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Guaifenesin and Insomnia: What Users Say

Brand names: Mucinex, Mucinex Maximum Strength, Humibid, Breonesin, Tussin Expectorant, Robafen, Family Meltus Chesty Coughs, Fenesin, Guaiatussin, Organ-1 NR, Scot-Tussin Expectorant, Guiatuss, Altarussin, Diabetic Tuss, Guiadrine G-1200, Xpect, Junior Meltus Chesty Coughs with Catarrh, Dristan Chesty Cough Guaiphenesin, Benadryl Chesty Forte, G Bid, Ganidin NR, Humibid Pediatric, Mucinex Children's Chest Congestion, Guaibid-LA, Aquamist, Amibid LA, Mucobid-LA, Guaifenex LA, Fenex-LA, Rompe Pecho EX, Guaifenesin LA, Humavent LA, Guiacough, GG 200 NR, Glytuss, Anti-Tuss, Diabetic Expectorant, Allfen Jr, Genatuss, Siltuss DAS, Gua-SR, Humigen LA, Altorant, Duratuss G, Robitussin Mucus + Chest Congestion, Guaifenex G, GG-Cen, Benylin E Calmylin Expectorant Siltussin DAS-NA Balminil Expectorant Drituss G Beechams Veno's for Kids Chesty Cough Junior Meltus Colour and Sugar Free Expectorant Help I Have Chest Congestion Bidex-400 Humibid E Fenesin IR Hill's Balsam Chesty Cough Beechams Veno's Expectorant Lemsip Cough Chesty Dristan Chesty Cough Mucinex for Kids Guaifen NR Buckley's Chest Congestion TabTussin 400 Siltussin DAS Diabetic Tussin Mucus Relief Refenesen Chest Congestion Relief Bronchoril Hytuss Mucaplex Tussin Mucus + Chest Congestion Air Power Diabetic Tussin Chest Congestion Giltuss EX Expectorant Giltuss Children's EX Expectorant …show all brand names

Insomnia: mentioned by 6 users (2.0%)

Based on user experiences from 306 Guaifenesin reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

dizziness 4.9%
nausea 4.9%
cough 3.9%
drowsiness 3.9%
pain 3.6%
vomiting 2.6%
diarrhea 2.3%
headaches 2.3%
insomnia 2.0%
upset stomach 2.0%

Reviews for Guaifenesin

Showing 6 reviews tagged with "insomnia". Clear filters to view all 306 reviews.
Commonly mentioned side effects
  • Sar...
  • Taken for less than 1 month
  • March 4, 2014

Guaifenesin for Bronchitis "I took Mucinex for a bad case of bronchitis. It worked very well and I was finally able to stop coughing and start breathing again. The only problem was that it interfered with my sleep. I was awake most of the night and was not tired the next day. I had to quit taking it."

6 / 10
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140 Report
  • Cap...
  • May 15, 2016

Guaifenesin for Cough "I was suffering from a severe virus-caused sore throat with terrible coughing. My PCP advised me to take Mucinex but at substantially greater dosage than the package recommends. I did so for about 3-4 weeks. The medication did help relieve my coughing, but it interfered so badly with my sleep that I had to discontinue taking it. I notice that other people have experienced sleep problems with Mucinex. There should be a warning about this on the package label."

6 / 10
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49 Report
  • Anonymous
  • Taken for less than 1 month
  • May 7, 2015

For Cough "Initially, it seemed to work wonders, but I cough when I really do not need to do so. I cannot get any sleep, I am nervous, and I have been thinking I am going nuts! I am stopping it immediately. It clears up the mucus, but the side effects are horrible."

5 / 10
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11 Report

Frequently asked questions

  • tom...
  • Taken for less than 1 month
  • September 23, 2021

Guaifenesin "I took this for muscle pain and soreness, which is a common off-label use recommended by my doctor. While it was pretty effective for relaxing muscles, it caused very bad sleeplessness, even when taking an Ambien. I had to stop use, as insomnia made the muscle pain worse! Catch-22..."

3 / 10
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4 Report
  • Not...
  • November 30, 2010

For Cough "My doctor recommended Mucinex a year ago, and I tried it, and the results were like speed for me. I could not sleep while on this stuff. So I tried something else. Finally realized I cannot take anything with guaifenesin in it."

2 / 10
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10 Report
  • Bob...
  • September 21, 2011

Guaifenesin for Cough "Very effective for the sinus congestion and sinus drip. However, continuous use resulted in leg cramps at night. Interfered with sleep. Research says that it can reduce blood flow to legs."

4 / 10
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41 Report

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