Semaglutide and Vomiting: What Users Say (Page 4)

• For...
• Taken for 6 months to 1 year
• May 17, 2022

Semaglutide for Weight Loss (Obesity/Overweight) "I started Wegovy in December 2021 at 281 lbs, and as of May 2022, I am weighing in at 246 lbs (35 lbs lost). I am on the full maintenance dose at 2.4 mg. I didn't notice many symptoms early on; however, as I got to the 1.7 & 2.4 mg, my side effect symptoms greatly increased - including vomiting, nausea, diarrhea, and a nasty burnt popcorn taste in my mouth. This medication will definitely cause you to lose weight as it completely takes away your appetite, but the combination of side effects, mostly the vomiting, makes me question if I will stay on this medication much longer. For reference, I take my medication on Saturday evening and suffer the side effects until about Thursday morning. From Sun-Wed, I find myself in/out of the bathroom throwing up when I attempt to eat the most basic of foods. I used to have a large passion for food, but I can't imagine eating some of my favorite things while these side effects take over. I would recommend for those suffering to lose weight with caution."

• Joh...
• Taken for 1 to 6 months
• March 7, 2023

Semaglutide for Type 2 Diabetes "I started with the 3 mg. Within a week, my bowel movements became loose. Other than that, it was fine. Started the 7 mg after a month. Within a week, I was nauseated constantly, along with diarrhea. The nausea got worse, and diarrhea continued. At three weeks, I had to stop taking it. The very next day, nausea stopped, and I have normal bowel movements again. I do not recommend this medication. Also, vomiting was a relief a few times."

• Ano...
• Taken for less than 1 month
• June 18, 2025

Semaglutide for Weight Loss (Obesity/Overweight) "Lost 10 lbs in 3.5 weeks, but the side effects mean I will be stopping. Diarrhea, vomiting, stomach cramps, headaches, bloating. Felt ill most of the time. Working and traveling problematic due to having to be close to a toilet!"

• Kas...
• Taken for 1 to 6 months
• September 29, 2021

Semaglutide for Cardiovascular Risk Reduction "I have been on Ozempic for 3 months now, the first day I vomited but haven’t since, nausea for the first month or so, and I got very constipated, but now all is good and I suffer no side effects anymore. So far, I have lost 22 kg, I have no sugar cravings, and my appetite is right down, making sure I eat healthy meals is the only challenge as I do not feel like eating. But I could not recommend this enough to anyone who really struggles with food and weight loss."

• Hat...
• Taken for less than 1 month
• July 19, 2022

Semaglutide for Cardiovascular Risk Reduction "This is the worst medication I have ever had. Side effects of egg burps, vomiting, bloating so bad. DO NOT TAKE THIS. 30% of people that try this drug end up having problems with it. DO NOT TAKE. You can't eat, everything that goes into you makes you want to throw up. DON'T TAKE! Never-ending nausea and weakness. DON'T USE, SAVE YOURSELF. Headaches....."

• Dck...
• January 13, 2021

Semaglutide for Type 2 Diabetes "I’ve been on Ozempic for 8 weeks, .25 starter dose for the first 4 weeks; it suppressed my appetite, a couple of mild headaches, and intermittent nausea. Moved to .5 at week 5 and have no desire to eat at all. It’s almost a problem as I feel so weak and have all-day nausea. Hard to tell if the nausea is from not eating, Ozempic, or both. At week 6, I also started taking Humira for spondyloarthritis; the combined side effects are brutal. Sick nearly 24 hours a day, constant nausea, vomiting with any exertion. Backed off the Ozempic to .25; the side effects are better, but still troubling. As a positive, I’ve lost 30 lbs in 8 weeks, all from not eating as I feel too sick and weak to walk or work out. The docs prescribed Zofran 8 mg po every 8 hours as needed. It helps, and I do manage to eat a couple of small meals. Weigh the benefits and downsides, but it does work. A1C dropped from 8.7 to 7.4 in the first 8 weeks and should continue downward with prolonged use and accompanied weight loss."

• Gre...
• Taken for less than 1 month
• September 27, 2019

Semaglutide for Type 2 Diabetes "Took first Ozempic shot in doctor's office. Felt okay through the week. Took second shot and started getting sick that night. Diarrhea and vomiting. My wife had to help me off the floor of the bathroom. Missed 2 days of work. Had to make an emergency visit to the doctor to get pills to stop vomiting. And the sulfur burps were horrible."

