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Guaifenesin Patient Tips

Written by C. Fookes, BPharm on Jul 7, 2017.

How it works

Guaifenesin increases the volume and reduces the viscosity (stickiness) of respiratory tract secretions. This makes coughing out these secretions easier.


  • Guaifenesin is used as an expectorant (promotes mucus secretion in the airways).
  • Use to relieve chest congestion occurring as a result of colds, flu, or allergies.
  • Makes coughs more productive. Guaifenesin will not stop coughing; however, coughing is important as it is the body's way to remove excess mucus.
  • Guaifenesin is generally well tolerated.


If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

  • Nausea and vomiting are the most commonly reported side effects; constipation, dizziness, headache, and rash are reported rarely. Side effects are generally mild at low dosages.
  • Do not use in children younger than 4.

Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. For a complete list of all side effects, click here.

Bottom Line

Guaifenesin is an expectorant that helps thin and remove mucus from the airways. It is generally well tolerated.


  • Guaifenesin does not need to be taken with food; however, it can be taken with food if it upsets your stomach.
  • Take exactly as directed by your doctor or on the label. Do not increase the dosage or take for longer than is recommended. Use a properly calibrated measuring spoon to measure liquid guaifenesin dosages.
  • Do not open, crush, break, or chew guaifenesin delayed-release capsules or tablets because this may cause too much of the drug to be released at once.
  • Drink extra fluids while you are taking guaifenesin to help loosen congestion and lubricate the throat.
  • Do not drive, operate machinery or perform other hazardous tasks until you know how guaifenesin affects you.
  • Protect guaifenesin liquid from light.

Response and Effectiveness

Some effects of guaifenesin should be noticed within 30 minutes of taking it orally; however, up to two days of regular dosing may be needed before the full effects are seen. Liquid guaifenesin lasts for approximately four to six hours. Delayed-release capsules or tablets last for up to 12 hours.


  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use guaifenesin only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that this information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. This drug information does not endorse drugs, diagnose patients or recommend therapy. It is an informational resource designed as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of this information. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2018 Revision Date: 2017-07-09 19:20:32