Methylnaltrexone User Reviews & Ratings (Page 2)

• wor...
• Taken for 6 months to 1 year
• March 20, 2018

For Opioid-Induced Constipation "After injection, within 5-15 minutes, it will produce a movement and will clean you out completely. It can be taken anytime you want to take it. Very little side effects will make you a little warm for about 1/2 hour, then passes. Works great for me, but can be pricey without insurance."

• Ann...
• October 23, 2009

For Constipation, Drug Induced "The doctor gave me this shot to see if it would work for me. I suffer from chronic constipation and painful bowel movements, often causing rectal and anal tearing. It took over 24 hours for it to work for me, but it was well worth the wait. I never had such a massive, normal bowel movement in my life, and I went two times! It was wonderful. Sorry for the details, but I can't have a bowel movement unless I overdose on a ton of laxatives. I am now getting a prescription for it, and I can't wait."

• Kma...
• Taken for 1 to 6 months
• April 25, 2023

For Opioid-Induced Constipation "I have been constipated for longer than I realized. I was managing, but then, six years ago, my constipation controlled my life. I’d be backed up for three weeks. I tried everything on the market. Relistor saved my life. I go every day now. Amazing."

• Chr...
• November 28, 2008

For Constipation, Drug Induced "I suffer from chronic pain and have been on and off opioid therapy for much of my adult life. Because I suffer from chronic pelvic pain, constipation is extremely painful for me. Unfortunately, natural and/or gentle laxatives were not strong enough for me, and strong laxatives were too hard on my system, so nothing was working for me until now. I have just started the treatments, so I am just taking a little less than the 4 ml dose, twice a week. So far, each time I have had my shot, I have had a 'normal' bowel movement within one hour. Overall, if you are struggling with constipation as a result of pain medications, this very well could be the solution for you. It has been for me."

• jcu...
• December 7, 2015

For Constipation, Drug Induced "I've been on hydromorphone 2 mg (Q 4 H), oxycodone/APAP 10/325 mg (Q 4-6 H), and OxyContin 40 mg daily for an accidental amputation. After landing myself in the hospital for diabetes-related illnesses, my doctors became concerned about me not having a bowel movement. They used Relistor as a last resort, and although it didn't work immediately, it worked the next day. I've been going nonstop since!"

• Ban...
• Taken for 1 to 6 months
• January 30, 2020

For Opioid-Induced Constipation "This medication is super expensive and does not even work. I’m unsure how it even got approved for OIC. At the time last year, Relistor was the only drug my insurance would pay for, so I tried it. I have been on opiates for over 10 years, first in pain management and now Subutex for recovery. Even at the highest dose, it did nothing, and I still was only going once a week. On my new insurance, I now take Linzess, which works a bit better, but I have to drink a cap full of Miralax as well. It also makes me super nauseous. Wish they could make a drug for this with less side effects."

• ste...
• July 8, 2009

For Constipation, Drug Induced "My father is 89 and has suffered from drug-induced constipation for years as a result of his pain management drugs. His first injection of Relistor yielded a substantial bowel movement in less than ten minutes. Since this initial treatment, he has experienced increased normal movements on a regular basis. There have been no adverse reactions to this medication."

• Jan...
• January 18, 2020

For Opioid-Induced Constipation "I couldn’t believe how expensive this medicine was, so I figured it must be worth the bang. I have only been on pain meds a short while from a car accident. I have been taking this medicine for a few days now, and it’s done absolutely nothing. It certainly wasn’t worth $700. I am very surprised. I thought it would be a godsend. I finally went back to OTC medicine to help me. I won’t be buying another prescription of this."

• And...
• February 2, 2010

For Constipation, Drug Induced "This is the best medicine available for drug-induced constipation, there is no doubt in my experience. My one concern is that it does involve some urinary retention, certainly when I was given the maximum dose of 12 mg. The lower dose of 8 mg caused less urinary retention, but I am only using Relistor once a week until we assess how much retention it is causing by ultrasound. The manufacturer is still saying urinary retention is not a side effect. I note the comment of urinary retention here. This could be a serious problem for those of us with underlying disease that involves urinary retention, such as ALD or some forms of MS, for example. Relistor is a great help otherwise."

• Ell...
• June 11, 2016

For Constipation, Drug Induced "The first time I took this, it worked within 5 minutes. I continued to take as directed for the next month. Absolutely nothing. Other than severe cramps, sweating, flushed, sick. I have been on and off of this for over 6 months. It has only worked 1 more time in 6 months."

