Tirzepatide and Diarrhea: What Users Say (Page 4)

• Sam...
• Taken for 1 to 6 months
• February 26, 2023

Tirzepatide for Type 2 Diabetes "It really does not control my glucose levels without Novolog and Tresiba. I’ve developed chills, shakes, nausea, and diarrhea. My doctor says it shows the shot is working. I’m not dealing with the level of neuropathy like Trulicity. Plus, my GFR came back by 10 points."

• Kat...
• Taken for 1 to 6 months
• September 2, 2024

Tirzepatide for Type 2 Diabetes "I began my journey on April 12th, 2024. I'm currently on my second dose of 7.5. A bit more stomach issues, diarrhea, and extreme fatigue. No desire to eat whatsoever. Since I've started, I have lost a total of 50 lbs. as of 9/2/24. Yes, I'm Type 2 diabetic, but I wanted to give this medication a try to see if it would be of any help for me to lose weight. It has far exceeded my expectations! It's been a bit rough, but I'm seeing great results. I'll continue on this journey with hopes of meeting my own personal weight loss goals."

• Anonymous
• Taken for 1 to 6 months
• June 26, 2023

Tirzepatide for Type 2 Diabetes "I took the 2.5 mg for four weeks, then I did the 5.0 mg for four weeks. I am now taking 7.5 mg. I am taking it for eight weeks. I did the research and studies on what to do. I do not eat fried foods. I do not eat sweet things, especially ice cream, which is my absolute favorite food. I have not been sick. I have not had diarrhea or been constipated. I do not overeat, which is in the instructions. My blood glucose has dropped 30 points. I won't know what my A1C is until I go back to my doctor for a test. My only problem is the cost. So far, I am doing very well on Mounjaro. It is very easy to use."

• Zep...
• Taken for less than 1 month
• August 1, 2024

For Weight Loss (Obesity/Overweight) "Pros: 20 lbs lost in 4 weeks, zero appetite, able to move joints freely, more energy. Cons: Diarrhea (gallbladder removed 13 years ago), hypoglycemic episode once in 3 weeks of use - learned to consume good carbs. Overall, the medication is working great for me, and I only wish I were able to start it sooner."

• She...
• Taken for 1 to 6 months
• May 23, 2023

Tirzepatide for Type 2 Diabetes "I started with 2.5 mg, then increased the dosage to 5.0 mg, and then 7.5 mg without any success. Skipped 10.0 mg and then moved up to 12.5 mg, and that is when the success came! I lost 25 lbs in 3 months, and it brought down A1c from 8.0 to 7.0. I had minor side effects such as diarrhea and some stomach upset. Overall, a very positive experience."

• Hop...
• Taken for 1 to 6 months
• May 16, 2023

Tirzepatide for Type 2 Diabetes "Not long after I began taking Mounjaro, my A1C dropped from 8.1 to 6.7. Finally, something that's helping. I’ve also lost some weight, although it's been a slow process. Now I’m beginning to have stomach issues along with diarrhea. Just makes me feel sluggish. I’m on the 10.0 dose, and the doctor said I may need to drop down to a lower dose. It's very easy to use. Giving myself a shot is not a problem."

• Pre...
• Taken for less than 1 month
• June 12, 2023

Tirzepatide for Type 2 Diabetes "First week, I had massive diarrhea and a splitting headache. Week 2 was better. Just a headache. Week 3, still have a headache. Down 8 pounds in 3 weeks. Blood sugar is fine. I find I don’t eat much. I have to force myself to drink too."

• Rob...
• Taken for 6 months to 1 year
• June 16, 2023

Tirzepatide for Type 2 Diabetes "I started at the lowest dose, even though I was switching over from Ozempic, and I had been on 7.5 mg of that for over a year or longer. It was out of stock, and they didn’t know when it would be back in. I switched to Mounjaro. I have been taking the once-a-week injection for about 6 months, I think. I am on 10 mg now. Yesterday, I had my A1C checked, and it had gone down from 6.7 in March to 5.9. I was thrilled. I’ve lost 19 lbs, which isn’t huge, but it’s something. I was 250 lbs and now 231 lbs. I’ve been pretty happy and eating less and feeling fuller longer. The side effects I’ve noticed are sometimes I have low sugars, but I need my insulin adjusted, and I have diarrhea every morning and occasionally during the day. I think I’m going to start a probiotic. The goal is to get off my insulin. That is the plan of me and my endocrinologists."

