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Leqvio User Reviews & Ratings (Page 3)

Leqvio has an average rating of 7.3 out of 10 from a total of 80 reviews on Drugs.com. 51% of reviewers reported a positive experience, while 5% reported a negative experience.

Reviews for Leqvio

Commonly mentioned side effects
  • Sus...
  • November 24, 2024

For High Cholesterol, Familial Heterozygous "Within 45 days after my first injection of Leqvio, my lipids decreased significantly. I was pleasantly surprised and quite pleased with the results. I am currently receiving the injection every 6 months."

9 / 10
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2 Report
  • Let...
  • Taken for 6 months to 1 year
  • January 30, 2025

For High Cholesterol, Familial Heterozygous "Initial lowered cholesterol, but later injections, severe rash appeared many days later, size of lemon at injection site. Very sore, red, and itchy, lasting many weeks. Antihistamines helped, as well as cold compression."

6 / 10
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1 Report
  • LWD...
  • Taken for 2 to 5 years
  • January 5, 2025

"Has lower overall count to < 110 and ratio is in range first time in life, received my 7th injection on November 24, but 3 days later dry skin patches popping out on my nose and around my mouth, on the sides of my head, back, and legs. Firmly believe Leqvio is the reason. Believe cholesterol is too low in my body and is having a negative impact on my immune system."

7 / 10
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1 Report

Frequently asked questions

  • jeg...
  • Taken for 6 months to 1 year
  • February 22, 2025

For High Cholesterol "Hives and hand numbness approximately 2.5 weeks after the second shot -- in the arm that received the shot. Severe body aches gradually faded after the first shot in about 4 to 5 weeks. I am not far enough along from the second shot to know if/when the body aches will fade."

8 / 10
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0 Report
  • cla...
  • Taken for 6 months to 1 year
  • March 21, 2025

For High Cholesterol "I was unable to use statins because of serious, severe side effects. I have had 2 injections so far and have had zero side effects. Leqvio has lowered my cholesterol levels to normal with the 2 injections! I will be continuing with these injections as prescribed. Very happy with the results. I am 70 and a female."

10 / 10
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  • Wil...
  • Taken for 6 months to 1 year
  • March 13, 2025

For High Cholesterol, Familial Heterozygous "The side effects listed are about right. Had some periods of dizziness too. I have had bouts of big-time fatigue, and I think that is a result of the Leqvio. The side effects are aggravating, but in general, are worth it for the results."

9 / 10
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  • Ano...
  • Taken for 6 months to 1 year
  • March 30, 2025

For High Cholesterol "My experience with Leqvio has been very good. My cholesterol went from 140 LDL to 50 LDL after the second shot. The shot was relatively painless, less than the flu shot. No side effects. I am a 61-year-old man who feels relieved not to have to take a statin every day."

10 / 10
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More FAQ

  • fem...
  • Taken for less than 1 month
  • April 19, 2025

For High Cholesterol, Familial Heterozygous "First of all, I see a functional dietitian. Following a strict diet, regular exercise, and taking magnesium, vitamin D, vitamin K, I was able to drop 20 lbs in a year. My starting cholesterol was 315 and with a low-fat, no seed oil, higher protein diet, I was able to get my cholesterol down to 235. My LDL-C was 170. CA score of 165. So here I am, I had my first shot of Leqvio. Side effects are exhaustion, headaches, and foot and hand cramps. Extra water and magnesium seem to help."

5 / 10
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  • Fra...
  • Taken for 6 months to 1 year
  • January 28, 2025

For High Cholesterol "I am 76 years old and female and eat a heart-healthy diet. I am scheduled for a 3rd injection in March. To begin with, my cholesterol levels were not much over the suggested limits, but since I have hereditary high blood pressure and a family history of heart attacks, Leqvio was prescribed. I didn't want to take another prescription pill since I was already taking 5 (3 for high blood pressure, 1 for thyroid, and 1 for acid reflux). I preferred an injection 2 times a year. It is given in the fat of the arm, not the muscle, so uncomfortable side effects were minimal and brief. The only other possible side effect was cramping from my calf to my foot, mostly at night. This subsided after about a month. My bad cholesterol dropped significantly, and my good cholesterol remained very good. Although it does mean another trip to the doctor's office for the nurse to give the injection, it is very quick."

