Tirzepatide and Constipation: What Users Say (Page 3)

• Ano...
• Taken for 1 to 6 months
• August 2, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I have been on Zepbound for 18 weeks with a dosage of 5 mg. I have had constipation, stomach aches, afraid to eat anything at this point to avoid the problems I have been having. I admit I have lost 50 lbs as of this morning. I'm beginning to wonder though if the weight loss is worth all the misery I have been having and the very limited food I can eat. I honestly don't feel a great deal better like I thought losing this much weight would make me feel. The fact that it is now a lifetime commitment doesn't make it any better either. I don't think I can eat and feel this way the rest of my life."

• ECT...
• Taken for 6 months to 1 year
• April 11, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "Effortlessly went from 250 lbs to 198 lbs in 9 months, with very minimal side effects! It took me this long to go through the gradual dosage increases. When I missed a few weeks here and there, I regained weight. I’ve been extra committed to the regularity of doses after that! My only side effects have been: some mild constipation (take mg citrate to fight that), very mild diarrhea, heartburn that increased as the dosage mg increased, although eating TUMS like candy took care of it (but expensive because I insist on having the TUMS that taste good to me), and injection site reactions (similar to a mosquito bite ≈ 3 days, managed with OTC cortisol cream and/or OTC roll-on 4% lidocaine). I used to have no off switch; was always hungry! Now, my mom (Wegovy) and I look at each other in amazement and ask, “Is this what it feels like to be normal?” She’s been up to 300 lbs, had bariatric surgery, we’ve both done keto, nothing lasted. She’s now 160!"

• Tam...
• Taken for 1 to 6 months
• February 23, 2023

Tirzepatide for Type 2 Diabetes "I am overweight and was sent to an endocrinologist by my PCP. A1C came back 6.9, and I received the dreaded diabetes diagnosis. The endocrinologist asked me about my eating habits and suggested Mounjaro once a week injection. Sceptical I was, but I was willing to try to get my weight down and get my A1C down. First injection, no severe vomiting or anything. The only side effect I had was the constipation, I was put on a stool softener and take fiber daily, which eliminated that side effect. Within two months, I was down 15 pounds, have not given in to eating a Boston crème doughnut, on which I tend to binge, limited on my intake of food because overindulging makes me feel lousy and gives me indigestion. Within three months, my A1C is down to 5.3, and my weight is still going down. Thank you so much to the researchers who created this drug because it has saved my life and gotten me on the road to better health. The needle doesn't even hurt when I self-inject. I am grateful."

• Mar...
• Taken for 6 months to 1 year
• August 18, 2025

For Weight Loss (Obesity/Overweight) "My start weight at 5'2" was 186 lbs. My insurance wouldn't cover the tirzepatide, so I found some online. It comes from a research lab and is shipped in a small vial. It's a powder form. You have to add BAC water and mix. Started in July 2024 at 0.25 mg every week. After 6 weeks, I bumped up to 0.5 mg every week. Decreased appetite, constipation, fatigue, and anxiety are the biggest side effects I have. I take Miralax and a doctor-prescribed Zofran for the nausea. At 1 year, I am still at 0.5 mg. I want to wean down to taking it every 2 weeks instead of 1 week. I can eat anything I want but do not want to put any weight back on, so I'm learning to make better choices. I also eat way smaller portions. I may take a few bites and then finish. It's important to take a multivitamin for hair and nails, etc. By not eating all of the foods, I'm not getting the nutrients the body needs. This drug is a miracle. It's so helpful and I didn't mind paying the $280 each month. Worth every penny. It's now a year and I'm 123 lbs."

• Ski...
• Taken for 1 to 6 months
• March 5, 2023

Tirzepatide for Type 2 Diabetes "In November 2022, my ACI was 7.4%, and I weighed 258 pounds at 67 years old. The wake-up call was when I renewed my life insurance, a big jump in premium due to the AC1 and weight. I was now tagged as a Type 2 Diabetic. I was referred to an endocrinologist who did extensive blood work. It was agreed to go on Mounjaro 2.5 mg. The first week I suffered some side effects such as nausea, constipation, and acid burps. Within 10 days, the symptoms subsided due to stool softeners, lots of fruit (berries), and Nexium. The first month I dropped 10 pounds with no dieting, just was not hungry at all. I had no cravings, especially for sweets like cookies, donuts, and candy-all things that I used to eat. Fast forward to March 2023, I am down to 217 pounds and 20 more to go. I am now on Mounjaro 10 mg, it's a bit strong, but the results are fantastic. My AC1 is now 5.6%, which is fantastic. The bad news is nothing fits- all new suits for the spring."

