Tirzepatide and Diarrhea: What Users Say (Page 3)

• Ano...
• Taken for 1 to 6 months
• May 29, 2025

For Obstructive Sleep Apnea/Hypopnea Syndrome "Dosage 2.5. Effective for sleep apnea and weight loss. Having side effects including queasiness, lightheadedness, diarrhea, constipation, Vitamin B12 blood test elevated to 1270. Starting weight 156. Now 147 after 7 doses."

• Dut...
• Taken for 1 to 6 months
• March 8, 2025

For Type 2 Diabetes "My appetite and being a lifelong ‘foodie’ hit a final conflict point four years ago when I lost my ability to work off my weight easily. My knee pain and depression combined to make me asocial, deeply uncaring about my condition and convinced of no hope. I am pretty miserable. At 15 mg a week, food has moved from center stage to a stronger support character. Only one bout of intestinal irritation has marred my experience with diarrhea, vomiting, pain. But my insulin levels remain superb and my glucose monitor has become a friend, not an inevitable betrayer."

• Anonymous
• Taken for 6 months to 1 year
• March 4, 2025

For Weight Loss (Obesity/Overweight) "It was rough in the beginning, with diarrhea, then constipation and heavy belching. The diarrhea ended after about a month, but constipation has continued. In addition to those symptoms, I experienced an undercurrent of nausea for several months, with it being more pronounced just after eating. After about eight months, the nausea abated for the most part. I started on the 2.5 and moved up in dosage every 2 months or so. I am entering month 10 and am on the 12.5 dosage. For the first 6-7 months, I lost approximately 1.5 lbs/wk, and over the last 2-3 months that has slowed down a little. I have lost a total of 50 lbs. The other side effect I've experienced is I sometimes have low blood sugar in the mornings, so I will have juice or something to help take care of it. It is easy to use, and despite the rough start, I am pleased with the results."

• Ano...
• May 20, 2025

For Weight Loss (Obesity/Overweight) "Side effect I’d say I’ve had is a little bit of diarrhea and nausea. I’ve been on it for over a year now. I’ve lost over 140 pounds, still have a lot more to go, but it also helps control my type two diabetes, brought my A1c down from 10.8 to 4.6. Very happy with that, but I just had to have my appendix out right away because it was just about to rupture. Never had a problem with it until recently, so a coincidence or is it the medicine? Who knows, but I do know that this medicine has been a godsend for me. I do have gastroparesis along with IBS, and I tried to take Ozempic before this, and it about killed me, so an ambulance had to come and get me on the Ozempic. I do know I’m able to handle Mounjaro a lot easier on my system. If it wasn’t for Mounjaro, I don’t know where I’d be with my health right now, trying to raise three kids under the age of 14. So thank you."

• Jac...
• Taken for 1 to 6 months
• May 15, 2025

For Type 2 Diabetes "2.5 and 5.0 worked fine with minimal side effects. Once I started 7.5, nausea and diarrhea took over. I’ve only taken 1 dose, and don’t plan on continuing 7.5. 5.0 lowered my blood sugar just fine."

• Nau...
• Taken for less than 1 month
• December 19, 2022

For Type 2 Diabetes "Happy holidays, everyone. This medication is making it impossible for me to do anything. Dr. prescribed it. Day 1 felt fine. Day 2, near the end of the day, I had no desire for food-nothing. Today is Day 3, and I’ve been nauseous all day, and near the end of the day, I started to get diarrhea. The nausea has been pretty bad, though I did work out (it made it worse, and I had to skip some of it). Also, today, because of nausea, I have not wanted anything to eat. I forced myself to have half of an English muffin with peanut butter, and then this evening, a Campbell's soup to go since I was feeling so sick. I will not be taking the second dose this coming week when it is due because I feel miserable. It has a 5-day half-life, which is why I didn’t want to take it to begin with in case of side effects. It seems a lot of people get these side effects, and what I’ve learned is I always seem to get the side effects of medication. Be cautious. It needs a reversal pronto!"

