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Zofran and Nausea: What Users Say (Page 2)

Reviews for Zofran

Commonly mentioned side effects
  • Mar...
  • April 30, 2016

For Nausea/Vomiting "I've been dealing with extreme nausea and vomiting for the past 6 months, and it finally got to the point where I couldn't take it anymore and went to the ER. They gave me Zofran through IV and was feeling better in about an hour. After I was released, I was on 4 mg every 8 hours, and for about a week, I was back to my old self. Then things started to go downhill, and they boosted it to 8 mg. Now it doesn't even work anymore and makes me more nauseous than I was before. I also got pretty bad constipation and headaches after taking the medication. Not to mention, if you're taking the tablets, be ready to handle the taste because it is DISGUSTING."

5 / 10
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19 Report
  • sur...
  • July 19, 2010

For Nausea/Vomiting, Radiation Induced "After radiation, my husband could not keep anything down. If he coughed, sneezed, brushed his teeth, or just consumed food, he would throw up. After taking this drug for three days, it has made a world of difference. It is costly, but worth the outcome."

9 / 10
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24 Report
  • ico...
  • March 3, 2009

For Nausea/Vomiting "This drug has saved my life at least once. I took it when I was pregnant and had unrelenting morning sickness that wasn't helped by any other medications. I'm now taking it again for nausea caused by severe pain (as well as the nausea caused in turn by pain medications, as I seemingly can't win on that one). But perhaps most importantly, it was the only drug that got me out of opiate withdrawal when I had the stomach flu. Without this, I would have been in the hospital because I couldn't otherwise keep anything down, and without opiate therapy, the withdrawal and the pain combined could easily have killed me. The only possible drawback is cost; even the generic would be completely out of reach for someone without insurance."

10 / 10
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23 Report

Frequently asked questions

  • Sic...
  • Taken for 1 to 6 months
  • May 30, 2018

For Nausea/Vomiting "I have easily upsettable IBS (irritable bowel syndrome), and this has been a wonder medicine for me. Sometimes when I get up in the morning, I am so nauseous I cannot function. The dissolvable tablet leaves me feeling better within a minute. It has also worked when I had the stomach bug. It is working wonderfully now with a depression medicine that I just started taking that has a side effect of nausea and vomiting. I was seconds away from throwing up and quickly popped one of these in my mouth... back to normal within thirty seconds! Zofran is a lifesaver!"

10 / 10
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13 Report
  • Lor...
  • Taken for less than 1 month
  • July 16, 2019

For Nausea/Vomiting "I caught a stomach virus last winter and was vomiting repeatedly. I couldn't keep anything down. I was nauseous, dizzy, and feverish. I felt like I was on a moving boat, and I couldn't move or even think without vomiting. After I threw up bile the 2nd day, I went to the ER. I vomited in the waiting room and 3 more times in the exam room. I was given Zofran, which helped a lot. I only threw up 2 or 3 more times after that. I was diagnosed with norovirus."

9 / 10
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  • Lee...
  • Taken for less than 1 month
  • May 24, 2019

For Nausea/Vomiting "Wow! I went to the ER on Tuesday night, and it is now Friday, and I was given Zofran for my nausea on top of everything else I was dealing with, and this crap has made me nothing but nauseous with lots of throwing up and constipated! Not sure how long this is supposed to last, but it’s freaking annoying, and I definitely don’t see myself taking this ever again."

1 / 10
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  • Ali...
  • Taken for less than 1 month
  • October 24, 2022

For Nausea/Vomiting "Went to a bad hospital with a diagnosis of heart failure. Endured three weeks there with severe nausea, no vomiting. Begged cardiologists and all staff for nausea meds. Cardiologist said, “It (nausea) has nothing to do with me (cardiologist).” Hospitalist, who had been on vacation, responded to my pleas. Zofran was magic! I swear it only took minutes to kick in. I took it for 8 to 10 days and have not needed it for the past year. I am an assertive individual, but I was sick. I should have threatened to leave the hospital, gone to the E.R., screamed, gone on a food strike (food actually eased the nausea), or done something sensational to get help. My insurance was paying thousands for me to be treated like a non-entity."

10 / 10
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  • rit...
  • Taken for less than 1 month
  • April 30, 2014

For Nausea/Vomiting, Postoperative "Was given Zofran for nausea in the recovery room before going to the same-day surgery unit prior to release. Ended up with nausea, dizziness, vomiting, and shivering. After the second vomiting episode, I was given Phenergan and was able to be released in another couple of hours."

