Medroxyprogesterone for Abnormal Uterine Bleeding User Reviews
Brand names: Provera, Depo Provera, depo-subQ provera 104
Medroxyprogesterone has an average rating of 3.2 out of 10 from a total of 913 reviews for the treatment of Abnormal Uterine Bleeding. 16% of reviewers reported a positive experience, while 68% reported a negative experience.
Reviews for Medroxyprogesterone
- Missy
- Taken for 1 to 2 years
- February 28, 2019
Provera (medroxyprogesterone) "I have been on this med several times, I am 48 years old going through menopause and have had abnormal bleeding off and on for 2 years. From what I understand, 10 days on this med is not going to make you stop bleeding. What it does is 'clean' you out first before it thins the lining enough to stop the bleeding. When I take it, I bleed worse for a couple weeks, clots come out and then it stops and stays stopped so all the ladies taking it for 10 days give it more time, please. The cramps are bad during the 'cleaning' phase also but trust me it will get better."
- ABano
- Taken for 10 years or more
- September 5, 2020
Depo Provera (medroxyprogesterone) "I have been on Depo for 10 years without missing an injection. I had no side effects and LOVED not having a period. Something in the drug has obviously been altered because I'm having a period now, and nothing else in my routine has changed. This began around February/March of this year (2020). I've still continued to get the injection, but am questioning what exactly has happened to the drug and why patients have not been informed about any changes to the drug."
Frequently asked questions
- Chris...
- Taken for 1 to 6 months
- June 9, 2020
Depo Provera (medroxyprogesterone) "I can't believe all the reviews I'm reading about the shot making you bleed for weeks or even months because now it's happening to me. I got the shot for the first time in late April and I started to bleed about 2 and a half weeks ago. And I'm still bleeding. This really sucks. Being on a period every day is not what I signed up for. I will NOT be getting it again and I just want my period to go back to normal. Would NOT recommend getting this to anyone!"
- Tamara
- Taken for 1 to 6 months
- April 15, 2021
Provera (medroxyprogesterone) "I am 48 years old and childless and started bleeding on January 2nd until February 12th. I went to the gynecologist, and she prescribed 10mg Provera for 21 days, and my cycle regulated. Lo and behold, I got pregnant with my first baby at the start of April. It's amazing! I have just begun a new journey, and I look forward to every single step."
Are you taking this medicine?
- Taza
- Taken for 1 to 6 months
- July 3, 2021
Depo Provera (medroxyprogesterone) "I’ve started the Depo Provera injection fairly recently on 24 May 2021. I was on my period, which I normally have for seven days, but with this injection my period went from normal flow to a dark brown, slow flow, which couldn’t fill a pad. It changed halfway through June to a medium-heavy flow. I called the doctor in the early stages because when I read the symptoms, it said spotting but not heavy flow period. When I spoke to her, it was like speaking to someone who doesn’t want to hear you. Not helpful at all. It’s now July, and I’ve been bleeding for a total of 42 days and counting. Will I get the second injection in August? Nope. Would I recommend it? Nope. It really mucks up your emotions. It has made me cry over stupid things. I had this injection so I could have sex without fear of pregnancy. Have I been able to have sex? No. My advice, once again, it’s not the one to get."
- GGano
- February 15, 2021
Depo Provera (medroxyprogesterone) "I have been on Depo Provera for 22 years. After my very first injection 22 years ago, I have had zero periods and zero breakthrough bleeding. Zero side effects. Nothing. This has been a blessing. I had my last Depo Shot on 1/12/21. My next one is not due until 3/30/21. Today I wake up and have bleeding. While I realize that this can be due to other causes, I was just reading that there are others experiencing this. Perhaps there is something wrong with a batch of the medication? Will see what happens from here and keep an eye on it."
- MsQueen
- Taken for 1 to 6 months
- September 18, 2020
Depo Provera (medroxyprogesterone) "I feel better knowing I'm not going through this horrible experience of Depo-Provera alone. I loved the Depo just because I didn't have periods over 5 years using this shot. And now to bleed every day longer than 10 days is very depressing. I would like to know what I can do to make this bleeding stop. This can't be healthy."
- OverT...
- Taken for less than 1 month
- May 31, 2020
Provera (medroxyprogesterone) "I've been currently taking Provera 10mg for about 28 days now. At first it stopped the bleeding altogether for the first week. Then I started to spot again and bleed. Now the bleeding is getting progressively heavier and the clots are getting larger, like they are huge. This is a nightmare. I'm having to empty my 25ml menstrual cup every hour or two. Hoping to get a hold of my OB by Monday. I'm feeling very weak and I have lots of cramping."
- Canad...
