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Linzess User Reviews & Ratings (Page 4)

Linzess has an average rating of 6.7 out of 10 from a total of 885 reviews on Drugs.com. 56% of reviewers reported a positive experience, while 26% reported a negative experience.

Reviews for Linzess

Commonly mentioned side effects
  • Ms ...
  • March 10, 2016

For Chronic Idiopathic Constipation "I have dealt with chronic constipation all my life. No matter how I change my diet, no matter how much I work out to keep things moving, I still get constipated. I can go weeks at a time with no BM and sometimes a whole month. I know this is definitely not normal. My doctor has done 3 colonoscopies and can't seem to find anything wrong. About 3 months ago, I went in with severe constipation and nothing I took helped. He gave me samples of Linzess. I was afraid to take them at first, but I was so miserable I said, 'What the heck, better out than in.' I took the Linzess and within 4 hours I was in the restroom. I still had to do just a little light pushing since the stool that was already in the rectal area was hard as a brick. I love Linzess."

10 / 10
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  • Khy...
  • Taken for 1 to 6 months
  • February 25, 2020

For Chronic Idiopathic Constipation "I have been diagnosed with CIC. I was 'normal' until after a hysterectomy a year ago. I didn't have a BM for 15 days after surgery and rarely have gone on my own since. I have to use enemas, suppositories, mag citrate, etc., to force a BM. If I take the 'wait and see' approach, I simply don't go. At all. I tried Amitiza and it did nothing but make me so nauseous and headaches that I couldn't function. Switched me to Linzess. I started on 72 mcg dose for 2 weeks and except for a few noticeable tummy gurgles, it did not work. Two weeks later I had to use mag citrate and an enema to get things flushed out. Dr. upped the dose to 144 mcg daily. It's been a full week and nothing but insane bloating and nausea. I have had every test under the sun and it all comes back normal. But this med has not worked either."

1 / 10
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  • Cat...
  • July 27, 2018

For Chronic Idiopathic Constipation "This medication is a lifesaver! I have had chronic constipation/ IBS my whole life. However, the last two years, I had a health scare that required me to be on high doses of narcotics until I finally had surgery to correct the problem. During this time, I tried stool softeners, senna tea, etc., to help with the constipation, but often times I would need an enema to help. After my surgery, between the increase in all the pain meds prescribed and the surgical pain, going to the bathroom was a nightmare. My surgeon had me on Colace stool softener, Miralax twice a day, and a senna stimulant, but they didn't work. Thankfully, she suggested this medication, and my God do I wish I found this YEARS ago! 2 hours after taking this medication, I felt the urge to go to the bathroom! I actually cried tears of joy to be able to go to the bathroom normally (husband laughed at me - lol). No hurt, no hard stools, no diarrhea, no adverse effects. Thank you, Linzess!"

10 / 10
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Frequently asked questions

  • com...
  • Taken for less than 1 month
  • February 6, 2014

For Chronic Idiopathic Constipation "Tried to get my husband to take this since it came out in January. I was tired of him moping around the house taking laxatives. He has opioid-induced constipation of the worst kind. He finally gave in and tried this and says it is a miracle. It worked within 3 hours and did the job. It also did it smoothly without pain. He will be taking it regularly from now on. He had to pay $30 copay with our insurance."

10 / 10
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  • DCG...
  • Taken for less than 1 month
  • February 10, 2020

For Irritable Bowel Syndrome with Constipation "I have gastroparesis / IBS-C, so I tried taking Linzess for 10 days. Each day my weight went up another 1/2 pound, my abdomen became more and more swollen, and my blood pressure skyrocketed. I've been off of it for 2 days now, and my BP is still 165/88 (usual for me is 125/70). Resting heart rate is still up 15 points, and I am completely swollen with fluid from my head to my feet. Gained 6 pounds of fluid since I have been on it. It only worked on the 1st day and did not work after that. Milk of Magnesia works much better than this drug and is a lot less expensive."

