Tirzepatide and Diarrhea: What Users Say (Page 4)

• RW3...
• Taken for 1 to 6 months
• February 11, 2024

For Weight Loss (Obesity/Overweight) "Started at 2.5 mg for two months and lost 15 lbs. I had lots of sulfur burps and diarrhea initially. The diarrhea lasted a week. The sulfur burps lasted a few months and were disgusting. No nausea or vomiting. Moved to 5.0 mg for two months and lost 5 lbs. Sulfur burps a problem for the first month. Second month of tirzepatide, no side effects, but no weight loss. I plan on asking for an increased dosage. Good drug and helps food not seem attractive."

• Tum...
• Taken for less than 1 month
• November 2, 2022

For Weight Loss (Obesity/Overweight) "I started the 2.5 Mounjaro injection prescribed by my doctor a week ago to help lose weight. I was happy that the injection was super easy and didn’t hurt at all. The first 2 days I felt great! I had zero appetite, even on the first day, and had to force myself to eat. By the 3rd day… it was a nightmare! I had nonstop diarrhea, the kind you get with colonoscopy prep stuff! I also experienced horrible, sulfur-like belching, especially when getting up in the morning, and had extreme pain in my lower back. Then, last night, I had extremely forceful vomiting, which is crazy because I don’t really have anything in my system! I still have the horrible diarrhea 7 days later, also pretty extreme fatigue, slight heartburn, and a nauseated feeling. I am just praying this stuff gets out of my system ASAP! I just wish someone could tell me how long before I feel better! I will not be using the rest of my Mounjaro injections after the experience I’ve had this first week."

• Kel...
• Taken for 1 to 2 years
• September 12, 2024

Tirzepatide for Type 2 Diabetes "Mounjaro worked well in the beginning. My BGL was lower, and I lost weight. After about 18 months, the control of my BGL was not as consistent. I experienced nausea and loss of appetite from the beginning, but that lessened over time. Recently, I have begun to experience severe diarrhea and belching for several days after taking a shot."

• Orl...
• Taken for 1 to 6 months
• September 9, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Lost 60 pounds in 4 months. Stomach pain and alternating diarrhea and constipation. I had recently been diagnosed with type 2 diabetes with an A1C of 6.6. Now my A1C is down to 5.5. My sleep apnea went from 27 incidents per hour to less than 2 per hour. I just started taking the 10 dosage. Every time I up my dosage, I have a few days of bad side effects, especially stomach pain, but after a while, they lessen, however, diarrhea or constipation never stops."

• Slo...
• Taken for less than 1 month
• May 17, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "Female, 52 years, beginning weight 177 lbs, 5'7. I took my fourth injection of 2.5 mg this morning. I've been eating about 500 calories/day. The first week I lost 2 lbs and I walked 3 miles 2 days and lifted weights 1 day. The second week back to 177 lbs, including 2 days in the gym. In the third week, I traveled and did not exercise or weigh myself. I ate out for Mother's Day and for a friend's baby shower. When I returned, I was 175 lbs. In 3 weeks, I've lost a total of 4 lbs. Side effects for me have been a little more tired-duh-less energy going in. This doesn't seem worth the cost. We meet with the doctor tomorrow about upping it to 5 mg. My husband has been diligent about walking 5-7 miles per day also on 2.5 mg, 500 calories/day, and has lost about 8 lbs. (He has more to lose than me). His side effects were little nausea the first week, a slight decrease in focus and energy, some mild headaches, and diarrhea. Says pooping is faster."

• Aut...
• Taken for 6 months to 1 year
• March 3, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I am 45 years old and female. I have been on Zepbound for eight months. I started at 275 lbs and am now at 235 lbs. The day after I first took it, my stomach was so full it hurt, just from my normal portion sizes. Over time, the dosage has increased to 7.5. I am a little more tired than usual, but that's a small price to pay. The vast majority of side effects occur when I overeat. There's no way to know which of these I will have then: pain in my stomach, egg burps, loud flatulence, and/or diarrhea. I have been sick a lot more than usual, along with swollen lymph nodes and hoarseness, but there's no way to know if they're related or not."

