Ozempic and Fatigue: What Users Say (Page 3)

• Suz...
• Taken for less than 1 month
• July 22, 2021

For Type 2 Diabetes "I’ve taken two doses of Ozempic .25 mg and been on the drug for 1 1/2 weeks. I won’t be able to continue. This is a very harsh drug, and the side effects are terrible, in my opinion. I did not suffer from nausea and vomiting but couldn’t eat, food tasted horrible, my body stopped absorbing fat (evidenced in my stools), had lightheadedness, and the worst fatigue imaginable. In 1 1/2 weeks, I’ve dropped 10 pounds and feel undernourished and dehydrated. Be careful!"

• Jen...
• Taken for less than 1 month
• August 19, 2021

For Type 2 Diabetes "I was prescribed Ozempic for Type 2 diabetes to help lower my blood sugar and to help with weight loss. The first week wasn't so bad, just a little fatigued and some upset stomach problems. The second week it kicked in overtime and hit me like a brick wall. I had no energy at all. Stayed in bed because it's all I could do. My stomach was so upset and nausea, vomiting, and diarrhea were so bad, it ran like water. I became more dehydrated with less energy. I have 4 autoimmune diseases and this was the sickest I have ever felt in my life. I almost went to the ER and if not for Covid, I would have. It felt like someone had been feeding me rat poison. It's the worst feeling ever. I truly don't know how this drug was approved by the FDA. I plan to take myself off it. Weight loss and blood sugar need to be done in a healthier manner. Lose weight fast and easy has consequences."

• Kat...
• Taken for 2 to 5 years
• October 10, 2024

For Type 2 Diabetes "I have been on Ozempic for Type 2 diabetes. Was overweight as well, I am 4'11 and had ballooned to over 170 pounds. I was taking medicine for blood pressure, anxiety, depression, you know, all the things. I started in March 2022. My A1c was 7.9. Today I am down to 105 (hold up, that is normal for my height). No more high pressure. Beginning, I wasn't sure I would get past the nausea, but I fought through it, and yes, it does go away. I have been on stool softeners for a while, so I have never had any issues going to the restroom. My A1c is 5.4 now. I don't feel good, though. I can't put my finger on it, but I am severely exhausted and fatigued. I will not trash this medicine because I think it works as it should and has been amazing for diabetics. I just wish I didn't feel like poo all the time. The side effects do subside over time. My doctor and I have found the perfect dosing and schedule for me to keep my blood sugar under control."

• Apr...
• Taken for 1 to 6 months
• August 25, 2021

For Type 2 Diabetes "I have been on Ozempic for 20 weeks now, and I still experience bloating, flatulence, nausea, and fatigue. My A1C went back to normal, but I feel sick all the time. My most horrible side effect is the rotten egg smell of my burps. I am also taking Toujeo and Janumet."

• Anonymous
• Taken for 1 to 6 months
• June 30, 2024

For Type 2 Diabetes "After 4-6 weeks, I still suffer various levels of intensities of nausea, but short-lived diarrhea, plenty of burping, and fatigue that is often overwhelming. Some days, no problems. I manage the symptoms by enduring until they ease up, or I may choose to seek fast relief using what's available. Its benefits are now close to 'tight control' and significant weight loss (overcoming the stagnant plateau of a period of weight loss)."

• Suz...
• Taken for 1 to 6 months
• June 20, 2022

For Cardiovascular Risk Reduction "I started Ozempic in January 2022. Began with the standard .25 for 4 weeks, then .50 for an additional 4. When I injected the 1 mg, I was sick constantly. Vomiting, fatigue, and horrible heartburn. I had to stop for several weeks as I was completely worn out. I started again with the .25 and am now on the .50, but I'm noticing I am much more hungry than I was the first time around. I was wondering if any of you have injected .75 and if you found it to be helpful? I am afraid to try the 1 mg again as sick as it made me."