• Ano...
• Taken for 1 to 6 months
• September 7, 2025

Tirzepatide for Type 2 Diabetes "75 yo. Female I have noticed excessive facial hair growth since I started Mounjaro 3 months ago. I have experienced frequent bouts of nausea and constipation, which I control with Zofran and laxatives. Lots of fluid is important."

• Lis...
• Taken for 6 months to 1 year
• March 29, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "Best method for weight loss and keeping the weight off. I've lost over 100 lbs and am finally comfortable in my skin again. When you change mg dosage, fatigue could be concerning, and it does happen. Working out helps, making sure you stay hydrated, and working out was the biggest help for me. I did have constipation, and it was managed. I did have hair thinning and started taking Nutrafol. I've struggled with my weight my entire life. Not anymore. I wish we could add photos, but we can't. Portion food sizes of what you can eat are minimized. The sugar cravings were gone. Not only did those cravings disappear, but so did the cravings for food that your body turns to sugar. For example, I haven't eaten a potato chip in over 7 months. No desire for breads, mayo, Miracle Whip, and numerous other things. I FEEL so much better. It is costly, but so is poor health and obesity. I wish big pharma would realize how many Americans struggle with obesity and cover this through insurance."

• Jus...
• Taken for 1 to 6 months
• January 15, 2023

Tirzepatide for Type 2 Diabetes "I’ve been taking Mounjaro now for 4 months. I was prescribed it to treat my type 2 diabetes as well as for weight loss. Let me just say this drug has been a miracle! I started out at 268 lbs (5 ft 6 in male), I am now at 225 lbs! Over 40 pounds in 4 months! The only other weight loss program that helped me like this was the military! Now let me just say it’s not all Mounjaro, I’ve changed my eating habits and changed what foods I’m actually eating, and boom, working like a dream. My A1C has also dropped from 7.5% to 5.8%, this drug is an amazing stepping stone to a healthier life. The only side effects I’ve experienced since starting are loss of appetite and constipation, not too bad in my opinion!"

• chu...
• Taken for 1 to 6 months
• June 1, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "5’ 8” and 272 was my starting stats. I did four weeks of 2.5 then went up to 5.0. I am only on my 6th week (4 2.5s and 2 5.0s) and I have already lost 30 pounds. Now, at 242, I am looking to take off another 30-50 pounds. I am trying to be put on a list to have a transplant and have to lose a certain amount of weight to make the list. I give the medication a 100% A+. If you need to drop weight, this is a great medication. Side effects: Constipation. Drink as much water as you can and be prepared to take laxatives to poo. I’m talking rock pebbles harder than pleasing a Gold-digger on a date, you’ll definitely have to take some laxatives to poo. I suggest flavoring your water. It helps. Candy: You will crave sugary candy like Gobstoppers, Sour Patch Kids, Skittles, pretty much anything you can get your hands on. Try dark chocolate almonds and just small nibbles of candy when you get really, really sleepy. Bottom line: It works! It's worth the hard rock poo."

• Sha...
• Taken for 1 to 6 months
• December 1, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "I started using Zepbound on October 31st of this year. The beginning dosage was 2.5 mg. I started to lose 1-3 lbs. a week. The dosage was increased to 5 mg, which I started on the 4th week. Current total loss of 11.5 lbs. My provider has suggested that I increase the dose to 7.5 mg for my next refill. I do have side effects: nausea, constipation, dry mouth. My appetite has diminished, but I have to make a conscientious effort to eat. Cravings for specific foods have gone as well. I have a fear of needles, but do not feel the injections or any discomfort associated with normal 'shots.' Overall, my experience has been a good one, but it is still early."

• DWA...
• Taken for 1 to 6 months
• October 14, 2024

Tirzepatide for Type 2 Diabetes "My doc insisted that I give this med a shot. My A1c was just over 7, but I am 59, 6’, and hit my heaviest weight in my life of 283.3 lbs on July 3, 2024. I started taking the 2.5 mg on July 12, 2024, and 3 months later, now at the 7.5 mg dose, I have lost 33 lbs! I do get acid reflux if I overeat (I still love food) and constipation if I don’t drink enough water, but otherwise, every Monday I give myself a shot - tired for a day and then back to normal. I had tried in the past to shed a few pounds, but nothing ever worked, so I had learned to live with it. This is some magic potion in the form of science that is giving me my life back. My goal is 225 lbs by the end of 2024 and 200 lbs in 2025. Biggest problem is my pants no longer fit!"

