Tirzepatide and Constipation: What Users Say (Page 4)

• Mar...
• Taken for 1 to 6 months
• October 28, 2024

Tirzepatide for Type 2 Diabetes "I started taking Mounjaro 2.5 mg in March of this year (2024). Every month, my doctor increased my dose to the next level. I was put on the medication to help with my A1C because it would go up and down but not at a normal number. After 3 months, it went from a 7 to 4.5. I was so happy with the result. I am currently on 15 mg and I am down 50 lbs (over 6 months) and A1C is staying at 4.5. My original goal was 30 lbs by September and 60 by next March. I am so excited that I am already close to my year weight goal loss. The only side effects that I have had were the sulfur burps, which I figured out how to control and prevent and stop. And occasional constipation, which I just increased fiber intake to help. Everyone's experience is different. I went into taking it and researching all the side effects and being careful. I am thankful to my doctor for helping me, and I am happy with the results so far."

• Lis...
• Taken for 1 to 6 months
• March 5, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "My experience is a lot better than I was expecting. I'm on the 2.5 mg a week. So far, the side effects are manageable. I barely get nauseous, but the constipation is real. I really like the once-a-week dosage because I don't particularly care for needles. My weight loss is slow, mainly due to a lack of working out. I'm extremely fatigued and just want to rest. The fatigue hits me early in the morning and late in the afternoon. Stay hydrated!"

• Lyn...
• Taken for 1 to 6 months
• December 20, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "I am happy with the results so far. I have lost 29 lbs in 13 weeks. My goal is 75 lb weight loss. My appetite is far less, and my cravings for sugar have much improved. I have had some constipation and 1 or 2 episodes of nausea but did not vomit. You have to drink water! I started on 2.5 mg and was increased to 5 mg. I'm worried to go to a higher dose due to potential increased side effects, as I have a history of kidney issues. However, since I started the medicine, my Hga1c is normal and lipid panel perfect."

• Moi...
• Taken for less than 1 month
• April 29, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "Been taking 2.5 ml for only 3 weeks now but have lost nearly 6 kg. I had one mouth ulcer the first week and one the second but none since, so possibly not related. The beginnings of constipation this week, but I increased my fiber intake, and I am now fine. No stomach cramping, but I was recommended to take a magnesium supplement before starting Mounjaro to head those off. I continue to take it. No cramping so far. No other symptoms. I do have Type 2 diabetes, high blood pressure, obesity, high cholesterol, and fatty liver disease. I simply had to lose weight. I have given up smoking 3 times in the past 4 years and gained 10 kg every time. (I don't smoke now.) I am 59. This medication is saving my life. If I lose weight again this week, I will stay on the low dose for another month. Appetite suppression has been very strong since week 1. The KWIK pen is so simple and pain-free. I live in Australia."

• J W...
• Taken for 1 to 6 months
• September 20, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "I am a 60 y/o female, 5’7” and 288# on August 2, 2024. I was borderline diabetic and felt as though something had to be done considering my family history of diabetes and heart disease. I began Zepbound at the 2.5 dose. Seven weeks later, I weigh 252 and am very happy with my progress. My goal weight is 185, which is realistic for my height. I’m not taking this to become thin, I’m taking it to become healthy. My adverse side effects have been severe constipation and gas, which are easily mitigated with laxatives and gas reducers. I am eating healthier and am no longer controlled by excessive sugar cravings. While I once ordered a large ice cream, I now order a small and split it with my husband. My diet consists primarily of vegetables, and I have to remind myself to include at least a little protein to balance my diet. I am focusing on my relationship with food so I can continue to succeed when I am no longer using the medication after 12 months. My co-pay is $25.00."

• Bri...
• Taken for 6 months to 1 year
• December 4, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Zepbound has been a godsend. I started at 244 lbs with a BMI of 36. I am down 60 lbs to 184. I started at the end of April, so just a little over 7 months. The only side effect I have had is the expected slow digestion, so you have constipation, with only having bowel movements every 2-3 days on average. However, some days you have a day where you have multiple movements in a day. Due to availability issues, I have not been on the proper dosing. Normally you start at 2.5 mg for the first month, then 5, 7.5, etc., for each month after until you max out at 15 mg. I started at 2.5 mg for the first month, but when I tried finding 5 mg, the only place was my insurance online pharmacy, and they only did 3-month prescriptions -- but 3 months at $100 (and the first month Eli Lilly gave me an $80 discount). I've only been able to find the 5 mg in order to not miss any doses. So, the good news is I was able to sustain the weight loss by staying at the same dose. If you can get it, it works great."

