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User Reviews for Sertraline to treat Depression

Also known as: Zoloft

Sertraline has an average rating of 6.9 out of 10 from a total of 1052 ratings for the treatment of Depression. 58% of those users who reviewed Sertraline reported a positive effect, while 21% reported a negative effect.

Sertraline Rating Summary

6.9/10 average rating

1052 ratings from 1122 user reviews.

Compare all 189 medications used in the treatment of Depression.


Reviews for Sertraline

Cobbette · Taken for 6 months to 1 year May 2, 2021

“I've been through so many antidepressants and none of them worked. One I was on for 7 months which CAUSED anxiety and didn't touch my depression. The psychiatrist who was doling out the meds never jumped in and said "Hey - This isn't working. Let's do something else". Just kept trying to fix the anxiety. The day after I stopped the drug - Viibryd - anxiety dropped 75%. Now she wants me to start Sertraline. I am so SCARED. Somebody please give me some encouragement. I'm about to lose my mind.”

1 / 10
iliketrees · Taken for 1 to 6 months May 1, 2021

“overall: eh I got the sertraline prescribed for depression specifically (that was the biggest issue at the time), but was essentially a sugar pill for that at 200mg reduced Social Anxiety by about 40% and non-complex PTSD symptoms about the same. It did nothing for/maybe made disordered eating worse in hindsight? Also helped reduce complex PTSD symptoms by maybe 10%. a lot of GI side effects but nothing intolerable. If your main issue is anxiety, even from multiple sources, I'd say it's a good bet”

6 / 10
Antonio · Taken for 1 to 6 months April 29, 2021

Zoloft (sertraline): “Zoloft really help me out my life back on track. I was hesitant at first reading through the side effects and put it off for a while. Once the therapist convinced me and I got on, it took me about a month to notice the effects. I just had some appetite suppression for the first weeks but that went away. It really feels like the was a missing puzzle piece in my life and I haven’t looked back since. (50mg)”

8 / 10

Frequently asked questions

Saved_MyLife September 9, 2019

Zoloft (sertraline): “I’m 36 and I’ve dealt with depression my entire life. I was also irritable. It would come, hit me hard, and then go away. I thought diets, sleep etc could help me. They would only at first. I gave Lexapro a try, my first medication ever. It helped some and I wanted to “settle” with Lexapro because at least my depression was at bay Two years ago I started Zoloft and it literally saved my life, marriage, memories with my kids, saved me from me. I truly didn’t know what normal life was like until I started Zoloft. It hasn’t changed me, it helped me be the true, happy me that would show up periodically. All those “organic” ways might help some people. Just don’t think “big pharma” can’t help you, like I did before I tried meds. I never ever ever thought I would be saying that. For two years now I’ve been alive, I’ve run my business like never before; I’m patient with my kids, my wife, my family. I hope so badly this review helps someone out there who is just like I was.”

10 / 10
JMM February 7, 2020

Zoloft (sertraline): “2 mths ago I was desperately going through these pages to find something positive about sertraline My had mother died and my daughter, 3 weeks after, went into treatment for 6 weeks for anorexia. Long story short, I had an acute panic/anxiety/depression event in early December. I started on Zoloft 25mg on Dec 11. I had most hours of feeling 'ok' but I was frustrated that I was still feeling that adrenalin and anxiety. By week 5 I was still frustrated by feelings of anxiety. Then everything lifted. I promise you will feel better. I absolutely promise. Stick with it. But do the work too! Go out! Exercise! Eat well! (I had no appetite!) Don't watch the news. Look for the small things. And read or listen to Claire Weekes on you tube (it's like your grandma giving you a talking to) xxx You will be better x”

9 / 10
Was scared to start September 3, 2020

Zoloft (sertraline): “About 6 weeks ago, I started Zoloft at 25 mg for GAD, mild depression, and some PTSD and OCD symptoms. Before you continue reading, please understand that my experience likely will not be yours, as is the case with every single review you'll read. Do not be scared to start. It absolutely helped. My overall mood didn't change much, but it helped the physical symptoms of my anxiety and helped me cope with my life stresses. I began to enjoy doing things I love again. I still had bad days, but I was overall functioning well and productive, although I still had not the best outlook on life. Side effects I experienced: insomnia, daily headaches similar to hangovers, shakiness, increased depression the first week, decreased appetite, menstrual changes, and decreased libido. Again, this is just my experience. Do not be afraid to give it a try, people are much more likely to leave negative reviews, I just wanted to leave a review to help others. Best of luck, you've got this!”