• Jan...
• Taken for 1 to 6 months
• November 30, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Minimal weight loss in 5 weeks. Continual feeling of acidic stomach, some reflux. Constipation if not taking a stool softener. It has decreased my appetite. It also lets me know if I eat a food high in flour or sugar with severe acid reflux. Overall, I feel miserable while on it."

• fat...
• Taken for 1 to 6 months
• June 16, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Just under 5 months. Down 36 pounds from size 16 to a 12/14. Almost 50. 5'9'. F. Started at 2.5, of course. Currently on 10mg. The biggest issue for me has been finding the medication in stock. It makes me not think of food until I'm hungry and then I eat a little something. I stay full a long time. I can only assume this is what normal people without food issues are like. I have lost upwards of 100 pounds with very hard work over a period of 2-4 years at two different times in my life. I need help this time around. Even when I was doing well with diet and exercise prior to this medication being available, all I did is think about how many calories I had eaten and how many I had left. I don't even count calories now. I have almost no interest in eating. The day before my injection is due, I am more hungry but still not eating more than 1800c. No real side effects aside from constipation in the beginning. It's amazing."

• Ano...
• Taken for less than 1 month
• September 4, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "This should not be taken if you're a paraplegic. Took it for 3 weeks and became so constipated I'm still trying to recover. Had to go to the ER twice. First time my BP dropped to 64/47. Hope this info helps someone."

• S-L...
• Taken for 1 to 6 months
• November 6, 2022

Tirzepatide for Type 2 Diabetes "I tried to leave a review, but for some reason, it wasn't posted, so I will try again. My doctor took me off of Mounjaro recently. I developed large welts about 24 hours after I injected the 75 doses and 10. My doctor fears I am developing an allergic reaction, so I am going back to the rival insulin alternative. (I had more side effects with the Ozempic: exhaustion, extreme nausea, and constipation, but hopefully, over time, they go away this time.) Too bad, because I really wanted to stay on Mounjaro. It should be noted that I really like Mounjaro very much. Well-controlled sugar, once I was on my maintenance dose of 10. For some reason, I gained five pounds while on Mounjaro, I never lost weight, where I lost about 15 pounds on the other mentioned insulin alternative. It seems that other patients on other review sites have this welt issue too. The issue should be reported not only to the doctor, but per the request of the manufacturer, please report to them as well."

• Wee...
• Taken for 1 to 6 months
• August 1, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Started on 2.5 for 4 weeks, lost 4.5 kg, forgot to eat, total loss of appetite, felt dizzy, probably because I wasn't drinking enough water. Week 5, went to 5 mg, lost just over 1 kg. Now in week 6, have been constipated, having to take laxative, will finish the 5 mg jab another 2 weeks and see how I feel. Amazing result in never hungry and, as a crisp lover, could never have another packet with all the salt, yuk! Usually have chicken fillets, chips, and bread and butter, just don't want bread at all, can only have two small chicken pieces, nothing else, and only because I know I have to eat something. Went to McDonald's with the grandkids, haven't told anyone I'm on this drug. Kids were happy as Nana couldn't finish her burger and chips. Have started craving fruit, which I never eat, will try and carry on and see if I can be sensible."

• peb...
• Taken for 1 to 6 months
• February 26, 2023

Tirzepatide for Type 2 Diabetes "Started this 7 weeks ago and have one more injection. The first set was at 2.5 mg from the gynecologist. Within the first week, I lost 5 pounds and by week 5 I saw a huge difference! I went from a 22 waist to a true size 18 and still shrinking. I was having trouble catching my breath before I started this. I had a couple of pains in my stomach, similar to gas pains like clockwork, the day after the injection. But it was bearable. Sometimes I get a smelly burp issue. But now I have lost 20 pounds at week 7 and feel amazing. Please do yourself a favor and take fiber daily, this medicine will get you constipated."

• Myk...
• Taken for 1 to 6 months
• December 20, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Have lost approximately 25 lbs in about 4.5 months. No major side effects. Occasional constipation, but I'm taking fiber supplement gummies, which help with regularity. Taking 7.5 mg dosage at present. Will increase to 10 mg next refill. I feel full for longer periods, which has helped control hunger bingeing. My goal would be to drop another 25-30 lbs. Still looking to start an exercise routine, which I can commit to, but life's demands interrupt my progress. I'm very grateful for this medicine."