• PRe...
• Taken for less than 1 month
• February 12, 2025

For Weight Loss (Obesity/Overweight) "On week number three, I started with stomach cramps and diarrhea. The night before, I had a huge helping of Boom Chicka Pop kettle corn. While the packaging states it only uses cane sugar, I came to the conclusion that this product (perhaps in the amount eaten) suddenly didn’t agree with me while taking Zepbound. I’ve lost 5 lbs in 2 1/2 weeks. Diarrhea and cramping subsided after 36 hours."

• Joa...
• Taken for less than 1 month
• November 10, 2024

For Weight Loss (Obesity/Overweight) "I'm a 64-year-old woman. 5'2" and weighed 177. I've lost 10 pounds in my first 3 weeks. With the heartburn, I had to force myself to eat last night when I wasn't really hungry. I think I ate the scrambled eggs too late in the evening. I had horrible diarrhea and vomiting. That was the first time that happened. I'm hoping it's just because I ate so late on such an empty stomach. I have had no desire to eat the first 3 or 4 days after injection. I have to remind myself to eat something."

• Chi...
• Taken for 6 months to 1 year
• June 15, 2023

For Weight Loss (Obesity/Overweight) "I have been on Mounjaro for almost a year. Started at 194 lbs, now averaging 145-150 lbs. In the beginning, I had the usual gastro effects - upset stomach, diarrhea, and no appetite even for water. Despite eating low calories, I lost slowly, about 1 lb a week. I had no energy to work out. If I tried staying on lower doses to minimize side effects, then the appetite would come back. After a few months, the gastro effects mostly went away, and I am left with sulfur burps, fatigue, irritability, and a general meh attitude about everything. I am someone who I would say has an addictive personality, and addiction runs in my family, and this drug works on your reward systems as well, so I’m not surprised it takes away my motivation. Despite the bad, it’s the only thing that has worked for me for weight loss. Currently, I take the injection every 14 days to minimize side effects and also to keep it affordable. Doing this keeps me at the weight I’m at, which I would like to be about 10 pounds less."

• She...
• Taken for 1 to 6 months
• June 7, 2023

For Type 2 Diabetes "I just finished my first month of Mounjaro 2.5 mg. I did experience some side effects on the first day: nausea, vomiting, and diarrhea, but the second day was better. After eating a small meal, I experienced bad sulfur-like burps throughout the day. So I took Pepto Bismol, and that worked like a charm! So before each one of my injections, I take a dose of it the first half hour before with no problems now."

• Car...
• Taken for 1 to 6 months
• October 13, 2024

For Weight Loss (Obesity/Overweight) "I lost 9 pounds the first month, and apart from a slightly upset stomach and heartburn for a few days, I was fine. I moved up to 5 ml on week 5, and after a few days, I started to get cramps and then vomiting. I have had bright yellow, watery liquid diarrhea. I thought I needed an ambulance, the pain was so bad. I will not be taking 5 ml after this."

• Kev...
• Taken for 1 to 6 months
• October 10, 2024

For Weight Loss (Obesity/Overweight) "It has worked, very positive results. No side effects after 11 weeks. I was on Saxenda and had many side effects, including episodes of gout, diarrhea, and indigestion (sulfur-tasting burps). I highly recommend it but caution folks to not rush increasing the dose (2.5 mg, then 5 mg, then 7.5 mg, etc. -- I took each dose for 4 weeks before increasing -- a friend skipped from 5 mg to 10 and became very ill). My only complaint is that it is very expensive for me because my insurance will not cover it for weight loss."

• A M...
• April 6, 2023

For Weight Loss (Obesity/Overweight) "Started Nov 12 and am down 27 pounds. I have been on 5 mg for 16 weeks due to a shortage of 7.5 mg, so weight loss has slowed down considerably, but I am not gaining! Very sick the first week with nausea and one night of vomiting and diarrhea, but after that, only indigestion at night and occasionally like the next day after the injection! Pleased with the outcome so far! Disappointed with not moving up due to a shortage of 7.5 mg."