6 / 10
2020 · Taken for 1 to 6 months January 14, 2020

Zoloft (sertraline): “Hello, I have been taking Sertraline for almost two months and I give it 10 out of 10, I feel amazing! In addition to taking the medication, I created my own healing plan: drink water, 8 hour sleep, cognitive behaviour therapy, cut off alcohol, caffeine and sugar, eat vegetables, fish, fruits and nuts, exercise 3 times a week, take vitamin D, B12, magnesium, spend time with friends and family, enjoy the sun, do something fun, meditate and do yoga (try these apps: Calm and Headspace). There is also a free app called Flow which help you to treat depression, have a reiki session and let go what is not making you happy (job, relationships, addiction), etc. Medication is great but you need to look at other aspects of your life as well to heal :-)”

10 / 10

More FAQ

Jay · Taken for 1 to 6 months June 8, 2020

Zoloft (sertraline): “I started taking zoloft after 8 months of post concussion syndrome symptoms. My anxiety and very low mood were affecting every aspect of my life. I was suicidal. I started with 50mg for the first month. Only side effects for me was a bit of nausea the first week and a lack of appetite. By week 4 we went up to 100mg and everything has improved significantly! I can separate emotions from facts which I couldn't do before. The people I thought were "against me" don't seem to bother me whatsoever now. I've gotten my life back. I have energy and an optimistic attitude. My friends and family have noticed in big ways. It's been a life changed for me. The only thing I would say are side effects Low libido Shortened Sleep. I usually wake up in the middle of the night now.”

10 / 10
wbb July 31, 2008

Zoloft (sertraline): “I remember reading people's opinions, online, of the drug before I took it and it scared me away from it. Then I finally decided to give it a try and it has been the best choice I have made. I have been on it for over 4 months and I feel great. I'm on 100mg and I don't have any side effects. When I first started I did notice that my hands would tremble but then it subsided. So honestly, don't listen to all the negativity because what doesn't work for some works amazing for others. So go based on youself and not everyone else. It may be a blessing in diguise. The pill is not meant to make you be all happy go lucky and see "butterflies and roses", its meant to help put the chemicals in your mind in balance so you can just be who you are and not overly depressed. I still get sad some times, but that is normal, that is life, and it's up to people to take control to make a change. I did so by getting on this pill.”

10 / 10
ozzy21 · Taken for 1 to 2 years December 23, 2020

Zoloft (sertraline): “A few a year ago I smoked a high strain of cannabis and a few days later started to have severe anxiety, something triggered and I went into a deep depression. I was living the life, amazing career and beautiful girlfriend, everything I could ask for. Then this hit and I was so deep into depression that I didn't want to continue anymore. Antidepressants were my last choice, and THANKFUL I did. I didn't want to get on them because I thought I was weak and couldn't get over it on my own. Symptoms were high depersonalization and feeling detached, hopelessness, isolation, etc. I thought it was over at age 24... but listen... It's not. I am living the best life now and have my dream job. Antidepressants do not make you weak. They make you brave and proud of yourself at the end of it. I have become a better person from all of this and you will too. Do not give up, because you will be back to normal. It took a good 6 - 8 months before they did their job. It takes awhile to kick in.”

10 / 10
Thistooshallpassxo · Taken for 1 to 6 months September 5, 2017

Zoloft (sertraline): “MOTIVATION MONDAY: to the lovely folks just like me who spend hours searching online forums looking for something to give you hope. I understand. I want to share what I've learned. When I was in my darkest place I would read reviews about meds not working or awful side effects. I was convinced no medication would work for me because of this. BUT this one did! Please know, there is a light at the end of the tunnel! ALWAYS. You are not alone. You are not crazy. Don't give up. You'll be feeling normal again before you know it. This too shall pass!”

