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Guselkumab and Headaches: What Users Say

Brand names: Tremfya

Headaches: mentioned by 4 users (3.7%)

Based on user experiences from 108 Guselkumab reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

joint pain 9.3%
pain 6.5%
fatigue 5.6%
itching 4.6%
chills 3.7%
headaches 3.7%
tiredness 3.7%
cough 2.8%

Reviews for Guselkumab

Commonly mentioned side effects
  • LC8...
  • Taken for 6 months to 1 year
  • October 4, 2019

For Psoriasis "Been on Tremfya for about a year now. I had some form of psoriasis on about 80% of my body before I began treatment. After the first injection, I had 70% clearer skin and 100% after the second. The needle is tiny, and it is really easy to give myself the injection with little to no discomfort. No joint pain, I have hypothyroidism, so I cannot comment on the fatigue side effects as I am always tired anyway. Did have minor headaches for a couple of days after injections. Loved the drug, but within the last month, I have started developing plaques on my scalp and elbows again. Sad doesn’t even begin to describe my emotions. I have another 4 weeks until my next injection, so we’ll see what happens. Heading back to the dermatologist if my symptoms worsen after that."

6 / 10
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19 Report
  • JCJ...
  • Taken for 1 to 2 years
  • March 16, 2022

For Plaque Psoriasis "Switched from Siliq to Tremfya due to insurance issues... not by choice. Tremfya, by far, the worst-performing injection. Psoriasis spots reappeared on my legs, so my derm prescribed a topical. Hadn't used topicals in years. The worst part: upper respiratory infections galore. Four in 2 months, with the most recent this week resulting in an ear infection requiring antibiotics. Head and body aches common with Tremfya as well. Not a good medicine for me at all."

2 / 10
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4 Report
  • Jul...
  • Taken for 1 to 6 months
  • May 14, 2025

For Psoriatic Arthritis "I have had 4 injections of Tremfya so far. It has cleared up the psoriasis, self-injections easy peasy. I have had headaches a couple of times a day that started after the 3rd injection. Side effects for me have been headaches off and on, feeling cold all the time, increased pain in my arches and back. It has made me put on shorts for the first time in 4 years (my legs were completely covered in plaques). It has boosted my confidence."

7 / 10
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0 Report

See also:

Frequently asked questions

  • sid...
  • Taken for 1 to 6 months
  • February 15, 2023

For Psoriatic Arthritis "Junk. Feel very lethargic...drains your soul. Headaches."

3 / 10
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8 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.