• Pri...
• Taken for less than 1 month
• May 20, 2022

For Type 2 Diabetes "My doctor put me on this because I was pre-diabetic, and he said I was insulin resistant. Since I’ve been taking it, I’m not as hungry, but my head hurts, and I always feel dehydrated, and so I’m peeing all day. I feel short of breath, and my chest has been feeling pains. I’m also experiencing constipation and constant light-headedness, and I’ve only been on it for 2 weeks. I may give it another 2 weeks, but not sure if the side effects are worth all this. I feel no energy, and my legs are always sore, and I’m so tired all the time. My way of living has suffered because I’m too tired to do anything and feel yuck all the time. Trying not to be frustrated because if this doesn’t help me, he wants to put me on Jardiance, but I hear so many horror stories about that one. This one isn’t as great as everyone said it would be, so who knows, maybe Jardiance will be better for me."

• Pat...
• Taken for 1 to 6 months
• August 29, 2022

For Type 2 Diabetes "I have been taking this drug for about 8 weeks, starting out with the 0.25 dose and now on the 0.5 dose. I have felt miserable the whole time, with nausea similar to pregnancy and with a revulsion to most food and smells of food cooking. Definitely low energy. I have lost weight, and I haven’t had my A1C checked since I started. I will see my doctor in a couple of weeks and will be telling her that I can’t continue to live this way. I’m 75 years young and don’t want to live the rest of my years feeling bad! Unusual, hiccup-type burps, coming out of nowhere and no appetite. Convenient once-a-week administration."

• Mem...
• Taken for less than 1 month
• September 3, 2021

For Type 2 Diabetes "I have Type 2 diabetes that I’ve kept under control by taking Metformin, Jardiance, and insulin. I saw a new endocrinologist 2 weeks ago who suggested I try Ozempic, with the hope of eliminating the insulin. She prescribed taking .25 mg initially for 4 weeks and then bumping up to .50, also reducing my insulin to 15 units and hopefully eliminating it later. She did say it could cause some stomach issues, but mainly said it could make you not want to eat much. I think in hindsight she downplayed the side effects. I took my first dose a week ago. The first 3 days were fine. The 4th day I started having foul-tasting belches and then got such severe stomach/gas cramping I almost went to the ER. I have a high pain tolerance, so for me to be in that much pain says a lot. I was able to finally get relief by drinking baking soda water, but then had extreme diarrhea, nausea, body aches, and fatigue. I missed 2 days of work. I called the doctor, and she said my symptoms were severe and to stop taking it. Horrible experience!"

• Bra...
• Taken for 1 to 6 months
• July 31, 2021

For Type 2 Diabetes "I have been taking Ozempic for about 4 months now. Haven’t had really bad side effects, but sometimes I feel just exhausted and somewhat out of breath. I also have muscle aches and fatigue. Not lost a lot of weight, maybe 2 lbs. I keep hoping. Does anyone else have similar side effects? Good luck and all the best results for everyone."

• S-L...
• Taken for 6 months to 1 year
• February 2, 2023

For Type 2 Diabetes "Major nausea ebbs and flows. Extremely bad fatigue off and on. More along the lines of exhaustion. No weight loss. I’m on a pretty high dose, 1.5, and am only about 15 lbs overweight. Diabetes type 2 most of my life, so this is a great drug. Hopefully, the next generation of these drugs will have fewer side effects for some of us. The nausea and fatigue are pretty overwhelming some days. A1c has improved, so I will stay on until something better comes along."

• Rob...
• Taken for 1 to 6 months
• March 1, 2025

"I have been taking Ozempic for five months, and I have lost 35 pounds. That’s the good part. I continue to have very bad fatigue, and when I upped my dose, I find myself nauseous and vomiting. I’m gonna continue taking it for a little while longer to reach my goal. So far, it has been worth it for me."

• jud...
• Taken for 1 to 6 months
• March 15, 2025

For Cardiovascular Risk Reduction "2-3 days per week I suffer from poor sleep and fatigue accordingly. Trying to get to sleep is bad, with body noises making it impossible. Also, constant burping with gas buildup, farting at night is awful, watery eyes. The other 4 days is fine. The days are not in a row and often vary each week. My rating of the medicine would vary on different days, bad days, bad rating."