- Taken for less than 1 month
- April 13, 2017
Provera (medroxyprogesterone) "I have been bleeding for 42 days. When I was at 31 days bleeding, I went to my doc and he gave me 10mg Provera for 10 days. I started the pill on a Thursday and Saturday, and Sunday no bleeding so I was super excited! Monday I started bleeding again and have been ever since, which is now 42 days. Had blood work and ultrasound just to be told all is normal. Anyone else experience this?"
- GGano
- January 4, 2021
Depo Provera (medroxyprogesterone) "I've been on Depo-Provera for over a decade with no side effects, no periods or breakthrough bleeding. I have never missed an injection, however, 3 weeks before my next injection, I'm bleeding. This is an unwelcome, painful surprise because I've been without a period for as long as I've been on this birth control, which has been almost 14 years. Something has changed with the medication."
- Rachel
- Taken for less than 1 month
- September 5, 2019
Provera (medroxyprogesterone) "I feel like everyone who left reviews here only left negative ones. But for me, the Provera pill helped me so much. I kept bleeding after my miscarriage at 8 weeks, for about 8 weeks - the bleeding was severe towards the end, and I've had enough. My doctor gave me a 14-day supply of Provera, and I stopped bleeding after 1 pill. My cycle has been reset now, so this worked for me very well."
- Kat
- Taken for 1 to 6 months
- February 10, 2020
Depo Provera (medroxyprogesterone) "Worst contraceptive ever. I had my first Depo shot on the 9th of Jan. Approximately two weeks after, I started spotting and then bleeding heavily. I am so mad that my doctor never indicated or told me about any of these side effects. I will not be going back for a second injection. Now, I feel like I am on a permanent menstrual cycle. If any of you ladies are really wanting to do something about this horrible drug, report it to the FDA. And also to Pfizer on their website. I believe this drug needs to be removed from the market. I don't think any woman wants to keep bleeding for months on end at a time."
- Amanda
- Taken for 1 to 6 months
- February 28, 2020
Depo Provera (medroxyprogesterone) "I got on the shot in early Nov 2019, it's now Feb 27th and I have been on a period since. Not a light period but a heavy 'blood clot' type one. I'll never get this shot again, and I will not recommend it to anyone."
- emma
- Taken for 1 to 2 years
- February 13, 2020
Depo Provera (medroxyprogesterone) "So I've been on this Depo-Provera shot since I was 16. I’m 18 now. I haven’t bled on my period for 2 years. This past week I started to spot. Now I'm getting really heavy bleeding that’s bright red. It’s just a little odd that I’ve been on it for 2 years and haven’t bled at all, and now all of a sudden I am. I am not sure if this is normal or not."
- Ms...
- Taken for 1 to 6 months
- May 19, 2019
Provera (medroxyprogesterone) "I do not recommend Provera for abnormal uterine bleeding. It caused me to bleed more and for a significantly longer time. The purpose of the Provera prescription (dose: two 10mg daily) was to reduce/stop my bleeding. I bled so much after taking it that I had to go to the ER because my blood count was dropping. My side effects were skin sensitivity, itching, hair shedding, loss of appetite, and intense pains in my legs. It’s been an entire nightmare!"
- Missy
- Taken for 1 to 2 years
- March 16, 2019
Provera (medroxyprogesterone) "I was bleeding for over a week and started taking Provera. My doctor gives me 6 months' worth, not 10 days' worth as I read over and over again on this forum (one 10mg pill once a day). I bled worse for 3 weeks, and as of now, for 5 days straight, no bleeding at all. It just takes time to work. The cramping and bleeding were bad for the 3 weeks 'cleaning out' phase. I felt horrible, but now I feel like a new woman. No cramps, no bleeding, and other than a little fatigue, no side effects from the Provera. I was on this med 2 previous times, and it worked the same both times. After I take it for a while, I stop and let my body rest from it until I bleed again, and my doctor puts me on it again. I hope this is helpful!"
- Banan...
- Taken for less than 1 month
- October 4, 2020
Depo Provera (medroxyprogesterone) "I took Depo-Provera injection many years ago. I never had a period or spotting from the first shot. I was on it for 6 years with no issues other than weight gain. I got the shot again on September 10, 2020. I started bleeding 10 days ago. The cramps are extreme to the point I don't want to get out of bed, which is not possible, as I have 3 children ages 8, 2, and 1, and am a stay-at-home mom. Over-the-counter medication does not help with the pain. There are too many of us experiencing the same things, and a lot of us have already taken Depo before with no issues."
