Tirzepatide and Diarrhea: What Users Say (Page 3)

• Chi...
• Taken for 6 months to 1 year
• June 15, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "I have been on Mounjaro for almost a year. Started at 194 lbs, now averaging 145-150 lbs. In the beginning, I had the usual gastro effects - upset stomach, diarrhea, and no appetite even for water. Despite eating low calories, I lost slowly, about 1 lb a week. I had no energy to work out. If I tried staying on lower doses to minimize side effects, then the appetite would come back. After a few months, the gastro effects mostly went away, and I am left with sulfur burps, fatigue, irritability, and a general meh attitude about everything. I am someone who I would say has an addictive personality, and addiction runs in my family, and this drug works on your reward systems as well, so I’m not surprised it takes away my motivation. Despite the bad, it’s the only thing that has worked for me for weight loss. Currently, I take the injection every 14 days to minimize side effects and also to keep it affordable. Doing this keeps me at the weight I’m at, which I would like to be about 10 pounds less."

• Pro...
• Taken for 6 months to 1 year
• February 25, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I’ve been on Zepbound since 8/1/24 (305 lbs, 5’6). So far, I lost 65 lbs, I’m 45 lbs away from my goal. My current dose is 10 mg. I experience side effects within 24 hours of injection administration, ranging from nausea, vomiting, belching, diarrhea, abdominal pain, fatigue, and dizziness. The side effects last about 24-36 hours. The medication definitely decreases my appetite and cravings. My doctor stopped my BP medication as I continue losing weight and my BP readings are good. My husband has noticed that I stopped snoring, lol. My plan is to reach my weight goal and stop the medication. I have changed my relationship with food. I look at food more as fuel for my body instead of indulging and overeating. I also introduced portion control and exercise, mostly walking and swimming. My insurance covers the medication."

• Lis...
• Taken for less than 1 month
• July 19, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "I have been on the lowest dose of Mounjaro, 2.5 ml, for 3.5 weeks. I'm averaging a loss of just over 2 lbs per week. I'm going slow on purpose. Definitely less thoughts about food and less appetite. Feel full way sooner. I usually eat pretty clean anyways but now I'm weightlifting twice weekly in addition to 30-minute walks. All about 4-5 days per week. I'm 59, so my endurance is different now. I do get nausea on and off, which doesn't bother me. Depending on how much vegetable matter I consume, my bowel movements are good. Sometimes I get a bit of diarrhea but nothing terrible. Because of my age and lack of exercise, my BMI and fat % is not as good as it should be, and I struggle with the inherited fat gene thing from my family history. I would highly recommend this product. I do not have any form of diabetes."

• SFG...
• Taken for 6 months to 1 year
• November 18, 2024

Tirzepatide for Type 2 Diabetes "On 7.5 g Mounjaro. Blood sugar numbers came down. Weight did not. Experienced many of the more common side effects, e.g., diarrhea, gas, increased GERD. Ate less, watched protein intake closely. Experienced acute pancreatitis that was caused by gallstones, including one that blocked a biliary duct. After gallbladder surgery, my primary care physician decided to take me off Mounjaro permanently. I want to stress that I do NOT believe the drug had a thing to do with the pancreatitis, as I had the gallstone symptoms far longer than I was taking Mounjaro."

• Den...
• Taken for 1 to 6 months
• March 28, 2023

Tirzepatide for Type 2 Diabetes "Type II diabetic and was on Ozempic but was having multiple issues getting it from the pharmacy. The doctor changed to Mounjaro. Had to start with the 10 mg dose as they were out of 7.5. A tiny bit of nausea in the beginning and had the runs but that subsided after about two weeks. Appetite suppression is great and I eat smaller portions and am satisfied. Lost 22 lbs in 4 months. 231 lbs - 209 lbs. 48 y/o female. I had a terrible time losing weight prior as I also have Hashimoto's, despite working out 4/5 days a week of strength training. Mounjaro finally got me over the hump."

• Mar...
• Taken for 1 to 6 months
• February 18, 2025

Tirzepatide "I have diarrhea, lower stomach pain, dry heaves every time I eat. I also have back pain, but that is not unusual. This pain might be a little different though. I didn't know to tell my doctor that I have had a vein occlusion in my right eye quite a few years ago. I don't know if that is important or not. I don't think I am reading as well. Not sure."