1 / 10
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  • Ron...
  • Taken for 1 to 6 months
  • March 1, 2014

For Irritable Bowel Syndrome with Constipation "Have suffered from Irritable Bowel Syndrome and Constipation for many years. Have been taking Linzess for 2 months now. I take it every morning 30-60 minutes before I eat, and it works wonderfully! I no longer have to deal with that bloated feeling and belly pain I would feel throughout the day. I also feel that I completely get my stools out, no longer deal with straining on the toilet. Having a bowel movement is now very easy for me and I no longer have to deal with these issues on a regular basis. You do have to take it every day and not skip a dose. You might get loose stools on the first couple of doses when you start Linzess, wasn't a big deal and went away after the first few days. Probably 'loosening' my stools up so I would no longer be constipated."

10 / 10
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  • Doe...
  • Taken for 1 to 6 months
  • February 14, 2019

For Chronic Idiopathic Constipation "I feel I need to share my history and reason for treatment with Linzess, as I see many negative reviews here. I have been completely dependent on laxatives for my entire adult life, I’m 44 years old, making me constantly sick. Obviously, this is not sustainable. I was reluctant to try this medication because other prescriptions have failed me in the past. My gastrointestinal doctor wanted me to at least try Linzess. And I must say, it’s a miracle! No pain, no cramps, no nausea! And it works like magic! Yes, you will have diarrhea."

10 / 10
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  • JDa...
  • Taken for 1 to 2 years
  • August 19, 2019

For Chronic Idiopathic Constipation "I have had horrible constipation issues for years. When I finally went to my gastroenterologist and they put me on Linzess, it really did change things. The first few times I took Linzess before I went to bed, which was a mistake, I won't go into great detail about that, but let's just say I had a mess or two to clean up. When I take it like I should, it works wonderfully, and I'm so thankful that there is something out there that actually works because I have tried everything. This medicine may not be for everyone, but it definitely has worked for me the past year and a half."

9 / 10
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  • Ker...
  • June 25, 2013

For Chronic Idiopathic Constipation "I just wrote a note of appreciation to the physician who prescribed LINZESS for me. I have been taking it now for about three months, and it has truly improved my life significantly. After suffering from constant constipation for over thirty years, I am so thankful to have this life-changing medication. It works consistently and predictably every day without any noticeable side-effects. If my schedule does not permit its use, for example having an early flight, I simply do not take it that day. For me, this medicine has been miraculous."

10 / 10
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  • Ecg...
  • Taken for less than 1 month
  • July 21, 2019

For Chronic Idiopathic Constipation "From viewing many of the comments, it seems that in some cases, this drug was incorrectly prescribed. This drug worked for me as I have a long history of mega-colon and chronic constipation. Even taking magnesium carbonate (the fizzy kind), I'd have diarrhea that would flow around the extensive compacted stool throughout the large bowel. Also, fiber would only create inflammation in my intestines. Linzess is minimally absorbed, which is good as I usually react badly to most modern drugs. I started on the low dose (72 mcg) first and then tried the medium (145 mcg) dose, which seems better. It took about 2 weeks to eliminate most of the compacted stool, so it may take a while to perceive effective results."

10 / 10
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  • Arl...
  • Taken for less than 1 month
  • August 5, 2013

For Chronic Idiopathic Constipation "My doctor said I have chronic constipation. Since laxatives stopped working, fiber supplements, water, fruit, and vegetables don't do anything for me. I had an entire bottle of Magnesium Citrate and it didn't do anything for me. I was so miserable and constipated that I didn't know what to do anymore. My stomach looked like a big balloon and I had gas. My doctor gave me 4 bottles of Linzess 145 mcg/capsule. I took it and it works. I am so happy I found out about Linzess. The first few days, the bowel motion was watery, but now it looks better. It's best to take it early in the morning with a tall glass of water. Within an hour, you will go. I am so happy to know about Linzess and I hope it keeps doing miracles for me. Recommended."

7 / 10
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  • GI ...
  • February 23, 2015

For Chronic Idiopathic Constipation "I have severe chronic idiopathic constipation. And Linzess usually works within 2-3 hours after taking it. It doesn't work every time, but if it works 2 times a week, then I'm happy. Without it, I only had a bowel motion once a month at the most. And that's after using magnesium citrate."