• kan...
• Taken for 1 to 6 months
• December 21, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "I am a 55-year-old female, 5’7 starting weight 250, started Zepbound 6 weeks ago. 1st month, 2.5 — moved up to 5 2nd month. Probably the most annoying, almost immediate side effects were GERD, bloating, and constipation. However, this did improve quickly when I added more fiber, avoided high-fat, saucy foods, and ate less. I do agree with the others… that it definitely helps your “hunger-food brain.” I can skip a meal without even noticing. I fill up eating a quarter to half of what I would normally eat. I begin getting nauseated while I eat, which makes me stop eating, of course. Now that I've increased from 2.5 to 5, the nausea is a little worse, but intermittent and tolerable. Hoping this will improve once my body adjusts. Overall, still very thankful for this opportunity to try Zepbound. I'm trying to find some type of a meal plan to follow, with sufficient protein and fiber, as well as other foods or supplements to prevent muscle loss, hair loss, constipation, and fatigue."

• WE...
• Taken for less than 1 month
• November 8, 2022

Tirzepatide for Type 2 Diabetes "Went to the doctor and asked for something to help lose weight. He prescribed this medication. Day 1 and 2... nothing. Day 3 woke up with horrible heartburn and sour sulfur burps and facts and was constipated. By day 3 evening, I no longer had constipation but just the opposite... diarrhea! And not just any kind, it was like yellow water and very acidic. It hurt! Had horrible gas and belching all day Saturday, and Sunday couldn't hardly leave the bathroom to go buy Imodium. Imodium helped with that, but the gas is now trapped, and my stomach hurts badly, and I am full of gas with bad heartburn and belching. I saw a correlation between fatty foods and severe side effects of this product. But unless you're a vegan, you eat fat, and that's a major problem with this product. It is now Monday night, and I cannot seem to get my work done, I hurt so badly. I will never take this product again, and I cannot in good conscience recommend it with all the terrible side effects. Shame on Mounjaro!"

• Ano...
• Taken for less than 1 month
• May 15, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "First 2 weeks on low dose was okay. Minor GI disturbances. I normally have loose stools but had well-formed stools during those 2 weeks. Stayed on low dose for the 3rd week. Was a little constipated at first, so ordered a large salad from my favorite café. Maybe that's what triggers everything. That night I could not sleep because my gout became very painful, and I had to deal with the diarrhea. I am now feeling pretty drained and weak. Generally feel a tad light-headed."

• mou...
• Taken for less than 1 month
• June 1, 2023

Tirzepatide for Type 2 Diabetes "My husband suffered from severe nausea, mostly at night, but also from loss of appetite, constipation, and increased fatigue. He could not even get out of bed after one injection. He will not take a second dose."

• Phi...
• Taken for less than 1 month
• June 21, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "Only two weeks into it (2nd shot) but working, do not feel hungry, eat small portions and eating because I know I need to. Do have to take a laxative as I get constipated, day after shot do feel some fatigue and take a nap in the afternoon."

• L9-...
• Taken for 6 months to 1 year
• March 17, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "I have lost 54 lbs. in 6 months. It’s been easy, my only issues have been constipation and some hair loss. I increased my dosage each month to 15 mg. I am now reducing my dosage to wean off the drug. I wish there was more information about stopping the drug. Also, I had to spend thousands of dollars because it’s so expensive. I worry about stopping the drug."

• WVN...
• Taken for 1 to 6 months
• December 27, 2022

Tirzepatide for Type 2 Diabetes "I started on the 2.5 dose in October, my doctor felt that the weight loss would help with my joint pain and lower my A1C. From day 1, I was extremely nauseous, had no desire to eat, had sulfur burps, and had constipation. I spoke with my doctor, who encouraged me to ride it out. On week four, I was stepped up to the 5 mg dosage. The doctor called in Zofran for stomach issues. On week six, I called her and said I could no longer function. During this time, I was so fatigued and was having heart palpitations and was barely able to walk 20 feet without being totally exhausted. I chalked it up to being so nauseous and not eating. Then my legs started to burn like I had walked up a steep hill and felt so sore and bruised I could barely sit. That week, I had my follow-up appointment with my doctor. I told her about my symptoms, and she said that rhabdomyolysis is not a side effect of Mounjaro. I was never dehydrated, but my CK levels were still 440 two weeks off the medication! Eight weeks later, and no improvement!"