• RBj...
• Taken for 1 to 6 months
• August 29, 2023

For Weight Loss (Obesity/Overweight) "I started using Mounjaro in March 2023, with a 2.5 mg dose, for weight loss. I shifted to 5 mg after 2 weeks; I stayed with each dose for around 2-3 months. I lost 10 kg by August (6 mo.). I had a freeze in weight loss for 5 weeks, then I lost 1.8 kg in 2 weeks when I took 10 mg. In terms of side effects, I experienced them during the first weeks of every upgrade in dose; like nausea and sometimes vomiting, headache, stomach pain, constipation and diarrhea, laziness, body ache, mood change; the worst was with 10 mg. As I have urticaria, I experienced an allergy at the needle site after week 10, which resolved in 3 days every time. This week I have pelvic, vaginal, and lower abdominal pain similar to period pain, although I have been menopausal for 4 years! I am happy about the results with minimal side effects."

• Hon...
• Taken for 1 to 6 months
• October 6, 2022

"I have been taking Mounjaro for 7 weeks. 4 weeks of that I was on the 2.5 mg dose and lost 15 lbs by the 4th week. The last 3 weeks I've been on the 5 mg and I've lost ZERO lbs. Seems kind of useless to take when you have all the side effects (constipation, diarrhea, bloating, gas, nausea, headache, severe fatigue) for 3 weeks straight with no weight loss. I am considering going off this medication, I think it was all just hype. I've also stopped having periods. 40 years old, SW 199, CW 185, GW 140. Also following website food/calories recommendations. I have no other disease, just obesity."

• Bel...
• Taken for less than 1 month
• April 3, 2023

For Type 2 Diabetes "I didn’t think anything could decrease my appetite, but boy did this! Completely lost it, so much so that, for 2 days, my blood sugar levels were not high enough to give any injections of my regular insulin or my long-acting one. Then I started to have diarrhea. It’s not fun! But if you’re looking for something to quash your appetite, this is it!"

• Ama...
• Taken for 1 to 2 years
• March 19, 2025

For Weight Loss (Obesity/Overweight) "I have lost nearly 80 lbs over the past 20 months. My A1c has improved greatly, as has my sleep apnea. My weight has remained stable at 152 lbs over the past 6 months, and I am able to resume skiing and hiking! I can keep up with my peers again! I have made major life changes with my diet/eating and resuming regular exercise, and I look forward to maintaining a healthier lifestyle for the rest of my life! I experienced uncomfortable diarrhea, gas, and unpleasant burping initially, which resolved. I also experienced hair thinning, but not severe. I now have a somewhat flattened butt, which I have read is known as Ozempic or Zepbound butt, and am working on weight training exercises to rebuild muscle in my legs, glutes, and arms. I would not recommend this drug to anyone who is not able or willing to put in the hard work of developing lifestyle changes and including exercise and diet, due to the muscle loss factor."

• Rwi...
• Taken for 1 to 6 months
• March 19, 2023

For Type 2 Diabetes "My A1C and glucose levels are great. I am not on insulin. Side effects are rotten. Nausea, GERD, constipation/diarrhea, headache, stomach pain, decreased appetite every shot lessens over the week. Had this with Ozempic and Trulicity too, but not as severe. I have seen no weight loss benefit despite a decent diet and moderate exercise 3-5 times per week. Other side effects I’m not sure are related: feeling of lump in throat, slight face rash, occasional blurred vision, tingling in hands."

• Pat...
• Taken for 1 to 6 months
• June 27, 2025

For Obstructive Sleep Apnea/Hypopnea Syndrome "Everything was okay while I was taking the 0.5 dose in April 2025, but once I began the 7.5 mg dose, I began to notice my blood pressure increasing, and by 9:48 a.m. on the very next day after taking this dose, my BP reading was 155/101 mm Hg with a pulse of 101. I had to call an ambulance and get to the ER. I don't think Zepbound is for people who already have high blood pressure, especially since it raises your heart rate. I already had diarrhea, and I had no appetite. Not replacing electrolytes fast enough, my blood sugar had dropped dangerously low. I was given hydralazine to bring my BP down quickly, 2 Tylenol, and Ativan to stabilize me before I had a stroke or heart attack. Everybody is different, so I urge you to really think about all of the pros and cons before taking Zepbound, even if you already have sleep apnea, which I have. I will be looking for alternative ways to lose the 23 pounds and continue my exercise routine along with the DASH and Mediterranean meal plans."

