, I came to the conclusion that this product (perhaps in the amount eaten) suddenly didn’t agree with me while taking Zepbound. I’ve lost 5 lbs in 2 1/2 weeks. Diarrhea and cramping subsided after 36 hours."

• Joa...
• Taken for less than 1 month
• November 10, 2024

For Weight Loss (Obesity/Overweight) "I'm a 64-year-old woman. 5'2" and weighed 177. I've lost 10 pounds in my first 3 weeks. With the heartburn, I had to force myself to eat last night when I wasn't really hungry. I think I ate the scrambled eggs too late in the evening. I had horrible diarrhea and vomiting. That was the first time that happened. I'm hoping it's just because I ate so late on such an empty stomach. I have had no desire to eat the first 3 or 4 days after injection. I have to remind myself to eat something."

• Ran...
• Taken for 1 to 6 months
• May 25, 2025

For Weight Loss (Obesity/Overweight) "I started on the 2.5 mg starting dose. After the second day, I was experiencing severe diarrhea, burping, nausea. These went away on Day 6. Very tolerable after then. I stayed on 2.5 for several months before going to the 5 mg dose, due to the intensity of my side effects. Started Day 1 of the 5 mg dose, and on the 3rd day after it I had tiredness, orthostatic hypotension (85/55 when standing up). At the 5th day, I am still having orthostatic hypotension - I maintained a water source. Spent 2.5 days without eating. I also vomited a couple of times during the 5 mg startup. Once this batch of side effects goes away, probably will be fine. I just think that a warning about the SEVERE side effects that make me functionally worthless should be discussed. I believe my side effects are a little more extreme than most, but folks should, at least, be informed."

• Car...
• Taken for 1 to 6 months
• October 13, 2024

For Weight Loss (Obesity/Overweight) "I lost 9 pounds the first month, and apart from a slightly upset stomach and heartburn for a few days, I was fine. I moved up to 5 ml on week 5, and after a few days, I started to get cramps and then vomiting. I have had bright yellow, watery liquid diarrhea. I thought I needed an ambulance, the pain was so bad. I will not be taking 5 ml after this."

• Kev...
• Taken for 1 to 6 months
• October 10, 2024

For Weight Loss (Obesity/Overweight) "It has worked, very positive results. No side effects after 11 weeks. I was on Saxenda and had many side effects, including episodes of gout, diarrhea, and indigestion (sulfur-tasting burps). I highly recommend it but caution folks to not rush increasing the dose (2.5 mg, then 5 mg, then 7.5 mg, etc. -- I took each dose for 4 weeks before increasing -- a friend skipped from 5 mg to 10 and became very ill). My only complaint is that it is very expensive for me because my insurance will not cover it for weight loss."

• Nau...
• Taken for less than 1 month
• December 19, 2022

For Type 2 Diabetes "Happy holidays, everyone. This medication is making it impossible for me to do anything. Dr. prescribed it. Day 1 felt fine. Day 2, near the end of the day, I had no desire for food-nothing. Today is Day 3, and I’ve been nauseous all day, and near the end of the day, I started to get diarrhea. The nausea has been pretty bad, though I did work out (it made it worse, and I had to skip some of it). Also, today, because of nausea, I have not wanted anything to eat. I forced myself to have half of an English muffin with peanut butter, and then this evening, a Campbell's soup to go since I was feeling so sick. I will not be taking the second dose this coming week when it is due because I feel miserable. It has a 5-day half-life, which is why I didn’t want to take it to begin with in case of side effects. It seems a lot of people get these side effects, and what I’ve learned is I always seem to get the side effects of medication. Be cautious. It needs a reversal pronto!"