Glipizide and Diarrhea: What Users Say

• Lef...
• June 24, 2020

For Type 2 Diabetes "I have type 2 diabetes; last year my HbA1c was 6.7. I was started on metformin and I had loose stools, liver problems and it wasn't even doing a great job for BG. I was then started on glipizide and I have no side effects and now HbA1c is 5.8"

• Mar...
• Taken for less than 1 month
• April 14, 2017

For Type 2 Diabetes "Four years ago, I tried Metformin for my type 2 diabetes and had a horrific reaction: severe fainting, stomach pains, diarrhea, cramps, and I discontinued it. I tried a second time a few weeks later and had the same horrific reaction. This week, I started Glipizide, and in five days, I see a drop in my insulin to 115 from 346 at the start of the week. NO pains, cramps, diarrhea, and I can't believe it. It feels like a miracle after my Metformin experience."

• big...
• April 16, 2011

For Type 2 Diabetes "I'm male, 52, and have been a diabetic for 11 years. For eight of those years, I was prescribed glipizide, and it worked very well for me in keeping my glucose levels under control. The only adverse side effect that I experienced was sensitivity to the sun and to my computer screen. Sunscreen lotion with SPF 30 protection solved that problem. A new PCP tried to switch me to metformin, but I was intolerant to that medicine (bloating and diarrhea)."

• Cla...
• Taken for 1 to 6 months
• December 12, 2017

For Type 2 Diabetes "I was diagnosed with type 2 diabetes 1.5 months ago. My A1C was 15.8, urine glucose over 500 (test max), and my first home blood glucose test was 577. My doctor had me start with one metformin 500 mg ER tablet a day for the first week, then two a day since then. I also was prescribed a 5 mg tablet of glipizide a day. My blood glucose has been in the 85-150 range the past month. I have modified my diet some. I did experience some diarrhea, though I am over it now."

• Fly...
• Taken for 5 to 10 years
• May 21, 2024

For Type 2 Diabetes "With Metformin, I had terrible kidney pain immediately as well as diarrhea. Have been taking Glipizide for 9 years, first 2.5 then after 5 years 5mg. BS runs about 112 and A1C 6.7. Beginning to have some early morning tremors and occasional shakes. Not sure if it's the Glipizide or not, so I'm researching new inexpensive drugs. I find some of these reviews downright scary! Not to mention expensive. I actually would recommend Glipizide."

• Day...
• January 27, 2015

For Type 2 Diabetes "I have been a Type 2 diabetic since 2007. I take Glipizide, which is very effective at keeping my blood sugar levels down. But every day it gives me an upset stomach and diarrhea, which has me miserable. Just yesterday, I had to stop what I was doing and rush home to the toilet. Horrible! Just imagine having terrible stomach pains and diarrhea every day! It wasn’t until recently that I realized this was a side effect of the Glipizide. I thought it was from foods containing gluten that I have been eating. I had tried Metformin, and that is just as bad. I’m in the process of asking my doctor if there is something else I can take that won’t upset my stomach so much. Right now, I’m in between jobs but need to get back to work! It’s hard to"

• Mis...
• Taken for 1 to 6 months
• March 7, 2025

For Type 2 Diabetes "I have been taking Glipizide ER 5 mg for about 2 months, added to Metformin 500 mg. No issues, other than a little diarrhea the first month. That has leveled off. It wasn't budging my numbers, though. I was running at 345 yesterday. Took 2 of the Glipizide ER 5 mg. My sugars this morning were at 125. Luckily, went to the doctor this morning, so he upped my new script to 10 mg for me to start once I run out of the current prescription, doubled up per his instructions. 2nd day, no real issues, but I guess a month out will be the real tell."

• hel...
• Taken for 2 to 5 years
• July 27, 2013

Glipizide for Type 2 Diabetes "I was put on Glipizide ER after having bad side effects from Metformin ER. Had the diarrhea with it. Have had no problems with Glipizide."

• Anonymous
• Taken for 2 to 5 years
• August 9, 2013

Glipizide for Type 2 Diabetes "I was on Metformin and had trouble with the diarrhea side effects. My doctor put me on Glipizide ER 10mg. It works great and I have no side effects. I also added Januvia to my therapy. My A1C is 6.4."

• Bad...
• Taken for less than 1 month
• February 29, 2020

For Type 2 Diabetes "I stopped my metformin and finally went to VA, and I told the doctor it gave me diarrhea, so he gave me glipizide, and now I am feeling better. I hope it stays this way."