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Bactrim and Nausea: What Users Say

Nausea: mentioned by 121 users (19.6%)

Based on user experiences from 616 Bactrim reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 19.6%
headaches 16.9%
anxiety 11.2%
rash 10.6%
fever 8.1%
dizziness 7.5%
loss of appetite 6.8%
itching 6.7%
chills 6.3%
allergic reaction 5.5%

Reviews for Bactrim

Commonly mentioned side effects
  • Sad...
  • April 21, 2021

For Urinary Tract Infection "Let me tell you, I was so nervous to start Bactrim after reading these reviews. I thought for sure I was going to have terrible side effects. Turns out, I’m completely fine. The most I’ve had is some nausea/lack of appetite but I get that with almost all antibiotics. Make sure you eat a meal ahead of taking each pill and drink lots of water. As long as you’re not allergic to sulfa drugs, I can almost guarantee that you’re going to be ok :). Remember, temporary side effects are better than a kidney infection!!"

9 / 10
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170 Report
  • Nik...
  • Taken for less than 1 month
  • February 4, 2021

For Bacterial Infection "No!!! Do not take this medicine. I was at the hospital a week ago for a severe UTI. They prescribed me Bactrim. They wanted me to take it twice daily for 10 days. I made it to day 6 and tonight I feel so bad. My legs are tingling, my tongue feels tingly, and my mouth is super dry. I’m having bad stomach cramps and my ears hurt. This is all from this medicine. I’ve been having severe headaches, nausea, and my anxiety is so bad. Please be very aware of taking this medicine."

2 / 10
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108 Report
  • kde...
  • Taken for less than 1 month
  • May 13, 2019

For Bacterial Skin Infection "Posting my experience to hopefully put some minds at ease as reading these reviews really scared me! I am very sensitive to antibiotics and have had adverse reactions to the past three I have taken. I was prescribed Bactrim for a nasty spider bite to help it & prevent further infection. On day two I already experienced immense relief from the pain and the bite started to shrink. I am now on day five and have had no side effects at all except some fatigue and minor nausea at night. Definitely bearable. Be sure to take a probiotic and remember everyone's body is different! I am happy I finally found an antibiotic that agrees with me."

8 / 10
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108 Report

Frequently asked questions

  • Col...
  • August 18, 2018

For Bacterial Skin Infection "I'm on Day 4 of a very high dose (2 tablets twice a day) and it's about the same as when I took it years ago (so far). On the second day, I felt queasy, my tongue and lips were a little irritable, my gut uncomfortable, generally crummy. By the end of the third day I was feeling better on all fronts and I expect/hope to be okay (using it for a MRSA boil; redness is going away rapidly!). I (almost) eliminated refined sugar, drink lots of water, and avoid too much sun. Why so many bad reviews? I guess people who do well (the vast majority) don't visit the site or leave comments. Hope this helps."

9 / 10
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105 Report
  • Wow...
  • Taken for less than 1 month
  • June 9, 2020

For Urinary Tract Infection "I was on this drug for only 2 days until I had the worst stomach pains ever, like it knocked the wind out of me. I had severe diarrhea with mucus and blood that lasted for weeks after discontinued use. It has been a month and I still have nausea with severe abdominal pains, headaches, anxiety, light sensitivity, white bumps on my gums. I’m scared that my organs are damaged, which I am currently being tested for. I have never had any of these symptoms before and was perfectly healthy! I am young too. This drug RUINED my life. I would rate this drug in the negatives if I could. Should not be allowed to be prescribed!"

1 / 10
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96 Report

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  • Jae...
  • Taken for less than 1 month
  • December 23, 2020

For Urinary Tract Infection "Honestly, not terrible. I was prescribed Bactrim, 2 doses/day for 7 days after they prescribed Keflex (which didn’t work). A little nausea after the first couple of doses, some indigestion, some lower back pain. As long as you drink lots of water with the pill and throughout the day, the side effects are pretty mild. I had ginger chews and Pepto for stomach issues that worked well. Eat a big meal before you take the pill too. Kombucha, yogurt, and probiotics during and after the course will help your stomach heal. I would much prefer this over a kidney infection. If you’re having major side effects from day one, perhaps try something different. Everyone reacts differently!"

7 / 10
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60 Report
  • Lau...
  • January 8, 2020

For Urinary Tract Infection "I was prescribed Bactrim for a UTI. I felt fine the first day. By day 2, I experienced horrible symptoms or side effects. I was having severe anxiety, nausea, increased heart rate, and shaking in my body. I called my doctor, and she said to continue taking it, but after reading all of these reviews, I've decided to stop taking the antibiotics. It's so scary to see so many other women going through the same thing!"

