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Provera and Tiredness: What Users Say

Tiredness: mentioned by 12 users (3.8%)

Based on user experiences from 316 Provera reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

bleeding 34.2%
cramps 23.7%
blood clots 11.7%
headaches 7.6%
spotting 6.3%
pain 5.4%
nausea 4.7%
heavy periods 4.4%
tiredness 3.8%
bloating 3.2%

Reviews for Provera

Commonly mentioned side effects
  • Anonymous
  • Taken for less than 1 month
  • May 7, 2014

For Abnormal Uterine Bleeding "I was bleeding for 7 weeks lightly, and then all of a sudden it came, and I was passing large clots and a lot of blood. My doctor put me on Provera 10mg twice a day. I had a horrible headache and felt tired, but my period did stop, which is great."

7 / 10
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  • Anonymous
  • January 23, 2011

For Abnormal Uterine Bleeding "I started taking Provera January 7th because I had 3 different periods in the month of December, regular (changed every 2-3 hrs), to light (barely noticed it, changed every 4-5 hrs), to extremely heavy with huge clots (literally changed every time I stood up because there would be a gush of blood). I was told to take it for about 2 weeks and that I would have a period afterward. I stopped bleeding, but I got my period a couple of days before the 2 weeks were up. The side effects I've had are nausea (seriously sick to my stomach, the mere thought of food almost made me regurgitate), and my body was extremely sore, and it made me tired. I still have pills, and honestly, I'm not sure if I should still be taking it, but I guess the pills work."

5 / 10
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  • Jly...
  • Taken for less than 1 month
  • May 11, 2017

For Abnormal Uterine Bleeding "I started my period in March. It's been mostly light bleeding, but on Friday it got pretty heavy. By Tuesday I was in the ER because I was just passing softball-sized balls every single time I stood up. I went to see my OB-GYN today, and he prescribed me Provera. Prior to taking it, I was still passing huge clots and just overall felt miserable. I've barely had an appetite and just felt so tired. Within two hours of taking this pill, I could feel the difference. I had more energy, I don't feel stabbing pain in my lower back from cramps, and I don't feel like a waterfall is going to come pouring out of me when I stand up. I know this is only the first day, and I still have 13 days to go on this pill, but so far it's been amazing."

10 / 10
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28 Report

Frequently asked questions

  • con...
  • Taken for 1 to 6 months
  • February 25, 2023

For Endometrial Hyperplasia, Prophylaxis "I am a 64-year-old woman who is 15 years post-menopausal. A polyp was removed from my cervix. I had an ultrasound of the uterus with a biopsy. The biopsy came back okay, and the lining of the uterus measurement was 15. Ultrasound showed probably a polyp. I had a hysteroscopy with D&C and the removal of a polyp. The gynecologist would like to do a hysterectomy. Since my test results came back as simple hyperplasia, my insurance questioned that suggestion. I was put on Provera 10 mg for the protocol of 90 days. I repeated the ultrasound and biopsy. Ten days after taking Provera, I started spotting light bleeding. A week later, I had a heavy period with large clots. My doctor prescribed Lysteda for 5 days, blood work, then back on Provera. No thank you. I am exhausted! I am struggling with my concentration, worrying about being able to change my pads before leakage, and feeling tired and weak, with headaches and chills. I won't take Provera or Lysteda. I am done with my uterus and had all this trouble. I don't want any more drugs. Hysterectomy time!"

1 / 10
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  • wag...
  • October 21, 2010

For Amenorrhea "I am 41 years old. This is my first time taking Provera. I had been bleeding very heavily for 2 months when my doctor prescribed this medication. I have been on it for one week thus far and just stopped bleeding. The doctor was right. The two side effects I have noticed are tiredness and very dry mouth. If these are the only side effects I experience, it's worth it."

9 / 10
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  • Bas...
  • Taken for less than 1 month
  • January 6, 2022

For Abnormal Uterine Bleeding "I was prescribed 10 mg of Provera daily beginning on December 16th to control a nine-month continuous menstrual bleed. It is now January 5th, and there are no signs of this nightmare ending. This drug has left me with side effects of anxiety, depression, exhaustion, heart palpitations, headaches, and of course still bleeding with clots the size of my fist! Doctors don’t return calls, and appointments aren’t available until over a month away! I’ve suffered far too long, and I’m about to give up. My quality of life is pretty low right now. I have an appointment with a new OB-GYN, so I’m hoping for answers and an end to this mess. Maybe I’ll be in bad enough shape for an emergency hysterectomy while I’m there. My career is about to end due to the inability to leave home without bleeding all over the place! I’m 49 years old, and I feel like I’ve wasted a year trapped in my home from this. This medication has been as useless."

