Skip to main content

Sertraline for Depression User Reviews (Page 5)

Brand names: Zoloft

Reviews for Sertraline

Commonly mentioned side effects
  • BAa...
  • May 22, 2015

Sertraline "Absolutely changed my life. I am a 20-year-old female who has struggled with depression and irritability since roughly 13. I tried meditation, I tried the 'power of positive thinking', I tried listening to podcasts, I tried counseling. Nothing helped me until Zoloft. I've been taking Zoloft for 5 weeks. I had minor side effects for the first couple of days (looser stool, headaches, stomach aches) but nothing I couldn't handle, and they went away after 2-3 days as I got used to the medication. I'm currently taking 50 mg and don't plan on increasing. I feel overall happier. I'm not as irritable, and things that I used to hate (going to work) are no longer even bad. I feel more myself, and like I'm not afraid to be outgoing. Highly recommended."

10 / 10
Was this helpful?YesNo
139 Report
  • Cos...
  • Taken for 2 to 5 years
  • February 29, 2020

"I have taken sertraline for 3 years and it's my miracle drug. No side effects at all but it took about a month to kick in and I have no intentions of not taking it. I cannot go back to the person I was."

10 / 10
Was this helpful?YesNo
86 Report
  • Lul...
  • Taken for less than 1 month
  • March 18, 2019

Sertraline "Week three, I am feeling amazing and back to doing the things I enjoy. The first two weeks were horrible with nausea, fog, and anxiety. But I read on the link that you need to stick it out. So I did, and I’m glad. 50mg perfect dose. I no longer dwell on my situation, and I see all the positives. I noticed I find it very hard to cry. The dog across the road died, and it was heartbreaking, but I couldn’t cry. I can still think, feel, and be creative."

10 / 10
Was this helpful?YesNo
101 Report

Frequently asked questions

  • Fil...
  • Taken for less than 1 month
  • May 13, 2024

Sertraline "I am on Zoloft 25mg for 2 weeks after Cymbalta, Trintellix, Paroxetine. I suffer from severe anxiety. The main problem now is insomnia. I sleep 3-4 hours interrupted. I think it works well for SAD but not sleeping is limiting the benefits. My suggestion as a 60-year-old experienced depressed individual is - whatever medication you are taking, try to start with minimum doses and stick with it for a while until you can. There's always time to increase, and in case you change antidepressants, it's easier. Try not to mix too many medicines, the chemistry in the brain takes time to adapt. Don't expect miracles from antidepressants. I mean, we all wish there was the magic pill, but an improvement is already a lot. Maybe us depressed individuals can't aim to feel 100% well. If you can read and question what the doctor gives you, they are not perfect. Good luck to all of you and keep on fighting, every day is a new beginning."

6 / 10
Was this helpful?YesNo
24 Report
  • Zat...
  • January 28, 2015

Sertraline "Lately I've been having really bad panic attacks, migraines, night terrors/nightmares every night. For three weeks, I started Zoloft last night, and it already started working within a night. I'm more calm and feel like my old self already."

10 / 10
Was this helpful?YesNo
159 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
  • Buc...
  • Taken for 10 years or more
  • January 3, 2014

Sertraline "I have to say that Zoloft saved my life. I have been on it for over 10 years, but about a year and a half ago, I switched to another pill just to try it. WHY I don't know, I should have never left Zoloft. I then started to take a muscle relaxer for a sore shoulder. BE VERY CAREFUL in taking other medications with any antidepressants. The dread, the worthlessness, the crying all came back. Back on Zoloft for about a week and I can function once again. THANK YOU ZOLOFT."

10 / 10
Was this helpful?YesNo
165 Report
  • Per...
  • July 15, 2009

Sertraline "From the first week when I took this medicine, I can feel a slight change and haven't felt depression or anxiety. But as the weeks pass, I felt much better. I've got my life back, social skills, and feel like everyone else. This drug has really helped to bring my life back."