1 / 10
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  • Anonymous
  • February 21, 2010

For Nausea/Vomiting "I was prescribed this medicine for morning sickness. I never vomit but always feel nauseated. It only works for me sometimes. Sometimes I feel like a million bucks, other times it's like I didn't even take any medicine."

7 / 10
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16 Report
  • mar...
  • Taken for less than 1 month
  • January 12, 2019

For Nausea/Vomiting "I have had severe nausea and vomiting 2 times in 2 weeks from eating seafood, so I'm guessing no more seafood. The nausea stopped after taking 2 pills. Threw up the first time, then the second one stopped it within 20 min. I'm so happy. The first time I had nausea, vomiting, and diarrhea for 5 hours, had to go to the emergency room. Once diarrhea stopped, they gave me this medication, and all stopped."

10 / 10
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8 Report
  • RDe...
  • September 2, 2017

For Nausea/Vomiting "I woke up this past Thursday with food poisoning. I was going to the doctor for some MRI results and told him that someone had given me leftover food from a picnic and there were a lot of mushrooms! More than one type, too. I had vomiting and nausea, so he gave me a shot of Zofran. I started to feel less nauseous immediately after the injection. I bought Gatorade on the advice of the doctor. Then I slept quite a few hours. By Friday, I was feeling 90% better. I did some research and found out I had all the symptoms of salmonella mushroom poisoning."

10 / 10
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  • Juj...
  • Taken for less than 1 month
  • January 30, 2021

For Nausea/Vomiting "Acute vomiting - was given IV push Zofran. Within minutes, a headache ensued. Massive headache, which I did not know or was told can be a side effect. Released from ER 2 hours later, MASSIVE MASSIVE HEADACHE! Headache got worse and worse over the next 3 days. Had to then take Excedrin for headache and had instant digestive pain - NEVER EVER IN MY LIFE HAVE I HAD DIGESTIVE PAIN! Within 24 hours, had shoulder pain in both shoulders - that radiated down both arms. Nausea gone and vomit gone the next day. Since Tuesday at the ER, I am bedridden still on Saturday with massive headache still - shoulder pain and what feels like an ulcer. I'd have been better off living through the vomit. Especially since at 61 years old - headache, digestive pain, shoulder pain have never ever been an issue for me."

1 / 10
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  • gal...
  • Taken for 5 to 10 years
  • April 18, 2022

For Gastroenteritis "I had my gallbladder removed and was diagnosed with gastroenteritis almost 10 years ago now! I never quite got better, I still have nausea and gut discomfort to this day, but I am sure anxiety has a lot to do with my issues. I take 4 mg Zofran when I feel really bad and haven't been able to eat. It really relaxes my stomach and allows me to feel like eating again. I have a pre-existing heart issue, which doesn't seem to be overly reactive when taking Zofran, but I don't take more than a couple pills a week. I also don't feel very dizzy when taking it, and if I did have a headache, it doesn't get worse with Zofran. Generally helps me more than hinders!"

9 / 10
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  • Mcr...
  • Taken for 1 to 6 months
  • June 14, 2019

For Nausea/Vomiting, Postoperative "I had a gastric plication done (like gastric bypass) and woke up after surgery profusely throwing up to the point they had to sedate me again to put the anti-nausea stickers behind my ears to keep me from vomiting as soon as I woke up again. Well, they gave me the Zofran to take at home, so I would take them every 4 hours before the last dose ran out and didn't feel nauseous ever again. Really great stuff."

9 / 10
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  • Joa...
  • Taken for 2 to 5 years
  • December 6, 2021

For Nausea/Vomiting "I use the sublingual. Every time I take it, I envision the guys designing this: 'We're making an anti-nausea sublingual medication? Great! Let's give it the nastiest fake berry flavor we can possibly come up with. That will help nausea, right?' It really is disgusting. I use it because it doesn't make me sleepy and dangerous to drive like promethazine does, but it's not nearly as effective. It works for queasiness, but on full-blown nausea, it's pretty worthless. But for just queasiness, it's relatively effective."

6 / 10
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  • Joa...
  • Taken for 2 to 5 years
  • December 6, 2021

For Nausea/Vomiting "I use the sublingual. Every time I take it, I envision the guys designing this: 'We're making an anti-nausea sublingual medication? Great! Let's give it the nastiest fake berry flavor we can possibly come up with. That will help nausea, right?' It really is disgusting. I use it because it doesn't make me sleepy and dangerous to drive like promethazine does, but it's not nearly as effective. It works for queasiness, but on full-blown nausea, it's pretty worthless. But for just queasiness, it's relatively effective."