• Mat...
• Taken for 1 to 6 months
• March 4, 2025

For Type 2 Diabetes "I am just getting back on after having to quit for hip joint replacement surgery. I am up to 7 mg now. My daily glucose level is going down. I’ve had some weight loss. But the side effects are discouraging. Excessive gas, burping, bloating, diarrhea, and fluttering inside my chest. These symptoms last 2 or 3 days after injection. I am going to continue injections in the hope the side effects get better."

• Den...
• Taken for 1 to 6 months
• March 28, 2023

For Type 2 Diabetes "Type II diabetic and was on Ozempic but was having multiple issues getting it from the pharmacy. The doctor changed to Mounjaro. Had to start with the 10 mg dose as they were out of 7.5. A tiny bit of nausea in the beginning and had the runs but that subsided after about two weeks. Appetite suppression is great and I eat smaller portions and am satisfied. Lost 22 lbs in 4 months. 231 lbs - 209 lbs. 48 y/o female. I had a terrible time losing weight prior as I also have Hashimoto's, despite working out 4/5 days a week of strength training. Mounjaro finally got me over the hump."

• Joj...
• Taken for 6 months to 1 year
• February 3, 2025

For Type 2 Diabetes "I started Mounjaro in March 2024 at 193 pounds and an A1C of 12.3. For almost 11 years as a type 1 diabetic. By July 2024, I was down to 153 pounds and an A1C of 7.75. I started off with the two, then went to the five, then to the seven, then to the 10. But after being on a 10, I started back developing an appetite, however, I exercised at least two hours per day faithfully in the gym. When I was on the number five, I had diarrhea a lot. When I made it to the 10, I just had a lot of belching, burping, saying that the 10 wasn’t doing much, I was still at like 150. I was bumped up to the number 12, and Lord have mercy on my soul. It almost took me out of here! I lost weight too fast. I got down to 116 pounds. I couldn’t. I didn’t have any desire to eat. I didn’t have any desire to drink. I would forget that I hadn’t been drinking anything. I would forget that I didn’t eat anything, and I’m still going to the gym every single day. It was until I dehydrated twice that I..."

• Jay...
• Taken for 1 to 6 months
• January 7, 2023

For Type 2 Diabetes "I started on 12-2-22. It’s 1-7-23. I’m now on 5 mg. My gallbladder was removed 10 years ago and I would have horrible gas, nausea, and diarrhea since surgery—until now! I was actually afraid to take this medication due to worsening my gallbladder tummy. All of those symptoms are gone. I just don’t eat much. I’m losing weight, probably 10 lbs so far. What I like about this med is that it’s a lifelong change. The injection is painless. I had 2 c-sections and I don’t feel the area around my stomach, so I put the injection there."

• Lis...
• Taken for less than 1 month
• July 19, 2024

For Weight Loss (Obesity/Overweight) "I have been on the lowest dose of Mounjaro, 2.5 ml, for 3.5 weeks. I'm averaging a loss of just over 2 lbs per week. I'm going slow on purpose. Definitely less thoughts about food and less appetite. Feel full way sooner. I usually eat pretty clean anyways but now I'm weightlifting twice weekly in addition to 30-minute walks. All about 4-5 days per week. I'm 59, so my endurance is different now. I do get nausea on and off, which doesn't bother me. Depending on how much vegetable matter I consume, my bowel movements are good. Sometimes I get a bit of diarrhea but nothing terrible. Because of my age and lack of exercise, my BMI and fat % is not as good as it should be, and I struggle with the inherited fat gene thing from my family history. I would highly recommend this product. I do not have any form of diabetes."

• Jot...
• Taken for 1 to 6 months
• January 15, 2024

For Weight Loss (Obesity/Overweight) "In 2023, I became concerned when I gained weight, leading to me being 202 pounds. After my first Mounjaro shot, I felt appetite suppression immediately. Two days later, I made the mistake of eating greasy, cheesy pizza, leading to nausea, and I threw it up. Try to eat nutritious and less fried food on it. Also, I experienced severe cramps and diarrhea. It was just my first week, though, and I was notified that nausea and gastrointestinal issues are common for the first 1-2 weeks. It definitely gets better as your body gets used to it. As I have taken long gaps of 10-14 days in between doses, mild gastrointestinal problems still occur, but it’s definitely more manageable than before. Overall, I am very satisfied with this medication. I am much more in control of eating and don’t binge. I also lost 12 pounds in 5 weeks!"