• Jot...
• Taken for 1 to 6 months
• January 15, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "In 2023, I became concerned when I gained weight, leading to me being 202 pounds. After my first Mounjaro shot, I felt appetite suppression immediately. Two days later, I made the mistake of eating greasy, cheesy pizza, leading to nausea, and I threw it up. Try to eat nutritious and less fried food on it. Also, I experienced severe cramps and diarrhea. It was just my first week, though, and I was notified that nausea and gastrointestinal issues are common for the first 1-2 weeks. It definitely gets better as your body gets used to it. As I have taken long gaps of 10-14 days in between doses, mild gastrointestinal problems still occur, but it’s definitely more manageable than before. Overall, I am very satisfied with this medication. I am much more in control of eating and don’t binge. I also lost 12 pounds in 5 weeks!"

• Jay...
• Taken for 1 to 6 months
• January 7, 2023

Tirzepatide for Type 2 Diabetes "I started on 12-2-22. It’s 1-7-23. I’m now on 5 mg. My gallbladder was removed 10 years ago and I would have horrible gas, nausea, and diarrhea since surgery—until now! I was actually afraid to take this medication due to worsening my gallbladder tummy. All of those symptoms are gone. I just don’t eat much. I’m losing weight, probably 10 lbs so far. What I like about this med is that it’s a lifelong change. The injection is painless. I had 2 c-sections and I don’t feel the area around my stomach, so I put the injection there."

• Anonymous
• Taken for 1 to 6 months
• April 22, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "Mounjaro eliminated my appetite. Foods I previously craved and binged on were no longer of interest. I felt full after a few bites. However, when my doctor increased the dose from 2.5 mg to 5 mg, I began having side effects and ended up in the ER with severe diarrhea that was causing dehydration. I stopped taking Mounjaro after 6 weeks, but I did lose about 15 lbs during that 6 weeks. I want to restart but am worried about the side effects again."

• Cha...
• Taken for 1 to 6 months
• September 19, 2024

Tirzepatide for Type 2 Diabetes "Taking the lowest dosage for 10 weeks. I’ve had to reduce my insulin dosage to avoid “lows.” I’m down about 15 pounds and my blood glucose numbers seem pretty stable. But I haven’t checked my A1C. The only negative side effect has been diarrhea, which seems to have subsided."

• Orl...
• Taken for 1 to 6 months
• September 9, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Lost 60 pounds in 4 months. Stomach pain and alternating diarrhea and constipation. I had recently been diagnosed with type 2 diabetes with an A1C of 6.6. Now my A1C is down to 5.5. My sleep apnea went from 27 incidents per hour to less than 2 per hour. I just started taking the 10 dosage. Every time I up my dosage, I have a few days of bad side effects, especially stomach pain, but after a while, they lessen, however, diarrhea or constipation never stops."

• TCC...
• Taken for less than 1 month
• January 28, 2025

For Weight Loss (Obesity/Overweight) "I am on week two of Tirzepatide and had nausea and vomiting almost every day. The vomiting is primarily at night, frequently accompanied by dry heaves, and can be intense. Diarrhea was the first week but better entering the second week. When I hit menopause, I had a very difficult time losing weight (I gained 20 pounds), even when on a clean diet with cardio four days a week. Since beginning meds, I have lost nine pounds and have very little to no appetite. My workouts are not as frequent due to the nausea and feeling tired. Even with negative side effects, I will stick with it in hopes my body will adjust. My weight gain has limited my ability to do my job, which requires a lot of bending and lifting. Just the nine pounds of weight loss has helped my knees not ache and more comfortable on the treadmill. I started at .25 mg, and the injection was no bother."

• Kel...
• Taken for 1 to 2 years
• September 12, 2024

Tirzepatide for Type 2 Diabetes "Mounjaro worked well in the beginning. My BGL was lower, and I lost weight. After about 18 months, the control of my BGL was not as consistent. I experienced nausea and loss of appetite from the beginning, but that lessened over time. Recently, I have begun to experience severe diarrhea and belching for several days after taking a shot."

• Win...
• Taken for 1 to 6 months
• February 9, 2023

For Weight Loss (Obesity/Overweight) "I am a doctor and was hoping I could use this Mounjaro for my patients - thought I would try it first. Began with 2.5 mg for four weeks. Very bothersome reflux and was popping Rolaids. I lost 7 lbs in the first month. My doc increased me to 5 mg, and I did OK for the first two shots. On the third injection, I developed sulfur burps and diarrhea. After the fourth shot - I developed gastroparesis (stomach not emptying at all), profound nausea, dehydration, and I am very gassy. I have not been able to function for 5 days. Praying I am better tomorrow as I have a shift in the ED. Not sure about prescribing this based on my own experience."