• Chu...
• Taken for 1 to 6 months
• June 3, 2019

Semaglutide for Type 2 Diabetes "I have taken Ozempic for about 6 months. I take it every Wednesday. By Wednesday night, I am experiencing the sulfur burps. Then comes the vomiting and diarrhea. This reaction has gradually gotten worse as time goes by. I ended up in the ER this last weekend to get fluids and to make sure I wasn’t getting pancreatitis. After four days of this, my digestive system is returning to normal. I have lost weight (26 lbs). But, if you can’t keep anything down, you certainly will. I consider this a dangerous drug, and the FDA needs to remove it from the approved drugs."

• 9ru...
• Taken for 1 to 6 months
• September 10, 2022

Semaglutide for Cardiovascular Risk Reduction "Absolutely horrific. I get it works for most people, but unfortunately not me (and should not be promoted as a miracle drug that can help all obese people lose weight, as it doesn't work for everyone). I took 0.25 (the smallest dose) for 3 weeks and nothing (I yo-yoed with my weight; lost a bit then gained it again). After 3 weeks (not sure why 3 weeks for me), the main side effects kicked in. Diarrhea/loose stools, constipation, vomiting, nausea. Worst side effect was for 3 nights in a row, at about 3 a.m. I projectile vomited. First night I almost aspirated and choked on my own vomit trying to make it to the toilet without throwing up. Second night, even though I had the bathroom bin next to my bed, I was still projectile vomiting, and I couldn't sleep as I had a panic attack that I'd pass away overnight and my family would find me dead as I couldn't breathe as I had undigested food stuck in my esophagus. Gave up after 5 weeks of the lowest dose."

• Thi...
• June 27, 2018

Semaglutide for Type 2 Diabetes "I've been taking this for 2.5 months. I've lost a solid 10 pounds. I take it right before bed so I can sleep off the initial side effects, if any. There is a little bit of diarrhea, nothing too crazy. I have major loss of appetite, I can eat half meals or half kids' meals and I'm always full after a few bites. Sugars are low. The major side effect is nausea, but it isn't every day. I've thrown up 3 times within the past 3 months, which is something I never did prior. It comes out of nowhere, and honestly, I'm unsure if it is this injectable or just from taking an iron supplement and vitamin. Could be the vitamin. I feel tired also, not sure if it's just work or a side effect. Overall, I'm happy with the injectable, plus it beats taking a pill every day."

• Lau...
• January 21, 2021

Semaglutide for Type 2 Diabetes "I started Ozempic mid-November, with my first injection at 25 mg. Within two days, I had the worst bloating, my stomach bulged. I felt horrible. I had nasty sulfur burps and gas. This lasted for 24 hours. I noticed a decrease in my sweet tooth, and I cut back on my food intake. I lost 10 lbs within the first 4 weeks of taking Ozempic. After 4 weeks, my doctor told me to increase my dosage to .50 mg. I delayed increasing it by 4 weeks. On Monday, I increased my dosage to .50 mg. Day 3, I got really sick, bloating, sulfur burps, and gas were horrible. I vomited at least 2 times. I was super hungry but couldn’t hold food down. All I wanted to do was sleep. By morning, I felt 80% better. Still burping and gassy, but not nauseous or vomiting anymore. I do not plan to continue to take the .50 mg. I will just stick with 25 mg. The misery I felt was excruciating, and I can’t handle it. My next appointment is next month, and I am curious to know if my A1C had decreased or not."

• Bis...
• April 7, 2023

Semaglutide for Weight Loss (Obesity/Overweight) "I am going on week 11 with Ozempic, and have lost 24 pounds. I have had all 5 of the main side effects, nausea, stomach pain, vomiting, diarrhea, and constipation. I am happy with the weight loss, so am learning to manage these. By trial and error, I've found that I can't eat much at one time (don't really want to), need to avoid fatty foods, drink lots of fluids, and take Senna laxative every night for the constipation, and keep Zofran around to help with nausea. Yes, these first few weeks have been difficult, but the weight loss is worth it to me. Plus, the side effects get less the longer I'm on Ozempic. I am currently on 1.0 mg and think that's quite enough. I am rarely hungry and often have to make myself eat. I hope to lose 65 pounds total."

• nau...
• December 30, 2020

Semaglutide for Type 2 Diabetes "I started Ozempic .25 mg subcut 8 days ago. I took my second dose yesterday. My first week, I ended up in the ED. I thought I had a bowel blockage or ileus. The ED visit was preceded by 6 hours of constant, sickening, odiferous belching, constant flatus, eruptive vomiting, cramping, and pain. A CT scan revealed gastric paresis. The event was precipitated by a fatty meal. I have since learned that the decreased gastric motility demands drastic changes in the volume of food intake, fat content, and most importantly, patience with what I consider to be major side effects. Now, I have no appetite. I am nauseated all the time, taking Zofran 4 mg before any meal. The belching is greatly reduced, same with flatus. I feel constipated, but that is easing off. I am avoiding high-fat foods and eating smaller portions. I am profoundly fatigued. Tomorrow, I am getting on the treadmill for 30 minutes each day to stimulate endorphin release to feel better. I have read the symptoms are reduced after 4-6 weeks."