9 / 10
Was this helpful?YesNo
194 Report

More FAQ

  • mic...
  • December 11, 2013

Sertraline "Before I started taking Zoloft for depression and anxiety, I was also suffering from insomnia. I was taking Ambien and Valium to help, but the Ambien was not really helping my insomnia. Maybe I got 3 hours of sleep or 5 hours on a good night. I suffered from panic and anxiety attacks. I went to therapy, and after some time, the doctor recommended Zoloft. I was hesitant at first, but I could not live like this anymore, so I started taking it about a year ago. Zoloft is the best thing I could have done. The first week or two I had side effects, but soon after, the depression lifted and anxiety was gone. I sleep great now."

8 / 10
Was this helpful?YesNo
153 Report
  • Ihi...
  • Taken for 2 to 5 years
  • July 25, 2024

"Sertraline has saved me from two serious incidents of debilitating depression and anxiety when no other method I tried worked. The first time I was prescribed sertraline, I came out of my depression in exactly 3 weeks after 8 years of hell. The second time depression hit, it took exactly 5 weeks to work. 100 mg of sertraline, 25 mg of pregabalin, and 7.5 mg of mirtazapine (for sleep) have restored my ability to live life. I know the depths of fear, despair, and hopelessness that come from major depression and horrific anxiety that leave you bedridden and unable to do the most simple of tasks, like sit up in bed or use the bathroom. I am so grateful to the psychiatrist at a hospital that put me on sertraline. The second time I fell into serious depression, after a breakup, I spent hours and hours, daily reading these reviews and hoping that sertraline would bring me out of my dark despair again. It did. It took longer, but it worked! I'm so grateful for this medication."

10 / 10
Was this helpful?YesNo
19 Report
  • Anonymous
  • Taken for 1 to 6 months
  • December 11, 2024

"I have been taking 75 mg for 8 weeks. I started on 25 mg and upped to 50 mg after 1 week. After 5 weeks it leveled out and the psychiatrist upped my dose to 75 mg. For the very first 2 weeks, anxiety and depression were worse. I was tearful and felt off balance. I had 2 very depressive days within these two weeks. Then, things gradually started to improve and the side effects (night sweats, increased anxiety and depression, nausea, and diarrhea) wore off. The diarrhea lasted about 5 weeks and the night sweats still happen occasionally but are a small trade-off for the life quality I now have. On this drug, I can feel all emotions. I can concentrate, have my appetite back, and want to go out and meet people and be active. This medicine has given me my life back and taken away the pain, which I can only describe as a deep 'soul pain.' Combined with EMDR therapy, meditation, and sport, I know I'm on the right track."

10 / 10
Was this helpful?YesNo
11 Report
  • Bla...
  • October 27, 2009

Sertraline "I was prescribed Zoloft for depression. I had tried Wellbutrin and Lexapro in the past with little results. With Zoloft, at first, the side effects were tough. Also, I was having sexual side effects. Lacking desire (which is not normal for me), and the inability to achieve orgasm. I decided to try taking my pills in the morning, rather than at night like I had been doing. After a couple of days passed with my new schedule, the sexual side effects subsided, and I'm back to normal with that. I never knew an antidepressant could help so much, but it has REALLY helped me!"

9 / 10
Was this helpful?YesNo
182 Report
  • the...
  • Taken for 1 to 6 months
  • December 11, 2024

Sertraline "It really helped me. I no longer panic or am depressed like I used to be. I love Zoloft, and I am taking 75 mg, and it's going very well, actually, especially since I literally thought I was never coming back from this depressive episode. It took me straight out of it. No side effects after the first two weeks. The only thing I felt was maybe an occasional upset stomach, but it went away completely."

9 / 10
Was this helpful?YesNo
11 Report
  • jay...
  • September 1, 2013

Sertraline "I have been taking Zoloft for 8 weeks and the result has been amazing. The beginning was rocky with nausea, heavy head, and fatigue, but it gets better. I am more confident, better at my job, I enjoy socializing far more, my relationship is saved, and I generally feel more balanced. I have had anxiety since childhood and struck depression in late teens, I am now 27. Not sure how long I will or should take Zoloft, but I am hugely relieved."

