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Quetiapine for Depression User Reviews (Page 4)

Brand names: Seroquel, Seroquel XR

Quetiapine has an average rating of 6.4 out of 10 from a total of 178 reviews for the treatment of Depression. 52% of reviewers reported a positive experience, while 27% reported a negative experience.

Reviews for Quetiapine

  • Someg...
  • Taken for 2 to 5 years
  • July 6, 2017

"First of all, for all the people writing reviews that haven't been on this drug for AT LEAST 4-6 WEEKS your reviews are almost invalid, this drug is as two-faced as many make it out to be and for those people they just aren't giving it enough time to see both sides of it. I have been on and off Seroquel for a few years now and currently taking 150mg at night for the past 3 months. It helped with anxiety and sleep which was great! I was less intimidated and anxious at school and with friends. However, it seriously affected my mood, constantly shifting from agitated to blunted, my concentration, my dreams, weight and eventually, over the course of about six weeks, caused one of the most serious relapses in my depression in years. Be careful!"

3 / 10
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  • 55 fe...
  • October 17, 2009

Seroquel XR (quetiapine) "It seems to be very helpful for my depression, anxiety, adult ADD, and overall mood. Seroquel XR also seems to have no noticeable side effects, and I sleep great. I've been taking 2 of the 300 mg, in the evening, now for 2 months."

9 / 10
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42 Report
  • Dougmac
  • July 12, 2015

"I'm 38, have struggled with depression, and been suicidal, searching for help since I was 13-14. Finally found a psychiatrist who understood. She prescribed 100 Seroquel daily and ECT. Only had 3 out of 4 ECT treatments. That, together with Seroquel, I have never felt better or more stable in my life. Still have issues with anxiety when writing essays. Was prescribed a 25 mg tablet to put under my tongue. It works great. I had trouble at first with medication as I was taking it morning and night. I would be falling asleep at pre-start meetings at work. I now take it nightly before bed. I sleep great and wake up refreshed. This drug works. You just have to work out the right time to take it."

10 / 10
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29 Report

Frequently asked questions

  • lilly...
  • Taken for 5 to 10 years
  • March 10, 2017

"I've been on quetiapine for a few years, I have had weight gain and I've put on a lot weight and now I'm diabetic type 2, but for me its been a small price to pay, I've have tried a lot of different drugs (antidepressants) over many years but for me quetiapine has saved my life in many ways before taking this drug I was very ill, I wanted to die not because I hated life or anything like that but I wanted to stop my awful thoughts I couldn't cope with anything in life, many times I was seeing things my life was hell, not sleeping, not going out fearful all the time, Even though I still have problems I never go anywhere on my own not even out by the front door,I know this drug has given me a small part of my life back."

10 / 10
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25 Report
  • Sienna...
  • Taken for 1 to 6 months
  • February 14, 2020

"Experienced headaches, dizziness, extremely sedating, leaves me with a feeling of complete numbness, I am simply hollow when on QUETIAPINE. My sister had the same reaction and our depression only grew worse."

2 / 10
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17 Report

Are you taking this medicine?

  • thebe...
  • Taken for 6 months to 1 year
  • September 13, 2012

Seroquel (quetiapine) "Seroquel was awful.. my doctor prescribed two 700mg at night and I slept so much! When I wasn't sleeping I was exercising, still I gained 30lbs. I had extreme paranoia, never knew where I was or how I got there, and always woke up in sleep paralysis. Made my depression, anxiety and bipolar worse."

1 / 10
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34 Report
  • Elain...
  • November 21, 2016

"I've been on this drug for four years, and I will admit, it did help me out at first. I was deeply depressed and going through some major life changing situations. As this calmed down and I developed spiritually, emotionally and mentally, I gradually decreased the dose. I was on 100mg the first year, the second year, 50mg, the third, 25mg, and the fourth, 12.5mg (cutting the 25mg pill in half.) I just got off of it two days ago, and I feel like a new person. I had no idea how much it tampered with my mind. I was in a fog for FOUR YEARS. Although I'm sleep deprived, achy, and irritable from the withdrawals (this med's withdrawals are heinous) I feel better than I have in four years. I do not recommend this drug- save your mind!"

2 / 10
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  • Gastr...
  • Taken for 2 to 5 years
  • May 20, 2017

Seroquel XR (quetiapine) "I was on this medication for around 3 years at different doses, anywhere from 50 mgs to 600 mgs. It was a very good medicine and helped a lot with my anxiety and depression and really calmed me down and was very helpful, but the weight gain was a killer. I would try to go off over and over and would have to keep going back to it because I would be in such bad shape without it. I had a love/hate relationship with it. I became pre-diabetic while on it. I finally was able to go off and stay off at one point. It's a great drug, but the side effects are horrible as far as weight gain."