• Hrk...
• Taken for less than 1 month
• May 17, 2023

Tirzepatide for Type 2 Diabetes "I started Mounjaro 7 days ago for type 2 diabetes and weight loss. Days 1, 2, and 3 were great. Appetite was almost nonexistent, great, right? Day 4, my vision started to blur. Days 6 and 7, reoccurring stomach aches and diarrhea. I’m now on day 7 and my vision is so blurry I can barely see up close or far away. My vision was 20/20 before starting this. The insert says it can make diabetic retinopathy worse, to my knowledge, I don’t have diabetic retinopathy. I have an appointment with a retina specialist tomorrow. Works great as an appetite suppressant, and it really lowered my blood sugar, however, I need to see. So it’s going to be a no for me."

• Yik...
• Taken for less than 1 month
• January 2, 2023

Tirzepatide "I started at the 2.5 mg dose for weight loss. I felt little to no appetite for the day. Then that night, I was throwing up and having severe diarrhea, like it was the worst stomach flu I’d ever had. I decided I’d not take it again. It would’ve helped me lose weight, just not the way I’d want."

• sls...
• Taken for 1 to 6 months
• November 22, 2022

For Weight Loss (Obesity/Overweight) "I started Mounjaro almost 5 weeks ago with the 2.5 injection. One shot weekly in my stomach area. I have lost 16 lbs so far and will be starting my new dose of 5.5 tomorrow for 4 weeks. I have been very pleased so far with Mounjaro. I am not hungry at all, in fact, I have to remind myself to eat. So far, the only side effects I've experienced are diarrhea, constipation, and I appear to have a change in how some things taste. Certain things I liked the taste of before now have a strange aftertaste. I am loving losing the weight and hopeful I will lose more."

• kjo...
• Taken for less than 1 month
• October 18, 2022

For Weight Loss (Obesity/Overweight) "I've been on 2.5 mg Mounjaro for exactly 2 weeks now for weight loss, and I have lost 8 pounds. I'm feeling great; however, I have had a stomach ache twice and diarrhea once. Can't eat too much, or my stomach will hurt. I'm also walking 3x/week and logging my food & beverage in an app - staying at 1200 calories or below is super easy on this med. I have felt more energetic on it - which might be because I am so excited that there could be a solution to my overweight problem! It seems like a long-awaited answer to my prayer - I'm feeling very hopeful and optimistic!"

• ILo...
• Taken for 6 months to 1 year
• June 26, 2023

Tirzepatide for Type 2 Diabetes "Lowered A1C from 8.7 to 7.2 in 90 days on the 2.5 mg. I have not checked on the 5.0 mg. Blood sugar is down from 180s to 110s. The blood sugars stay consistent for the most part. I know which foods will raise it, such as corn products and wine, though it does not go beyond 130s for me. Started on 2.5 mg and just raised to 7.5 mg, which is hard to get. It took 3 months of backorder. If I overindulge in food or wine, I will not have a pleasant night. Nausea and diarrhea will happen. It helps with appetite control. This starts happening with the 5.0 mg, but I have really noticed the difference in the 7.5 mg. I typically need a snack between meals, now I can go longer without feeling so hungry or jittery. I have yet to lose any weight, but I think it will come as I continue with the 7.0 mg. I have lowered my Toujeo dosage from 82 to 50 units per day. It is a big drop with each higher dosage. I believe I will be in the 30s by the time I step up to the 10.0s. I also take Metformin XL."

