Lupron and Sexual Dysfunction: What Users Say

• Len...
• July 13, 2016

For Prostate Cancer "Eight months into Lupron plus Casodex, and I am refusing the next three-month shot. PSA went from 5.7 to 0.2 to 0.1, and I am just finishing up nine weeks of radiation. GL scores were mostly 9's, but no metastatic found. To say a less common side effect is loss of libido is just plain BS. About a month after the first shot, I was done with sex. The doctor said once the testosterone is gone, that's normal. Little aches and pains linger, my testicles shrink, I lost all hair under my arms and it's slow-growing elsewhere. Sometimes I seem to be in a fog mentally. Hot flashes like you wouldn't believe until they offered me other meds, which help somewhat. I put on five pounds of blubber below the belly. Lack of energy as well. It works, but I think doctors keep you on it too long for stage 1 or 2 cancers."

• Fly...
• Taken for 5 to 10 years
• January 13, 2017

For Prostate Cancer "At age 60, biopsy showed prostate cancer, PSA was 10. Had it out. After it was out, PSA was still ten. Started Lupron, and PSA dropped to 0 for two years. Then my doc suggested I go without the Lupron... I did for 8 months, and my PSA climbed to 4. Back on Lupron, and it dropped to zero. Did Lupron for another year, then went off of it again. Why? The side effects: bad arthritis, hot flashes, weight gain, 30 lbs in the first two months, then no more. No libido, and everything shrinks. No body hair. It was a joy to get off that stuff for a while, but my PSA started climbing again. Now back on Lupron, but no change in PSA. Went to a monthly shot, my PSA stayed at 4. Added Casodex, grew boobs, really bad. My PSA is now 2. I've been fighting cancer now for 6 years."

• Eti...
• October 31, 2015

For Prostate Cancer "Stage 2B prostate cancer. Proton beam therapy coupled with six months on Lupron. Dreaded getting the second 3-month shot. Side effects: Almost total loss of libido and sexual function within 30 days-lasting for several months post-usage; debilitating hot flashes (2X/hour, 24/7); 15 pounds of weight gain; 50% increase in cholesterol under the same diet; dangerous liver impact (GGT > 130) without alcohol use; significant breast growth."

• dOC...
• Taken for 1 to 6 months
• February 13, 2017

For Prostate Cancer "Hot sweats were the thing most mentioned and most noticeable. My apologies for lack of empathy to all those who I've known going through them. Muscle mass loss and decreased exercise tolerance. My total weight lifted in a usual workout fell to about 1/3. Dry scaling skin and increased dry hair. However, my creeping male pattern baldness was certainly less noticeable. Testicular size and libido took a hit."

• pos...
• Taken for 1 to 2 years
• February 6, 2016

For Endometriosis "I was diagnosed with stage 4 endometriosis after my first laparoscopy in June 2015. Following my first surgery, I started Lupron injections in hopes of slowing the endo growth. I had three rounds of Lupron causing terrible side effects, which included, but were not limited to: fatigue, night sweats, mood swings, joint pain, severe abdominal pain, lack of sex drive, natural lubrication, and anxiety. In December 2015, my second laparoscopy and six months of Lupron left me with stage 3 endometriosis. The doctor wanted to continue with six more months of Lupron and another surgery. I declined such an offer. I am very unhappy with how this drug affected my life. My body will never be the same after Lupron. Don't take this drug."

• Az-...
• Taken for 1 to 6 months
• May 29, 2020

"My prostate cancer was treated with radiation in 2003 but came back around 2013, and PSA has climbed all the way to 14.8 now in 2020, so thought it was time to try something. Lupron gave me horrible side effects, including severe hot flashes, about 2 every hour, 24/7, nausea, dizziness, tiredness, weight gain, constant urination, very low libido, etc. On the positive side, I only had one 3-month shot, and my PSA went from 14.8 down to 0.3, however, I am not going to take another shot and will see how it goes. Will try to eat and exercise better."

• any...
• Taken for 2 to 5 years
• December 2, 2024

For Prostate Cancer "I have been on Lupron for 20 months now, and it reduced my PSA from .64 to undetectable. The side effects for me have been hot flashes a couple of times a day, loss of body hair, 20 pounds of weight gain, and complete loss of my sexual function and appetite. I will be going off Lupron when this shot wears off in a couple of months. I have been receiving the 6-month shot. I am 67 years old and have high-risk prostate cancer, have had my prostate removed, and went through 38 rounds of radiation. I feel I am doing as well as can be expected and do everything I like to do minus my libido. Good luck to all!"

• Eag...
• Taken for 6 months to 1 year
• November 28, 2024

For Prostate Cancer "The 7 months of treatment I am on, along with 9 weeks of radiation, appears to be working well. My PSA (with stage 3 prostate cancer) went from 7+ to 0.05. That said, I am fighting brain fog, fatigue, slight weight gain, loss of sexual interest, nearly chronic dry cough, general itching, and joint and muscle pain. Looking forward to the product wearing off starting around 6 weeks from now. Strongly recommend resistance exercise, it helps a great deal!"

• Tom...
• June 16, 2016

For Prostate Cancer "Been on this drug for 15 months. No libido at all, day sweats, night sweats, and hot flashes, irritability, and erratic memory episodes. PSA from 30 to 0.01 after radiation and continues today."