Tirzepatide and Constipation: What Users Say (Page 5)

• Bob...
• Taken for 1 to 6 months
• August 7, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I have been taking Mounjaro for 7 weeks. During this time, I’ve only lost 16 pounds. The last four weeks, I have not lost a single pound! This is a very expensive drug, and the results should be better than what I’m getting! I’m on the 2.5% dose regimen. I increased my exercise program yesterday, and now I’m fast walking 2 miles each day. I’m not impressed at all with this drug. I’ve had a lot of constipation issues, which have been overcome by excessive amounts of laxatives. Don’t think this is a miracle drug because it’s not. I am not happy to date. I have spent out of pocket around $546.00."

• Lif...
• Taken for less than 1 month
• August 9, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "I was recommended weight loss pre-knee surgery and decided to try Mounjaro. I am a 55-year-old female, at least 12 kilos overweight. I have been using it for 3 weeks now (2.5 mg) and have lost 2 kg. There was no nausea, and I manage slight constipation with poached pears and yogurt or a prebiotic. I realized very quickly that I needed to eat smaller amounts more regularly as opposed to my previous habit of waiting until I was really hungry - I didn’t eat badly before, but my food portions were larger, and I regularly consumed alcohol. I tried a sip of champagne after 2 weeks of Mounjaro, and it tasted horrible. The combination of eating less, feeling satisfied, sleeping better, and weight loss has already changed my life for the better."

• Fat...
• Taken for 6 months to 1 year
• February 6, 2025

Tirzepatide for Type 2 Diabetes "My experience has been very good. I took drastic steps to change eating habits, cutting carbs where possible. Rather than eating chips at home, I go through 6 lbs of carrots per week. I divorced French fries. Aside from that, I still eat what I want when dining out. Dropped from 330 lbs to 262 lbs in 8 months. No side effects aside from constipation - daily fiber and stool softeners make that manageable. I feel that part of the weight loss was simply the change in diet, but the Mounjaro certainly helped. I'm on the 2.5 dosage."

• Joh...
• Taken for 1 to 6 months
• June 20, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Lost 10 kg in 3.5 months with daily exercise and a calorie-controlled diet. It does not eliminate the cravings, though, I always have them. Just needed the mindset that this is an expensive drug and I have to make it work. No side effects at all compared to what I experienced with Saxenda. Saxenda gave me the most horrible constipation I've ever had in my life. I genuinely thought I was gonna end up in A&E for impacted stool. I'm very happy with Mounjaro."

• kat...
• Taken for 6 months to 1 year
• June 5, 2024

Tirzepatide for Type 2 Diabetes "I started with the lowest dose for Type 2 diabetes. My A1C was 7.5. I immediately noticed I just wasn't hungry. Otherwise, no side effects. I have been on 15mg for several months now, except when I have to get a lower dose due to non-availability of the drug in my area. My A1C is now down to 5.6, and I have lost 87 lbs. I started at 325 lbs. I have some constipation, but it is manageable. I had noticed increased muscle weakness in my thighs, and I could barely walk without fear of falling. My doctor thought it was a lack of protein. After several days of high protein drinks, I felt much better. After a few weeks, I was back to normal. This is a great drug. I just wish it were more readily available."

• RBj...
• Taken for 1 to 6 months
• August 29, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "I started using Mounjaro in March 2023, with a 2.5 mg dose, for weight loss. I shifted to 5 mg after 2 weeks; I stayed with each dose for around 2-3 months. I lost 10 kg by August (6 mo.). I had a freeze in weight loss for 5 weeks, then I lost 1.8 kg in 2 weeks when I took 10 mg. In terms of side effects, I experienced them during the first weeks of every upgrade in dose; like nausea and sometimes vomiting, headache, stomach pain, constipation and diarrhea, laziness, body ache, mood change; the worst was with 10 mg. As I have urticaria, I experienced an allergy at the needle site after week 10, which resolved in 3 days every time. This week I have pelvic, vaginal, and lower abdominal pain similar to period pain, although I have been menopausal for 4 years! I am happy about the results with minimal side effects."