• Ala...
• Taken for 1 to 6 months
• August 19, 2023

Tirzepatide for Type 2 Diabetes "I started with 2 1/2, went up to five, and then now I am at 10. I lost a few pounds a week, although my appetite is much less than usual. The side effects have been very minimal, mostly headache, sore throat, and hoarseness seems to linger, never really goes. Constipation can be an issue at times, that only for myself, but other people I know on the same drug. My PA is working very closely with her and paying attention to absolutely everything closely. I feel that it’s a safe drug so far if you have a doctor or PA that is on board with you and to a full degree of attention. My hope is that once my A1c is in order, I will be able to discontinue the drug completely, although some studies recommend that not to be probable, again, working closely with my doctor and care team. Thank you for your time."

• Fat...
• Taken for 6 months to 1 year
• February 6, 2025

Tirzepatide for Type 2 Diabetes "My experience has been very good. I took drastic steps to change eating habits, cutting carbs where possible. Rather than eating chips at home, I go through 6 lbs of carrots per week. I divorced French fries. Aside from that, I still eat what I want when dining out. Dropped from 330 lbs to 262 lbs in 8 months. No side effects aside from constipation - daily fiber and stool softeners make that manageable. I feel that part of the weight loss was simply the change in diet, but the Mounjaro certainly helped. I'm on the 2.5 dosage."

• Ano...
• Taken for 1 to 6 months
• April 15, 2025

Tirzepatide for Obstructive Sleep Apnea/Hypopnea Syndrome "Sleeping more soundly, no more snoring, and also taking for weight loss. Had some constipation at the beginning. Took 3 teaspoons of fiber daily until I got regular, and now one teaspoon of Metamucil daily. Lost 7 pounds in 2 months so far."

• Lif...
• Taken for less than 1 month
• August 9, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "I was recommended weight loss pre-knee surgery and decided to try Mounjaro. I am a 55-year-old female, at least 12 kilos overweight. I have been using it for 3 weeks now (2.5 mg) and have lost 2 kg. There was no nausea, and I manage slight constipation with poached pears and yogurt or a prebiotic. I realized very quickly that I needed to eat smaller amounts more regularly as opposed to my previous habit of waiting until I was really hungry - I didn’t eat badly before, but my food portions were larger, and I regularly consumed alcohol. I tried a sip of champagne after 2 weeks of Mounjaro, and it tasted horrible. The combination of eating less, feeling satisfied, sleeping better, and weight loss has already changed my life for the better."

• Deb...
• August 9, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "It's been a pretty good experience. The top dose I take is 7.5. Side effects: tiredness, a little dizziness, and some constipation. Make sure I eat something, this drug makes you forget about eating. This is what I contribute my dizziness to. I make sure I eat all 3 meals. More like 1/2 portions now. This is teaching me portion control. I've lost 32 lbs in 4 months."

• Aco...
• Taken for 1 to 6 months
• July 21, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "I’m 63 years old, 5’7”, and when I started Zepbound on May 8th, 2024, I weighed 240 lbs. Now I’m down to 200 lbs! Started with 2.5 mg like most people, then 7.5 mg. The side effects were minimal, just some slight constipation when I first started, now nothing. All my cravings for fatty junk food, potato chips, ice cream, candy, etc., are gone. I still eat mostly anything I want, but half the portions, then I feel full. If you are overweight and if your insurance company pays for Zepbound, I highly recommend it."

• Ano...
• Taken for 1 to 6 months
• March 31, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "No problems at all. At first, I was constipated and was fine after adding MiraLAX to my diet. I wish I could get it cheaper because my insurance doesn’t cover it. I also noticed that I sleep better because of my sleep apnea."

