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Perampanel and Depression: What Users Say

Brand names: Fycompa

Depression: mentioned by 4 users (5.6%)

Based on user experiences from 72 Perampanel reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

dizziness 16.7%
anger 12.5%
hallucinations 8.3%
tiredness 8.3%
drowsiness 6.9%
memory loss 6.9%
depression 5.6%
increased appetite 5.6%
seizures 5.6%
upset stomach 5.6%

Reviews for Perampanel

Showing 4 reviews tagged with "depression". Clear filters to view all 72 reviews.
Commonly mentioned side effects
  • gra...
  • Taken for 6 months to 1 year
  • September 27, 2014

Perampanel for Seizures "My boyfriend started this medication for better seizure control. He has had personality changes, confusion, aggression, hostility, delusions, depression, and severe thought problems that caused him to have antipsychotic and antidepressant medication increased because of existing bipolar disorder. Our relationship is about over because of this medication. We will see the neurologist ASAP to see if he can get off this medicine. Scared because it's addictive. He had similar reactions to Vimpat with suicidal thoughts."

3 / 10
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57 Report
  • dan...
  • March 29, 2017

Perampanel for Epilepsy "I did a 6-week trial of this, and it made me psychotic for about 2 hours once I had gotten my blood level up. High as a kite, aggressive, and talking backwards. So I went off it and had terrible withdrawal in the form of depression and suicidal thoughts. I have temporal lobe epilepsy, and I think I am on the more psychotic end of the spectrum, so I was more vulnerable to those side effects. I was a second-degree black belt at the time. I judge all drugs by my ability to do a decent back kick without falling over. It failed the back kick test as well."

1 / 10
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19 Report
  • AVM...
  • Taken for 2 to 5 years
  • January 22, 2023

Perampanel for Seizures "I have a large arteriovenous malformation (AVM) that stretches across part of my temporal and frontal lobes. I had tonic-clonic seizures at least once a week, sometimes at work, on the train, while walking, while shopping… basically anywhere. I have been prescribed different medications in the past, including Topamax, Keppra, Trileptal, Mogadon, Lamotrigine, and Tegretol, but they have not worked. Fycompa is the only medication that has been able to control my seizures. Yes, I do get side effects such as severe migraines if I’m more than 1 hour late taking it, anger problems, weight gain, lethargy, depression, poor sleep, unable to focus, slurred speech, memory issues, and I feel like I’m high/tipsy 1-2 hours after taking it. But I willingly accept these side effects as long as I never have a seizure in a public place again. I’m a civil engineer and cannot afford to have seizures on an active construction site. I love Fycompa!"

10 / 10
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5 Report
  • Pat...
  • Taken for 1 to 6 months
  • December 24, 2015

For Epilepsy "Increased seizures, suicidal thoughts, depression, walking ability is unsteady. I really am not having much success with this drug."

1 / 10
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3 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.