- Keke
- Taken for 10 years or more
- May 22, 2020
Depo Provera (medroxyprogesterone) "I've been on Depo-Provera for 20 years and was very happy, but then when I moved out of state last year, I started bleeding. I've been bleeding for over 2 years now, and I am so depressed over this annoyance, and my hubby is too. I really want sex, but with the blood clots and non-stop bleeding, I feel like I'm going crazy. I have tried everything the doctor has given me, but it just won't stop, and I'm sick of it. I'm mad and wish this bleeding would just go away so I can try to be happy and work on my depression. Somebody, please help me to stop this bleeding, 2 years is too much."
- aries...
- March 8, 2008
Provera (medroxyprogesterone) "I had abnormal uterine bleeding and I didn't know why. I started passing clots & was bleeding irregularly. I thought, at first, that I was having a miscarriage. I went to my GYN. She prescribed Provera 10mg once a day for 10 days. I just finished my prescription & the only problem that I'm having now is sensitive breast. Other than that, my bleeding has completely stopped."
- Summer
- Taken for 1 to 6 months
- June 6, 2020
Depo Provera (medroxyprogesterone) "I got the Depo-Provera in January - the only one I had. My heavy bleeding started the very next day, and now 5 and a half months down the line, I am still bleeding a heavy period every day!! Doctors cannot work out why or what is going on!!"
- Tabbi
- Taken for 1 to 2 years
- August 21, 2020
Provera (medroxyprogesterone) "I was 47, and one day my normal period wouldn’t stop for 3 months. It then got really heavy. After two doctors' ultrasounds and blood work, my doctor put me on Provera 10mg once a day every day. After a month, I stopped bleeding altogether. I did this for 6 months and had no problems. Then I stopped taking them and expected problems, but went 8 months without a period. I thought finally menopause had arrived. I’m 49, almost 50 now, and guess what showed up today. I’m calling today to get another prescription. The only issue I had was really bad headaches."
- JNK
- Taken for less than 1 month
- August 20, 2020
Depo Provera (medroxyprogesterone) "I was on Depo from 2008-2011 with zero side effects. My periods were gone completely after the first shot, and I had no weight gain and minimal mood swings. Fast forward to July 2020, after having finished having children, I got the shot again. I've now been bleeding heavily every day for three weeks straight. Looking at this review forum makes me think the manufacturer made a change in early 2019 that quite obviously is not working with the majority of women's menstruation. Who wants to bleed every day for a year?! NO ONE. I WILL NEVER GET THIS SHOT EVER AGAIN. NEVER."
- Best...
- Taken for 6 months to 1 year
- August 3, 2016
Provera (medroxyprogesterone) "This medicine has been a complete life changer for me. Having heavy periods, 4 months nonstop bleeding, I am 40 years old. I was prescribed 10 milligrams for 10 days. If it wasn't for this medicine, my everyday life would be unbearable. Some drugs aren't for everyone. This one is by far the best. Everyone says it can cause cancer, it has bad side effects. Doesn't everything in life cause cancer and have bad side effects? This drug is so helpful for prolonged uterine bleeding. I would recommend this to anyone. This medicine saved me from a complete hysterectomy, so why everyone voices their opinions on it? Don't take it, go on and bleed and deal with it, and quit complaining about it. Maybe if it wasn't for the stress in your life, your periods would be regular."
- Hater...
- Taken for less than 1 month
- February 16, 2020
Depo Provera (medroxyprogesterone) "I thought I would get Depo after a pregnancy scare. My first jab was given at the beginning of August 2019. I bled from the next day onwards, right up to when the next one was due. So, I decided not to have it. It’s now mid-Feb and I am still bleeding. I have had the occasional day where I think it’s over and it comes right back. In total, over 6 months, I have had 5 days of non-bleeding! It is almost like a form of torture. I thought it would be out of my system by now!! DO NOT HAVE THIS, IT WILL BE THE BIGGEST REGRET OF YOUR LIFE!!"
Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.
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- Medroxyprogesterone injection
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- Medroxyprogesterone Injection (400 mg/mL)
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Provera, Depo Provera, depo-subQ provera 104
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- MedroxyPROGESTERone monograph
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- Medroxyprogesterone Injection (FDA)
- Medroxyprogesterone Injection ER (FDA)
Other brands
Provera, Depo Provera, depo-subQ provera 104
Provera (medroxyprogesterone) "I've been taking Provera 10 mg once a day since March 20, 2021 because I have irregular bleeding and 2 fibroids. My period has not stopped or slowed down at all. Last month it was just seven days, but this month, it's been on for two weeks. It seems like it wants to stop but then I'll have spotting before full-on bleeding, and it seems to happen after I take the pill. I was told this medication would stop my period and correct the irregular bleeding, but it has done nothing of the sort. I feel, if anything, it's causing me to continuously bleed."