Skip to main content

Primidone and Fatigue: What Users Say

Brand names: Mysoline

Fatigue: mentioned by 4 users (3.7%)

Based on user experiences from 109 Primidone reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

dizziness 14.7%
tremors 11.0%
drowsiness 7.3%
nausea 7.3%
tiredness 7.3%
disorientation 4.6%
brain fog 3.7%
depression 3.7%
fatigue 3.7%
irritability 2.8%

Reviews for Primidone

  • Anonymous
  • July 21, 2019

For Benign Essential Tremor "I am 76 and started on primidone 50 mg twice a day approximately a year ago for hand tremors. I had difficulty with eating and turning pages in a book. It was embarrassing in public. The medication immediately handled the tremors but left me sleepy all day and rather in a cloud. I am now back to tremors and have asked for an increase of dosage, however, the doctor is holding off for tests to determine dizziness issues. Carotid test was good as was the MRI, so now I have decided to take 50 mg at night only to see if the sluggishness goes away and perhaps the sleepiness too. I think primidone is worth the try. Overall, it has been good for me."

9 / 10
Was this helpful?YesNo
98 Report
  • Anonymous
  • October 24, 2009

For Seizures "I have been using this medication for approximately 35 years. I have had two healthy children during this time. I am now in my 50s and find that I am experiencing tiredness, fatigue, and incoordination to the extent that I stumble or run into people or things easier than before. Whether this medication is a cause of my clumsiness or not, I am not sure. It has helped to control my seizures since my last one in 1975."

9 / 10
Was this helpful?YesNo
20 Report
  • Anonymous
  • July 13, 2009

Primidone for Benign Essential Tremor "I found Mysoline effective for my essential tremor, but the side effects of tiredness, lack of energy, plus reduced sexual function (difficulty in ejaculating) is quite frustrating."

7 / 10
Was this helpful?YesNo
93 Report
  • Ana...
  • Taken for less than 1 month
  • October 5, 2019

For Benign Essential Tremor "I started primidone 3 weeks ago for. Tremors essentially (get it) 75-80% better. Only side effect is minor GI issue and minor fatigue. Benefit definitely outweighs the risk. I'm on 50 mg once a day."

9 / 10
Was this helpful?YesNo
37 Report

Are you taking this medicine?

Your review helps others make informed decisions.
Write a review
Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.