8 / 10
Was this helpful?YesNo
146 Report
  • DRE...
  • Taken for 2 to 5 years
  • March 25, 2025

"I was on sertraline for 2-3 years. It probably helped me slightly in the very beginning, when my depression was at its peak. I did not have any positive experience past that. Getting off it was one of the worst experiences. For the 4-5 months it took me to get off of it, I experienced 'false flu' and 'brain shock' symptoms. This would happen after about 2-3 days of not taking it (following months of dosing down to 1 pill every 2 days, then half a pill every two days, etc.). Those days when I experienced the withdrawals erase any of the positive effects I may or may not have experienced. Note that I never increased my dose, which some have found success with. I always figured that'd make it worse. I've taken Lexapro as well. Neither helped me reach my goal of having little to no anxiety and depression. However, improving my diet and working out more often, as well as finding hobbies and therapy, did wonders for my mental health."

3 / 10
Was this helpful?YesNo
4 Report
  • Sha...
  • Taken for less than 1 month
  • September 4, 2016

Sertraline "I have been on 50mg of Zoloft for a little over 3 weeks now. For the first week, I noticed no change, then gradually I was feeling better. It has given me more energy, and I feel I have a more positive attitude. I was overeating a lot due to stress and depression that has completely subsided. Since I started taking it, I have lost 19 pounds. That has also really helped with my depression. I am scared of my body getting used to it and going back to my regular habits. As for now, I am happy."

10 / 10
Was this helpful?YesNo
113 Report
  • Abb...
  • Taken for 1 to 6 months
  • August 16, 2017

Sertraline "I took Zoloft (generic) shortly after my anxiety got horribly severe. I took Lexapro a few years ago but didn't like the sexual side effects. My doctor put me on Prozac, but that appeared to put me into a deep depression. I had never had depression, just anxiety, but I couldn't get out of bed, I was just paralyzed. After a few weeks of that, I decided to try Zoloft. Within the first three weeks, I felt tremendously better. By 6 weeks, I felt totally back to normal and NO sexual side effects! This has been my miracle drug."

10 / 10
Was this helpful?YesNo
105 Report
  • A...
  • June 27, 2016

"I have been in a major depression for 3 years, and possibly a minor depression before that. I also have anxiety and social phobia. I have been on Sertraline for almost two months now, and I noticed an enormous difference in the first few days. I started to smile, laugh, make eye contact, and the fear of public is slowly easing! I cannot describe how bad life was before Sertraline. I am 34 years old and have been living a life that wasn't a life at all. Now I am feeling better than I have ever felt. I do get dry mouth, but oh, to laugh again! (Worth it). I am usually not a person who even uses Tylenol, so for me to try this, I was desperate. I don't feel high, nor drugged, or even out of my body! I feel whole."

10 / 10
Was this helpful?YesNo
112 Report
  • Sar...
  • Taken for 1 to 6 months
  • September 5, 2018

Sertraline "When my doctor prescribed me Zoloft, I was scared of the side effects and put off taking it for a few days. Now I could not be happier that I started taking it though. I have been on 50mg for almost 5 weeks and have not noticed any side effects. My depression has gotten so much better. I wake up excited about the day and just feel generally happy, nothing feels so difficult anymore. I haven’t cried once since starting the medication, whereas beforehand I was crying every day and all I wanted to do was lay in bed. My friends and family, as well as myself, have all noticed a huge difference in me. I’m so happy with my progress on Zoloft so far. I am hoping that it helps improve my general and social anxiety soon because I have not seen much of an improvement there, but I know it can take 8 weeks. Definitely recommend this medication and don’t be scared to start taking it! The side effects are rare, and it will be the best decision of your life."

