Tirzepatide and Constipation: What Users Say (Page 4)

• Ano...
• Taken for 1 to 6 months
• July 26, 2025

For Obstructive Sleep Apnea/Hypopnea Syndrome "My stats on the front end of the Zepbound medication were 293 lbs at 6 feet tall. BMI was well over 40. I had constant fatigue and didn't sleep well (I am also on a CPAP). I started on 0.25 mg for 1 month and lost about 6 lbs. I then went to 0.5 mg for the past two months and have lost 18 lbs for a total of 24 lbs in 3 months. I have asked to go to 7.5 mg to help me get to my weight loss goal. My main side effect has been constipation, Miralax is helping with that. I also run 4 times a week, and exercise is very important when on Zepbound."

• Lis...
• Taken for 1 to 6 months
• March 5, 2025

For Weight Loss (Obesity/Overweight) "My experience is a lot better than I was expecting. I'm on the 2.5 mg a week. So far, the side effects are manageable. I barely get nauseous, but the constipation is real. I really like the once-a-week dosage because I don't particularly care for needles. My weight loss is slow, mainly due to a lack of working out. I'm extremely fatigued and just want to rest. The fatigue hits me early in the morning and late in the afternoon. Stay hydrated!"

• Duc...
• Taken for 1 to 6 months
• October 16, 2022

For Type 2 Diabetes "I was using Ozempic, but Dr. switched to Mounjaro. It has been terrible! I lost a lot of weight on Ozempic but gained some back since being on Mounjaro. Also, my blood sugar rose 10-15 points since switching! I have had numerous side effects, mainly headaches and constipation. When giving it, it always seems to leak back out of my skin, and I've tried stomach, arms, thighs- all the same! I am not happy."

• Ano...
• Taken for 1 to 6 months
• April 15, 2025

For Obstructive Sleep Apnea/Hypopnea Syndrome "Sleeping more soundly, no more snoring, and also taking for weight loss. Had some constipation at the beginning. Took 3 teaspoons of fiber daily until I got regular, and now one teaspoon of Metamucil daily. Lost 7 pounds in 2 months so far."

• MJs...
• Taken for 1 to 6 months
• February 17, 2023

For Type 2 Diabetes "3.5 months from 2.5 mg to 5.0 mg. Even before starting 7.5 mg, my experience has been positive. Less stressful, as if my cortisol levels are low. No desire to drink alcoholic beverages. Appetite suppressed, loss of inches before any noticeable weight loss. Slow loss of excess weight. PCOS symptoms have mostly disappeared, however, when refills were not available, all symptoms almost immediately presented again, including desire to snack. Constipation is noticeable at 5.0 mg. Starting 7.5 mg now. 22 lb of excess weight lost after 3.5 months of use."

• Bob...
• Taken for 1 to 6 months
• April 10, 2025

For Obstructive Sleep Apnea/Hypopnea Syndrome "I was obese and had sleep apnea. After 5 months of Zepbound, I have lost 45 lbs., and my sleep apnea has subsided. Along with starting the medicine, I started an exercise program. I walk over 10K steps a day and use lighter weights with multiple sets to maintain and increase muscle mass. I also increased the amount of water I drink. I have a 40 oz. mug that I always have with me and am usually drinking 120 oz. per day. I stopped drinking alcohol 2 months into taking Zepbound. I have more energy and feel much better than I did when I was obese. The only side effect that I experienced was constipation. I combated that by taking a low dosage daily of Dulcolax. I could have never lost the weight I have without Zepbound. I intend to keep up my exercise program after stopping Zepbound, and hopefully my weight gain will be minimal."

• Ano...
• Taken for 1 to 6 months
• August 27, 2025

For Weight Loss (Obesity/Overweight) "While Mounjaro significantly reduces appetite and food noise, it creates gastric distress and constipation. I feel sick most of the time. I've lost 5 lbs a month consistently for 6 months. I have used Mounjaro, not a substitute compounded version."