• Hon...
• Taken for 1 to 6 months
• October 6, 2022

Tirzepatide "I have been taking Mounjaro for 7 weeks. 4 weeks of that I was on the 2.5 mg dose and lost 15 lbs by the 4th week. The last 3 weeks I've been on the 5 mg and I've lost ZERO lbs. Seems kind of useless to take when you have all the side effects (constipation, diarrhea, bloating, gas, nausea, headache, severe fatigue) for 3 weeks straight with no weight loss. I am considering going off this medication, I think it was all just hype. I've also stopped having periods. 40 years old, SW 199, CW 185, GW 140. Also following website food/calories recommendations. I have no other disease, just obesity."

• Ala...
• Taken for 1 to 6 months
• January 4, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "My wife had been on Mounjaro for several months and had seen dramatic weight loss. Our bro-in-law had a prescription but had a reaction, so he gave his supply to me. (My insurance doesn't cover it.) After 5 months, I had lost 50+ lbs. In 15 months, my wife lost over 170 pounds. Both of us combined our course with a keto diet: low carbs, high fat, and protein. The wife's sisters had also seen similar results while also using the keto diet. I am not diabetic, but my wife is. She has cut her use of insulin to the bare minimum and will still occasionally have low blood sugar. While I have run out of my supply, I used 5, 7.5, and 10. My wife has had a more managed regimen, gradually increasing to her current 12.5. Our only real side effect has been constipation. We are trying to handle that with an increase in eating more fiber and fiber supplements, along with using laxatives. To deal with our decreased food intake, we are both also taking vitamin supplements."

• Kay...
• Taken for 6 months to 1 year
• May 25, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "I have been using Mounjaro for weight loss for 9 months. I have lost 90 pounds and have had very minimal side effects. Some nausea occasionally and constipation. I am so grateful to have been prescribed the Mounjaro, as I no longer have heartburn and have alleviated having to take omeprazole daily. My sleep apnea has improved, I no longer snore like I used to and no longer need a sleep mask. The aches and pains have decreased substantially, and I have more energy than I have had in years. I was pre-diabetic, and all of my labs have improved. I am hopeful to be able to continue with the prescription, however, I would be unable to afford the current copay. I fear if I have to stop, I will be back to my same obese status as I was a year ago. The medication not only curbs the appetite but also stops the 'food noise.' If you have this issue, this will totally make sense. If not, I envy you."

• Aje...
• Taken for 1 to 6 months
• August 11, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "The BEST EFFECT is that I was free from thinking about food for the first time in my long life. The downsides that I am still working with are being constipated, getting chills, and stomach pain. I have to take Miralax every day, and some days I do not feel well, and yet, it is well worth it to not be obsessed with food anymore. I am on 5 mg. I was concerned about self-injection but found that to be a non-issue. I do get a rash around the area, and my skin itches."

• Jil...
• Taken for 1 to 6 months
• April 13, 2025

Tirzepatide "I have been on Zepbound for 3 months. I had previously adopted a low-fat, vegetarian diet, so I have not had many gastric issues related to taking this medication. I have noticed an increase in constipation, but this is remedied by taking prunes and increasing fluids and fiber (I've found psyllium capsules help). Planning meals while on Zepbound, I've found to be helpful, especially with the constipation, as I am sure to add beans and other fiber-rich nutrients to the meals. If I do not plan meals, it's too easy not to eat or make something quick that is missing some of the needed nutrients. It should be noted that I started seeing a nutritionist at the same time I started Zepbound to give myself the best opportunity for success. I highly recommend this, and nutritionists are often covered by insurance."

• pop...
• Taken for less than 1 month
• July 20, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "Stomach pains, bloated. Constipation, but early days. Only taken 2 doses so far, so hoping body will accept okay in the next few weeks. Looking at weight loss so far, 5 kilos, so hoping 20 plus by year end."