• CMH...
• Taken for 6 months to 1 year
• July 13, 2023

For Weight Loss (Obesity/Overweight) "Started Jan 6 at 191. 57F, 5'6'. July 12, 143. So almost 50# in 6 mo. First month or so on 2.5, I had mild nausea (Zofran worked great), indigestion (Pepcid chewables for that), and occasional constipation. Diarrhea maybe twice. Experienced some fatigue initially, but likely the result of very low calorie intake. Have been on 5 mg since, with only mild constipation. This drug is an absolute game changer for me. I had tried for almost 2 years to drop the weight with diet and exercise with basically zero success. Now I'm approaching my lowest adult weight with minimal effort! Biggest downfall is having to spend money on new smaller clothes."

• Sco...
• Taken for 1 to 6 months
• March 18, 2025

Tirzepatide for Type 2 Diabetes "So far, so good until yesterday. I think I ate too much, and then the stomach pain started, and diarrhea followed all night. As I tried to ingest water, I became nauseous and had to throw up, but that decreased the pain. I think I’m just getting used to the drug since this was my first dose of 7.5 mg pen."

• Dru...
• Taken for 1 to 6 months
• April 12, 2025

Tirzepatide for Type 2 Diabetes "Currently on 750 Mounjaro. 2nd injection on Wednesday, had a 17-hour episode of vomiting and diarrhea on Sunday afternoon into Monday morning. I did not take the 3rd injection the following Wednesday. By Friday, I had the hungry horrors and joint pain in my hips and knees. Weight loss about 25 lbs, and my A1C only came down from 7.5 to 7.1 in the 5 months I’ve been on Mounjaro. If you take these meds, please listen to your body and the way it reacts to these meds."

• Don...
• Taken for 1 to 6 months
• November 20, 2024

For Weight Loss (Obesity/Overweight) "So far, I have lost about 2 lbs per week. Side effects include some constipation and periodic diarrhea. I am taking 10 mg subcutaneously weekly. I have been taking it for a month and have noticed a marked decrease in appetite without stimulant-type effects! I am very pleased with this medication."

• Ama...
• Taken for 1 to 2 years
• March 19, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I have lost nearly 80 lbs over the past 20 months. My A1c has improved greatly, as has my sleep apnea. My weight has remained stable at 152 lbs over the past 6 months, and I am able to resume skiing and hiking! I can keep up with my peers again! I have made major life changes with my diet/eating and resuming regular exercise, and I look forward to maintaining a healthier lifestyle for the rest of my life! I experienced uncomfortable diarrhea, gas, and unpleasant burping initially, which resolved. I also experienced hair thinning, but not severe. I now have a somewhat flattened butt, which I have read is known as Ozempic or Zepbound butt, and am working on weight training exercises to rebuild muscle in my legs, glutes, and arms. I would not recommend this drug to anyone who is not able or willing to put in the hard work of developing lifestyle changes and including exercise and diet, due to the muscle loss factor."

• CHI...
• Taken for 1 to 6 months
• September 4, 2024

Tirzepatide for Type 2 Diabetes "When I first started taking Mounjaro, I didn't feel like eating at all, and I started to lose weight quickly. In fact, I lost 9 pounds in two weeks. I had diarrhea about three times a day in the beginning, it wasn't until about three months for that to stop. But now I have issues with belching and gas. I am now down 50 lbs, which is great, but I lost a lot of muscle tone. All in all, my blood sugar is doing great. I do recommend staying hydrated and taking some anti-gas meds if stomach pain persists."

• Mk6...
• Taken for 1 to 6 months
• March 10, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I started in January 2025 with the 2.5 dose. For the first two weeks, I experienced nausea and diarrhea off and on. For the last two weeks, I was fine. I am on my second week of 5 mg. The first week, I was so sick - I take the shot late Friday afternoon - I was in bed most of the day on Saturday with nausea and fatigue. I did vomit once. Sunday was the same. The rest of the week, I felt fine. Second shot last Friday - I was okay on Saturday - able to function but very nauseous. Woke up on Sunday and spent most of the day in bed due to nausea and fatigue. The anti-nausea medicine helps but not so much for me. Today I am functioning with some nausea. The benefits of this drug are obvious. I don't eat as much as I did before the medicine. I've lost 16 lbs so far. The nausea bothers me. I should be able to function and not get sick every weekend after a shot. I no longer have diarrhea - I am constipated instead. When I take Miralax, I cannot think about it or I get sick."