• mbh...
• Taken for less than 1 month
• September 4, 2018

Semaglutide for Type 2 Diabetes "I started Ozempic 2 months ago, and it did nothing, so the doctor upped it to 1 mg a week. That's when the vomiting started and the sulfur belches started. My doctor took me off of it, and my sugar soared through the roof. I called back 2 weeks later, and she put me back on it. I started this past Saturday, and so far my numbers are still high, and I am nauseous, having bad gas and sulfur burps. I'm not sure this is gonna work. I am also worried because I have a history of diabetic retinopathy."

• Anonymous
• Taken for less than 1 month
• March 25, 2022

Semaglutide for Type 2 Diabetes "After 2 injections of .25, I started having watery diarrhea. On day 3, I woke up and the diarrhea had leaked out and was in my underwear. I started violently vomiting that same evening. This was day 4 of diarrhea, now with vomiting. My blood sugar levels kept crashing. I rushed to the ER, I had an X-ray, every lab work/panel you can think of, and a CT scan - nothing. Ozempic is the only culprit. I am texting this review from my hospital bed. I was admitted and put on fluids and a liquid diet. They are trying to keep the nausea under control and stop these symptoms before it affects my kidneys from being dehydrated. The Ozempic has been thrown in the garbage, but I don't know how long the nightmare from that so-called medicine will last."

• Com...
• Taken for less than 1 month
• June 10, 2023

For Weight Loss (Obesity/Overweight) "Started on May 23 at a 0.125 mg dose and spent the entire Memorial Day weekend sicker than I've ever been. I didn't put two and two together until after I took my second dose on May 30. Two nights later, I woke up with my body uncontrollably shaking, and I had my hand on my phone, ready to call 911. I didn't take my third dose on June 6 and don't plan to ever again, despite my doctor telling me to take a two-week break and retry it. He says the side effects are typically more tolerable after a two-week break, but I'm not willing to chance it. Since day one, my symptoms have been extreme fatigue, making it impossible for me to function in daily life. I can't do my job and I'm hardly able to be there for my kids without pushing myself as if my life depended on it. I've been missing out on everything for over three weeks because all I can do is go from bed to couch. Additionally, I've experienced severe confusion, heaviness in my head, nausea, and vomiting, and I've lost 16 pounds."

• Jca...
• Taken for less than 1 month
• June 25, 2019

Semaglutide for Type 2 Diabetes "Horrible, debilitating fatigue, needing naps that I’ve never needed daily! Painful intestinal pressure and gas that wakens me from sleep, that cannot be burped or passed out. No noticeable difference in my blood sugar levels (my A1C was already 5.6). A little vomiting. If this fatigue does not subside, I believe I will stop using and seek other alternatives. I hate this, I want my life back."

• jma...
• Taken for 1 to 6 months
• January 27, 2023

Semaglutide for Cardiovascular Risk Reduction "I started on the lowest dose of Ozempic in October 2022. One injection, in my thigh, once a week. I didn't make it past the first 4 weeks or the lowest dose. My physician hoped that since I do not have a gallbladder, many of the reported side effects of nausea and vomiting would not affect me. Wrong. First week and all things went well. I experienced no real side effects and had decreased appetite and energy. I slept well and was active. Second, third and fourth weeks, not so good. Modified my entire diet, but could barely eat or drink anything but a little chicken. Constant and severe nausea, vomiting, sleep deprivation, headaches, body aches, and zero energy for the next three weeks. It was like having a severe case of stomach flu for 4 weeks. Oh, I lost weight, between 18-20 lbs. Unfortunately, this is not a sustainable way of life. I couldn't function; I didn't leave my house for a month. I pulled myself off of it, and it took another 3 months to recover fully."

• Hop...
• Taken for 1 to 6 months
• January 7, 2022

Semaglutide "I've been on Rybelsus for about 6 weeks now and am up to the 7 mg dose. I was placed on it to help lose PCOS-induced weight gain. It took about a month to get used to (minor vomiting, nausea, constipation, and diarrhea during the adjustment). I've lost almost 15 lbs, my anxiety levels have plummeted, and my skin is the clearest it's been in ages. I no longer have sugar or processed carb cravings, which I think is helping all of this. I'm lucky that my insurance is fully covering the medication since it is pricey."