• Rwi...
• Taken for 1 to 6 months
• March 19, 2023

Tirzepatide for Type 2 Diabetes "My A1C and glucose levels are great. I am not on insulin. Side effects are rotten. Nausea, GERD, constipation/diarrhea, headache, stomach pain, decreased appetite every shot lessens over the week. Had this with Ozempic and Trulicity too, but not as severe. I have seen no weight loss benefit despite a decent diet and moderate exercise 3-5 times per week. Other side effects I’m not sure are related: feeling of lump in throat, slight face rash, occasional blurred vision, tingling in hands."

• Ano...
• Taken for 1 to 6 months
• March 31, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "No problems at all. At first, I was constipated and was fine after adding MiraLAX to my diet. I wish I could get it cheaper because my insurance doesn’t cover it. I also noticed that I sleep better because of my sleep apnea."

• Son...
• Taken for 1 to 6 months
• March 19, 2025

Tirzepatide for Type 2 Diabetes "Started on 2.5 mg in December and have titrated up every 4 weeks to 12.5 mg currently. So far I have been losing 2-3 lbs a week and have lost 34 lb, and up until now I haven't really noted any serious side effects other than occasional constipation and slight nausea if I don't eat something small every few hours, or if I eat something really fatty. The last two titrations I have noticed some extreme fatigue and being cold on the first day after my shot, but then it usually starts to go away on the 2nd day and I feel better. I have also noticed that if I try to push through the tiredness and try exercising, I usually feel better. I have tried to stick to a 1200-1500 calorie diet and do eat a lot more fruits and veggies, and I feel better than I have in a long time. Overall, it’s been a good experience and I’m super excited to see how much more weight I can lose."

• Rev...
• December 29, 2022

Tirzepatide for Type 2 Diabetes "I was prescribed this medication after having an ESG procedure to help with weight loss and in hopes of reversing Type 2. I also have PCOS and a family history of Type 2. After being on this medication, I am down at least 10 lbs (don’t remember my weight when I started), and my blood glucose is not in the diabetic range. My A1C was 5.9, down from 7.9, and I expect that to be lower on my next labs. I do have some side effects, the most prominent is constipation. Miralax helps. I used to get a headache after injection, but I take ibuprofen beforehand, and that helps. I also inject my thigh, not my stomach, and I do it before bed. I have to remember to eat and drink water. I would recommend this medication. I hope I’ve lost enough weight to get off and stay off. So far, so good."

• Anonymous
• Taken for 1 to 6 months
• March 17, 2025

For Weight Loss (Obesity/Overweight) "I am on my fifth week today. Have very little appetite and burning in my throat and nausea. Have been constipated also. The burning in the throat is the worst. I told them and prescribed nausea pills. I took one tonight, but it's not helping. Feel like I am going to void. Took Roland. Nothing helps. I was on semaglutide 2 years ago and never had this burning in my throat. Constipated on both. Am losing weight faster after 4 weeks. Right now, I can’t even imagine increasing the dose because of this awful burning in my throat."

• Flo...
• Taken for 1 to 6 months
• June 1, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "I began taking Mounjaro in November 2022. I am 61 years old, weigh 194.6 lbs, a post-menopausal female with no other health issues to note. Since then, I have lost approx. 50 lbs and feel absolutely GREAT! In addition to the Mounjaro, I took weekly B12 shots, a multivitamin, a magnesium supplement, apple cider vinegar capsules, and a chromium supplement. I took the last injection on May 2, 2023 (weighing 144.6 lbs) and have continued with supplements. After 1 month, I am weighing 146.4 lbs. I do find myself having cravings at times and could eat more, but have been able to discipline myself to continue to eat in moderation and try to be more active since I definitely feel more energetic. My goal is to maintain below 150 lbs. I am a huge fan of this drug and have experienced very few side effects while taking it. I did experience indigestion and some constipation relieved by the supplements listed above."

