Semaglutide and Tiredness: What Users Say (Page 5)
Brand names: Ozempic, Rybelsus, Wegovy
Reviews for Semaglutide
- edw...
- Taken for 1 to 6 months
- June 15, 2023
Semaglutide for Type 2 Diabetes "I started using Ozempic at the beginning of April 2023. It has helped me control my blood sugar levels, I have also lost 16 pounds, but the weight loss seems to have halted. It's now June 2023. For the last two weeks, I have felt tired the day after injecting it, and my blood pressure didn't change on the days I was tired."
- Car...
- Taken for 1 to 6 months
- April 24, 2023
Semaglutide for Weight Loss (Obesity/Overweight) "I am on week 4 of Wegovy, the first 2 doses were 0.25 mg. The last 2 were 0.5 mg. I've had stomach pains and nausea to the point I'm in tears, it aches so much. My weight is going from 221 lbs to 215 lbs, I'm 5'9". I hardly eat for fear of worsening stomach issues. While my pharmacist says the side effects should go away by now, they haven't. I also have no energy, want to sleep, and have a hard time getting my blood sugar above 98, that's after a healthy meal with protein and a vegetable. Not sure this is worth it."
Frequently asked questions
- Ozempic Side Effects to Watch For
- Wegovy vs Ozempic: Which is Right for You?
- Tirzepatide vs semaglutide: How do they compare?
- Why am I not losing weight on Ozempic?
- Ext...
- Taken for 1 to 6 months
- January 18, 2023
For Weight Loss (Obesity/Overweight) "I took my first injection on Dec 17, 2022, so I'm 4 1/2 weeks in (1 month). I'm on the 2.4 mg injection. Started at 30 units. Lost 9 lbs the first week. Gained weight the following weekend over Christmas, and also a bit over New Year's weekend. As of this morning, I'm down from 238.6 lbs to 218.4 lbs...that's 20 pounds in a month, including the weight I had to lose twice from gaining over the holiday weekends! I take my injections on Saturday. Side effects: nausea on Sunday, very, very light. Enough to notice, but not uncomfortable. Tired on Monday mornings. Take B12 and fine in a couple of hours. A little bit more tired on Tuesday mornings. Again, B12 and fine. Feel good on Wednesdays. Thursday, I have an abundance of energy. Friday afternoons, I can feel the rumblings of hunger, but don't really feel like eating. Saturday, it's time for the injection again, so the rumbling stops. I haven't experienced any other side effects."
- Jji...
- April 2, 2023
Semaglutide for Weight Loss (Obesity/Overweight) "Awful. I felt tired and like I had morning sickness the whole time. Was on one month of .25 mg and two months on .5 mg. It never got better. I was constipated and on the verge of throwing up constantly. Also started post-menopausal bleeding despite being on HRT. All of this, and I only lost a whopping 9 pounds despite barely being able to eat even cereal. Your diet turns to garbage because you just stick to stuff that won’t make you feel more nauseous. You will not learn how to eat properly; just how not to eat foods that make you throw up. I just switched to phentermine, and I’ve already lost two pounds in 5 days. My energy is back. Zero side effects and less than $15/month. Read the long-term reviews, people. Unless you are going to stay on this for life, which I would never do seeing how it messed with my hormones, you will 100% gain it all back and then some."
Are you taking this medicine?
Your review helps others make informed decisions.- Zow...
- Taken for less than 1 month
- June 19, 2022
Semaglutide for Cardiovascular Risk Reduction "I've taken this to help with decreasing my appetite and got a higher BMI, I'm just under 15 stone. On 1 mg and talk about feeling tired, feeling a bit sick too. I not long woke up with bad reflux and nearly being sick that I couldn't breathe properly! (Basically nearly choked in my sleep!) I don't eat rubbish or drink fizzy pop, so I know it's not that. My throat hurts with the reflux. I really hope it doesn't stay for days or be sick often."
- Ano...
- Taken for less than 1 month
- May 27, 2025
Semaglutide for Type 2 Diabetes "I have been taking 7 mg Rybelsus for 2 weeks now. Amazingly, I have lost 13 lb in weight, no sickness, constipation as yet. However, extremely tired, don't know if this is a side effect or just body adjusting. Will see if these changes over time."
More FAQ
- Does Ozempic cause muscle loss and how to prevent it?
- How much does semaglutide cost?
- How does semaglutide work for weight loss?
- Where and how should Ozempic be injected?
- Daw...
- Taken for less than 1 month
- May 24, 2023
Semaglutide for Weight Loss (Obesity/Overweight) "Just started this new medication, and I’m on my second injection of the .25 mg. The side effects I have had are slight abdominal pain, acid reflux, nausea, and tiredness. I am 5’8 and was 244.5 lbs. To date, I am now 239 lbs - I’ve lost 6 lbs since 5-21-23. I weigh in every Sunday to stay on track of my weight and what it is. The side effects are mild, and I am going to stick with it because, like so many others, I’m tired of being TIRED… the weight has to go, and I encourage you to try this."