10 / 10
Grateful October 2, 2019

Zoloft (sertraline): “Hi guys - just like all of you I scrolled these reviews for hours both before and during my Zoloft treatment. I’ve been on Zoloft 5 weeks now (7 weeks if you include the first two weeks on 25mg which is below therapeutic dose). I tried two SSRI’s before Zoloft and each made me violently ill or suicidal. The side effects of Zoloft have been minimal none - just a mild headache as I up my dosage. I have currently moved up to 100mg, week 6!! My experience has been incredibly positive. I let go of things easier such as fights with partner and I don’t have horrible recurring thoughts. I still have had a total of about 8 bad days over the course of Zoloft but that is life!! This is not a magic pill. In fact - my anxiety has subsided so much that I’ve become incredibly bored! What do I do with all this free time?! It’s made me reach my life’s purpose and it has given me hope. Please don’t give up. I wish I tried Zoloft sooner. Sending love and hope to you all x”

8 / 10
Anonymous · Taken for 6 months to 1 year June 9, 2020

“Back in February I started having hot flushes, then felt dizzy and odd day a bit down, then a week later I had anxiety, which I had the same in 2007 when my mum died, so my doctor put my on sertraline, I went from a dose 25mg to 50mg and true for the first two months I had every side effect, head aches, blurred vision, cloudy brain, sick, anxiety, up and down days but came on this group to keep my positive and kept with them, now 5 months on I'm almost back to myself I do have odd days but that's life, and just get over it, so for anyone just starting sertraline, please be ready for a few weeks of feeling really rubbish but believe me u will soon start to feel better and it will work for u so hang in there, As we all deserve to be happy.”

10 / 10
Anonymous August 5, 2008

Zoloft (sertraline): “I've been on Zoloft 50mg for over two years. I am a more relaxed and easy-going person because of Zoloft. Prior to starting the medicine, I was anxious all the time, worried constantly about everything, and suffered periods of depression and hopelessness. Now I am a better wife, friend, and person in general.”

9 / 10
Stone · Taken for 1 to 6 months June 7, 2020

Zoloft (sertraline): “I’m 50 and have struggled with anxiety because of my 26 year relationship with my wife. After 60 days I don’t have the breakdowns any more and can function. Zoloft helped me to close off to her and begin to feel safe emotionally. It really works.”

9 / 10
Anonymous November 2, 2020

Zoloft (sertraline): “I’m 28, 106 lbs & never taken anything like this before. I went through a very bad breakup which I think led to me having a couple of mild panic attacks. After the 2nd panic attack I saw a psychiatrist. He told me that if we could deal with my mild depression that the anxiety/panic attacks would go away. He started me on 50mg of Zoloft. I’m reading through these reviews & see that most people start on 25mg. The first few days my panic attacks got SEVERE. I had suicidal thoughts I never had before. I was constantly tense with fear, couldn’t eat or sleep. I almost went to the hospital. I was scared to be around family or out in public. It was AWFUL. I felt paralyzed. After 7 days I decided to stop taking it and have been in bed for the last two days. I’m already feeling SO much better but still feel like it needs to get out of my system more. I’m very traumatized. They say things can feel worse before it gets better but to me that is a very dangerous game to play!”

1 / 10
Smiley · Taken for less than 1 month August 23, 2020

Zoloft (sertraline): “Surprisingly, positive effects from Zoloft started the next morning after taking my first 25mg dose at dinner the night before. I felt so good, I thought this is what normal is. I haven’t felt this good in I don’t know how long. My doctor offered counseling in addition to the Zoloft, but it works so well, I don’t think I need it.”