1 / 10
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79 Report

More FAQ

  • Vga...
  • Taken for less than 1 month
  • December 18, 2019

For Urinary Tract Infection "Had not read side effects, so did not realize what I felt was caused by the med. My first day on Bactrim, I had side effects of feeling achy and depressed. By day 3, I was shaking, shivering, anxious, and insomnia. By day 5, nausea, dizziness, 100 heart rate, very low blood pressure, extreme anxiety. Pain everywhere, pain in my kidneys, very dehydrated, painful muscle spasms. Day 6, was going to go to the emergency room when I realized it could be the Bactrim and read side effects. Find it difficult to believe a doctor would give this to anyone. It was horrible."

1 / 10
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58 Report
  • Lis...
  • November 24, 2015

For Kidney Infections "Please don't let anyone scare you into not taking this. If you're like me with new medicine, you go online and research every little side effect and review, and convince yourself not to take it. I was really scared to take this as I had bad reactions to Macrobid and Ciprofloxacin, and after reading these reviews, I just knew it was going to be the same way. I'm on day two, no side effects other than a little nausea and a headache. That's the worst of it. We'll see how it goes by day 7, but so far this has been the best antibiotic I've taken."

10 / 10
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74 Report
  • Sup...
  • January 7, 2015

For Urinary Tract Infection "Something really bad happened to me 14 years ago that caused trauma to the urinary tract. Ever since I have used Bactrim on a regular basis to flush out my bladder and urethra of bacteria because my body does not do a sufficient job through urination. If you take it on an empty stomach, it will make you feel really sick, but the medicine is awesome and I highly recommend it."

10 / 10
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77 Report
  • Tha...
  • Taken for less than 1 month
  • December 30, 2019

For Sinusitis "Bactrim for yearly sinus infection related to fall allergies works every time. Three days and inflammation and pressure subsiding. Yes, some nausea and need to follow up for yeast afterwards. Drink lots of water. Best antibiotic for me since I’m allergic to penicillin and its relatives."

9 / 10
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45 Report
  • EJa...
  • July 11, 2013

For Acne "I'm 25 years old and still get those under-the-skin cystic pimples on my face. It is mild but one or two of those monsters just stand out. I've tried Retin-A, every single face wash I can think of, oil-free moisturizers, toners, oil-free makeup. I mean I've done it all, even the DIY remedy for acne. Well, the dermatologist put me on Bactrim, and I have been on it now for about 4 weeks, and my face is CLEAR. I mean I've NEVER seen it this clear! I'm just looking in the mirror all the time because I cannot believe it. Very happy with the results. He said I would have to be on them for a while, but I'm okay with it. It does cause a little nausea, but it's nothing I can't handle and it doesn't last too long. Overall, very happy."

10 / 10
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79 Report
  • kho...
  • Taken for less than 1 month
  • December 16, 2014

For Bacterial Skin Infection "I was put on this medicine for a skin infection. I was reluctant to start it because of all the horror stories on the Internet. It does make me nauseous, and it gives me a slight headache. Advil and Benadryl help with those side effects. I'm on the fourth day, and my infection is nearly cleared. I was also given a Bactroban skin cream, and that stuff is great. A pleasant side effect has been my skin clearing. I had perfect skin up until I hit 25, and then suddenly I had cystic acne on one side of my face. I was reluctant to take anything because it wasn't that bad, but the Bactrim has pretty much cleared it up."

8 / 10
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73 Report
  • Ans...
  • Taken for less than 1 month
  • July 28, 2013

For Urinary Tract Infection "I was prescribed Bactrim DS 2x a day for 10 days to clear a urinary tract infection. I was having nausea, acid reflux, and intestinal/digestive issues that felt like irritable bowel syndrome or stomach flu by the 3rd day. After the 5th day, I decided to stop taking it, and the infection is gone along with all side effects. I am glad I decided to stop taking it, it seems Bactrim DS 2x a day was a bit too much for me."

5 / 10
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81 Report
  • Kay...
  • May 3, 2020

For Acne "I have been on Bactrim Rx for about three weeks now, and I already see a dramatic improvement in my skin. All my cystic bumps are gone, haven’t had any active breakouts since the day I started it. My skin feels smooth and looks alive and glowing. My only problem was that it made me very nauseous (as most antibiotics do for me), so I would have to take it after a full meal. But I highly recommend talking to your dermatologist about this medication if you are tired of suffering and being depressed about your skin. It’ll be 100% worth it!"

10 / 10
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29 Report
  • Anonymous
  • December 20, 2011

For Bacterial Infection "This was not right for me. I had a severe reaction while taking this and had to go to the emergency room. Racing/irregular heartbeat, nausea, shaky legs felt weird, red blotches, slurring speech, red eyes, feverish, and generally felt very unwell."

