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Synthroid and Joint Pain: What Users Say

Joint pain: mentioned by 8 users (4.2%)

Based on user experiences from 191 Synthroid reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

tiredness 17.3%
hair loss 14.1%
depression 13.6%
fatigue 12.6%
weight gain 12.6%
anxiety 8.4%
insomnia 5.8%
brain fog 4.2%
joint pain 4.2%
pain 4.2%

Reviews for Synthroid

Commonly mentioned side effects
  • Paw...
  • Taken for 2 to 5 years
  • April 18, 2018

For Hashimoto's disease "Had my thyroid removed 2 years ago. Was put on Synthroid and have felt terrible ever since. Weight gain, joint and muscle pain, blurred vision, tremors, hair loss, constipation, irregular heartbeat, stomach problems, and the list goes on. Doctor tells me my numbers are fine, and I should be put on an antidepressant. Really. That's because they don't know enough about thyroid disease and keep pushing the drugs. This drug is next to poison, but no one listens to us. We are held hostage to these doctors that don't care. Where do we turn to because we are suffering. Help!"

1 / 10
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136 Report
  • miz...
  • December 30, 2016

For Hypothyroidism, After Thyroid Removal "I ended up with an emergency complete thyroidectomy after an ultrasound revealed the tumors (2 in each lobe of my thyroid) had grown and were the culprit for me having to turn my head to the left to swallow food or even drink liquid. After years of taking levothyroxine, I was put onto the brand name Synthroid. At worst, my levels were 86.4. Yes, you read that correctly. My hair falls out in clumps, I feel tired, exhausted, have body aches and joint pain, and chronic fatigue, etc. Now my routine is to take my Synthroid at bedtime with vitamin C. I wake up fine, I'm down from 325 to 181, and I feel great! Please remember your thyroid takes weeks/months to change, you won't notice anything three days to a month into taking this."

10 / 10
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67 Report
  • Ale...
  • June 14, 2019

For Hypothyroidism, After Thyroid Removal "I have been on a roller coaster ride for the last 3 to 4 years. Every time my levels are checked, they come back off. I had been on Levoxyl 100 for years and don’t recall having any issues. Due to a health insurance change, I was switched to levothyroxine 100 and problems started happening. On levothyroxine 100, my levels would be out of whack, and the doctors switched the dosage to 112, and I thought I was dying. Within a couple of days, my joints, back, neck, and feet would ache. I started getting palpitations, it felt like I was having a heart attack. I ended up in the ER because of a fast heart rate and heaviness and numbness on the left side of my body. Doctors thought I was having a stroke. I was switched to Syntheroid 100. 6 days on it. I have such bad pain throughout my body and joints. My legs feel as if they are swelling. I have tried Armour and immediately developed double vision and dizziness. I have stomach issues and gluten sensitivity."

2 / 10
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40 Report

Frequently asked questions

  • Aya...
  • December 6, 2017

For Underactive Thyroid "I used Synthroid (25, 50, or 75) for over more than 10 years, but had to use the original, not the generic, because the generic does not work in some people. I've not been operated on, but for over 2 years, I've been using NatureThroid (32.5) instead, which was recommended by my ND, and I have to say that all my side effects that Synthroid caused had gone. I almost lost all my hair and had terrible heartbeats, headaches, joint pains, etc. I do not have Hashimoto, and really don't know if it works for people with this condition, but I tried NatureThroid, and I am very happy with the results."

1 / 10
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41 Report
  • Ave...
  • Taken for 1 to 6 months
  • October 27, 2022

For Underactive Thyroid "I've been on this medication for a month. 50 mcg. It makes me so tired I can barely stay awake to work during the day. It makes it very hard to concentrate. I didn't have fatigue or brain fog before starting this medicine. It has improved my joint pains, itching, and the ringing in my ears."

4 / 10
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  • ann...
  • Taken for 6 months to 1 year
  • April 21, 2023

For Underactive Thyroid "I had a thyroidectomy after Hashimoto's for 20 years. I was on Synthroid for a year. Had severe joint pain and swelling in throat and abdomen (edema). I'm someone who never sweats, but on this med, that's all I did. Everyone said it was menopause, but since I switched to Levoxyl, that has stopped. Couldn't lose any of the 60 lbs I gained last year. It did get me to euthyroid, but I didn't feel it. Just started, so I hope Levoxyl will help me fit into my size 8s again."

2 / 10
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  • Dub...
  • Taken for 6 months to 1 year
  • January 26, 2015

For Underactive Thyroid "It's official! My levels are normal and my hair is no longer falling out. Joint pain is also gone."

10 / 10
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147 Report
  • Syn...
  • Taken for 2 to 5 years
  • November 13, 2022

For Hashimoto's disease "Currently on Synthroid 125 mcg, 22-year-old male. The medication does not get rid of symptoms, and I feel like death every day on it. Brain fog, joint pains."

1 / 10
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13 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.