• CPA...
• Taken for 1 to 6 months
• July 17, 2024

For Type 2 Diabetes "I started the medication in November of last year. I started with 5 mg and incrementally increased the dosage up to 15 mg. The small hypodermic needle made it easy to inject. At 10 mg, I reached a plateau with the weight loss. I eventually went up to 15 mg and stayed on that dose for 2 months. The primary reason for taking it was for type 2 diabetes, and I benefited from weight loss as I was also overweight. As of today, I have lost 35 lbs but stopped the Mounjaro about a month ago. My appetite seemed to slowly get back to normal, which is not a good thing. I also did intermittent fasting, so that helped a lot with the cravings, etc. I also get some bouts of constipation, but my diet made up for that. My urine smelled different. I pray there were no effects on my kidneys. My blood sugars are normal. My A1C is 5.2, so I chose to stop the medication and continue the weight loss journey naturally."

• Kir...
• Taken for less than 1 month
• June 25, 2024

For Weight Loss (Obesity/Overweight) "Benefits: Completely stopped the food noise and cravings for fatty and sweet foods, decreased appetite within the first 2 days of injection. Injection not painful at all, tiny needle. Side effects: feelings of fatigue for 2 or 3 days after injection, can feel very bloated due to constipation. Feelings of a lump in the throat due to some acid reflux. Sometimes feel more emotional than normal. Increased periods, 2 periods within 1 month, very heavy and prolonged, appetite increased slightly on last 2 days before next injection due. Can feel shaky/weak if not eating enough calories due to decreased appetite. 1st month of use experience on 2.5 mg."

• Moi...
• Taken for less than 1 month
• April 29, 2025

For Weight Loss (Obesity/Overweight) "Been taking 2.5 ml for only 3 weeks now but have lost nearly 6 kg. I had one mouth ulcer the first week and one the second but none since, so possibly not related. The beginnings of constipation this week, but I increased my fiber intake, and I am now fine. No stomach cramping, but I was recommended to take a magnesium supplement before starting Mounjaro to head those off. I continue to take it. No cramping so far. No other symptoms. I do have Type 2 diabetes, high blood pressure, obesity, high cholesterol, and fatty liver disease. I simply had to lose weight. I have given up smoking 3 times in the past 4 years and gained 10 kg every time. (I don't smoke now.) I am 59. This medication is saving my life. If I lose weight again this week, I will stay on the low dose for another month. Appetite suppression has been very strong since week 1. The KWIK pen is so simple and pain-free. I live in Australia."

• Bri...
• Taken for 6 months to 1 year
• December 4, 2024

For Weight Loss (Obesity/Overweight) "Zepbound has been a godsend. I started at 244 lbs with a BMI of 36. I am down 60 lbs to 184. I started at the end of April, so just a little over 7 months. The only side effect I have had is the expected slow digestion, so you have constipation, with only having bowel movements every 2-3 days on average. However, some days you have a day where you have multiple movements in a day. Due to availability issues, I have not been on the proper dosing. Normally you start at 2.5 mg for the first month, then 5, 7.5, etc., for each month after until you max out at 15 mg. I started at 2.5 mg for the first month, but when I tried finding 5 mg, the only place was my insurance online pharmacy, and they only did 3-month prescriptions -- but 3 months at $100 (and the first month Eli Lilly gave me an $80 discount). I've only been able to find the 5 mg in order to not miss any doses. So, the good news is I was able to sustain the weight loss by staying at the same dose. If you can get it, it works great."

• Don...
• Taken for 2 to 5 years
• August 19, 2025

For Weight Loss (Obesity/Overweight) "I've been on Mounjaro for over two years. I'm part of a study for mortality and morbidity for clients with risk for heart attacks. Criteria included obesity, high cholesterol, and HTN. Within six weeks of starting Mounjaro, I was off my BP medication. Over the first year, I lost 70 pounds. The side effects that I experienced early on were indigestion and belching. That resolved after about three months. The biggest side effect for me is constipation. Learning how to manage constipation is important. My Mounjaro is on hold now because of extremely elevated amylase and lipase 10 times the normal level. I was asymptomatic for nausea, vomiting, or abdominal pain, which I'm thankful for. While I've been off for over a month, my digestive enzymes have normalized, and my pancreas appears normal via ultrasound. However, I'm anxious to get back on Mounjaro, perhaps at half the dose 7.5 mg because I again am having food cravings, I feel hungry all the time, and have gained about 10 pounds off the medicine. I believe the side effects for me are less worrisome."