10 / 10
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  • Tha...
  • Taken for 1 to 2 years
  • June 19, 2019

For Chronic Idiopathic Constipation "I have suffered from constipation all of my life. I’m 44 years old, and I would barely have 2 bowel motions (BMs) a month. My GI doctor gave me Linzess a year ago and told me to take 145 mg twice a day. OMG, it worked so well. Now I take only 145 mg on a Wednesday and Saturday. This medication was heaven-sent because it has really helped a lot of people, including myself. As far as side effects, the only side effect I’ve had was watery stool. That’s why my GI reduced it to 145 mg once a day. But heck, I only take it twice a week, and I have a BM every other day as long as I take it twice a week. But hey, there’s no cramping or painful BMs as laxatives always did."

8 / 10
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  • CPa...
  • April 16, 2020

For Chronic Idiopathic Constipation "Have had problems with constipation following abdominal surgery. Dr. prescribed Linzess 72, and it worked perfectly right away, with no aftereffects whatsoever. I hope others with constipation problems consider this medication."

9 / 10
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  • Kay...
  • Taken for 1 to 6 months
  • September 12, 2019

For Chronic Idiopathic Constipation "I have had chronic constipation for 15 plus years. It's unbearable pain, very depressing pain. So intense, I have passed out with pain from trying to poop. I found Linzess about two months ago, and I love it. Sometimes it's rough due to diarrhea, but it's worth it to me. The price is unbelievable. To everyone that takes Linzess, go to Prescription Hotline, it's for people that can't afford their meds. I thought, yeah right, $432.00 for Linzess. They got it for me through their manufacturer, and I get it for $49.99 a month. That is awesome, I can afford to keep taking it. They are super about helping you. Good luck."

10 / 10
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  • JPa...
  • Taken for less than 1 month
  • March 19, 2019

For Irritable Bowel Syndrome with Constipation "I will never take this again! It works all right. Starts out as regular BM and then goes into diarrhea. Having diarrhea is one thing, but when it gives you no warning and just starts flowing out, that's another. I've tried this for a few weeks; some days weren't too bad, but the last time I took it at 5:30 a.m., and after about a half hour, it started to work. It was a nightmare. Though I was home, I couldn't even make it to the bathroom. Later, at about 9:30, I thought it was okay and went to aerobics class, and luckily I had a pad on as it started again. This med is too, too harsh."

1 / 10
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  • Con...
  • Taken for 1 to 2 years
  • August 11, 2019

For Chronic Idiopathic Constipation "Linzess is truly a miracle answer to my prayers. I’m not sure how this voodoo medicine works, but it works!! It has been years of cramping and discomfort until I found Linzess. Rectal fissures requiring surgery, hemorrhoids, etc. I would go 3 weeks without pooping WHILE taking stool softeners. Nothing worked. I could down 3 bottles of Miralax and water, senna tablets, along with some of those magnesium drinks in one sitting and still NOTHING. Linzess is MAGIC. I sometimes get diarrhea from using it, but it dulls the pain, so it’s nothing like regular diarrhea. Anyway, if you have chronic constipation and have tried everything (or not), Linzess is for you!!"

10 / 10
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  • TBa...
  • Taken for less than 1 month
  • June 20, 2017

For Chronic Idiopathic Constipation "I am a 21-year-old female who suffers from IBS-C. Before this medication, I would only go to the bathroom about once a week or sometimes go two weeks without going. I have been on Linzess 145 mg for a week now, and it has changed my life forever! My doctor prescribed me to take it in the morning with 2 fiber gummies 30 minutes before breakfast. I now go to the bathroom twice a day! My cramps are not bad and go away once I use the bathroom. I don't experience any dizziness. I almost did not take this medication because of the negative reviews, but I'm glad I looked past it! Ask your doctor for coupons as well, I got a coupon for a 90-day supply for $30. Good luck!"

10 / 10
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  • Bda...
  • Taken for less than 1 month
  • July 11, 2014

For Chronic Idiopathic Constipation "I was hospitalized for a week because of a bout with diverticulitis. As a result, my intestines, so I was told, stopped pushing waste through. I was constipated for 3 weeks! My doctor gave me samples of Linzess. It was a miracle! I began having bowel movements on the first day! Some mild diarrhea, but I'm going and there is no cramping, no aches, no bloating. Amazing. I have had constipation issues for years, but not anymore! I highly recommend trying it! Thanks Linzess!"