8 / 10
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  • Shali...
  • August 22, 2011

Seroquel (quetiapine) "I was diagnosed with mild bipolar disorder, depression, post-traumatic stress disorder, and generalized anxiety. Most of my adult life, I had insomnia. I use Seroquel 50 mg once a day and Celexa. The Seroquel stopped the racing thoughts, generalized anxiety, allowed me to sleep well at night, and I'm able to think things through rationally. Seroquel is the best medicine for me. I love it. I used to only take it at night as I would fall asleep immediately, but now I'm able to take it during the day."

10 / 10
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  • Dan
  • Taken for 6 months to 1 year
  • July 17, 2021

Seroquel XR (quetiapine) "I have been on the Seroquel XR 50 mgs and it absolutely works better than anything I have ever taken for anxiety. And I've taken every SSRI under the sun, valium, clonidine, gabapentin, and vistaril all in the past. This medication is a life saver. It does make me feel drowsy 3-4 hours after taking it so it should be taken around dinner time. My doc first started me on it first thing in the morning and I was dozing off by noon. But other than that it has been a lifesaver. Almost no anxiety, I sleep better, my appetite is good, my mood is good & confident. For me it even helps to relax my muscles. I'm so glad my doc took a chance and prescribed this medication off-label for my anxiety. It has given me a new lease on life."

10 / 10
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  • Death
  • September 19, 2019

"I was put on Seroquel for depression and psychosis which was troubling paranoia, weird thoughts, and hallucinations. I also suffered from severe insomnia for years. Seroquel has seriously helped with my awful thoughts and improved my self-esteem. I have an easier time with other people and my grades have gone up in school. Unfortunately, some of the side effects are troubling because it's not reliable for insomnia. I can stay awake for 2-3 days or sleep for 20 hours. I'm very tired and I often pass out. I've lost weight and my appetite. Another good thing about it is that it got rid of the horrible hallucinations I have from sleep deprivation that are much worse than my usual ones. My parents and doctor don't like that I'm on this drug. For years, people have been telling me to exercise, eat healthy, sleep well while forgetting that depression makes everything impossible, don't listen to people who say this- you know what works for your body. Seroquel has been great for me, but some of the side effects are concerning."

7 / 10
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  • Jac
  • Taken for 1 to 6 months
  • June 19, 2019

"I’ve never been a great sleeper but if I took an entire pill (100 mg) I could be out for over 12-15 hours. So I cut in half (50mg), 10-12 hours. Quarter of a tablet (25mg), 8-10 easily. So for that I’m grateful. I’m on pristiq for depression but which works well. However I’ve decided against taking even a quarter pill nightly as I’m noticing my depression is worsening and I’m crying constantly."

5 / 10
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  • Crod
  • Taken for 1 to 6 months
  • June 1, 2021

"So I take for BPD and bipolar. Best med I've ever taken and tolerate it very well. It takes a few weeks to work like it should but you will feel some relief in about 5 days. you will sleep soundly and wake up rested it is a strong sedative. I feel that sleep relates to depression and anxiety. I have experienced zero weight gain I'm lucky I guess. You will wake up sedated but it goes away in about 30 min but I also take a stimulant, so that might be part of it, but I also wake up happy and ready for the day. The things that used to bother me no longer do with this med. It gave me my life back."

10 / 10
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  • Thisguy
  • Taken for 10 years or more
  • September 14, 2019

"I have TBI, Organic Personally Disorder. I hate this med, I've been on it for almost 15 years it does not help my anxiety or depression, it does help my mood swings a bit but I feel like a zombie all day. I'm constantly anxious to the point of having chest pains and depressed with low self worth. It's never helped me and when I don't take it my symptoms explode. Garbage med for sure"

3 / 10
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  • SGP
  • Taken for less than 1 month
  • February 5, 2017

"I'm 32 years old, bipolar, OCD tendencies. Have been taking Seroquel XR for over a week now. At first it seemed to trigger a manic episode that lasted for 5 days. For someone who typically spends most of his time on the depressive side, this was heaven. LOL I take 100mg a day just before bed time, have no trouble getting to sleep, am able to stay asleep and don't find it too difficult to wake up. I normally have consuming and unwarranted anxiety. This has been greatly suppressed. I find it much easier to control my anger and in general my emotions have become much more stable. There have been no negative side-effects. I still feel like I need an additional anti-depressant as my normal "base level" is too low but am otherwise satisfied"

8 / 10
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  • Ripley
  • Taken for 6 months to 1 year
  • July 10, 2018

"I had severe, endogenous postpartum depression...melancholic in nature with insane amounts of agitation, anxiety and psychotic features. Quetiapine saved my life. When I first started I felt BAD...but after 4 weeks I adjusted and slowly went back to normal. I would not suggest this unless you are as severely ill as I was. But if you have that agitated restless depression this drug is a miracle. 150 mg is the sweet spot for me, extended release. Give it time and the side effects will lessen. Weaning off on the other hand? Its a god damn nightmare. I'm in the process of weaning and each step down is pretty uncomfortable so NEVER go off cold turkey."