9 / 10
IBS/Crohn's fighter · Taken for 6 months to 1 year June 23, 2020

Zoloft (sertraline): “I have been taking Zoloft for several months. I have IBS which flares up when I'm anxious, and Zoloft really helps with that. It has very few side effects and I feel more like myself when I'm taking Zoloft. I do have one small complaint: when I miss a few consecutive doses I tend to get dizzy. But that's it! Other than that, I have no issues with Zoloft. It's very subtle, and it certainly has improved my mood.”

9 / 10
Mich · Taken for 1 to 6 months February 10, 2020

Zoloft (sertraline): “This drug saved my life. I started having chronic anxiety and depression very suddenly, and insomnia. I am so thankful for the positive and encouraging reviews on websites like this, because they helped me push through this difficult time, and I hope to do the same for someone else. I agree with many other reviews that it does get worse before it gets better. My anxiety increased at first, I think out of desperation for each day to finally be the day I would feel normal again. But it takes time and patience, and there will be ups and downs. I started seeing improvement around 4 weeks, but took a dive again around week 5 before increasing my dosage. Now I am at about week 7-8 and I would say 90% myself again. I highly recommend doing therapy too, and Xanax has helped curb the increased anxiety while my body adapts. Side effects are minimal, just nausea if I don’t take it with food. Zoloft helped me get my mind back under control and enjoy life again!”

10 / 10
Igobyharris October 2, 2020

Zoloft (sertraline): “I literally felt something happy the first day. I'm not kidding. I took my first pill at 6:15 10:00am, I felt like I couldn't complete a sentence without thinking really hard about it... Then noon came, I got off early from work...I came home, and felt fantastic. I felt good. I'm very intune with my body. I can tell if I'm getting a cold sore days before I get one, and I can tell this/that just by taste in my mouth, or how I smell something. I take other meds, but this one, Zoloft, I actually felt something positive the first day. I believe this is going to be good for me. I used to take Paxil CR, but if I didn't take it absolutely on time, or whatever,...I was off for a week (or in jail).. no, I'm not kidding, my depression has taken me places you don't wanna know... My experience today is that I actually feel happier than I have in months... I guess I'm lucky that way! :)”

10 / 10
Lisa September 23, 2020

Zoloft (sertraline): “Last February-April I had a really bad bout with anxiety and depression I tried Prozac and Cymbalta and had really bad side effects with both of them. I started 25mg of Zoloft in May 2020. About a Month later I went to 50mg and now am up to 75mg. I may even consider going to 100mg. The Anxiety was better pretty quickly...the fatigue/depression took a bit longer...still some improvement needed, but so much better. I have also noticed that my PMS is barely noticeable. Very little to no agitation in the days before my period. My advice would be to increase slowly and allow time for improvement. It is gradual and can take months...but worth the wait.”

10 / 10
Dani F. September 6, 2016

Zoloft (sertraline): “I told myself that if a miracle happened and this worked, that I would write a review. Let me start off by saying that this drug, literally, saved my LIFE. I've always battled anxiety and panic attacks, and was on a small dose of Paxil and that seemed to take the edge off. I took it on and off for years. After I had my second baby at 28, I got terrible postpartum depression. I had thoughts of suicide, racing thought constantly, couldn't nap and took forever to fall asleep at night. I literally spent three months just thinking and obsessing over how horrible I felt. I wanted to crawl out of my skin and die. I was barely showering, brushing my teeth and hair and would stay in the same sweatpants and shirt for days. I could go on forever by I'll get to the point. After three months of pure hell, I went to my doctor for help. I was prescribed 50 ML of Zoloft. After being on it for 4 weeks, I stopped taking it because it wasn't working. After going another 2 weeks feeling miserable, I went to my doctor again. She recommended we up the dose and stay on it for atleast 6 weeks. Well, after two weeks on 100 ML, I realized I was feeling better. I would go minutes without thinking negatively, then I would go hours, then full days. It feels SO good to feel like myself again. I truly thought I would be miserable forever. Please get help and try something if you are feeling terrible. Everyone is curable with the right drug and right dose. I wish I got help sooner. TRY THIS! It will work! If for some reason it doesn't, try something else! GET HELP NOW! I was doing the same thing you are - googling all types of antidepressants convinced there was no cure and they would never work. Stop spending your life wondering when you will be yourself again. You WILL get better and be 100% your old self again with an antidepressant!”