• Joe...
• Taken for 1 to 6 months
• October 17, 2024

For Type 2 Diabetes "Terrible side effects: lower stomach pain, sleeping too much, and fatigue. I've only been taking for two months at 0.25 mg and 0.5 mg each month. I hope for better results when I increase to 1 mg next week..."

• NEW...
• Taken for 1 to 6 months
• March 7, 2025

For Type 2 Diabetes "I started out on 0.25 once a week and then 0.5 for two more weeks. I am now at 1.0. I experienced a little nausea in the beginning, but it has subsided. I find it interesting that I don't crave salty foods and actually turn them down. I am craving salads, which I find interesting. I've lost 7 pounds in 5 weeks, and now with the increase, about a pound every two days. The best part is I am on Metformin and Janumet, with a daily blood sugar averaging 340. With the addition of Ozempic, my average blood sugar has been at 122. My A1C has dropped from 11 to 9, all in a very short time. I suffered heart failure last year, and my refraction rate is now back to normal at 55 percent. I am now experiencing some fatigue, but that could just be my body adjusting to all the meds on board. I feel I now have a brighter future ahead, especially with the normal sugar level, and am planning to do a lot of outdoor activities this summer. I've also gone back to water aerobics and have my life back."

• Ric...
• Taken for 1 to 6 months
• June 25, 2025

For Weight Loss (Obesity/Overweight) "So far, so good. Six weeks on. Constipation's been an issue. Definitely has cut my appetite down, and I lost my taste for my weekend beer and have a glass of wine or two. Everything else has been fun. Little fatigue I’ve noticed, but hopefully I continue to lose weight."

• Not...
• Taken for 1 to 6 months
• October 3, 2024

For Type 2 Diabetes "Still early, so this may change as time goes on. I am currently taking 0.5, increasing after the next dose. In the beginning, I had stomach pain and sickness, but these symptoms died down after I learned to eat more protein and not to skip meals. Another thing that bothered me at first was fatigue. I could not keep my eyes open. I slept a lot, and if I had something to do that day, it took everything in me just to make it through the day. These symptoms also subsided after I stopped skipping meals. I would be lying if I told you my choice to start taking Ozempic wasn't to help me lose weight. That was one of the major selling factors for me. Anyone who knows anything about diabetes knows you do pack on the weight, and any help shedding those unnecessary pounds is a plus. I can't say I have lost a lot of weight yet, but with what little time I have been on Ozempic, I can see a decent decrease in my weight. As for my diabetes, my A1C will tell in time."

• kem...
• Taken for 1 to 6 months
• October 3, 2024

For Type 2 Diabetes "My doctor switched my medication from automatic insulin to Ozempic, taken once a week, along with daily long-acting insulin injections. I lost my appetite, my mouth feels tasteless, and no food appeals to me, so I have to force myself to eat. My blood sugar levels have been unpredictable, fluctuating between highs of 250 and lows of 60. One minute it’s very low, and after eating, it shoots up, then drops again. I decided to stop the long-acting insulin last Sunday, at the start of the fourth week when my Ozempic dosage was increased from 0.25 to 0.5. Since then, things have slightly improved—my blood sugar isn’t running too low anymore, but it is still high. During this time, I’ve also developed severe heartburn, sleeplessness (only a few hours of sleep at night), and sluggishness, among other symptoms. I contacted my doctor yesterday."

• ste...
• Taken for less than 1 month
• April 30, 2025

"I was astonished by how quickly my appetite vanished, and it has not returned. My weight is steadily dropping because I only need one meal a day. My side effects are 1. I find myself a little headachey, nothing too severe. 2. I have a constant dry mouth. That is a bit annoying. 3. My sleep patterns are affected. Also annoying. 4. Energy levels are down. 5. My desire for alcohol is way down. That's a good thing. I'm only 2 weeks into it, but getting this hunger monkey off my back is extraordinary. I would never have thought it possible. My first meal of the day is brunch, and then that's it, I don't have any further desire for food for the day and don't even think about it."