• RW3...
• Taken for 1 to 6 months
• February 11, 2024

For Weight Loss (Obesity/Overweight) "Started at 2.5 mg for two months and lost 15 lbs. I had lots of sulfur burps and diarrhea initially. The diarrhea lasted a week. The sulfur burps lasted a few months and were disgusting. No nausea or vomiting. Moved to 5.0 mg for two months and lost 5 lbs. Sulfur burps a problem for the first month. Second month of tirzepatide, no side effects, but no weight loss. I plan on asking for an increased dosage. Good drug and helps food not seem attractive."

• Tum...
• Taken for less than 1 month
• November 2, 2022

For Weight Loss (Obesity/Overweight) "I started the 2.5 Mounjaro injection prescribed by my doctor a week ago to help lose weight. I was happy that the injection was super easy and didn’t hurt at all. The first 2 days I felt great! I had zero appetite, even on the first day, and had to force myself to eat. By the 3rd day… it was a nightmare! I had nonstop diarrhea, the kind you get with colonoscopy prep stuff! I also experienced horrible, sulfur-like belching, especially when getting up in the morning, and had extreme pain in my lower back. Then, last night, I had extremely forceful vomiting, which is crazy because I don’t really have anything in my system! I still have the horrible diarrhea 7 days later, also pretty extreme fatigue, slight heartburn, and a nauseated feeling. I am just praying this stuff gets out of my system ASAP! I just wish someone could tell me how long before I feel better! I will not be using the rest of my Mounjaro injections after the experience I’ve had this first week."

• Cjl...
• Taken for 1 to 6 months
• June 14, 2023

Tirzepatide for Type 2 Diabetes "I was started on Mounjaro at the end of Jan 2023. My A1C was 10, and I am 41, about 5 ft 9 in. I weighed about 350 lbs. I had no energy, had sleep apnea, hurt all the time, and could not even walk without running out of breath. I was miserable. Finally, I talked to my doctor, and she decided to try me on this. After a little struggle getting insurance to cover it and get the med in stock at my pharmacy, I got going on this new journey. About 2 months in, I started having major diarrhea and vomiting. Had to take a break for a week and then started doing my injections in my thighs instead of my belly, and that has made it a lot more bearable. I do still get diarrhea and sulfur burps for 3, sometimes 4 days after my shot, but nothing major. Now my A1C is 6, my blood glucose averages 75, and I am weighing in at 270 lbs. I can walk now without running out of breath and without being in major pain. I have made other changes, such as watching what I eat, stopping drinking soda, and started trying to walk."

• Slo...
• Taken for less than 1 month
• May 17, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "Female, 52 years, beginning weight 177 lbs, 5'7. I took my fourth injection of 2.5 mg this morning. I've been eating about 500 calories/day. The first week I lost 2 lbs and I walked 3 miles 2 days and lifted weights 1 day. The second week back to 177 lbs, including 2 days in the gym. In the third week, I traveled and did not exercise or weigh myself. I ate out for Mother's Day and for a friend's baby shower. When I returned, I was 175 lbs. In 3 weeks, I've lost a total of 4 lbs. Side effects for me have been a little more tired-duh-less energy going in. This doesn't seem worth the cost. We meet with the doctor tomorrow about upping it to 5 mg. My husband has been diligent about walking 5-7 miles per day also on 2.5 mg, 500 calories/day, and has lost about 8 lbs. (He has more to lose than me). His side effects were little nausea the first week, a slight decrease in focus and energy, some mild headaches, and diarrhea. Says pooping is faster."

• N R...
• Taken for 1 to 6 months
• July 4, 2024

Tirzepatide for Type 2 Diabetes "I have started with 2.5 mg dose once every week on 16th April 2024. They gave me 4 rounds of this dose. Then they started with 5 mg dose once every week. Initially, I was feeling nausea, diarrhea, sour burps, and dizziness, and gradually it decreased. When I started to take 5 mg, the same symptoms, apart from diarrhea. This time I had severe constipation on the 3rd day of the 5 mg dose, but I took some home remedy and laxative medicine. Still experiencing constipation. But the good thing is my appetite has reduced significantly, I am eating like a 5 to 10-year-old child. Feeling energetic, I lost around 6 kg in weight. Sugar level is under control, reduced Humalog dose."