• BLB...
• Taken for 6 months to 1 year
• May 29, 2023

Tirzepatide for Type 2 Diabetes "I started Mounjaro in July '22 after losing 50 pounds (243 to 193, 5'2") on Trulicity. I am now closing in on losing 50 pounds on Mounjaro (approaching 143 lbs) and can honestly say that it has changed my life. My cravings for sugar are nearly gone. I drink 2 protein shakes each day and have found eating healthy and eating smaller portion sizes easy. I am a person who had horrible hyperemesis gravidarum during pregnancy, so I knew I would have the side effect of being nauseous. And I do become quite nauseous for the 2 days after the injection. However, I am able to manage this pretty easily as it passes quickly. Going from 12.5 mg to 15 mg was too much for me. I do best on the 10 mg. I do get minor constipation and occasional tiredness, but overall I feel 100 times better than I did 100 pounds heavier and I am no longer in the diabetic range."

• Suz...
• Taken for 6 months to 1 year
• February 26, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I began my weight loss journey in late January 2024. Over the next 12 months, I lost 40 pounds. However, I've hit a plateau for the past four months, since the end of November 2024, and it's now February 25, 2025. I still need to lose at least another 40 pounds. Zepbound has been a significant help in my journey. My clothes fit much better, and I've gone from a size XXL to a medium. In addition to Zepbound, I also strength train, maintain a healthy diet, and track my calorie intake. The only side effects I've experienced with Zepbound are occasional acid reflux, mild nausea, and some constipation. Currently, I am on 12.5 mg, but my doctor has decided to update my dosage to the 15 mg to see how I do on that dosage. Hopefully, it will kick me over the plateau and I will end up losing the next 40 pounds that I need to. Other than that, I love Zepbound. I think it’s great."

• Kim...
• Taken for 6 months to 1 year
• February 21, 2025

For Weight Loss (Obesity/Overweight) "The compounded tirzepatide works great for weight loss, and it’s much cheaper! I have lost 40 pounds in 6 months, so it works very well. Side effects I’ve experienced are constipation, but it gets better in time, especially with the right diet. It’s easy to inject."

• Anonymous
• Taken for 6 months to 1 year
• February 19, 2025

Tirzepatide for Type 2 Diabetes "Severe nausea and stomach pain within the first 2 days of taking, then settles the next 5. Always feel a pressure in the stomach - not pain, not really uncomfortable, just a noticeable presence. Constipation for 4-6 days despite taking extra fiber and water."

• Fir...
• Taken for less than 1 month
• March 18, 2023

Tirzepatide for Type 2 Diabetes "I am surprised by how quickly it has changed my appetite. My first injection of 2.5 mg was two days ago, and after a very small meal, I am completely full for hours. I’ve had constipation and feel bloated, or at least unpleasantly full. Hoping this will pass. I ate a bowl of turkey chili for dinner yesterday, and at noon today, I still have no desire (or room) to eat. I had a glass of water to take my morning meds and a cup of coffee this morning, and I’m still full."

• Dav...
• Taken for 1 to 6 months
• February 9, 2025

Tirzepatide for Type 2 Diabetes "I have been taking Mounjaro for 5.5 weeks. I've been on 2.5 mg the whole time. Although this dosage is considered a starting dose and not a therapeutic dose, I have seen a drop in fasting blood sugar from 110 down to 60 (I'm also taking metformin and glipizide). I have had few negative side effects (mild constipation) and have lost 8 lbs. I will talk to my Endo about moving up to 5.0 next and try to start reducing my metformin and glipizide dosages. Note: Although some people have some other major side effects, this drug affects everyone differently. You don't know how until you try it - this includes increasing your dosage."

• ARV...
• Taken for 1 to 2 years
• February 11, 2025

Tirzepatide for Type 2 Diabetes "It is excellent for control of Type 2 diabetes. Fasting glucose stays below 100 mg/dL exactly for one week. Appetite is suppressed completely. The only side effect that is very troublesome is constipation with secondary discomforts. Regular laxative is the only way to counter this."