8 / 10
Was this helpful?YesNo
92 Report
  • Wac...
  • October 9, 2018

"My symptoms were anxiety, depression & intrusive/repetitive thoughts. I struggled initially with side effects when starting on 50mg (deepened depression, headaches, dry mouth & insomnia), which I had reduced to 25mg during week 1, which I found helped. Week 2, I raised again to 50mg and the side effects began to wear off. I continued on 50mg until week 4 and showed small signs of improvement (sleeping longer, reduced anxiety and depression), I had good days and bad days! I spoke with my GP, who increased my dosage to 100mg and have been taking for 1 week. I noticed some mild side effects resurfaced initially, but faded after a few days. I am now beginning week 6 and I am beginning to feel fantastic and back to my old self. I have read other posts on here seeking inspiration and positive feedback, so wanted to give something back. If you can get through the early phases and stick with this med 4-6 weeks, and if compatible, the Sun will certainly shine once more."

10 / 10
Was this helpful?YesNo
95 Report
  • Ser...
  • Taken for 1 to 6 months
  • December 6, 2014

Sertraline "I took Sertraline for Moderate Depression which it was exceptionally good at diminishing. I have been taking it for just under 6 weeks for moderate depression, social anxiety and generalized anxiety. It worked for depression the best, by far; however, not half as good for the anxiety, perhaps because it requires a higher dose and longer intake. Definitely consider Sertraline for depression, its side effects were minimal (if any because it was so unnoticeable)."

10 / 10
Was this helpful?YesNo
137 Report
  • Wee...
  • January 28, 2013

Sertraline "Zoloft is amazing. I was put on Lexapro when I was about 18, gained about 20 lbs and felt like a numb zombie for about a year. Tried Celexa for about a year - a little better, but I was still getting very depressed. Then I tried Zoloft (50mg for a month and 100mg since). I've been on it for about 2 years. Depression and anxiety are minimal. I rarely have to use my Xanax. The only side effect I've had is dry mouth, but it's minimal at worst. My appetite and sleep patterns are normal. As with the others I've tried, my sex drive is very low and I had moderate headaches for the first couple of weeks, so I won't pick on Zoloft for that. Overall, extremely satisfied, I can't imagine my life without it."

10 / 10
Was this helpful?YesNo
145 Report
  • Liz...
  • Taken for less than 1 month
  • March 5, 2016

Sertraline "So far, this drug has saved my life. After experiencing a traumatic experience, I spiraled into a heavy depression coupled with anxiety. It's only been one week, and I'm no longer crying daily, and the hopeless feeling is subsiding. It's also helped stop the obsessive thoughts I've been having about the traumatic event."

9 / 10
Was this helpful?YesNo
121 Report
  • Mil...
  • April 18, 2014

Sertraline "After years of trying different medications, sertraline has finally been the most useful and compatible one for me. If only I had found this years ago as it has lifted my depression, improved my social skills, and eased my obsessive-compulsive disorder symptoms (would trigger after anxiety)."

9 / 10
Was this helpful?YesNo
136 Report
  • Hop...
  • Taken for 1 to 6 months
  • October 14, 2015

Sertraline "I've been on Zoloft for 3 months now. Initially, I suffered from side effects such as shivering, loss of appetite, drowsiness, and insomnia. These symptoms lasted for about three days. I was scared at first and planned on trying another medication for anxiety. However, I called my cousin who is a nurse, and she told me to try cutting the pill in half. I took my cousin's advice and cut the pill in half, taking only 25mg a day, which works really well for me. I'm 5'4, 130 lbs. I no longer suffer from anxiety. After taking Zoloft, I realized that I was suffering from depression. Zoloft alleviates my anxiety and has greatly helped with my depression. I now feel happier and more motivated to do things right away without procrastinating. Life-changer!"

10 / 10
Was this helpful?YesNo
119 Report
  • ano...
  • February 2, 2014

Sertraline "I'm 16, and over the course of a few months, I started becoming more and more depressed and anxious. After trying a few other medications along with none at all (only therapy), I started taking Zoloft as it has helped others in my family. The first 10 days (started at 25mg) were horrible - suicidal thoughts, no appetite, headaches, and terrible anxiety. But once I hit 2 weeks, I felt so much better. I'm now 6 weeks in and on 75mg. I feel amazing, still get headaches but I'm not sure if it's related. I feel almost 100% myself. I'll give it a few more weeks and see if I need to maybe get to 100mg, but honestly, this medication saved my life."

9 / 10
Was this helpful?YesNo
138 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.