• Ame...
• Taken for 6 months to 1 year
• September 10, 2024

For Weight Loss (Obesity/Overweight) "We don't all lose weight quickly with this. I've taken Ozempic, then Tirzepatide for 29 weeks today. Starting weight was 187 lbs, now down 25 pounds. I maintained my weight on diets and with exercise until I was about 32 when I had a thyroidectomy and was diagnosed with Hashimoto's disease. I've tried 20+ diets, and the only one that works for me is the HCG diet. I have to eat 500-800 calories per day to lose a little weight. And... I'm hungry so much of the time. Hunger is my enemy. After reading lots of reviews, I knew I'd be a slow loser, and I am still thrilled with the results!!! Hunger doesn't rule my world. I eat about 1000 calories a day, naturally, and try to eat less than 150 g carbs, 25 g+ fiber, and 90 protein. I'm now on 7.5 mg of Tirzepatide. I had horrible diarrhea and nausea for 3 weeks at about week 7. Now I take loperamide hydrochloride 1-2/week to stop the diarrhea. Worth it!!!"

• Ano...
• Taken for 1 to 6 months
• April 23, 2025

For Obstructive Sleep Apnea/Hypopnea Syndrome "I am only able to get this drug because I have OSA, even though I have struggled with weight issues for years. I have been on Zepbound for 5 weeks. I have lost 10 pounds so far. I have also had 2 full days of bad “sewer burps,” gas, and bad diarrhea. I ate sugary foods one day I was sick, the other time I was sick I have no idea what I had done wrong. Both the burps and the diarrhea are bad and nasty. One day I had to stay home from church, and the second day I was at work (that created a certain level of anxiety for me). I have noticed a huge difference in food cravings and appetite. Sometimes I have struggled to find something I actually wanted to eat. I have eaten a greater amount of fruits (especially raspberries, strawberries, apples, and bananas). I eat protein bars (20 grams) 3-4 days per week, and I try to drink as much water as I can hold. I am recovering from Achilles tendinopathy followed by a broken patella, so I have not been exercising yet."

• Ail...
• February 22, 2025

Tirzepatide for Type 2 Diabetes "The first time I used Mounjaro, I had absolutely no side effects other than being full and not wanting to eat. Months later, I begged my doctor to give it to me again to help me lose weight. I’ve been on it the second time, and I’ve had severe diarrhea for over a week. And I didn’t lose an ounce! I’m eating so little food, wanting to lose weight, that I’m shocked at how much and how long the diarrhea is lasting. I weigh myself each Saturday morning, then do the shot. Write it on the calendar to track my weight loss. No change from the start to last week. Bummer, so I’ll continue to finish my prescription and look at the end results."

• Ste...
• Taken for 1 to 6 months
• July 28, 2024

For Weight Loss (Obesity/Overweight) "I’ve lost about 10 pounds in probably 6 to 8 weeks. I feel okay on this drug. I have experienced some tiredness and fatigue, and some diarrhea as well, but nothing too bad. There was only one week where it was bad enough that I might rethink using it. Now it’s mild and lasts for about 2 days post-shot. Some blurry vision as well. I most likely won’t stay on this drug for the long haul."

• MEN...
• Taken for 1 to 6 months
• March 12, 2025

For Weight Loss (Obesity/Overweight) "This has helped overcome the weight loss plateau I have experienced post-menopause in a way which no other eating or exercise regimes have managed to achieve. My overall food intake has probably not reduced significantly, but it is easier to manage with fewer cravings and feeling fuller for longer. I think the metabolic effects have been key to the weight loss of slightly under 2 lb a week. Increased appetite has been apparent on day 6. I have had to increase the dose to 10 mg weekly over 9 weeks, having experienced minimal appetite suppression on 2.5 mg weekly. The main side effect has been noticeable fatigue, which I try to offset by administering the medication at nighttime. It wears off as the week progresses. Time will tell whether I will habituate to this side effect. Looser stools have been apparent in the first few days, but no other gastrointestinal symptoms. Overall, I am very pleased with the results, and the tiredness, while not desirable, is bearable given the outcome."