• Ala...
• Taken for 1 to 6 months
• January 4, 2025

Tirzepatide for Weight Loss (Obesity/Overweight) "My wife had been on Mounjaro for several months and had seen dramatic weight loss. Our bro-in-law had a prescription but had a reaction, so he gave his supply to me. (My insurance doesn't cover it.) After 5 months, I had lost 50+ lbs. In 15 months, my wife lost over 170 pounds. Both of us combined our course with a keto diet: low carbs, high fat, and protein. The wife's sisters had also seen similar results while also using the keto diet. I am not diabetic, but my wife is. She has cut her use of insulin to the bare minimum and will still occasionally have low blood sugar. While I have run out of my supply, I used 5, 7.5, and 10. My wife has had a more managed regimen, gradually increasing to her current 12.5. Our only real side effect has been constipation. We are trying to handle that with an increase in eating more fiber and fiber supplements, along with using laxatives. To deal with our decreased food intake, we are both also taking vitamin supplements."

• Joh...
• Taken for 1 to 6 months
• June 20, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "Lost 10 kg in 3.5 months with daily exercise and a calorie-controlled diet. It does not eliminate the cravings, though, I always have them. Just needed the mindset that this is an expensive drug and I have to make it work. No side effects at all compared to what I experienced with Saxenda. Saxenda gave me the most horrible constipation I've ever had in my life. I genuinely thought I was gonna end up in A&E for impacted stool. I'm very happy with Mounjaro."

• 123...
• Taken for 1 to 6 months
• September 16, 2024

Tirzepatide for Weight Loss (Obesity/Overweight) "I began this treatment in April. It is now mid-September. I have lost 20 pounds. It is very easy to use, which is a big deal for those who have a needle phobia. In the beginning, I had very few side effects. After going to the 7.5 mg dose, I started to experience constipation and nausea. To combat this, I began a small fiber intake routine and requested Zofran from my doctor. Both are very effective for those side effects. I am now on a 12.5 mg dose and doing well. I feel I am close to a maintenance dose. This medication was quite effective. I am a small person, menopausal, and struggled with losing weight. Losing 20 lbs for my size is a very big deal. Through this process, I have learned better eating habits, keeping my portions small to maintain a healthy weight and continuing my exercise routine even if I am not losing weight. All in all, this was a win-win for me."

• kat...
• Taken for 6 months to 1 year
• June 5, 2024

Tirzepatide for Type 2 Diabetes "I started with the lowest dose for Type 2 diabetes. My A1C was 7.5. I immediately noticed I just wasn't hungry. Otherwise, no side effects. I have been on 15mg for several months now, except when I have to get a lower dose due to non-availability of the drug in my area. My A1C is now down to 5.6, and I have lost 87 lbs. I started at 325 lbs. I have some constipation, but it is manageable. I had noticed increased muscle weakness in my thighs, and I could barely walk without fear of falling. My doctor thought it was a lack of protein. After several days of high protein drinks, I felt much better. After a few weeks, I was back to normal. This is a great drug. I just wish it were more readily available."

• Son...
• Taken for 1 to 6 months
• March 19, 2025

Tirzepatide for Type 2 Diabetes "Started on 2.5 mg in December and have titrated up every 4 weeks to 12.5 mg currently. So far I have been losing 2-3 lbs a week and have lost 34 lb, and up until now I haven't really noted any serious side effects other than occasional constipation and slight nausea if I don't eat something small every few hours, or if I eat something really fatty. The last two titrations I have noticed some extreme fatigue and being cold on the first day after my shot, but then it usually starts to go away on the 2nd day and I feel better. I have also noticed that if I try to push through the tiredness and try exercising, I usually feel better. I have tried to stick to a 1200-1500 calorie diet and do eat a lot more fruits and veggies, and I feel better than I have in a long time. Overall, it’s been a good experience and I’m super excited to see how much more weight I can lose."

• Anonymous
• Taken for 1 to 6 months
• March 17, 2025

For Weight Loss (Obesity/Overweight) "I am on my fifth week today. Have very little appetite and burning in my throat and nausea. Have been constipated also. The burning in the throat is the worst. I told them and prescribed nausea pills. I took one tonight, but it's not helping. Feel like I am going to void. Took Roland. Nothing helps. I was on semaglutide 2 years ago and never had this burning in my throat. Constipated on both. Am losing weight faster after 4 weeks. Right now, I can’t even imagine increasing the dose because of this awful burning in my throat."