1 / 10
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60 Report
  • Ash...
  • Taken for less than 1 month
  • November 16, 2017

For Kidney Infections "I was a bit of a moron and let a UTI go for too long. I had pain on and off for a few months in my back. Pee was cloudy, frequent urination... all that good stuff, but two days ago, I woke up and felt absolutely terrible. I was so nauseous, couldn’t eat anything, awful headache, chills, and the worst back pain I had ever felt. I went to the doctor, and she wrote this for me. I took two pills yesterday, and already today I feel a hundred times better. I don’t believe it is for everyone, obviously, due to the mixed reviews, and my mother had taken it before, and it had awful effects on her as well, but I do believe it’s worth trying because for me, it’s been wonderful. I couldn’t even bend over yesterday, and today all I have is slight dull pain in my back. Worked perfectly."

10 / 10
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37 Report
  • Anonymous
  • August 16, 2009

For Bacterial Skin Infection "I was prescribed this for a nasty spider bite that got infected. The infection started getting better after one day, but the nausea is 24/7. I could hardly eat anything and had trouble sleeping because of the horrible feeling in my stomach. I was prescribed 2 pills a day for 10 days. The pills were large."

6 / 10
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64 Report
  • krs...
  • Taken for less than 1 month
  • October 6, 2015

For Urinary Tract Infection "I've taken my fair share of medications for UTIs, and so far, this one seemed to be the most effective as far as relieving symptoms quickly. My doctor prescribed me to take two pills a day for 10 days. I felt relief from UTI symptoms as soon as the 2nd or 3rd day. That being said, it has some nasty side effects. They say you can take it with or without food, and I'm guessing that because it makes your stomach feel horrible either way. I've experienced diarrhea, painful gas and bloating, and nausea since the first day of taking it. From my experience, this can usually be expected with strong antibiotics. My advice would be to take a probiotic to help counterbalance! I've done it before, and it helps me."

8 / 10
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42 Report
  • Sar...
  • Taken for less than 1 month
  • November 30, 2015

For Kidney Infections "Really effective, but really terrible side effects. UTI and kidney infection both cleared up quickly, which I'm grateful for, and ultimately that's the point. But I had nausea and vomiting, dizziness, diarrhea, joint aches, itchy skin, sore throat, loss of appetite... I felt way better with the infection than I did on the medication. But it's all temporary."

7 / 10
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41 Report
  • Bri...
  • March 21, 2017

For Urinary Tract Infection "The ONLY side effect I had from this medicine so far is very slight fatigue right after I take it. Had a pretty bad UTI, took the first dose (2 a day every 12 hours), and within a short amount of time there was no more burning, fullness feeling, or pain. I take this for 10 days and I am on day 7. And no dizziness, nausea, vomiting, or anything. Don't be afraid to take this medicine BUT! EAT BEFORE YOU TAKE IT!! Like a full meal! I think many people aren't doing this, and you should."

10 / 10
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35 Report
  • Ckr...
  • Taken for less than 1 month
  • November 6, 2018

For Kidney Infections "I went to the ER and was diagnosed with a severe kidney infection. I was prescribed Bactrim, 2 a day for 10 days. I’m on day 6, and I’ve felt some nausea, headaches, and mild body aches, and I’ve been very sleepy. BUT as far as the pain from my kidney and chills, etc., I feel A LOT better!! I didn’t have any allergic reactions."

9 / 10
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28 Report
  • Anonymous
  • August 9, 2011

For Bacterial Skin Infection "I cut my finger on a piece of metal under the seat of my car and developed a skin infection. Had the infection drained, but was also prescribed Bactrim twice a day for 10 days. After 2 days, I saw my finger start healing up, and within the 10 days, it was completely healed. I only experienced mild nausea and some insomnia. Other than that, it did a great job! Very satisfied."

10 / 10
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49 Report
  • Bre...
  • August 16, 2016

For Urinary Tract Infection "I called the doctors due to weird symptoms after my 5th day of taking this medication. This concludes (chills, nauseous, diarrhea, headache, and even numbness throughout my entire face, lips, and mouth, and the shakes). The pain I get from my UTIs (burning sensation, hard to pee, and hurts). I felt like Bactrim made my pains worse, the burning was 100x worse! I felt as if I was dying!!!! I even had severe insomnia up until 6-7 am! Called the doctors and they said I should have called when the headaches and shakes came along! Cut me off it immediately and prescribed me Macrobid instead. Hope it helps!!"

1 / 10
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29 Report
  • Anonymous
  • Taken for less than 1 month
  • October 13, 2014

For Urinary Tract Infection "It's currently 12:30 am, and I'm wide awake on a school night typing this. I didn't exactly have all the symptoms of a urinary tract infection, but I always have the urgency to pee. I went to urgent care, and the doctor prescribed me Bactrim. I've been on it for 3 days (today will be my 4th), and I have yet to see results. According to some of you, it doesn't start working until the 5th day, which still gives me hope since the doctor told me it would work within 2 days. What I have been seeing is nausea, diarrhea, shakiness, insomnia, extreme headaches, and loss of appetite. I really hope this works. The constant urge to pee pretty much ruins what little social life I have. Having to make constant trips to the bathroom doesn't fit well with football games."

3 / 10
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46 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.