• Cjl...
• Taken for 1 to 6 months
• June 14, 2023

Tirzepatide for Type 2 Diabetes "I was started on Mounjaro at the end of Jan 2023. My A1C was 10, and I am 41, about 5 ft 9 in. I weighed about 350 lbs. I had no energy, had sleep apnea, hurt all the time, and could not even walk without running out of breath. I was miserable. Finally, I talked to my doctor, and she decided to try me on this. After a little struggle getting insurance to cover it and get the med in stock at my pharmacy, I got going on this new journey. About 2 months in, I started having major diarrhea and vomiting. Had to take a break for a week and then started doing my injections in my thighs instead of my belly, and that has made it a lot more bearable. I do still get diarrhea and sulfur burps for 3, sometimes 4 days after my shot, but nothing major. Now my A1C is 6, my blood glucose averages 75, and I am weighing in at 270 lbs. I can walk now without running out of breath and without being in major pain. I have made other changes, such as watching what I eat, stopping drinking soda, and started trying to walk."

• Anonymous
• Taken for 6 months to 1 year
• March 4, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "It was rough in the beginning, with diarrhea, then constipation and heavy belching. The diarrhea ended after about a month, but constipation has continued. In addition to those symptoms, I experienced an undercurrent of nausea for several months, with it being more pronounced just after eating. After about eight months, the nausea abated for the most part. I started on the 2.5 and moved up in dosage every 2 months or so. I am entering month 10 and am on the 12.5 dosage. For the first 6-7 months, I lost approximately 1.5 lbs/wk, and over the last 2-3 months that has slowed down a little. I have lost a total of 50 lbs. The other side effect I've experienced is I sometimes have low blood sugar in the mornings, so I will have juice or something to help take care of it. It is easy to use, and despite the rough start, I am pleased with the results."

• Mar...
• Taken for 1 to 6 months
• February 18, 2025

Tirzepatide "I have diarrhea, lower stomach pain, dry heaves every time I eat. I also have back pain, but that is not unusual. This pain might be a little different though. I didn't know to tell my doctor that I have had a vein occlusion in my right eye quite a few years ago. I don't know if that is important or not. I don't think I am reading as well. Not sure."

• Nic...
• Taken for 1 to 6 months
• February 2, 2023

Tirzepatide for Type 2 Diabetes "I started this shot about 2 months ago. My doctor prescribed the 2.5 first. I took it on Saturday morning, so I had the weekend to see how it made me feel. By Weds, I had flu-like symptoms for the day and missed work. The nausea lasted for the first few weeks, but I've completed my box of 5 mg, and I haven't had any nausea with it. However, I do have sulfur burps when I eat too much. And I have to force myself to drink water. But I rarely eat between meals, and I am down 20 pounds. I just picked up my new prescription of 7.5 and will take my first dose Saturday. I'm in my 50s, I am 5'3" and I started at 267 pounds. I have been on metformin for years. I've had severe diarrhea on metformin and would be in the bathroom multiple times a day with watery stool. I also ate everything in sight and snacked constantly. Now I have normal bowel movements. I also do not sweat profusely as I did on metformin. I have to say this shot has changed my life, and I am happy I am on it."

• Nic...
• Taken for 1 to 6 months
• February 2, 2023

Tirzepatide for Type 2 Diabetes "I started this shot about 2 months ago. My doctor prescribed the 2.5 first. I took it on Saturday morning, so I had the weekend to see how it made me feel. By Weds, I had flu-like symptoms for the day and missed work. The nausea lasted for the first few weeks, but I've completed my box of 5 mg, and I haven't had any nausea with it. However, I do have sulfur burps when I eat too much. And I have to force myself to drink water. But I rarely eat between meals, and I am down 20 pounds. I just picked up my new prescription of 7.5 and will take my first dose Saturday. I'm in my 50s, I am 5'3" and I started at 267 pounds. I have been on metformin for years. I've had severe diarrhea on metformin and would be in the bathroom multiple times a day with watery stool. I also ate everything in sight and snacked constantly. Now I have normal bowel movements. I also do not sweat profusely as I did on metformin. I have to say this shot has changed my life, and I am happy I am on it."