• Dia...
• Taken for 6 months to 1 year
• June 2, 2019

Semaglutide for Type 2 Diabetes "I’ve been on Ozempic about 8 months. I went to the 1 mg dose pretty quickly. My sugars became normal. I was losing about 5 lbs every two weeks. My A1C went from 6.8 to 5.6. No side effects at all. I’ve lost about 30 pounds overall. About 6 weeks ago, I got sulfur burps, then nausea, then vomiting. I vomited 9 times over maybe 6 hrs. Thought it was food poisoning. Yesterday, I again got sulfur burps followed by nausea and then vomiting. This morning again, burps, vomiting, and watery diarrhea. Thought it odd it would again be food poisoning. I never get sick. Then thought maybe it was E. coli or gastroparesis. Then I happened upon this site and started reading the reviews of Ozempic. I don’t know why it would take so many months for any side effects to show, but it sounds like this is most likely the cause of my vomiting and diarrhea. I took my last dose two days ago. I take it every two weeks. I think I’ll cut back to 0.50 next time and see what happens."

• No ...
• March 1, 2020

Semaglutide for Type 2 Diabetes "Victoza was no longer working to lower my A1C, so my doctor prescribed Ozempic. It’s been 4 weeks. Since I’d been on the maximum dosage of Victoza, she assumed it would be a smooth transition to the maximum dose of Ozempic. While it did reduce my blood sugar, I’ve had every side effect: nausea, vomiting, explosive diarrhea, heart palpitations, heartburn, and disgusting burping. Some days, I can’t leave the house. I didn’t immediately realize that these symptoms were related to the medication, so I continued to inject the maximum dosage. I thought I had a horrible bug. After the second week, I made the connection. So I went down to a half dose, but that wasn’t enough. Now I’m down to .25. I’m still having side effects, so for now, I am on 2 Prilosec, 2 Zofran, and 4 Imodium per day. My blood sugars are down, sometimes dangerously low. I lost weight, but of course, I would with the nausea, vomiting, and diarrhea. I’m going to try to stick it out."

• Not...
• Taken for 1 to 6 months
• July 24, 2025

Semaglutide for Weight Loss (Obesity/Overweight) "I started this medication about 4 months ago and have lost almost 40 lbs on it. That was great until my last dosage increase that sent me to the hospital for almost a week with little to no motility in my entire gut and pain like I have never experienced. I couldn’t keep any food down or liquids and had to be on an IV for five days straight. This medication started out working great for me with the occasional vomiting and upset stomach. I think this medication truthfully should be taken off the market for how much damage it can create, but like I said it is not for everyone, and is certainly not for me. Best advice I can give is to listen to your body!!"

• she...
• Taken for 1 to 6 months
• May 21, 2019

Semaglutide for Type 2 Diabetes "I started at a dose of 0.25 mg Ozempic, advancing to 1 mg weekly. The first week, I experienced reduced appetite and some nausea. Within 3 months, I have lost 35 pounds, and my HgA1C went from 9 down to 6. I have, on several occasions, experienced nausea and vomiting if I overate or had very greasy food. It does reduce your appetite substantially. I found eating my main meal at lunch and soup for supper has reduced nausea."

• blh...
• Taken for less than 1 month
• May 31, 2024

Semaglutide for Weight Loss (Obesity/Overweight) "First dose 0.25mg, had slight stomach pain/discomfort. Later that same night, my appetite disappeared. Just seeing a fast-food commercial on TV made me feel nauseous. I thought if that's the worst of the side effects that affect me, then I'll be very happy with that. By the next day, stomach pain and nausea increased. By 4:00 am, BAM! Diarrhea, severe stomach pain, projectile vomiting, headache, chest pain, severe itching mainly on the palms of my hands and arms. I truly thought 'this must be what it feels like to be poisoned!' I was scared. It is now the next day and I feel fine. A little tired from lack of sleep from feeling so sick. I think I will do my second dose next week...but I'm quite nervous of a repeat of feeling like I was dying from the stomach pains and vomiting. Will I continue with this drug?...jury is still out! On the positive side, I've already lost 5 pounds; but of course, I can't & don't want to eat, too much nausea and vomiting."

• adr...
• Taken for 1 to 6 months
• July 21, 2025

Semaglutide for Weight Loss (Obesity/Overweight) "It’s changed my life. If you can get past the nausea and occasional vomiting, it’s well worth it. Zofran helps. I’ve always lost weight by eating less and not being hungry. I’ve lost 50 pounds since the end of January. I will be continuing it."