6 / 10
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  • Fai...
  • Taken for less than 1 month
  • December 4, 2021

For Nausea/Vomiting "Zofran made me feel worse and more nauseous rather than helping. I sincerely feel compassion for everyone that has experienced this from this medicine, and yet your doctor has not believed you or looked at you in disbelief, not having sincere compassion, empathy, and kindness when you know that taking it made you feel more nauseous immediately, throwing up as you combatted the watery feeling trying not to, and realizing the medicine made you feel worse instead of better. My daughter also was prescribed Zofran during a time that she was nauseous. I did not tell her initially of my prior experience taking Zofran because I realized medicines have different effects on different people. Of course, I was hoping it would help her and my daughter would feel better immediately or soon after taking it. She experienced the side effects that I did and told me adamantly she’s not taking any more Zofran! It made her feel more nauseous and worse instead of better. I understand."

1 / 10
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  • Ano...
  • April 11, 2018

For Nausea/Vomiting "Zofran helped greatly, went from vomiting constantly to nothing - it's amazing. The problem is that if you just take it, you will still vomit, you need to wait, and the nausea takes 10 minutes to stop."

9 / 10
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6 Report
  • Mal...
  • May 5, 2017

For Nausea/Vomiting "Was given Zofran tablets that dissolve a few months ago for the stomach flu, and it worked wonderfully. Now, they gave it to me in an IV, which worked for a few hours, but the tablets they sent home didn't help me with the nausea, only stopped the dry-heaving. Also, didn't last 8-12 hours, only lasted about 4."

3 / 10
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10 Report
  • MHa...
  • April 4, 2017

For Nausea/Vomiting "I was given Zofran after having my gallbladder removed. The nausea wasn't from the procedure, but came on when I was finally able to eat and the broth soup was placed in front of me. For at least a month prior, I'd been getting nauseous just from seeing food no matter how hungry I was (and after fasting for surgery, I was absolutely starving!). I was given Zofran in my IV, and it did absolutely nothing. My surgeon then gave me a prescription for the pill form, but again, it did nothing to help my nausea."

1 / 10
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7 Report
  • Sud...
  • Taken for 1 to 6 months
  • February 24, 2018

For Nausea/Vomiting "I have an extreme fear of nausea and vomiting. It’s so bad I get nauseated when someone coughs. I was given Zofran, and it was perfect for when my anxiety was making the fear harder to deal with. Then I got salmonella poisoning, and it didn’t work whatsoever. I took three 4 mg 20 minutes apart, hoping it’d help, and it didn’t. A few days after taking antibiotics for salmonella poisoning, I’m still a little nauseated (Zofran doesn’t work) and can’t do much. Thinking about going and getting a higher dose."

7 / 10
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  • Vin...
  • Taken for 1 to 6 months
  • September 7, 2018

For Nausea/Vomiting "I take another drug that causes severe nausea. Zofran was prescribed; the nausea stopped, but the other side effects from Zofran were so overwhelming that I had to stop taking it. The side effects were diarrhea, headaches, blood in stool, dizziness, and yes, nausea. I couldn't drive, so I'll live with the nausea until I see my endocrinologist again and (maybe) he suggests something else. Bottom line: the side effects of Zofran outweigh the benefits."

4 / 10
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  • Ale...
  • September 23, 2015

For Nausea/Vomiting "Sometimes have really terrible heartburn due to my birth control pills, and sometimes causes bad nausea. Wanted an alternative to promethazine. Works great for taming the nausea, but the side effects were pretty annoying. Terrible backache and constipation. Oh man. Won't be taking these unless I'm dying or something."

7 / 10
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8 Report
  • Anonymous
  • January 13, 2010

For Nausea/Vomiting "I received this medicine with Stadol for a migraine. Within 20 min, I vomited. I hadn't vomited with the migraine, just had nausea. I got out of bed once after a few hours and threw up again, then again after trying only water. So... this didn't work at all for me, but I'd never had either of the two drugs before."

3 / 10
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7 Report
  • Rip...
  • Taken for 2 to 5 years
  • March 30, 2025

For Nausea/Vomiting "Pleasant taste, disintegrates quickly, and feels a little like Pepto-Bismol how it 'coats' your gut. To be honest, it's only slightly better working than Pepto, but certainly more convenient and better tasting. I'm a little shocked at the listed side effects... it's very tame to me, never anything negative on the 8 mg pill. If anything, it just doesn't do the trick... (nausea from recurring diverticulitis)."

7 / 10
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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.