Leqvio User Reviews & Ratings (Page 3)

• Let...
• Taken for 6 months to 1 year
• January 30, 2025

For High Cholesterol, Familial Heterozygous "Initial lowered cholesterol, but later injections, severe rash appeared many days later, size of lemon at injection site. Very sore, red, and itchy, lasting many weeks. Antihistamines helped, as well as cold compression."

• Sta...
• Taken for 6 months to 1 year
• March 14, 2024

For High Cholesterol, Familial Heterozygous "I could not take statins without side effects. Sore muscles, aching joints. I was crying at night, could not sleep. After using Leqvio for 2 doses, I don't even need to take any statins. I also changed the way I eat."

• Gui...
• Taken for less than 1 month
• October 19, 2024

For High Cholesterol "In 2022, I got my first Leqvio injection in the doctor's office. I loved the results, my HDL cholesterol went to normal for a long period of time. This is the only medicine my body tolerated without any secondary effects. I beg my doctors to please get me back on, they prescribe, but insurance declined, subject to a letter of necessity, but that fails to fulfill the purpose. The doctor's office claims they did submit insurance claims, they never got it. I still need this injection. I have conventional Medicare Part B and D."

• cla...
• Taken for 6 months to 1 year
• March 21, 2025

For High Cholesterol "I was unable to use statins because of serious, severe side effects. I have had 2 injections so far and have had zero side effects. Leqvio has lowered my cholesterol levels to normal with the 2 injections! I will be continuing with these injections as prescribed. Very happy with the results. I am 70 and a female."

• jeg...
• Taken for 6 months to 1 year
• February 22, 2025

For High Cholesterol "Hives and hand numbness approximately 2.5 weeks after the second shot -- in the arm that received the shot. Severe body aches gradually faded after the first shot in about 4 to 5 weeks. I am not far enough along from the second shot to know if/when the body aches will fade."

• Sus...
• November 24, 2024

For High Cholesterol, Familial Heterozygous "Within 45 days after my first injection of Leqvio, my lipids decreased significantly. I was pleasantly surprised and quite pleased with the results. I am currently receiving the injection every 6 months."

• rev...
• Taken for 1 to 6 months
• April 26, 2024

For High Cholesterol "The Leqvio injection was a brief stop at the cardiologist's office. Typical, brief shot in the back of the arm. Easy. They held me there for ~15 minutes to ensure no injection symptoms. The nurse administering the injection did it very well. No pain or discomfort. I don't have serum numbers yet so I am unable to speak to the effectiveness, but I wish all my meds could be this easy."

• Ano...
• Taken for 6 months to 1 year
• March 30, 2025

For High Cholesterol "My experience with Leqvio has been very good. My cholesterol went from 140 LDL to 50 LDL after the second shot. The shot was relatively painless, less than the flu shot. No side effects. I am a 61-year-old man who feels relieved not to have to take a statin every day."

• LWD...
• Taken for 2 to 5 years
• January 5, 2025

"Has lower overall count to < 110 and ratio is in range first time in life, received my 7th injection on November 24, but 3 days later dry skin patches popping out on my nose and around my mouth, on the sides of my head, back, and legs. Firmly believe Leqvio is the reason. Believe cholesterol is too low in my body and is having a negative impact on my immune system."

• Ano...
• Taken for 1 to 6 months
• July 21, 2025

For High Cholesterol "I was previously on Repatha for a year and began unbearable side effects, so I was changed to Leqvio. About 3 weeks after my first injection, I began having migraine headaches, intense neck and lower back/muscle pain, fatigue, chest pain, and purpura on my right arm. The symptoms are beginning to lessen now that I am three months in and due for my next injection, which I will not be taking. It did keep my cholesterol level down but not as well as while taking Repatha. My triglycerides raised considerably to a high level."

• Red...
• Taken for 1 to 6 months
• July 16, 2025

For High Cholesterol "Just had my 2nd infusion. First one, no issues besides tenderness in arm of injection. 2nd one, I received 2 days after being on a cruise/flying and all kinds of coughing people. Was OK when I went in, but the next morning felt lightheaded and like I had a horrible cold. Hubs started feeling sickly also, so I am not sure if we got some germs on our travel or if the Leqvio was my culprit. Lasted around a week. Onward, I take warfarin for a mechanical heart valve. On a substantial amount (17 mgs) but normally numbers do not change much. During the period of my first infusion, I needed to start adding more warfarin to my daily dosage. After my second infusion, I realized that the dates of my adding extra started in this time period. I have raised my numbers to 20 mg a day, I was on around 17 mg prior. Correlation? Who knows but will consult with the doctor at Mayo Clinic at the end of the month. Curious if anyone else has had these issues..."

• drc...
• Taken for less than 1 month
• May 7, 2025

For High Cholesterol "Started first injection 2 weeks ago. A week later, very loose bowels for three days. I don't have any muscle and joint pain like the statin drugs caused. But I am very fatigued during the day, my legs are weak. Even after sleeping 8 hours. But if it lowers my LDL and I don't have to have bypass surgery again, I can live with it. I plan on starting strength training with weights to see if I can counteract the fatigue, plus B12 supplement."