10 / 10
Daddyo August 20, 2020

“Comments abound on this page regarding Sertraline's negative side effects. I don't understand why people bother to leave negative feedback as all side effects mentioned are in the information leaflet that come with the medication. Furthermore, most negative reviews are from folk who have not stayed on this medication long enough to experience anything positive. You need to give it at least 8 weeks to see the benefits, if you don't you may be missing a glorious opportunity to get better. Your doctor should tell you these things beforehand.”

8 / 10
Boo January 8, 2019

Zoloft (sertraline): “I started taking Zoloft yesterday and after reading hundreds of reviews, I have to share my own experience. Don't listen to all of the negative reviews and give this drug a shot. No matter what you try, there is a chance it won't work and there will be side effects. Your best bet to getting better is to just TRY and give it time to see if it works for you. Last night I took my first pill and was waiting for the worst to happen after reading about the side effects. But all of a sudden, my bed became comfortable. Food had flavor. I started to smile and actually felt like talking to one of my friends. I willingly took a shower and I felt like singing and dancing. I felt completely sober and like myself... just without any of my depression or anxiety. I am facing some of the side effects, but that glimpse of what my life would be like without depression/anxiety gave me so much hope for this drug.”

10 / 10
brossi228 June 9, 2010

Zoloft (sertraline): “Withoug Zoloft I would probably be dead or killed. I have been taking Zoloft for 19 years. Since my daughter was born the doctors have tried to take me off, but the depression started again. I did counseling and reduced the dose, but to be completely off makes me mean. I snap at people, easily irritated, road rage, body feels like it will explode with anxiety. It has never effected my sex drive. No weight gain can be blamed on Zoloft, probably feeling more sociable and going out to eat has caused a little weight gain. No headaches. Thanks for reading and I hope I helped. ”

9 / 10
Michibelle April 21, 2014

Zoloft (sertraline): “I was suffering from being a slave to my negative thoughts, making assumptions about my relationship that my partner was cheating on me or having a secret life, constantly being controlling over where things go in the house, how things should be, really severe mood swings and ridiculous anger which I would ignite a lot of arguments and have the urge to get physical and just completely lose it and not think rationally. My marriage was on the verge of failure due to my negative actions and my husband was at his breaking point. My doc prescribed me 50mg of Zoloft and I finally started it, I'm on week 2 and I feel incredibly calm, content and full of life again. I feel like I can handle situation in a positive manner.”

9 / 10
Anne5335 January 18, 2009

Zoloft (sertraline): “I am 55 years old and have been taking Zoloft over 20 years. For me it has been a miracle medicine. I find I am much more on an even keel and while some things still upset me, it's far less than without Zoloft. I find too I am much more rational in my thought processes and am more confident of choices I make. I have several medical conditions that contribute to feeling depressed, overwhelmed, and yes, even suicidal but since I began my therapy with Zoloft, I want to live. Without Zoloft, I did not. I encourage anyone who feels depressed to seek help by finding the right medication for you. Life is hard enough without having to cope with feelings of severe negative emotions. I am so grateful for whoever created Zoloft.”

10 / 10
Fireworks January 18, 2021

Zoloft (sertraline): “I went to the doctor for anxiety and was prescribed Lexpro which has worked in the past for me, but for some reason it didn’t work this time. The doctor had me stop Lexpro immediately and start 25 mg of Zoloft. I started on 25 mg and increased over the next 4 weeks to 150mg. Let me just say the next few weeks was horrible and reading these reviews encouraged me and made me want to push through. I skipped over all the bad reviews to stay focus. I took Xanax at night just to help sleep but just bared through the day with nothing. I had lost 27 pounds in 5 weeks. I was beginning to think it wasn’t going to work. On the 5th week I got up and couldn’t walk. Let me just say I felt a big difference going into the 6 week. The medicine finally kicked in. God heals by miracles and by medicine”

10 / 10

This information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.