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Glipizide and Upset Stomach: What Users Say

Brand names: Glucotrol, GlipiZIDE XL, Glucotrol XL

Upset stomach: mentioned by 5 users (6.7%)

Based on user experiences from 75 Glipizide reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

diarrhea 13.3%
weight gain 9.3%
nausea 8.0%
upset stomach 6.7%
dizziness 5.3%
headaches 5.3%
tremors 5.3%
bloating 4.0%
stomach pain 4.0%

Reviews for Glipizide

Commonly mentioned side effects
  • CSm...
  • Taken for less than 1 month
  • October 23, 2014

For Type 2 Diabetes "I was originally on Metformin 500mg. It got to a point where my A1C was going up so my dr put me on 1000mg (1x in the morning and 1x with dinner). My stomach couldn't handle it. My blood sugar levels were up and down. So I asked my dr if I could try something else. She put me on 2.5mg Glipizide ER and I feel so much better on it! I don't have the stomach issues and my blood sugar levels are lower and more stable. I'm glad I switched to Glipizide! I won't know my A1C until December but I expect it to be much better."

10 / 10
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102 Report
  • Gam...
  • Taken for less than 1 month
  • October 2, 2014

For Type 2 Diabetes "After having a severe reaction to Metformin, the doctor put me on Glipizide. While I don't faint on this medication, the side effects have been horrible for me. My sugar does seem to be better after being high for so long, it's finally below 160 most of the time. However, I am severely dizzy and foggy-headed constantly, to the point I stopped driving. I also have a bad lower backache, nausea, and stomach upset any time I eat, blurry vision (I have perfect vision, so this bothers me), and I've noticed some changes in my emotional response to things as well, such as anger and a bit of depression - which I've never had. The effects have been bad enough that I've had to take off work several days in a row as well as miss school."

5 / 10
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63 Report
  • Sug...
  • Taken for less than 1 month
  • September 15, 2017

For Type 2 Diabetes "I just started using glipizide 5 mg 3 weeks ago in combination with metformin 1000 mg twice a day. It is a powerful medicine, as I noticed my sugar was 300, and 3 hours later, it was down to 100. My body was shaking, and my stomach was not feeling well. I was told to take medication and eat 30 minutes later, and then take metformin after the meal. Since my numbers didn't go much over 150, the doctor said we didn't need to up to the 10 mg a day she thought I would need after the 3 weeks. I was avoiding insulin and was prescribed glipizide, I realize I must start doing it without it. Just use one medication, or my stomach will suffer. I had a belly ache and later had to go to the toilet. I also have headaches and need more lotion since I am itchier."

10 / 10
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30 Report
  • Sug...
  • Taken for less than 1 month
  • September 15, 2017

For Type 2 Diabetes "I just started using glipizide 5 mg 3 weeks ago in combination with metformin 1000 mg twice a day. It is a powerful medicine, as I noticed my sugar was 300, and 3 hours later, it was down to 100. My body was shaking, and my stomach was not feeling well. I was told to take medication and eat 30 minutes later, and then take metformin after the meal. Since my numbers didn't go much over 150, the doctor said we didn't need to up to the 10 mg a day she thought I would need after the 3 weeks. I was avoiding insulin and was prescribed glipizide, I realize I must start doing it without it. Just use one medication, or my stomach will suffer. I had a belly ache and later had to go to the toilet. I also have headaches and need more lotion since I am itchier."

10 / 10
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30 Report
  • Day...
  • January 27, 2015

For Type 2 Diabetes "I have been a Type 2 diabetic since 2007. I take Glipizide, which is very effective at keeping my blood sugar levels down. But every day it gives me an upset stomach and diarrhea, which has me miserable. Just yesterday, I had to stop what I was doing and rush home to the toilet. Horrible! Just imagine having terrible stomach pains and diarrhea every day! It wasn’t until recently that I realized this was a side effect of the Glipizide. I thought it was from foods containing gluten that I have been eating. I had tried Metformin, and that is just as bad. I’m in the process of asking my doctor if there is something else I can take that won’t upset my stomach so much. Right now, I’m in between jobs but need to get back to work! It’s hard to"

8 / 10
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32 Report

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