• cro...
• Taken for less than 1 month
• November 3, 2013

For Constipation, Chronic "My 1st 12 mg injection cramped me severely with sweating & nausea. Got to go about 20 mins later, had been 4 days. Have been on pain meds for 21 yrs and finally found this medicine. Getting ready for 2nd injection, hope the cramping ain't as bad as the first time."

• Anonymous
• July 24, 2019

For Opioid-Induced Constipation "I have been experiencing OIC and have been using every OTC and natural remedy available. The issue has been ongoing for several months. I took my first Relistor injection 5 hours ago without success. I added some suppositories, magnesium citrate, and a Fleet enema and expelled some gas and a few pellets of poop. Why have I not experienced a bowel motion, and what can I expect with another injection tomorrow? This problem is totally incapacitating."

• Eda...
• March 19, 2018

For Constipation, Chronic "I'm going on the 3rd month of usage, it absolutely helps with constipation. I have had every test possible, and they show no major problems. The gut still hurts every day. There's definitely a physical problem with the digestive tract. Cancer was ruled out, no heart problem, yet in so much pain and hard to pass stool without Relistor. Any doctors out there can give me any recommendations as to what to do next. I'm desperate. Thanks to all of you."

• Too...
• July 14, 2017

For Constipation, Drug Induced "Before Relistor or Movantik, anyone in this world experiences trying to pass a friggin' baseball?? Literally true. I was on a miracle drug called Movantik for 1 month, $435.00!!! And they are pills, 1 pill on an empty stomach with a bottle of water, say 8 am, on the pot within 30 minutes, oh, what a relief it is!! My insurance wouldn't cover it :( because it's not on their formulary list, but will cover Relistor for $2000.00. But if this works like Movantik, it's my miracle drug. I'm just scared of the side effects from Relistor, I had slight side effects with Movantik, such as withdrawal symptoms, not every day, so wish me luck, my 1st dose is tomorrow morning. 7/14/17"

• Sto...
• September 7, 2020

For Constipation, Chronic "I am prescribed Relistor shots once a day for opiate-caused constipation. I realize I'm supposed to take all meds as prescribed, but this is the only med I take that I take for it to work the best. I found taking it every day only lessens the effects of the drug, thus the benefits as well. What helps a great deal is if, when I wake, I drink a cup or two of some form of hot drink, be it coffee or hot water with lemon and honey, which is what I use. Then wait like 5 minutes and do your shot. When I went from everyday use, which within a month was basically totally ineffective, to using it three times a week with the hot drink before, I am a totally new person who can actually get out and live my life. I had no idea how much of life was being stolen away from me until I got a taste of it back! Oh, I also drink the hot liquid on the off days. Give it a couple of weeks to start regulating. Enjoying it! I hope others out there find this helpful. It's been a lifesaver for me."

• Kdm...
• Taken for 1 to 6 months
• August 17, 2021

For Opioid-Induced Constipation "I was given samples of Movantic and Symproic, both of which caused withdrawal of a level 6 on a scale of 1-10. Finally, my insurance, after 2 denials for Symproic, stated a list of meds I had to try first, including Amatiza, Lactulose, Linzess, Miralax, Senna, and at the bottom was Relistor. I had used all the above for years with no effect. Injured in a patient lift in 2003, I have 8 herniated discs, torn rotators, spinal stenosis, etc. I tried Relistor, 3 giant pills at 1 time. Researching, I found to take it 30 minutes before food or, as I did initially, 6 hours after the last food and last Oxycodone 15 mg. Now I do as recommended, get up, no oxy (unless, as usual, I can't move from pain and I take 1/2 a 15 mg). I take my 3 Relistor 45 minutes before food. 2 hours later, I'm on the toilet, and I have less withdrawal than Symproic or Movantic. I thank my GI MD for pursuing this with verifications from my PCP as to previous meds. I give Relistor tabs 9/10 due to size."

• Mog...
• Taken for less than 1 month
• September 11, 2021

For Opioid-Induced Constipation "With the first dose of Relistor, I had a moderate bowel movement with some straining. Later that day, I had severe nausea, stomach pain, and intense, forceful vomiting. I was so dizzy that I could not stand up. These symptoms lasted for a couple of hours. The side effects were bad enough that I will not take another dose."