10 / 10
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  • Leq...
  • Taken for 1 to 6 months
  • February 20, 2025

For High Cholesterol "Nothing seemed to work to lower my cholesterol to acceptable levels, but using Leqvio along with a statin and ezetimibe brought my total cholesterol to 126. I have had no side effects from Leqvio. My only criticism is the cost."

10 / 10
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  • Div...
  • Taken for 1 to 6 months
  • March 15, 2023

For High Cholesterol "I am having the most severe muscle pain and tight muscles I have ever had since I have been on Leqvio. Has anyone else had this?"

4 / 10
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123 Report
  • Anonymous
  • Taken for 1 to 6 months
  • May 8, 2023

For High Cholesterol "Side effects, hives, itching, pain with urination, headaches, dizziness, blurred vision, and sweating."

1 / 10
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69 Report
  • Sus...
  • Taken for 1 to 6 months
  • May 25, 2023

For High Cholesterol, Familial Heterozygous "Have had significant hair loss. Pain in legs and knee joints. Both knees have cartilage and meniscus damage, with no previous history of knee injury or knee-related issues."

4 / 10
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48 Report
  • Eli...
  • Taken for 6 months to 1 year
  • April 3, 2024

For High Cholesterol "About a month after Leqvio shot, I get heartburn, nausea, belly cramps, fatigue. Numbers are good, but not liking the side effects. Anyone else having similar issues?"

7 / 10
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28 Report
  • San...
  • September 4, 2024

For High Cholesterol "Two weeks after the first injection, I developed pain in my hips, lower back, ankles, feet, hands, including toes and fingers, burning with urination, burning in my eyes, fatigue, and headaches."

2 / 10
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14 Report
  • Dav...
  • Taken for 1 to 6 months
  • August 6, 2023

For High Cholesterol "Leqvio works very well to lower the LDL cholesterol, but I am having substantial weakness in my legs. No other side effects. Would hope there is some way to eliminate the weakness."

10 / 10
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24 Report
  • Eli...
  • Taken for 1 to 2 years
  • May 22, 2024

For High Cholesterol "Had high hopes, but too many gastrointestinal side effects. Also muscle pain and stiffness. Lowers cholesterol but 2 months after the shot, I still have side effects."

7 / 10
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14 Report
  • rog...
  • Taken for 6 months to 1 year
  • May 19, 2024

For High Cholesterol "Not sure if this is related to Leqvio or not, however, since beginning the Leqvio regimen I have experienced an increased level of muscle and joint pain and reduced mobility."

6 / 10
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15 Report
  • Mlh...
  • Taken for 1 to 6 months
  • March 12, 2023

For High Cholesterol, Familial Heterozygous "I had a terrible reaction to Repatha, so I requested Leqvio. I had my first dose 3 months ago, and I haven't had any problems with it at all. I have my second dose scheduled in another 2 weeks."

10 / 10
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25 Report
  • L h...
  • Taken for 6 months to 1 year
  • May 28, 2024

For High Cholesterol "It has lowered my LDL. However, I have noticed that my skin started to wrinkle a great deal after my third shot. Has anyone else experienced this symptom? It is my only adverse reaction."

8 / 10
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12 Report
  • Anonymous
  • Taken for 6 months to 1 year
  • May 6, 2023

For High Cholesterol "Took first dose in October 2022. Bad cholesterol was 105. Second dose in January. Bad cholesterol was 45 in February. Cardiologist was amazed!! Feel much better this summer."

10 / 10
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16 Report
  • Anonymous
  • Taken for 1 to 6 months
  • January 13, 2025

For High Cholesterol "After my first injection, all seemed fine, but two weeks in I have arthralgias of the fingers and severe constipation, dry lips."

4 / 10
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3 Report
  • Mar...
  • Taken for 6 months to 1 year
  • April 18, 2024

For High Cholesterol "Leqvio helped me lower my cholesterol levels significantly. I cannot take statins because of the bone and muscle pain. However, I have bone and muscle pain even with taking Leqvio."

9 / 10
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6 Report
  • Fre...
  • Taken for 2 to 5 years
  • June 29, 2024

For High Cholesterol, Familial Heterozygous "Have just received my 4th injection. Further to my May '23 post. Cholesterol has remained low, slight muscle pain continues, believe it has contributed to some hair loss. Feel overall more energetic."

9 / 10
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5 Report
  • Jay...
  • Taken for 1 to 6 months
  • September 5, 2024

For High Cholesterol "Painful joints when moving around after sitting. Troublesome cough. Feeling nauseous frequently, especially in the morning before breakfast."

7 / 10
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4 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.