Tirzepatide and Constipation: What Users Say (Page 5)

• jak...
• Taken for 1 to 6 months
• May 20, 2025

For Weight Loss (Obesity/Overweight) "I have used it for a month now. For weight loss. I have lost 12 lbs in 1 month. I have had good results. It does make me constipated though. I am taking a week off of it and have been going to the bathroom more normally. I will resume it again in a few days."

• ARV...
• Taken for 1 to 2 years
• February 11, 2025

Tirzepatide for Type 2 Diabetes "It is excellent for control of Type 2 diabetes. Fasting glucose stays below 100 mg/dL exactly for one week. Appetite is suppressed completely. The only side effect that is very troublesome is constipation with secondary discomforts. Regular laxative is the only way to counter this."

• Rev...
• December 29, 2022

Tirzepatide for Type 2 Diabetes "I was prescribed this medication after having an ESG procedure to help with weight loss and in hopes of reversing Type 2. I also have PCOS and a family history of Type 2. After being on this medication, I am down at least 10 lbs (don’t remember my weight when I started), and my blood glucose is not in the diabetic range. My A1C was 5.9, down from 7.9, and I expect that to be lower on my next labs. I do have some side effects, the most prominent is constipation. Miralax helps. I used to get a headache after injection, but I take ibuprofen beforehand, and that helps. I also inject my thigh, not my stomach, and I do it before bed. I have to remember to eat and drink water. I would recommend this medication. I hope I’ve lost enough weight to get off and stay off. So far, so good."

• Flo...
• Taken for 1 to 6 months
• June 1, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "I began taking Mounjaro in November 2022. I am 61 years old, weigh 194.6 lbs, a post-menopausal female with no other health issues to note. Since then, I have lost approx. 50 lbs and feel absolutely GREAT! In addition to the Mounjaro, I took weekly B12 shots, a multivitamin, a magnesium supplement, apple cider vinegar capsules, and a chromium supplement. I took the last injection on May 2, 2023 (weighing 144.6 lbs) and have continued with supplements. After 1 month, I am weighing 146.4 lbs. I do find myself having cravings at times and could eat more, but have been able to discipline myself to continue to eat in moderation and try to be more active since I definitely feel more energetic. My goal is to maintain below 150 lbs. I am a huge fan of this drug and have experienced very few side effects while taking it. I did experience indigestion and some constipation relieved by the supplements listed above."

• BLB...
• Taken for 6 months to 1 year
• May 29, 2023

Tirzepatide for Type 2 Diabetes "I started Mounjaro in July '22 after losing 50 pounds (243 to 193, 5'2") on Trulicity. I am now closing in on losing 50 pounds on Mounjaro (approaching 143 lbs) and can honestly say that it has changed my life. My cravings for sugar are nearly gone. I drink 2 protein shakes each day and have found eating healthy and eating smaller portion sizes easy. I am a person who had horrible hyperemesis gravidarum during pregnancy, so I knew I would have the side effect of being nauseous. And I do become quite nauseous for the 2 days after the injection. However, I am able to manage this pretty easily as it passes quickly. Going from 12.5 mg to 15 mg was too much for me. I do best on the 10 mg. I do get minor constipation and occasional tiredness, but overall I feel 100 times better than I did 100 pounds heavier and I am no longer in the diabetic range."

• Mag...
• Taken for less than 1 month
• May 6, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I am on my 4th week of 2.5 mg. Mild side effect of constipation, which I have managed with diet. Definitely reduced appetite, no desire to eat the usual chocolate, ice cream, or crisps, or late evening snacking. Then, a day after my 4th injection, I was, for the first time, suffering with wind, including the dreaded burps. Very little appetite. That was followed by a very bad bout of diarrhea, which saw me rushing to the loo all through the night. Settling down now after 24 hours. Not eaten today yet. Hoping this won't happen again, especially as I am due to increase dosage to 5 mg next week."

• Rwi...
• Taken for 1 to 6 months
• March 19, 2023

Tirzepatide for Type 2 Diabetes "My A1C and glucose levels are great. I am not on insulin. Side effects are rotten. Nausea, GERD, constipation/diarrhea, headache, stomach pain, decreased appetite every shot lessens over the week. Had this with Ozempic and Trulicity too, but not as severe. I have seen no weight loss benefit despite a decent diet and moderate exercise 3-5 times per week. Other side effects I’m not sure are related: feeling of lump in throat, slight face rash, occasional blurred vision, tingling in hands."