• Cor...
• Taken for 1 to 6 months
• July 29, 2022

For Cardiovascular Risk Reduction "I used this medicine for 3 months to help me lose an excess weight of 30 lbs. I lost 10 lbs. Initially, I had a few side effects: nausea and indigestion. But by the third month, I felt really sick. I asked for blood tests because I was so exhausted. My blood tests were perfect. The indigestion and heartaches got worse. Eventually, it became unbearable. I'm burnt out, so it just made my condition worse. Zombie. For people who support it well, it's great. But if you have a digestive sensitivity, it's at your own risk. I last used the medicine 10 days ago, and I still have digestive problems and heartaches, as well as fatigue. But the fatigue was present before the use of this drug. I lost 10 pounds out of 30 pounds in a month and a half. Then I didn't lose any more, and I continue to be careful. The drug works for 7 days, so it's been 10 days. It is completely eliminated from our body after 5 weeks. It is especially the fatigue that causes me problems. But it's normal when you're still in indigestion."

• joh...
• Taken for 1 to 6 months
• June 16, 2025

For Type 2 Diabetes "Reduced blood sugar from 10 to 7.1. Killed my hunger completely, no more food cravings. Side effects became disabling, had to discontinue using. Became bloated, nausea was bad, 1st time I have vomited in 50 years, fatigue, constipation, going to the emergency room as no doctors available to help."

• Ris...
• Taken for 1 to 6 months
• May 15, 2025

For Weight Loss (Obesity/Overweight) "I have been on Ozempic for about 3 months. Started at 0.25, then went to 0.5, then went to 1.00 2 weeks ago. Had some minor side effects (a little stomach upset, fatigue) with the lower doses, but just this past week, I have started severe diarrhea. I literally can't keep anything in my system. It is working okay... I have lost almost 15 pounds, but I am going to adjust the dosage down if the diarrhea doesn't stop. I also have had a huge increase in burping, which is manageable. Overall, I have positive things to say about this medication, but I think that dosing is pretty specific to the person and should be discussed with your primary doctor if severe side effects continue."

• Che...
• Taken for 1 to 6 months
• August 24, 2024

For Type 2 Diabetes "Have been on Ozempic for about 2-3 months at 0.25. Experienced/experiencing: nausea, heartburn, fatigue, light-headedness, constipation. Nausea has calmed down but still occurs. Heartburn has developed over the last month and is definitely not subsiding. Seems I am always tired. Sometimes getting up, I become light-headed and off balance. Constipation is quite prevalent even with eating high fiber fruit and vegetables, and I am doing my best to drink plenty of water, starting with hot lemon water and honey every morning. I do not know if I would recommend this drug or not. Everyone is different. Thank you."

• Oze...
• Taken for 1 to 6 months
• September 17, 2022

For Type 2 Diabetes "I started Ozempic in January 2022. First week, I had extreme diarrhea with blood and mucus (always constipated before this). Endocrinologist told me he didn’t think it was Ozempic, but I went off it. Diarrhea, etc., continued. Ended up having to get a colonoscopy and was diagnosed with Ulcerative Colitis. Endocrinologist wanted to put me back on Ozempic. We figured the diarrhea, etc., was just the colitis. Started it back up five weeks ago. No diarrhea, back to constipation, nauseous every day, extreme fatigue. Also now diagnosed with Retinal Vasculitis. But my inflammatory markers are high. Not sure if this all started because of Ozempic. Just increased to 0.5 mg today, so we will see. It just seems like an odd coincidence. No appetite, but no weight loss either. Hair loss, but could be from colitis."

• C01...
• Taken for less than 1 month
• June 28, 2021

For Cardiovascular Risk Reduction "I am a week in; no appetite, nausea present but not as bad as the first three days on treatment, fatigue and constipation slightly. Will be back in a few weeks for update."