1 / 10
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  • fer...
  • Taken for 1 to 6 months
  • September 15, 2017

For Abnormal Uterine Bleeding "Ok, I went on this 10 mg 2x a day for about 4 weeks now. I needed to start because I hemorrhaged so bad in a single day my hemoglobin dropped from 12 to 9, and then to 8 as I continued to hemorrhage for 2 weeks after. As a result of hemorrhaging, I could not breathe, my heart was racing from dehydration, and my body used all of my iron and ferritin, and then started destroying bone marrow to try and make hemoglobin. I started Provera when my hematologist started ferritin infusions and was afraid any bleeding would kill me. This medication causes me shortness of breath, a racing heart, rashes, lethargy, vomiting, muscle pain; oh, and I have been spotting since I started it! I feel worse than when I was literally dying before taking it."

1 / 10
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  • Anonymous
  • March 25, 2010

For Amenorrhea "Today is my third day on Provera (generic). I have never taken this medication before, so we will see what happens. So far, I haven't had any other side effects besides a little bit of dizziness, it also gets me very tired. I hope this medication works for me like it has for others. I was prescribed Provera to try to restore my periods. I have never been regular but not so irregular either, if that makes sense... basically, I get a period every month (except last month), but I'm never sure when! I conceived my first baby naturally (5 years ago) without any medications, and now I can't seem to get pregnant naturally again."

7 / 10
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  • Jlg...
  • August 29, 2015

For Abnormal Uterine Bleeding "I have PCOS and have done for nearly 20 years. Periods, lucky if I had one a year, then started to have irregular bleeds. Was sent for biopsy and scan results showed complex focal hyperplasia. Gyn put me on Provera, 3 daily. I am now entering my 5th week of really heavy bleeding and large clots, along with being depressed, tired, and ruling my life. Was talk of hysterectomy, but I'm petrified of such a major operation. Any help will be gladly appreciated."

1 / 10
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10 Report
  • Tam...
  • Taken for less than 1 month
  • September 10, 2021

For Endometrial Cancer "I’m on this for early-stage womb cancer. An attempt to salvage my womb and reverse the growth of tissue with cancer in it. The first 2 weeks were fine. I slept well and felt calm. After 2 weeks, I began getting vaginal cramping and a pelvic cramping/jabbing sensation. I then got a period that lasted for around 2.5 to 3 weeks. I read that this is the uterus lining breaking down and being expelled. I have also read the uterus lining will rebuild. I’m getting spotting/blood every day. I’m not sure if this is normal or indicative of something to worry about?! Having read comments on here, no other women have taken Provera for the same condition as me. Most women go for a hysterectomy straight away. The Provera is working fine for me… the vagina and urethra have become super sensitive. The pelvic pain continues. I assume this is a side effect. I feel lethargic every day, another side effect."

9 / 10
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  • Not...
  • Taken for 1 to 6 months
  • November 10, 2021

For Abnormal Uterine Bleeding "My doctor put me on Provera 10 mg. I’ve been suffering with bleeding and clots. A blood test also showed I have low iron and am anemic. I have constipation too. After taking Provera for about 3 months, still bleeding irregularly. Legs feel heavy, looks like I swallowed a damn soccer ball. Got terrible cramps, feel exhausted, get terrible headaches. Feels like my body is giving up on me. So sick and tired of being sick and tired. Just want my life back, my energetic healthy self."

1 / 10
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  • Pin...
  • June 4, 2017

For Birth Control "My last normal cycle was the 23rd of March 2017. On the 10th of April, I started spotting, on the 11th, it stopped. Then I started spotting on the 14th, then it stopped on the 15th, then started bleeding on the 18th of April until the month ending, very heavy and lots of clots. I went to the clinic and then they sent me for an ultrasound and blood test. I didn't have the money to do these, so the following week I checked myself into the emergency room at the hospital. They gave me Provera to stop the bleeding, which stopped in 5 days of taking 2 pills 3 times a day. The scans came back negative for any growths. I started bleeding again on the 24th, now taking Provera prescribed at 2 pills 2 times a day. It's day 5, still bleeding from the 24th. I'm so tired..."

6 / 10
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