• Aje...
• Taken for 1 to 6 months
• August 11, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "The BEST EFFECT is that I was free from thinking about food for the first time in my long life. The downsides that I am still working with are being constipated, getting chills, and stomach pain. I have to take Miralax every day, and some days I do not feel well, and yet, it is well worth it to not be obsessed with food anymore. I am on 5 mg. I was concerned about self-injection but found that to be a non-issue. I do get a rash around the area, and my skin itches."

• Ano...
• Taken for 1 to 6 months
• May 4, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "Zepbound has been wonderful. Started at 2.5, now starting 7.5. Working. Side effects: some nausea, constipation, but not bad. Injection site reaction, but within 3 or 4 days, fading away. Really an easy medication to tolerate. Glad I am on Zepbound."

• PAW...
• Taken for 1 to 2 years
• August 18, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "This drug is very helpful for me with weight loss. After checking the side effects, I have quite a few. Constant constipation, nausea, pain, inflammation, as well as additional thyroid issues, to name a few. Now, I'm concerned about my choice in using this drug. For me, it's very easy to administer the medication."

• Fir...
• Taken for less than 1 month
• March 18, 2023

Tirzepatide for Type 2 Diabetes "I am surprised by how quickly it has changed my appetite. My first injection of 2.5 mg was two days ago, and after a very small meal, I am completely full for hours. I’ve had constipation and feel bloated, or at least unpleasantly full. Hoping this will pass. I ate a bowl of turkey chili for dinner yesterday, and at noon today, I still have no desire (or room) to eat. I had a glass of water to take my morning meds and a cup of coffee this morning, and I’m still full."

• Dia...
• Taken for 1 to 6 months
• December 25, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Started 5 mg 2 weeks ago and am doing great. Appetite significantly decreased. Have so far lost 11 lbs. and have 35 lbs more to lose. Constipation is my only concern. Working on that, but since I am not eating as much, I don’t think I will go as often. Grateful for this drug. It provides an easy way to lose weight. Thanks."

• dem...
• Taken for 1 to 6 months
• April 28, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "Does everything it says. I love it, the only side effect I have is extreme constipation. I've been taking it for about 5 months and down 46 lbs, and I feel much better. I have chronic pain in my lower back, but with weight loss, it helps a little."

• Ano...
• Taken for 1 to 6 months
• April 29, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "My wife has been taking it since January this year and has lost just a hair over 50 lbs. It has done very well for her and the weight is staying off. The only side effects noticed so far are that it makes you very gassy, somewhat indigestion, and every now and then a little constipation."

• Ano...
• Taken for less than 1 month
• April 26, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I am on my 5th week. Just started 5 mg Friday 04/25/25. I started 03/28/25 on the 2.5 mg. My second day I was nauseous, but nothing Sprite and Zofran couldn’t fix. Fast forward to today. I have been sleeping really well, inflammation is gone, my hunger and food noise is gone. Now I notice the day before my shot day I start to crave some, but I just drink my water to stay full. Also, a little minor constipation. I take a stool softener with my morning vitamins, which helps, plus water, water, water!! I am loving this medicine so far, I am down 10 lbs, which I don’t think that’s bad in 5 weeks."

• Sun...
• Taken for 6 months to 1 year
• June 13, 2023

Tirzepatide for Type 2 Diabetes "My A1C was 11 in December 2022. By March 2023, it went down to 7, and I lost 35 lbs. It is June 2023, my A1C is 6, and I have lost 48 lbs. I experienced some nausea and some constipation. Watching my portions and staying away from fried, fatty foods was key. I’m on the maintenance dose of 15 mg and feeling great."

• Kat...
• Taken for 1 to 6 months
• December 4, 2024

Tirzepatide for Type 2 Diabetes "I had previously taken Byetta, Ozempic, and Trulicity. With each, I maybe lost 10-12 pounds. I started Mounjaro on August 1, 2024. I weighed 195 pounds. Four months later, I have not had any nausea. I do have some tiredness and constipation. As of December 1, 2024, I have lost 32 pounds. Hope to continue for at least four more months. Would like to lose another 20 pounds if possible. Hope to find a way to keep the weight off! Feel so much better. Was wearing size 16-18, now 12-14! My A1C went from 7.4 to 5.7!! Best news!! All other blood work numbers improved, especially cholesterol. I have very little craving for sugar or meat but try to eat at least four ounces of meat per day!"