• Nic...
• Taken for 1 to 6 months
• February 2, 2023

Tirzepatide for Type 2 Diabetes "I started this shot about 2 months ago. My doctor prescribed the 2.5 first. I took it on Saturday morning, so I had the weekend to see how it made me feel. By Weds, I had flu-like symptoms for the day and missed work. The nausea lasted for the first few weeks, but I've completed my box of 5 mg, and I haven't had any nausea with it. However, I do have sulfur burps when I eat too much. And I have to force myself to drink water. But I rarely eat between meals, and I am down 20 pounds. I just picked up my new prescription of 7.5 and will take my first dose Saturday. I'm in my 50s, I am 5'3" and I started at 267 pounds. I have been on metformin for years. I've had severe diarrhea on metformin and would be in the bathroom multiple times a day with watery stool. I also ate everything in sight and snacked constantly. Now I have normal bowel movements. I also do not sweat profusely as I did on metformin. I have to say this shot has changed my life, and I am happy I am on it."

• Nic...
• Taken for 1 to 6 months
• February 2, 2023

Tirzepatide for Type 2 Diabetes "I started this shot about 2 months ago. My doctor prescribed the 2.5 first. I took it on Saturday morning, so I had the weekend to see how it made me feel. By Weds, I had flu-like symptoms for the day and missed work. The nausea lasted for the first few weeks, but I've completed my box of 5 mg, and I haven't had any nausea with it. However, I do have sulfur burps when I eat too much. And I have to force myself to drink water. But I rarely eat between meals, and I am down 20 pounds. I just picked up my new prescription of 7.5 and will take my first dose Saturday. I'm in my 50s, I am 5'3" and I started at 267 pounds. I have been on metformin for years. I've had severe diarrhea on metformin and would be in the bathroom multiple times a day with watery stool. I also ate everything in sight and snacked constantly. Now I have normal bowel movements. I also do not sweat profusely as I did on metformin. I have to say this shot has changed my life, and I am happy I am on it."

• Gre...
• October 15, 2023

Tirzepatide for Type 2 Diabetes "I am 5'9", 64 years old, and female. I weighed in at a high normal body weight, but my A1C was nearly 13. My doctor tried Metformin with fast and long-acting insulin and also Januvia, and my blood sugars were horribly unstable, dropping to 45 in the middle of the night and waking up over six hundred. I also have fatty liver disease with stage four cirrhosis. I've been on Mounjaro for eight weeks and lost 24 pounds, which still leaves me at the higher end of normal body weight, but my A1C fell to 7 after a month. I am on the 5 mg but wish I had stayed at 2.5 for a while, as the side effects like bloating, indigestion, and diarrhea have started again, and I don't really need a lot of weight loss. The fact that it breaks down fat in the liver and controls my diabetes is the best thing. The worst thing is the waves of nausea, fatigue, and dizzy spells I get in the first few days after taking it, but it's still worth it."

• Jan...
• Taken for less than 1 month
• November 24, 2024

Tirzepatide for Type 2 Diabetes "I've only had 2 shots and 2 days until the next one. I find it very convenient to administer. However, I have had some nasty side effects! I've had diarrhea, nausea, vomiting, fatigue. I will continue taking the medication hoping the side effects will 'calm down.'"

• Bec...
• Taken for 6 months to 1 year
• May 30, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "I had insulin resistance and was overweight. I started taking Mounjaro and have lost 34 lbs and am now within 8 lbs of my goal weight. I have not increased my physical activity. My A1C has gone from 7.0 to 5.4. I started taking it 7 months ago. I have been on the 10 mg dosage for the last 2 months. I find that it is very easy to use. The side effects at first were nausea and diarrhea. They were very severe at first, but have calmed down and now I might experience some slight nausea the day after my injection. I also find that I really do not have any interest in food and do not feel hungry. I need to eat small meals of mostly protein and get full on very little food. Another side effect that seems to have gotten worse in the last 2 or 3 months is extreme fatigue. I find that I have very little energy."

• Joy...
• Taken for 1 to 6 months
• April 20, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "I started this medication on 2/2/23; I am 36 years old, 5'5", and 179 pounds. As of today, 4/20/23, I weigh 160 pounds. Since 2019, I have not been able to lose weight after I had my son. I exercised routinely and would gain, lose, gain, lose, but couldn’t get past 171 lbs. My doctor saw my hopelessness, and luckily I have a Health Savings Account (HSA) that can cover this medication for 7 months. I haven’t had any major side effects. It actually has corrected issues. I don’t have diarrhea anymore; that was practically a daily thing for the last year before I started this medication. I feel healthier taking this medication. I exercise three times a week, and I’m trying to create a practical routine after I have to stop this medication. I’m on 7.5 mg and currently will stay at that dose. I highly recommend it. I’m not diabetic, but my fasting glucose was in the mild range, which leads me to believe that has been my problem over the past 4 years."