• Hal...
• Taken for 1 to 2 years
• July 30, 2025

For High Cholesterol "WEEK 1 1. Post-administration [SQ Abdominal Area] Pain at the injection site. 2. Moderate to severe tiredness [Lethargy] lasting 4 days. 3. Irregular heart rhythms [Atrial Tachycardia] [Sinus Tachycardia]. 4. Generalized muscle aches and pains [Specifically in Legs]. 1. Increased vertigo coupled with moderate headaches [Frontal headaches]. WEEK 2 2. Mild intractable nausea requiring OTC antiemetic drugs. 3. Painful muscle cramping [Specifically in Legs & Feet, Toes]. 4. Out of control blood glucose levels [Requiring introduction of Insulin]. WEEK 7 1. Urinary urgency [Specifically at night]. 2. Painful hands, burning sensations in tendons of digits [Fingers]. 3. Cough with constant production of thick mucus [Bronchitis]. 4. Weakness in lower extremity [Legs]. WEEK 12 1. Frequent onsets of sudden severe vertigo and leg weakness. 2. Continued out of control blood glucose levels [Requiring higher doses of Insulin]."

• Wil...
• Taken for 6 months to 1 year
• March 13, 2025

For High Cholesterol, Familial Heterozygous "The side effects listed are about right. Had some periods of dizziness too. I have had bouts of big-time fatigue, and I think that is a result of the Leqvio. The side effects are aggravating, but in general, are worth it for the results."

• Fra...
• Taken for 6 months to 1 year
• January 28, 2025

For High Cholesterol "I am 76 years old and female and eat a heart-healthy diet. I am scheduled for a 3rd injection in March. To begin with, my cholesterol levels were not much over the suggested limits, but since I have hereditary high blood pressure and a family history of heart attacks, Leqvio was prescribed. I didn't want to take another prescription pill since I was already taking 5 (3 for high blood pressure, 1 for thyroid, and 1 for acid reflux). I preferred an injection 2 times a year. It is given in the fat of the arm, not the muscle, so uncomfortable side effects were minimal and brief. The only other possible side effect was cramping from my calf to my foot, mostly at night. This subsided after about a month. My bad cholesterol dropped significantly, and my good cholesterol remained very good. Although it does mean another trip to the doctor's office for the nurse to give the injection, it is very quick."

• OCD...
• Taken for 1 to 6 months
• August 8, 2025

For High Cholesterol "Overall good experience with this drug, not had any side effects, I did lose a bit of weight but that's mainly because I went on a low fat low carb diet. The only complaint I have is regarding the area where the needle and the medication go in... it's a bit painful and bruised for a couple of days. Second jab done today hope it does its job and I'll be taken off it in the near future."

• Leq...
• Taken for 1 to 6 months
• February 20, 2025

For High Cholesterol "Nothing seemed to work to lower my cholesterol to acceptable levels, but using Leqvio along with a statin and ezetimibe brought my total cholesterol to 126. I have had no side effects from Leqvio. My only criticism is the cost."

• Div...
• Taken for 1 to 6 months
• March 15, 2023

For High Cholesterol "I am having the most severe muscle pain and tight muscles I have ever had since I have been on Leqvio. Has anyone else had this?"

• Anonymous
• Taken for 1 to 6 months
• May 8, 2023

For High Cholesterol "Side effects, hives, itching, pain with urination, headaches, dizziness, blurred vision, and sweating."

• Sus...
• Taken for 1 to 6 months
• May 25, 2023

For High Cholesterol, Familial Heterozygous "Have had significant hair loss. Pain in legs and knee joints. Both knees have cartilage and meniscus damage, with no previous history of knee injury or knee-related issues."

• Eli...
• Taken for 6 months to 1 year
• April 3, 2024

For High Cholesterol "About a month after Leqvio shot, I get heartburn, nausea, belly cramps, fatigue. Numbers are good, but not liking the side effects. Anyone else having similar issues?"

• San...
• September 4, 2024

For High Cholesterol "Two weeks after the first injection, I developed pain in my hips, lower back, ankles, feet, hands, including toes and fingers, burning with urination, burning in my eyes, fatigue, and headaches."

• rog...
• Taken for 6 months to 1 year
• May 19, 2024

For High Cholesterol "Not sure if this is related to Leqvio or not, however, since beginning the Leqvio regimen I have experienced an increased level of muscle and joint pain and reduced mobility."

• Eli...
• Taken for 1 to 2 years
• May 22, 2024

For High Cholesterol "Had high hopes, but too many gastrointestinal side effects. Also muscle pain and stiffness. Lowers cholesterol but 2 months after the shot, I still have side effects."

• Dav...
• Taken for 1 to 6 months
• August 6, 2023

For High Cholesterol "Leqvio works very well to lower the LDL cholesterol, but I am having substantial weakness in my legs. No other side effects. Would hope there is some way to eliminate the weakness."