• Lad...
• Taken for 6 months to 1 year
• April 25, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "I started taking Mounjaro on September 1, 2022. My starting weight was 192 lbs, I'm 38 years old and 5'3". By February 2023, I weighed in at 135 lbs. I experience severe nausea, sour stomach, sulfur burps, and constipation on every dose I was on. I was only able to go to 5 mg, as 7.5 mg about done me in. I went back to the 5 mg. I've always been active, worked out, etc., but after a few life events, I struggled to lose 10 lbs! This was a game changer for me. It quieted the food noise, the cravings, etc. I was able to eat just a few bites of whatever meal and then done. I didn't want to eat! My nighttime snacking is gone. I didn't even like the smell of McDonald's french fries. Now, my mom tried it also, but she never had any of the horrible symptoms, and the food noise quieted a little bit. She got up to 7.5 mg but couldn't get anything in stock for the 10 mg. She didn't lose the significant weight that I did and has now switched to Ozempic due to stock issues."

• Hap...
• Taken for 1 to 6 months
• April 10, 2023

Tirzepatide for Type 2 Diabetes "Mounjaro has been wonderful in reducing my blood sugar. However, the side effects feel like sometimes they are going to be the death of me. I experience nausea, constipation, and stomach pain. But if this is how it has to be to control my sugar, I can handle it. The only real trouble I am having is being able to get it through my pharmacy as it is often out of stock due to people using it for weight loss. I think diabetics should be given the first chance to receive this medication."

• SBu...
• Taken for less than 1 month
• March 30, 2023

Tirzepatide for Type 2 Diabetes "It's easy to use, however, the side effects are horrible. I have had all of the listed side effects. Constipation, nausea, and vomiting are the worst. It feels like a rock in my gut, however, it's a little better than Ozempic, which I puked every day. So I'm sticking with the Mounjaro for now."

• Jil...
• Taken for 1 to 6 months
• April 13, 2025

Tirzepatide "I have been on Zepbound for 3 months. I had previously adopted a low-fat, vegetarian diet, so I have not had many gastric issues related to taking this medication. I have noticed an increase in constipation, but this is remedied by taking prunes and increasing fluids and fiber (I've found psyllium capsules help). Planning meals while on Zepbound, I've found to be helpful, especially with the constipation, as I am sure to add beans and other fiber-rich nutrients to the meals. If I do not plan meals, it's too easy not to eat or make something quick that is missing some of the needed nutrients. It should be noted that I started seeing a nutritionist at the same time I started Zepbound to give myself the best opportunity for success. I highly recommend this, and nutritionists are often covered by insurance."

• Alb...
• Taken for less than 1 month
• May 17, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Many friends have had various reactions to the shots. One had severe cramps and stopped using. In a couple of weeks, the cramps went away. I am on 2.5 going into my 4th week. I get some stomach gurgling, but the main reaction is constipation. I was very regular before usage. I use OTC drugs to manage the problem. After the 4th week, I am going on 5.0. My weight loss so far is 7 lbs. I started at 219. To go along with the shots, I put myself on a low-carb diet. Lots of protein and fiber."

• 215...
• Taken for 1 to 6 months
• November 11, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "First things first. I'm a 40-year-old woman. My height is 5'9", and my starting weight was 214. During my first month on Zepbound 2.5 mg, I experienced fatigue, dry mouth, and slight constipation. I'm on my second month dosage of 5 mg now, and I'm experiencing nausea and migraines. This is my sixth injection, and the weight fell off during the first month, and now I'm at a standstill. I'm weighing in at 195 for the last 2 weeks. During my first month, I had no carbs at all. I made sure I had at least 120 g of protein a day, and I weight trained four times a week, getting my goal of 10,000 steps a day. I haven't kept that same training routine these past two weeks, which is why I probably haven't lost any weight. I'd say the medicine really works. I'm not looking to stay on long-term. Since I hit 40, I've struggled with weight, perimenopause, etc. This has been a game changer."

• Dee...
• Taken for 1 to 6 months
• November 4, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Started on Zepbound 8/16/24. Have concentrated on protein and vegetables, fruit, and occasional treat. Have lost 31 lbs as of 11/2/24. Side effects have been constipation, which was remedied with OTC collagen and senna. Occasional nausea, especially in the beginning of tx. No longer get hungry and, most importantly, no longer get the cravings for unhealthy food. Recently started walking as it is much easier now with 30+ pounds down. Signed up for 2 exercise classes: yoga and weights. Dilkind has been a game changer for me. Presently on 2.5 injections. Easy to use."

• Ano...
• Taken for 1 to 6 months
• April 9, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I have been taking medication for 16 weeks and lost 35 lbs. I have had some problems with stomach issues, but they come and go. I have had some constipation and diarrhea with the increase and the start of taking the medication. Sometimes it can be bad, but for the most part, I feel like the med is working."