• Ano...
• Taken for 1 to 6 months
• June 26, 2025

For Weight Loss (Obesity/Overweight) "Have had a lot of success with Zepbound at the low dose of 2.5 mg. I’ve lost about 30 pounds in four months. My biggest problem was abdominal distention. I’ve started drinking a quarter or half a glass of prune juice at night, and it’s really helping with my relief of constipation. I also think it’s helped with my stomach distention because I’m able to go to the bathroom every day."

• Bec...
• Taken for 6 months to 1 year
• June 21, 2025

For Weight Loss (Obesity/Overweight) "52 years old, 5 ft 6 inches, female, gave birth naturally to 6 children, all now adults. Started in October 2024 at 91.4 kgs, waist at 104 cm, wearing size 14-16 clothes (Australian sizes). I read all the reviews (about 500) before I started and chose to mitigate adverse reactions: (ONLY Bioceuticals brands) I took powdered magnesium 3 times a week for muscle health, daily live probiotics for gut health, daily prebiome fiber in smooth and creamy Greek yogurt with berries and prunes for bowel health. Drank lots of water and ate smaller portions for dinner at about 5 pm. I don’t have time for exercise (although I had just done a whole year of 3 x personal training a week prior to starting MJO - only losing 4 kgs!). Fast forward to June 2025, I currently weigh… drum roll… 68 kgs! My waist is now 79 cms, my upper arms have lost 6 cms, hips lost 14 cms. I am wearing size 10-12 and cannot be happier! Only occasionally did I get dizzy or constipated."

• Deb...
• August 9, 2024

For Weight Loss (Obesity/Overweight) "It's been a pretty good experience. The top dose I take is 7.5. Side effects: tiredness, a little dizziness, and some constipation. Make sure I eat something, this drug makes you forget about eating. This is what I contribute my dizziness to. I make sure I eat all 3 meals. More like 1/2 portions now. This is teaching me portion control. I've lost 32 lbs in 4 months."

• Mar...
• Taken for 1 to 6 months
• October 28, 2024

For Type 2 Diabetes "I started taking Mounjaro 2.5 mg in March of this year (2024). Every month, my doctor increased my dose to the next level. I was put on the medication to help with my A1C because it would go up and down but not at a normal number. After 3 months, it went from a 7 to 4.5. I was so happy with the result. I am currently on 15 mg and I am down 50 lbs (over 6 months) and A1C is staying at 4.5. My original goal was 30 lbs by September and 60 by next March. I am so excited that I am already close to my year weight goal loss. The only side effects that I have had were the sulfur burps, which I figured out how to control and prevent and stop. And occasional constipation, which I just increased fiber intake to help. Everyone's experience is different. I went into taking it and researching all the side effects and being careful. I am thankful to my doctor for helping me, and I am happy with the results so far."

• Jud...
• Taken for 1 to 6 months
• January 22, 2025

For Type 2 Diabetes "I started Mounjaro 8 weeks ago. I’m 69 years old with T2D and weighing 234 lbs. I now weigh 214. I start on 7.5 this weekend. I have had light nausea and light constipation, and the lovely burps, but other than that, all is good. I eat better, no hunger 24/7, and I feel so much better. No more metformin. Yay!!!!"

• Aco...
• Taken for 1 to 6 months
• July 21, 2024

For Weight Loss (Obesity/Overweight) "I’m 63 years old, 5’7”, and when I started Zepbound on May 8th, 2024, I weighed 240 lbs. Now I’m down to 200 lbs! Started with 2.5 mg like most people, then 7.5 mg. The side effects were minimal, just some slight constipation when I first started, now nothing. All my cravings for fatty junk food, potato chips, ice cream, candy, etc., are gone. I still eat mostly anything I want, but half the portions, then I feel full. If you are overweight and if your insurance company pays for Zepbound, I highly recommend it."

• Ala...
• Taken for 1 to 6 months
• August 19, 2023

For Type 2 Diabetes "I started with 2 1/2, went up to five, and then now I am at 10. I lost a few pounds a week, although my appetite is much less than usual. The side effects have been very minimal, mostly headache, sore throat, and hoarseness seems to linger, never really goes. Constipation can be an issue at times, that only for myself, but other people I know on the same drug. My PA is working very closely with her and paying attention to absolutely everything closely. I feel that it’s a safe drug so far if you have a doctor or PA that is on board with you and to a full degree of attention. My hope is that once my A1c is in order, I will be able to discontinue the drug completely, although some studies recommend that not to be probable, again, working closely with my doctor and care team. Thank you for your time."