• Lei...
• Taken for less than 1 month
• July 16, 2021

For Opioid-Induced Constipation "I've just started taking this medication, so I can't say about the longevity, whether it'll always work the same, etc. BUT so far it works great. I take 3 of the 150 mg tablets, and in about 2 hours I have a bowel movement. I've been on morphine and dilaudid for about 12 years, and I've always had issues with painful constipation. The OTC laxatives usually cause so much pain I'd avoid them, only using Miralax every now and then. I really like Relistor because the stomach cramps are minimal compared to laxatives. The poops were still kind of hard, but maybe I just have to get the hard ones out before they start forming softer. I wish more came out, but maybe if I take it longer it will get better."

• Pai...
• Taken for 1 to 6 months
• March 20, 2015

For Constipation, Drug Induced "I've had mixed results with this. Been on 180 mg of Oxy IR and 75 mcg Fentanyl for years. When my doc increased my Fentanyl to every 48 hours, all my plumbing stopped. I never had any problems, ever! I fought with the constipation, not going for 6 weeks+ sometimes. I don't know what hurts worse...? Anyway, the Relistor works here and there. I don't have insurance, and at $75 a 12 mg injection, I can't afford not to go!!! I just gave myself a 12 mg shot yesterday, and another today, 24 hrs apart. Nothing. I haven't gone in 3 weeks now. This is not good. The laxative route does nothing as well. I'm frustrated... Any suggestions?"

• Jal...
• Taken for 1 to 6 months
• April 2, 2015

For Constipation, Drug Induced "Constipation due to opiates has been extremely bad for me. Along with Relistor, I'm still taking laxatives and suppositories. I'm on my second month with one shot every other day, and only twice did I not have to use a suppository. Wondering if I have something else going on."

• Bee...
• Taken for less than 1 month
• January 11, 2021

For Opioid-Induced Constipation "So I took a shot of Relistor, and I've been backed up for over a month. I could feel it helping out, but it takes some time, so I gave it 24 hours, and then I went to get a colon irrigation, and let me tell you, it was almost painless. I say it works. No adverse effects, and I finally felt like things were working again because before it felt like everything was closing down whenever I tried to poop. I feel like a new man. Get some help, guys. Try an enema after a while if Relistor doesn't work. Watering the dry stool will make it almost painless. Good luck :)"

• loc...
• Taken for less than 1 month
• October 2, 2016

For Constipation, Drug Induced "My doctor just put me on Relistor. It's been 6 weeks since I had a small bowel movement. This is my 6th day of 12mg shots, and I've only had one small bowel movement, like a rabbit! Something’s gotta give. I have cramps, nausea, sweating like crazy, severe cramps. I don't know what to do next? Help."

• Anonymous
• April 11, 2010

For Constipation, Drug Induced "I've been going on and off opiates for around 8 years since my chronic pain began. I would go off the medicines to get relief from the horrible constipation they caused. A few years ago, I discovered that I was constipated even when I would go off the medicines, so I must have messed something up by using laxatives for so long. I tried the subcutaneous Relistor that I had been desperately waiting for for years, and unfortunately, it didn't help."

• Moo...
• Taken for 1 to 6 months
• December 24, 2024

For Opioid-Induced Constipation "I have been on Oxycodone for over 3 years to treat severe pain. Up until a month ago, my go-to OIC relief was Dulcolax liquid, which sometimes worked and sometimes did not work with a single dose. However, about 2 months ago, my pain management doctor introduced me to Relistor. The results have been amazing! I usually get relief in 15-30 minutes. The worst result I have experienced was about 2 hours before a bowel movement. And, when I say bowel, I mean EVERYTHING flushes out! So far, the only negative side effect for me has been flatulence."

• Pea...
• Taken for less than 1 month
• July 31, 2019

For Constipation, Chronic "I have had chronic constipation due to taking methadone for severe nerve damage and my nerves now not working in my colon and stomach properly. I have been on opioids for over 26 years. From reading some of these reviews, I wonder if some of you may have similar issues and that may be why many meds may or may not work for you. You may want to check with your doctor about the possibilities. OIC is the first issue thought of, but in some cases, there may be more to it, so I have learned. I'm hoping this info can at least help someone. I have taken my first dose today of three 150 MG tabs 30 min before eating first thing in the AM. I will be starting out by taking this dose for 3 days in a row. I am hopeful because Movantik worked well more than not, however, it was always a violent clearing out of my system and the withdrawal side effects were unbearable for me, so I am a bit fearful of these side effects from Relistor. I will be back to share how or if this med works for me enough."