• N R...
• Taken for 1 to 6 months
• July 4, 2024

Tirzepatide for Type 2 Diabetes "I have started with 2.5 mg dose once every week on 16th April 2024. They gave me 4 rounds of this dose. Then they started with 5 mg dose once every week. Initially, I was feeling nausea, diarrhea, sour burps, and dizziness, and gradually it decreased. When I started to take 5 mg, the same symptoms, apart from diarrhea. This time I had severe constipation on the 3rd day of the 5 mg dose, but I took some home remedy and laxative medicine. Still experiencing constipation. But the good thing is my appetite has reduced significantly, I am eating like a 5 to 10-year-old child. Feeling energetic, I lost around 6 kg in weight. Sugar level is under control, reduced Humalog dose."

• TCC...
• Taken for less than 1 month
• January 28, 2025

For Weight Loss (Obesity/Overweight) "I am on week two of Tirzepatide and had nausea and vomiting almost every day. The vomiting is primarily at night, frequently accompanied by dry heaves, and can be intense. Diarrhea was the first week but better entering the second week. When I hit menopause, I had a very difficult time losing weight (I gained 20 pounds), even when on a clean diet with cardio four days a week. Since beginning meds, I have lost nine pounds and have very little to no appetite. My workouts are not as frequent due to the nausea and feeling tired. Even with negative side effects, I will stick with it in hopes my body will adjust. My weight gain has limited my ability to do my job, which requires a lot of bending and lifting. Just the nine pounds of weight loss has helped my knees not ache and more comfortable on the treadmill. I started at .25 mg, and the injection was no bother."

• Bec...
• Taken for 6 months to 1 year
• May 30, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "I had insulin resistance and was overweight. I started taking Mounjaro and have lost 34 lbs and am now within 8 lbs of my goal weight. I have not increased my physical activity. My A1C has gone from 7.0 to 5.4. I started taking it 7 months ago. I have been on the 10 mg dosage for the last 2 months. I find that it is very easy to use. The side effects at first were nausea and diarrhea. They were very severe at first, but have calmed down and now I might experience some slight nausea the day after my injection. I also find that I really do not have any interest in food and do not feel hungry. I need to eat small meals of mostly protein and get full on very little food. Another side effect that seems to have gotten worse in the last 2 or 3 months is extreme fatigue. I find that I have very little energy."

• Hrk...
• Taken for less than 1 month
• May 17, 2023

Tirzepatide for Type 2 Diabetes "I started Mounjaro 7 days ago for type 2 diabetes and weight loss. Days 1, 2, and 3 were great. Appetite was almost nonexistent, great, right? Day 4, my vision started to blur. Days 6 and 7, reoccurring stomach aches and diarrhea. I’m now on day 7 and my vision is so blurry I can barely see up close or far away. My vision was 20/20 before starting this. The insert says it can make diabetic retinopathy worse, to my knowledge, I don’t have diabetic retinopathy. I have an appointment with a retina specialist tomorrow. Works great as an appetite suppressant, and it really lowered my blood sugar, however, I need to see. So it’s going to be a no for me."

• Joy...
• Taken for 1 to 6 months
• April 20, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "I started this medication on 2/2/23; I am 36 years old, 5'5", and 179 pounds. As of today, 4/20/23, I weigh 160 pounds. Since 2019, I have not been able to lose weight after I had my son. I exercised routinely and would gain, lose, gain, lose, but couldn’t get past 171 lbs. My doctor saw my hopelessness, and luckily I have a Health Savings Account (HSA) that can cover this medication for 7 months. I haven’t had any major side effects. It actually has corrected issues. I don’t have diarrhea anymore; that was practically a daily thing for the last year before I started this medication. I feel healthier taking this medication. I exercise three times a week, and I’m trying to create a practical routine after I have to stop this medication. I’m on 7.5 mg and currently will stay at that dose. I highly recommend it. I’m not diabetic, but my fasting glucose was in the mild range, which leads me to believe that has been my problem over the past 4 years."

• Sam...
• Taken for 1 to 6 months
• February 26, 2023

Tirzepatide for Type 2 Diabetes "It really does not control my glucose levels without Novolog and Tresiba. I’ve developed chills, shakes, nausea, and diarrhea. My doctor says it shows the shot is working. I’m not dealing with the level of neuropathy like Trulicity. Plus, my GFR came back by 10 points."