• Ano...
• Taken for 1 to 6 months
• June 2, 2025

Tirzepatide for Type 2 Diabetes "It has been great! My A1C has gone down, I'm using a lot less insulin, and losing weight. I've lost weight slowly, but the other benefits have been great! The symptoms I have experienced are fatigue, loss of appetite, changes in the taste of food, constipation, and hair loss. The hardest part is the price of the medication. It has fluctuated from $25 to $365. Not knowing what I am going to pay month to month has left me in a bind. I am really frustrated because I am getting priced out of a medication that is obviously helping me but not affordable."

• RBj...
• Taken for 1 to 6 months
• August 29, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "I started using Mounjaro in March 2023, with a 2.5 mg dose, for weight loss. I shifted to 5 mg after 2 weeks; I stayed with each dose for around 2-3 months. I lost 10 kg by August (6 mo.). I had a freeze in weight loss for 5 weeks, then I lost 1.8 kg in 2 weeks when I took 10 mg. In terms of side effects, I experienced them during the first weeks of every upgrade in dose; like nausea and sometimes vomiting, headache, stomach pain, constipation and diarrhea, laziness, body ache, mood change; the worst was with 10 mg. As I have urticaria, I experienced an allergy at the needle site after week 10, which resolved in 3 days every time. This week I have pelvic, vaginal, and lower abdominal pain similar to period pain, although I have been menopausal for 4 years! I am happy about the results with minimal side effects."

• Hon...
• Taken for 1 to 6 months
• October 6, 2022

Tirzepatide "I have been taking Mounjaro for 7 weeks. 4 weeks of that I was on the 2.5 mg dose and lost 15 lbs by the 4th week. The last 3 weeks I've been on the 5 mg and I've lost ZERO lbs. Seems kind of useless to take when you have all the side effects (constipation, diarrhea, bloating, gas, nausea, headache, severe fatigue) for 3 weeks straight with no weight loss. I am considering going off this medication, I think it was all just hype. I've also stopped having periods. 40 years old, SW 199, CW 185, GW 140. Also following website food/calories recommendations. I have no other disease, just obesity."

• Kay...
• Taken for 6 months to 1 year
• May 25, 2023

Tirzepatide for Weight Loss (Obesity/Overweight) "I have been using Mounjaro for weight loss for 9 months. I have lost 90 pounds and have had very minimal side effects. Some nausea occasionally and constipation. I am so grateful to have been prescribed the Mounjaro, as I no longer have heartburn and have alleviated having to take omeprazole daily. My sleep apnea has improved, I no longer snore like I used to and no longer need a sleep mask. The aches and pains have decreased substantially, and I have more energy than I have had in years. I was pre-diabetic, and all of my labs have improved. I am hopeful to be able to continue with the prescription, however, I would be unable to afford the current copay. I fear if I have to stop, I will be back to my same obese status as I was a year ago. The medication not only curbs the appetite but also stops the 'food noise.' If you have this issue, this will totally make sense. If not, I envy you."

• Kim...
• Taken for 6 months to 1 year
• February 21, 2025

For Weight Loss (Obesity/Overweight) "The compounded tirzepatide works great for weight loss, and it’s much cheaper! I have lost 40 pounds in 6 months, so it works very well. Side effects I’ve experienced are constipation, but it gets better in time, especially with the right diet. It’s easy to inject."

• Dav...
• Taken for 1 to 6 months
• February 9, 2025

Tirzepatide for Type 2 Diabetes "I have been taking Mounjaro for 5.5 weeks. I've been on 2.5 mg the whole time. Although this dosage is considered a starting dose and not a therapeutic dose, I have seen a drop in fasting blood sugar from 110 down to 60 (I'm also taking metformin and glipizide). I have had few negative side effects (mild constipation) and have lost 8 lbs. I will talk to my Endo about moving up to 5.0 next and try to start reducing my metformin and glipizide dosages. Note: Although some people have some other major side effects, this drug affects everyone differently. You don't know how until you try it - this includes increasing your dosage."