- Cad...
- Taken for 1 to 6 months
- April 7, 2025
Semaglutide for Weight Loss (Obesity/Overweight) "Mixed review: I took Wegovy for 5 months, hoping to ultimately lose 15-20 pounds. I didn’t start losing weight until I started the 1.7 mg dosage (third month), and at that dosage, I was exceedingly tired and achy. I lost 10 pounds in 4 months but stopped taking it because of these side effects. Four months later, without Wegovy, I’m still down 5 pounds. My insurance partially covered this with a significant copay because I also have cardiovascular risks. I’d recommend only if you don’t experience the same side effects."
- Nap...
- Taken for less than 1 month
- November 30, 2024
For Weight Loss (Obesity/Overweight) "No side effects until the end of week 2, spontaneous vomiting after lunch today. Nausea & immediately vomited until stomach empty. Feeling more tired than usual. Felt really cold last evening—used heating pad for warmth."
- Ted...
- Taken for 1 to 6 months
- February 12, 2025
For Weight Loss (Obesity/Overweight) "This drug has definitely helped with decreasing my appetite and decreasing sugar cravings. I've been on semaglutide for 6 weeks and have lost 13 lbs so far. As far as side effects go, I've experienced some tiredness, nausea, and some stomach discomfort. Nothing debilitating. I'm going through a weight loss center. I go once a week for counseling and injections. I started out at 0.25 injection the first 30 days and am now up to 0.5 injections once a week."
- Win...
- Taken for less than 1 month
- March 19, 2025
Semaglutide for Type 2 Diabetes "Ozempic has made me not want to eat much at all. When I first started, I had stomach cramps, gastro, but that is slowly passing. I often feel tired and have to take an afternoon nap as I can’t keep my eyes open."
- Ano...
- Taken for 1 to 6 months
- May 17, 2023
For Weight Loss (Obesity/Overweight) "It helped reach a reasonable goal of 20-25 pounds in about 5 months. The drawback for me was it made me tired and a little nauseous the few days after the weekly shot. It does suppress your appetite. Alcohol and bad foods will make you feel worse. And you will lose more weight from that. I would do this again. Hopefully won’t need much for maintenance."
- Sha...
- Taken for 1 to 6 months
- October 28, 2024
Semaglutide for Type 2 Diabetes "Type II diabetic with kidney disease. Been on Ozempic 18 weeks, and at 2.0 for 4 weeks. I felt great at 1.0, but not at 2.0. Lethargy and headaches non-stop now. Will see Dr. to go back to 1.0 after blood work. Good news: A1C went from 7.3 to 6.5. Glucose now close to normal range. Previously was between 260-335. Kidney function increased from 30-37. Lost 44 lbs. I am 62 and on disability."
- Liz...
- May 15, 2023
Semaglutide for Type 2 Diabetes "I am on the 3rd week of the 1 mg dose. I started with .25 for 4 weeks, then to .50 mg. My A1C is down from 9.9 to 7.8. I am 70 years old with HBP. My appetite has decreased. I started having constipation with 1 mg. I continue to have queasiness and tiredness since taking it. I lost 10 lbs since starting mid-January to mid-May."
- Dur...
- Taken for 1 to 6 months
- March 24, 2025
For Weight Loss (Obesity/Overweight) "Seven weeks using a weekly shot. That part is so easy. It killed off my appetite, but I'm only losing 1 lb a week; I expected it to work faster. I was on 0.25 for a month, then 0.5 this month. I tend to have heartburn, and it has been much worse, but is starting to calm down. The meds also gave me constipation and a lot of gas. The constipation is getting better. I've been tired. But I'm still taking it. I have lost my craving for sugar and have found that I'm attracted to healthy foods, although I don't eat much. I plan to continue on the semaglutide for some months more. Diets never worked for me. This works, just slowly."
- VDC...
- Taken for less than 1 month
- June 30, 2025
Semaglutide for Weight Loss (Obesity/Overweight) "I am super tired after the 3rd day, hoping it stops. Also, I can't eat much of anything. More like snacking is all I can do right now. No way I could eat a full meal. 1/4 of a sandwich puts my belly on 100% full. Hope this is normal. Thx."
- lol...
- Taken for 1 to 6 months
- September 26, 2024
For Weight Loss (Obesity/Overweight) "So far, I've been on it for one month. I lost 7 lbs, my goal is 10, so I've decided to stay on it one more month. I do get nauseated and exhausted quicker than usual, but if I sit for a minute, it usually passes. It definitely helped my calorie deficit. I had to tell myself to eat because I wasn't hungry most of the day, but very thirsty, so I drank about 1/2 to one gallon of water a day. It has diminished my cravings for sweets as well, I don't even want it. Good luck to everyone, I'm sure, as with anything, results are different for everyone. Be safe and eat fresh."