• kjo...
• Taken for less than 1 month
• October 18, 2022

For Weight Loss (Obesity/Overweight) "I've been on 2.5 mg Mounjaro for exactly 2 weeks now for weight loss, and I have lost 8 pounds. I'm feeling great; however, I have had a stomach ache twice and diarrhea once. Can't eat too much, or my stomach will hurt. I'm also walking 3x/week and logging my food & beverage in an app - staying at 1200 calories or below is super easy on this med. I have felt more energetic on it - which might be because I am so excited that there could be a solution to my overweight problem! It seems like a long-awaited answer to my prayer - I'm feeling very hopeful and optimistic!"

• Jan...
• Taken for less than 1 month
• November 24, 2024

Tirzepatide for Type 2 Diabetes "I've only had 2 shots and 2 days until the next one. I find it very convenient to administer. However, I have had some nasty side effects! I've had diarrhea, nausea, vomiting, fatigue. I will continue taking the medication hoping the side effects will 'calm down.'"

• Anonymous
• Taken for 1 to 6 months
• June 26, 2023

Tirzepatide for Type 2 Diabetes "I took the 2.5 mg for four weeks, then I did the 5.0 mg for four weeks. I am now taking 7.5 mg. I am taking it for eight weeks. I did the research and studies on what to do. I do not eat fried foods. I do not eat sweet things, especially ice cream, which is my absolute favorite food. I have not been sick. I have not had diarrhea or been constipated. I do not overeat, which is in the instructions. My blood glucose has dropped 30 points. I won't know what my A1C is until I go back to my doctor for a test. My only problem is the cost. So far, I am doing very well on Mounjaro. It is very easy to use."

• She...
• Taken for 1 to 6 months
• May 23, 2023

Tirzepatide for Type 2 Diabetes "I started with 2.5 mg, then increased the dosage to 5.0 mg, and then 7.5 mg without any success. Skipped 10.0 mg and then moved up to 12.5 mg, and that is when the success came! I lost 25 lbs in 3 months, and it brought down A1c from 8.0 to 7.0. I had minor side effects such as diarrhea and some stomach upset. Overall, a very positive experience."

• Hop...
• Taken for 1 to 6 months
• May 16, 2023

Tirzepatide for Type 2 Diabetes "Not long after I began taking Mounjaro, my A1C dropped from 8.1 to 6.7. Finally, something that's helping. I’ve also lost some weight, although it's been a slow process. Now I’m beginning to have stomach issues along with diarrhea. Just makes me feel sluggish. I’m on the 10.0 dose, and the doctor said I may need to drop down to a lower dose. It's very easy to use. Giving myself a shot is not a problem."

• Kat...
• Taken for 1 to 6 months
• September 2, 2024

Tirzepatide for Type 2 Diabetes "I began my journey on April 12th, 2024. I'm currently on my second dose of 7.5. A bit more stomach issues, diarrhea, and extreme fatigue. No desire to eat whatsoever. Since I've started, I have lost a total of 50 lbs. as of 9/2/24. Yes, I'm Type 2 diabetic, but I wanted to give this medication a try to see if it would be of any help for me to lose weight. It has far exceeded my expectations! It's been a bit rough, but I'm seeing great results. I'll continue on this journey with hopes of meeting my own personal weight loss goals."

• Pre...
• Taken for less than 1 month
• June 12, 2023

Tirzepatide for Type 2 Diabetes "First week, I had massive diarrhea and a splitting headache. Week 2 was better. Just a headache. Week 3, still have a headache. Down 8 pounds in 3 weeks. Blood sugar is fine. I find I don’t eat much. I have to force myself to drink too."

• Rob...
• Taken for 6 months to 1 year
• June 16, 2023

Tirzepatide for Type 2 Diabetes "I started at the lowest dose, even though I was switching over from Ozempic, and I had been on 7.5 mg of that for over a year or longer. It was out of stock, and they didn’t know when it would be back in. I switched to Mounjaro. I have been taking the once-a-week injection for about 6 months, I think. I am on 10 mg now. Yesterday, I had my A1C checked, and it had gone down from 6.7 in March to 5.9. I was thrilled. I’ve lost 19 lbs, which isn’t huge, but it’s something. I was 250 lbs and now 231 lbs. I’ve been pretty happy and eating less and feeling fuller longer. The side effects I’ve noticed are sometimes I have low sugars, but I need my insulin adjusted, and I have diarrhea every morning and occasionally during the day. I think I’m going to start a probiotic. The goal is to get off my insulin. That is the plan of me and my endocrinologists."