10 / 10
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19 Report
  • Green...
  • Taken for 1 to 2 years
  • May 31, 2015

"I suffered from high anxiety, panic, deep depression - started on Seroquel 25 morning and 25 night, coupled with 75mg Tofranil at night. These two combinations saved my life. Seroquel took some getting used to, have gained some weight and had some vision problems, but all in all feeling so much better, would highly recommend Seroquel for anxiety related issues."

10 / 10
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  • DruggED
  • January 23, 2019

"My psychiatrist worked me up to 200mg after my first suicide attempt in April 2018. I thoroughly enjoy how easy it is to fall/stay asleep on this drug. But when I got back to college I was excessively tired throughout the day, needing multiple naps and looots of caffeine to even stay awake during classes. I just went down to 150mg per day and already feel better sleepiness wise, even naturally waking up a bit earlier instead of requiring 10+ hours of sleep. In terms of other side effects, I always attributed the cravings and binging to my restriction/eating disorder, but didn't think until now that it may be because of the drug. I have been bothered by feeling the need to literally eat spoonfuls of sugar multiple times a day. As for depression/suicidality, I haven't really noticed a difference. "

5 / 10
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  • Renpen
  • Taken for 5 to 10 years
  • February 5, 2018

"I agree with previous poster...these reviews look badly faked. "Seroqel saved my life! " "This drug saved my life!" Seroqel does not inspire the kind of robotic (yes) automated rubbish in these reviews. Who reads them? Take it only as a last resort for sleep. Try to ignore the severe appetite stimulating effects or you will gain LARGE amounts of weight. It helps me sleep. Not pleasantly. Not without vivid, lucid dark heavy awful dreams/nightmares. If I wasn't having counselling/ hadn't enormous faith in my psychiatrist I wouldn't be on it. Big pharma stoops and stoops and still stoops lower."

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  • revdi...
  • June 29, 2018

"I was prescribed quetiapine medication by a Psychiatrist primarily for being in a delusional state from severe anxiety and lack of sleep. Looking back I realize that I was suffering depression. This was not my first time experiencing depression and had taken SSRI's and MAOI's in the past as well as zopiclone long term for sleep. Zopiclone helped for a while and then stopped working. Was a zombie on SSRI. I am now only taking 50mg of quetiapine before bed and sleep every night and wake up refreshed. Have experienced no depression since taking this drug since 2015. I am so glad that I finally found a treatment that works. Side effects are weight gain (exercise and watch diet) and elevated sugars so need to check blood twice a year."

10 / 10
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18 Report
  • Huckl...
  • October 14, 2018

"I take 25 mg at night before going to bed, then I get really hungry so I hit the fridge right around midnight for left-over goodies, or a quick ham sandwich. It does makes me sleepy but does not help me sleep, especially when I'm craving that ham sandwich. And forget taking this during the day. It can make you really sleepy. Lately I've been having bouts of inexplicable melancholia and I am beginning to think it's the quetiapine. Aside for the appetite (which I have problems with), I do not think it is a good sleeping med. Nor does it help my depression. I guess everyone who takes it experiences different things. Bottom line, if you have no issues with it, just take it as prescribed."

5 / 10
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  • Anonymous
  • December 13, 2011

Seroquel (quetiapine) "Have been on Seroquel for 4 weeks for depression. I take it before bed. Still experiencing a 'hangover' type feeling in the mornings. I gained 8 pounds in the first 3 weeks I took it. Makes me want to eat even when I am not hungry. However, I am not crying as much, can handle day-to-day life better, and I haven't had chest pain or racing heartbeats since I started, which is a great improvement."

7 / 10
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30 Report
  • Anonymous
  • September 18, 2011

Seroquel XR (quetiapine) "Seroquel XR is very good. It boosts up my energy. After trying other medications, this is the best, with little side effects. In the morning, you feel like staying in bed and weight gain because of hunger cravings."

9 / 10
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  • maira...
  • Taken for 1 to 6 months
  • October 20, 2020

"I started quetiapine 25 mg at bed time with 150 mg sertraline my mood was not good then I added 25 mg quetiapine at morning with 100 mg sertraline and I am now feeling well with quetiapine but some times I still have depression attacks. I am not sure what to do next."

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12 Report
  • dynad...
  • January 29, 2009

Seroquel (quetiapine) "I have been on Seroquel for several years, and it has helped greatly with my symptoms. I have run out of it a few times and could really tell the difference. Other than a few adjustments to my dosage, Seroquel has been great."

10 / 10
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33 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.