10 / 10
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  • Jon...
  • Taken for less than 1 month
  • April 11, 2016

For Chronic Idiopathic Constipation "I have had stomach and bowel movement issues since I was 2. I have tried everything. Reflexology, acupuncture, medicines, and drank mineral oil for 10 years. I took one 145 mg pill and in 6 hours, I actually had a bowel movement and several more to follow in the next 6 hours. I weighed myself the next day and I had lost 3 pounds. It does have some not so great side effects, but I am happy that I can go. I don't take it every day because it is too much for me, I can't sit on the toilet all day, but I do take it every other day. It's working for me!"

9 / 10
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  • KRA...
  • Taken for 1 to 6 months
  • December 12, 2013

For Chronic Idiopathic Constipation "I have Irritable Bowel Syndrome with constipation. My doctor put me on Linzess 145. I was told to take it 30 minutes before my first meal. However, my schedule doesn't permit me to do so. I take it whenever my bowels are slowing down and I need some help (about once a week). Immediately, I start feeling the effects, starting with gas, then painless bowels that I can literally feel my stomach emptying. On average, it makes me go to the bathroom for 3 hours. It all depends on how much is in there. All in all, love."

10 / 10
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  • LAC...
  • June 22, 2014

For Irritable Bowel Syndrome with Constipation "Have had YEARS of irritable bowel syndrome with constipation. Bowel movement usually only twice per week...in and out of the bathroom for several hours, cramping and pain that would sometimes give me cold sweats. Then exhaustion and residual intestinal ache all day. No one understood. Fiber was useless. Several bouts of diverticulitis. Never realized that IBS and constipation could contribute to the development of diverticulosis. To me, Linzess is a miracle. Yes, you do need to be near a bathroom and the bowel motions are mostly liquid in the first 2 weeks I have been taking it. But NO PAIN, RESIDUAL ACHE, OR EXHAUSTION! I can take it and go to work. Going out...just get up a little earlier. I even feel better and more energetic overall."

8 / 10
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  • RLR...
  • Taken for 1 to 6 months
  • May 16, 2024

For Chronic Idiopathic Constipation "I am a 43-year-old female and have dealt with severe chronic constipation issues for a good portion of my life. I have tried everything to the point of losing my mind. I started on Linzess 290 in 2021 and took it exactly as prescribed - in the morning with LOTS of water 30 mins before breakfast. All it ever did was make me bloated & partially work maybe 2 times out of 10, so I quit taking it. Fast forward to March 2024. My symptoms were getting worse, so I saw my gastro dr again and figured I'd give it another shot out of desperation. Took it again as directed for 2 weeks with the same issues as they were in 2021. So I did some reading of reviews and saw others having success taking it at night after eating, so I decided to do the same...this has been a game-changer for me! I take it every other night about 20 minutes after I eat dinner and drink a huge glass of water with it, and the next morning...RELIEF! I feel like a new person! I pray it continues to work like it has been."

10 / 10
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  • LIf...
  • Taken for 1 to 6 months
  • November 22, 2014

For Chronic Idiopathic Constipation "From infancy to my 50s, I've used it all - phenothalein laxatives, castor oil, fiber, Miralax, enemas, bisacodyl, exercise, hydration, Zelnorm while it was available, and on and on. Only the phenothalien/old Ex-lax formula laxatives and Zelnorm were of use. Phenothalien also required drinking 8-16 ounces more fluid when you were already congested, adding painfully to existing distension and then needing to wait up to hours. Since that laxative was removed from the US market in the 2000s, availability now is very limited; Zelnorm was recalled by the FDA for strokes and cardiac issues (and did cause punch-in-the-gut cramping.) Linzess is amazing, reliable, no pain, some diarrhea, but complete control and great increased quality of life!"

10 / 10
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  • Jen...
  • February 15, 2014

For Irritable Bowel Syndrome with Constipation "I am a 37-year-old female who has been suffering from Irritable Bowel Syndrome-C for almost a year now. I went from having a bowel movement every 5 to 7 days to having one daily on this medication. I've been taking it for a month now, and it started working right away. I do not have to run to the bathroom, like some users have mentioned. You take it in the morning, and about 30 to 60 minutes later, it creates a movement. It has been so wonderful to feel 'normal' again. However, the two drawbacks I have noticed are, one, it doesn't really help with bloating (which is probably my main complaint), and the cost is an issue. I have three months of free samples, then the cost is right around $200 a month."

8 / 10
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