- Mav...
- Taken for 1 to 6 months
- April 16, 2023
Semaglutide for Type 2 Diabetes "I started Ozempic 5 weeks ago for type 2 diabetes, high cholesterol and triglycerides, and high blood pressure. I am obese at 5'2" and 222 lbs. I had no bad effects with feeling nauseous, etc., from day one, starting at a dose of 0.25 for the first month. However, I have had seasonal affective disorder for most of my life and feel slight depression during the winter months. I did not feel bad before starting, but from the first week, I was very tired and depressed. I was in slow motion, and for the last 5 weeks, I've felt more and more depressed. My stomach felt so heavy, and I could barely eat 900 calories a day. I realized that was not good for me and tried to eat more, but sometimes the only way to up the calories was to eat junk. I was worried after 5 weeks, so I have just stopped the meds. After 5 weeks, I lost 7 lbs. My cholesterol went from 260 to 237, my A1C went from 6.2 to 6.4 (I'd been working on that before). I will now try more lifestyle changes, and I'm starting to feel my old self again."
- Tom...
- Taken for 1 to 6 months
- May 1, 2023
For Type 2 Diabetes "During the 4th week of taking .25 mg of Ozempic, I developed severe vomiting for three days. I have an ostomy and experienced very high output while vomiting. The vomiting and high-output ostomy have stopped, but I continue to be very tired and sleep a lot. I lost about 15 lbs during this period. I assume most of this was water weight. My last dose was 11 days ago, but my appetite continues to be minimal. I recently had a HA1C, and it was down to 5.9 from 6.4 six months ago. I have also taken Metformin during this time."
- jos...
- Taken for less than 1 month
- September 2, 2024
Semaglutide for Type 2 Diabetes "Scared of taking any medications. Thus far, it has been dropping my numbers, however, I have been waking up and having difficulty falling back asleep. I am a bit tired during the day. Thus far, it looks like it is working."
- Mae...
- Taken for 1 to 6 months
- June 26, 2025
"Constant headache, tiredness, lack of energy. I didn’t want to go out or do anything with family or friends, but mainly because I had constant headaches that were not being relieved by my prescription medicine."
- cor...
- Taken for 6 months to 1 year
- November 7, 2024
Semaglutide for Type 2 Diabetes "It’s working, my overall caloric intake has substantially decreased. Some weight loss, but disappointed with the amount. I expected 25 lbs of weight, and I only got 15 or so. My A1C is in a good place at 6.3. I feel lethargic and have dry mouth often."
- Aus...
- Taken for less than 1 month
- March 1, 2025
Semaglutide for Type 2 Diabetes "Male, 45, 101 kg (225 lb). Three weeks in. Still on 0.25 mg. Definitely less appetite and fine on a wrap for lunch and a light dinner. Have lost 4 kg (9 lbs). Occasionally feel a bit queasy, but never nauseous. Also feeling quite tired, but that could be the lower calories or lower blood sugar. Positive results from this initial phase. It definitely does what it says on the box."
- Mar...
- May 26, 2025
Semaglutide for Weight Loss (Obesity/Overweight) "This is a miracle pen, started on 5/22 155 lbs today 5/26 150 lbs. No side effects except the day I took the shot, got very tired in the afternoon. Eating protein shakes, not hungry at all. Hopefully, my insurance continues to pay for it!"
See also:
Mounjaro
Mounjaro is used for type 2 diabetes to help lower blood sugar levels. Mounjaro has also been shown ...
Rybelsus
Rybelsus tablets are used to improve blood sugar control in adults with type 2 diabetes, and may ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Zepbound
Zepbound (tirzepatide) is an FDA-approved weekly injection for weight loss and obstructive sleep ...
Wegovy
Wegovy (semaglutide) an FDA-approved weekly injection for weight loss and to reduce heart risks ...
Victoza
Victoza helps control blood sugar levels and reduce the risk of serious heart problems in people ...
Saxenda
Saxenda (liraglutide) injection is used for weight loss in obese or overweight patients. Includes ...
Alli
alli blocks the absorption of some of the fat that you eat and is used to treat obesity. Learn ...
Amphetamine
Amphetamine is a stimulant and is used to trat narcolepsy and attention deficit disorder. Includes ...
Tirzepatide
Tirzepatide is a once-weekly injection used for weight loss, sleep apnea, and type 2 diabetes ...
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For Type 2 Diabetes "So far, so good. The first time (and only time so far) I took Wegovy, it did make me nauseous and tired for a full day. I hope this doesn't happen every time. After a few days, I didn't feel the need to eat as much. Hopefully, it brings my blood sugar down and I lose a few pounds."