• J W...
• Taken for 1 to 6 months
• September 20, 2024

For Weight Loss (Obesity/Overweight) "I am a 60 y/o female, 5’7” and 288# on August 2, 2024. I was borderline diabetic and felt as though something had to be done considering my family history of diabetes and heart disease. I began Zepbound at the 2.5 dose. Seven weeks later, I weigh 252 and am very happy with my progress. My goal weight is 185, which is realistic for my height. I’m not taking this to become thin, I’m taking it to become healthy. My adverse side effects have been severe constipation and gas, which are easily mitigated with laxatives and gas reducers. I am eating healthier and am no longer controlled by excessive sugar cravings. While I once ordered a large ice cream, I now order a small and split it with my husband. My diet consists primarily of vegetables, and I have to remind myself to include at least a little protein to balance my diet. I am focusing on my relationship with food so I can continue to succeed when I am no longer using the medication after 12 months. My co-pay is $25.00."

• 123...
• Taken for 1 to 6 months
• September 16, 2024

For Weight Loss (Obesity/Overweight) "I began this treatment in April. It is now mid-September. I have lost 20 pounds. It is very easy to use, which is a big deal for those who have a needle phobia. In the beginning, I had very few side effects. After going to the 7.5 mg dose, I started to experience constipation and nausea. To combat this, I began a small fiber intake routine and requested Zofran from my doctor. Both are very effective for those side effects. I am now on a 12.5 mg dose and doing well. I feel I am close to a maintenance dose. This medication was quite effective. I am a small person, menopausal, and struggled with losing weight. Losing 20 lbs for my size is a very big deal. Through this process, I have learned better eating habits, keeping my portions small to maintain a healthy weight and continuing my exercise routine even if I am not losing weight. All in all, this was a win-win for me."

• Lyn...
• Taken for 1 to 6 months
• December 20, 2024

For Weight Loss (Obesity/Overweight) "I am happy with the results so far. I have lost 29 lbs in 13 weeks. My goal is 75 lb weight loss. My appetite is far less, and my cravings for sugar have much improved. I have had some constipation and 1 or 2 episodes of nausea but did not vomit. You have to drink water! I started on 2.5 mg and was increased to 5 mg. I'm worried to go to a higher dose due to potential increased side effects, as I have a history of kidney issues. However, since I started the medicine, my Hga1c is normal and lipid panel perfect."

• DAS...
• Taken for less than 1 month
• May 29, 2025

For Obstructive Sleep Apnea/Hypopnea Syndrome "Starting 4th week of 2.5 mg. It wears off some by the end of the week. Dr. raised it to 5 mg for the next month's prescription. I am down 10 lbs in 3 weeks. Appetite is now easy to control and say no to the food/snack crazies. Very slight constipation is the only side effect I have noticed. It does work but is not affordable for me. $350 for the 1st month was the vial and syringe and out of pocket. Easy to use. Insurance declined it. $499 for the 2nd month. I can't afford it. I have researched it and found that you can buy the tirzepatide peptides online for considerably less money. I may regret it, but I am going to try it. I have seen very high numbers of happy people who went this route."

• Ano...
• Taken for 1 to 6 months
• May 29, 2025

For Obstructive Sleep Apnea/Hypopnea Syndrome "Dosage 2.5. Effective for sleep apnea and weight loss. Having side effects including queasiness, lightheadedness, diarrhea, constipation, Vitamin B12 blood test elevated to 1270. Starting weight 156. Now 147 after 7 doses."

• Anonymous
• Taken for 6 months to 1 year
• March 4, 2025

For Weight Loss (Obesity/Overweight) "It was rough in the beginning, with diarrhea, then constipation and heavy belching. The diarrhea ended after about a month, but constipation has continued. In addition to those symptoms, I experienced an undercurrent of nausea for several months, with it being more pronounced just after eating. After about eight months, the nausea abated for the most part. I started on the 2.5 and moved up in dosage every 2 months or so. I am entering month 10 and am on the 12.5 dosage. For the first 6-7 months, I lost approximately 1.5 lbs/wk, and over the last 2-3 months that has slowed down a little. I have lost a total of 50 lbs. The other side effect I've experienced is I sometimes have low blood sugar in the mornings, so I will have juice or something to help take care of it. It is easy to use, and despite the rough start, I am pleased with the results."