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Guaifenesin and Headaches: What Users Say

Brand names: Mucinex, Mucinex Maximum Strength, Humibid, Breonesin, Tussin Expectorant, Robafen, Family Meltus Chesty Coughs, Fenesin, Guaiatussin, Organ-1 NR, Scot-Tussin Expectorant, Guiatuss, Altarussin, Diabetic Tuss, Guiadrine G-1200, Xpect, Junior Meltus Chesty Coughs with Catarrh, Dristan Chesty Cough Guaiphenesin, Benadryl Chesty Forte, G Bid, Ganidin NR, Humibid Pediatric, Mucinex Children's Chest Congestion, Guaibid-LA, Aquamist, Amibid LA, Mucobid-LA, Guaifenex LA, Fenex-LA, Rompe Pecho EX, Guaifenesin LA, Humavent LA, Guiacough, GG 200 NR, Glytuss, Anti-Tuss, Diabetic Expectorant, Allfen Jr, Genatuss, Siltuss DAS, Gua-SR, Humigen LA, Altorant, Duratuss G, Robitussin Mucus + Chest Congestion, Guaifenex G, GG-Cen, Benylin E Calmylin Expectorant Siltussin DAS-NA Balminil Expectorant Drituss G Beechams Veno's for Kids Chesty Cough Junior Meltus Colour and Sugar Free Expectorant Help I Have Chest Congestion Bidex-400 Humibid E Fenesin IR Hill's Balsam Chesty Cough Beechams Veno's Expectorant Lemsip Cough Chesty Dristan Chesty Cough Mucinex for Kids Guaifen NR Buckley's Chest Congestion TabTussin 400 Siltussin DAS Diabetic Tussin Mucus Relief Refenesen Chest Congestion Relief Bronchoril Hytuss Mucaplex Tussin Mucus + Chest Congestion Air Power Diabetic Tussin Chest Congestion Giltuss EX Expectorant Giltuss Children's EX Expectorant …show all brand names

Headaches: mentioned by 7 users (2.3%)

Based on user experiences from 306 Guaifenesin reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

dizziness 4.9%
nausea 4.9%
cough 3.9%
drowsiness 3.9%
pain 3.6%
vomiting 2.6%
diarrhea 2.3%
headaches 2.3%
insomnia 2.0%
upset stomach 2.0%

Reviews for Guaifenesin

Commonly mentioned side effects
  • cou...
  • December 6, 2010

Guaifenesin for Bronchitis "Made coughing a lot easier after feeling like I was going to die from the phlegm that was blocking my air passage. I didn't give it a full 10 because it gave me a slight headache and a bit numb/tingling feeling all over my body but nothing to be alarmed about. Oh my goodness what a difference. I can breathe and finally sleep knowing I'm not going to choke to death. Thank you Mucinex."

9 / 10
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116 Report
  • Sic...
  • June 9, 2013

Guaifenesin for Cough "I had a runny nose, blocked ears, headache, and sore throat with mucus. It's great! I took one pill and saw relief, so 4 hours later I took the second one. Now I am wide awake. It's almost 4 am. Take it earlier."

10 / 10
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66 Report
  • Bro...
  • January 30, 2013

For Bronchitis "When I was using it in cough syrup without measuring it, I sometimes got a headache. However, taking the recommended maximum dose of 6 tablets per day (that is, every 4 hours), I have had no side effects except for a bit of mental fuzziness. It really helps me to expectorate thick mucus. A great side benefit is not having to endure that horrible taste that guaifenesin has! Very inexpensive (less than 15 cents per day) and very helpful for non-productive cough!"

10 / 10
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16 Report

Frequently asked questions

  • Cha...
  • Taken for less than 1 month
  • August 31, 2018

For Cough "I used guaifenesin for mucus relief with a cough. I drank a full bottle of water with it and 30 minutes later, ate supper. At 12:30, I woke up with vomiting and severe diarrhea. Blood pressure went sky high (from a normal low). Headache and dizziness. I couldn’t eat for 2 1/2 days because of the nausea. Blood pressure went back to normal after 24 hours. I have used other cold medicines, and every one would make me at least slightly nauseous. I didn’t know they all contained this ingredient. This seems to be abnormal for this medicine, so I think I may be allergic."

1 / 10
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  • Kwe...
  • Taken for less than 1 month
  • October 16, 2016

For Cough "Not long after taking my first dose of extra-strength Benylin for a persistent cold/respiratory infection, I became so dizzy I couldn't stand up and had to lie down. I closed my eyes and nodded off and woke up a while later feeling a little woozy but not dizzy. My head hurt the rest of the day. It did seem to help bring up phlegm that afternoon. I think I would take a half dose next time."

7 / 10
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4 Report

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  • Sky...
  • December 29, 2022

Guaifenesin "When I first started using Mucinex, an oval-shaped pill, about seven years ago for cough congestion, they worked great. As the years progressed, whenever I had similar symptoms, Mucinex worked less and less. I switched to the liquid formula about three years ago with the same results. I am on day three of using Mucinex congestion and cough medicine. I will never take this medicine again because I feel a lot worse after starting it. I can't sleep because of excessive coughing that I didn't originally have, headache, which I rarely get, and nausea. Not worth it. I'll try home remedies the next time."

2 / 10
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  • Cho...
  • October 14, 2017

Guaifenesin for Bronchitis "I had tried this product in 2005, and it was not effective. So I gave it another chance to so-called redeem itself. Well, this is definitely not for me, it made me feel worse. I developed a headache."

1 / 10
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11 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.