Bactrim Dosage
Generic name: sulfamethoxazole 800mg, Trimethoprim 160mg
Dosage form: tablet
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BACTRIM is contraindicated in pediatric patients less than 2 months of age.
Urinary Tract Infections and Shigellosis in Adults and Pediatric Patients, and Acute Otitis Media in Children:
Adults: The usual adult dosage in the treatment of urinary tract infections is 1 BACTRIM DS (double strength) tablet or 2 BACTRIM tablets every 12 hours for 10 to 14 days. An identical daily dosage is used for 5 days in the treatment of shigellosis.
Children: The recommended dose for children with urinary tract infections or acute otitis media is 40 mg/kg sulfamethoxazole and 8 mg/kg trimethoprim per 24 hours, given in two divided doses every 12 hours for 10 days. An identical daily dosage is used for 5 days in the treatment of shigellosis. The following table is a guideline for the attainment of this dosage:
| Weight | Dose–every 12 hours | |
|---|---|---|
| lb | kg | Tablets |
| 22 | 10 | – |
| 44 | 20 | 1 |
| 66 | 30 | 1½ |
| 88 | 40 | 2 or 1 DS tablet |
For Patients with Impaired Renal Function: When renal function is impaired, a reduced dosage should be employed using the following table:
| Creatinine Clearance (mL/min) |
Recommended Dosage Regimen |
|---|---|
| Above 30 | Usual standard regimen |
| 15–30 | ½ the usual regimen |
| Below 15 | Use not recommended |
Acute Exacerbations of Chronic Bronchitis in Adults:
The usual adult dosage in the treatment of acute exacerbations of chronic bronchitis is 1 BACTRIM DS (double strength) tablet or 2 BACTRIM tablets every 12 hours for 14 days.
Pneumocystis Jiroveci Pneumonia:
Treatment: Adults and Children:
The recommended dosage for treatment of patients with documented Pneumocystis jiroveci pneumonia is 75 to 100 mg/kg sulfamethoxazole and 15 to 20 mg/kg trimethoprim per 24 hours given in equally divided doses every 6 hours for 14 to 21 days.11 The following table is a guideline for the upper limit of this dosage:
| Weight | Dose–every 6 hours | |
|---|---|---|
| lb | kg | Tablets |
| 18 | 8 | – |
| 35 | 16 | 1 |
| 53 | 24 | 1½ |
| 70 | 32 | 2 or 1 DS tablet |
| 88 | 40 | 2½ |
| 106 | 48 | 3 or 1½ DS tablets |
| 141 | 64 | 4 or 2 DS tablets |
| 176 | 80 | 5 or 2½ DS tablets |
For the lower limit dose (75 mg/kg sulfamethoxazole and 15 mg/kg trimethoprim per 24 hours) administer 75% of the dose in the above table.
Prophylaxis:
Adults:
The recommended dosage for prophylaxis in adults is 1 BACTRIM DS (double strength) tablet daily.12
Children:
For children, the recommended dose is 750 mg/m2/day sulfamethoxazole with 150 mg/m2/day trimethoprim given orally in equally divided doses twice a day, on 3 consecutive days per week. The total daily dose should not exceed 1600 mg sulfamethoxazole and 320 mg trimethoprim.13 The following table is a guideline for the attainment of this dosage in children:
| Body Surface Area | Dose–every 12 hours |
|---|---|
| (m2) | Tablets |
| 0.26 | – |
| 0.53 | ½ |
| 1.06 | 1 |
More about Bactrim (sulfamethoxazole / trimethoprim)
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